Masterclass GUIDES
Extracellular Matrix (ECM) Products Cytal® Wound Matrix Urinary Bladder Matrix [UBM] Technology
Introduction
Keywords
This Masterclass Guide is a concise overview aimed at exploring the use of a clinically advanced product called Cytal® Wound Matrix in wound management solutions and how to incorporate this into your practice.
■ Cytal Wound Matrix ■ Extracellular Matrix Technology ■ Temporary Scaffold ■ Kick-start Effect ■ Wound Healing
What is Cytal® Wound Matrix? ■ Cytal® Wound Matrix stems from Urinary Bladder Matrix
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■ Chronic Wounds ■ Trauma Wounds ■ Acute Wounds ■ Wound Reconstruction ■ Angiogenesis
Figure 1: Cytal® Wound Matrix
(UBM) technology. It is a sterile, porcine-derived, naturally occurring extracellular matrix (ECM) scaffold that facilitates the management of complex wounds.
■ Integra's UBM technology provides an environment that
facilitates a remodeling process by the body resulting in the formation of site-appropriate tissue. This is tissue that closely resembles the original, both structurally and functionally1,2.
■ Cytal® Wound Matrix has been associated with a modified
inflammatory response: it provides an environment where the body is more likely to exhibit a higher ratio of M2 (proremodeling) to M1 (pro-inflammatory) macrophages, which may “kick-start” wound healing1-3.
■ Cytal® Wound Matrix has been designed for complex wounds. It is available in a range of layering configurations and sizes with varying resorption profiles which can be adapted to the wound being treated. Cytal® Wound Matrix is conformable to allow for close contact with the wound bed. The pre-fenestrated design supports effective fluid management and wound drainage.
How Does Cytal® Wound Matrix Work?
■ Cytal® Wound Matrix is appropriate for acute wounds (including
trauma wounds and second-degree burns) and chronic wounds, and may be used alone or concomitantly with the powder form.
Figure 2: Cytal® Wound Matrix is available in 4 pre-fenestrated layering configurations
Cytal® Wound Matrix supports wound healing and tissue deposition by providing a temporary collagen scaffold that facilitates cellular infiltration, supports angiogenesis1,3-5 and promotes rapid revascularization6-9. ■
Provides a structural scaffold: Cytal® Wound Matrix stems from porcine UBM, which is rich in collagen – a key structural protein in the human body. When applied to a wound, this threedimensional scaffold acts as a temporary framework where cells can adhere to the collagen VII of the matrix, migrate through the open, porous structure, and support the deposition of new tissue3,10,11.
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Supports a shift in the inflammatory response: Cytal® Wound Matrix provides a solution that enables a transition in wound environment from a pro-inflammatory state towards a proremodeling state1,2,12 to facilitate the formation of site-appropriate tissue.
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Mitigates the complexity of reconstructive surgery:6,7 Cytal® Wound Matrix facilitates rapid primary closure,6-8 may be used over exposed avascular structures6-8 and may support limb salvage6,8,13.
In contaminated wounds that have been cleaned and/or debrided, Cytal® Wound Matrix products have facilitated successful wound management14-16.
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Wound Masterclass - Vol 4 - July 2025