Masterclass GUIDES
Extracellular Matrix Products MicroMatrix® Dermal Repair Powder Urinary Bladder Matrix [UBM] Technology
Introduction
Keywords ■ MicroMatrix® ■ Temporary Scaffold ■ Wound Healing ■ Acute Wounds ■ Kick - start effect
This Masterclass guide is a concise overview aimed at exploring the use of a clinically advanced product called MicroMatrix® Dermal Repair Powder in wound management solutions and how to incorporate this into your practice.
■ Chronic Wounds ■ Extra-Cellular Matrix Technology
■ Wound
Reconstruction
What is MicroMatrix®?
How does MicroMatrix® work?
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MicroMatrix® Dermal Repair Powder stems from the Urinary Bladder Matrix (UBM) technology. It is a sterile, porcine-derived, lyophilized naturally occurring extracellular matrix (ECM) in particle form that facilitates the management of complex wounds.
MicroMatrix® Dermal Repair Powder supports wound healing and tissue deposition by providing a temporary collagen scaffold that facilitates cellular infiltration, supports angiogenesis1,4,5,6 and modulates inflammation1,2,3.
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Integra's UBM technology is an ECM scaffold that supports a transition of the host immune response from a scarring- type response to a remodeling response that facilitates deposition of vascularized, siteappropriate tissue, tissue that closely resembles the original tissue, both structurally and functionally1,2.
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MicroMatrix® Dermal Repair Powder has been associated with a modified inflammatory response: it provides an environment where the body is more likely to exhibit a higher ratio of M2 (pro-remodeling) to M1 (proinflammatory) macrophages, which may “kick-start” wound healing1,2,4.
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MicroMatrix® Dermal Repair Powder is easy to apply and provides intimate contact with the wound bed. It is particularly relevant in irregular wounds, where it helps address challenging contours and geometries (uneven, tunneling, and undermined areas). It may be used as a powder or as a paste when mixed with saline solution, with no need to staple or suture. MicroMatrix® Dermal Repair Powder is appropriate for acute wounds and chronic wounds and may be used alone or concomitantly with other collagen-based dermal matrices.
Figure 1: MicroMatrix®
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Wound Masterclass - Vol 2 - September 2024
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Micromatrix®: Provides a Structural Scaffold: MicroMatrix® Dermal Repair Powder stems from porcine UBM Technology, which is rich in collagen – a key structural protein in the human body. When applied to a wound, this three-dimensional scaffold acts as a temporary framework where cells can adhere, migrate, and proliferate supporting the deposition of new tissue1,4,5,6.
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Features a collagen-based structure that supports the body's wound healing process and the deposition of site-appropriate tissue, with function and structure similar to normal tissue1,7-12.
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Modulates the Inflammatory Response: the host response to MicroMatrix® Dermal Repair Powder has been shown to quickly transition from an initial pro-inflammatory response toward a more pro-remodeling immune response1,2.
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Facilitates Cellular Proliferation and extracellular matrix Deposition: the presence of MicroMatrix® Dermal Repair Powder supports the proliferation of cells and production of new extracellular matrix (ECM) proteins1,3,13.
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Provides a Site for Vascular Ingrowth: the collagen scaffold allows for the migration and attachment of endothelial cells into the scaffold necessary for the formation of new capillaries, and integration into the existing blood supply1,3,13.
Figure 2: Clinical Wounds Suitable for MicroMatrix®
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