Masterclass GUIDES
Extracellular Matrix (ECM) Products Cytal® Wound Matrix Urinary Bladder Matrix [UBM] Technology
Introduction This Masterclass guide is a concise overview aimed at exploring the use of a clinically advanced product called Cytal® Wound Matrix in wound management solutions and how to incorporate this into your practice.
What is Cytal® Wound Matrix? ■ Cytal® Wound Matrix stems from the Urinary Bladder Matrix
(UBM) technology. It is a sterile, porcine-derived, lyophilized naturally occurring extracellular matrix (ECM) in a 2D sheet form that facilitates the management of complex wounds.
Keywords ■ Cytal® Wound Matrix ■ Extracellular Matrix Technology ■ Temporary Scaffold ■ Kick-start Effect ■ Wound Healing ■ Chronic Wounds
■ Trauma Wounds ■ Acute Wounds ■ Wound Reconstruction ■ Angiogenesis
Figure 1: Cytal® Wound Matrix
■ Integra's UBM technology is an ECM scaffold that supports
a transition of the host immune response from a scarringtype response to a remodeling response that facilitates deposition of vascularized, site-appropriate tissue, tissue that closely resembles the original tissue, both structurally and functionally1,2.
■ Cytal® Wound Matrix has been associated with a modified
inflammatory response: it provides an environment where the body is more likely to exhibit a higher ratio of M2 (proremodeling) to M1 (proinflammatory) macrophages, which may “kick-start” wound healing 1,2,4.
■ Cytal® Wound Matrix has been designed for complex wounds.
It is available in a range of layering configurations and sizes with varying resorption profiles which allow to adapt to the treatment to the targeted wound. Cytal® Wound Matrix is conformable to allow for intimate contact with the wound bed. Its prefenestrated design supports effective fluid management and wound drainage.
■ Cytal® Wound Matrix is appropriate for acute wounds
(including trauma wounds and second-degree burns) and chronic wounds and may be used alone or concomitantly with powdered collagen-based dermal matrices.
How does Cytal® Wound Matrix work? Cytal® Wound Matrix supports wound healing and tissue deposition by providing a temporary collagen scaffold that facilitates cellular infiltration, supports angiogenesis1,4,5,6 and modulates inflammation1,2,3. ■
Provides a Structural Scaffold: Cytal® Wound Matrix stems from porcine UBM Technology, which is rich in collagen – a key structural protein in the human body. When applied to a wound, this three-dimensional scaffold acts as a temporary framework where cells can adhere, migrate, and proliferate supporting the deposition of new tissue1,4,5,6.
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Features a collagen-based structure that supports the body's wound healing process and the deposition of site-appropriate tissue, with function and structure similar to normal tissue1,7-12.
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Modulates the Inflammatory Response: the host response to MicroMatrix® Dermal Repair Powder has been shown to quickly transition from an initial pro-inflammatory response toward a more proremodeling immune response1,2.
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Facilitates Cellular Proliferation and extracellular matrix Deposition: the presence of MicroMatrix® Dermal Repair Powder supports the proliferation of cells and production of new extracellular matrix (ECM) proteins1,3,13.
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Provides a Site for Vascular Ingrowth: the collagen scaffold allows for the migration and attachment of endothelial cells into the scaffold necessary for the formation of new capillaries, and integration into the existing blood supply1,3,13.
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Mitigates the Complexity of Reconstructive Surgery7,8 as it may be used over exposed avascular structures7,8 Cytal® Wound Matrix Facilitates rapid primary closure7,8,9 and may support limb salvage7,9,1.
Figure 2: Cytal® Wound Matrix is available in 4 pre-fenestrated layering configurations
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Wound Masterclass - Vol 4 - June 2025