2005 MCRI Annual Report

Murdoch Childrens Research Institute

Murdoch c hildrens r esearch i nstitute

Murdoch Childrens Research Institute is a world class child health research institute that discovers ways to prevent and treat conditions affecting babies, children and adolescents, helping them lead happy, healthy lives.

Our team of more than 670 researchers, has created an international reputation for the institute. We are an independent, non profit organisation supported by government, corporate and private donors. We are affiliated with the University of Melbourne and based at the Royal Children’s Hospital in Melbourne.

Vision

• To be a major global contributor to the creation of knowledge that leads to improved children’s health Mission

• To obtain knowledge to improve the health of children in Victoria and around the world

Goal

• We aim to be one of the top five child health research institutes in the world

Objectives

We conduct globally competitive research that capitalises on our strengths across the disciplines of laboratory, clinical and public health research. We drive enterprise, initiative and cross disciplinary interaction by taking advantage of the clinical opportunities and insights provided by co location at the Royal Children’s Hospital.

Values

• Innovation

• Integrity

• Teamwork

• The excitement of discovery

Our history

Professor David Danks, with support from Dame Elisabeth Murdoch, Sir Jack Brockhoff and others, established the original Murdoch Institute in 1986. It quickly became a world class centre of genetics research and clinical genetics services.

In early 2000, under the leadership of Professor Bob Williamson, the Murdoch Institute and The Royal Children’s Hospital Research Institute merged to form the Murdoch Childrens Research Institute, with a broader focus in child health research. The clinical genetic services are now managed by Genetic Health Services Victoria – a wholly owned entity of MCRI.

In 2005, under the leadership of Professor Terry Dwyer, the institute underwent a major restructure, aligning our research groups into themes to consolidate activities to ensure we stay globally competitive. The restructure has seen the institute grow from having 40 to 60 research groups.

Key partners

chair M an’s report

In his first year of leadership, our director Professor Terry Dwyer AO MD MPH implemented significant strategic change to the structure in the Murdoch Childrens Research Institute. This has fostered continued growth and research successes which have led to improvements in child health.

Strategy & growth

The board worked closely with Terry Dwyer to drive a new strategic plan. The institute was restructured into six major research themes, each managed by a new leader and executive team.

Institute staff increased by one third to 670, and the number of researchers formally associated with the institute increased by 50 per cent to more than 900. This strong growth placed extra pressure on both management and funding, however the new structure improved operations through better communication and research collaboration. In addition there has been a greater emphasis on performance based allocation of internal funding and increased engagement of the Royal Children’s Hospital (RCH) clinicians in research.

We continued to enhance our key relationships with the RCH and the University of Melbourne’s Department of Paediatrics, to work together to improve child health.

Royal Children’s Hospital redevelopment

We strongly supported the Victorian Government’s decision to commit more than $800 million to building a new RCH on a site immediately to the west of the current hospital. The redevelopment includes provision for approximately 13,000 square metres of space for the institute, which is equivalent to the space we presently occupy.

However, our growth since the merger in 2001 and plans for future development will mean this will be inadequate by 2011, which will be when the new facilities are due to be completed. Consequently we are engaged in constructive dialogue with all involved to ensure that appropriate provision will be made for our expected requirements of about 30,000 square metres by 2011. Provision will also need to be made for growth beyond that time, if the new RCH campus is to fulfil the Victorian Government’s objective of being Australia’s “leading edge” paediatric facility.

Research funding

MCRI experienced further growth in research activities with income supporting research rising from $34 million to $40 million in 2005. Operating costs remained low with less than one per cent of total expenditure spent on fundraising and significantly less than 10 per cent spent on administration as a whole. Our total income from research grants increased to $27 million, which included more than $4.3 million in funding from the National Health and Medical Research Council. In a highly competitive environment, this increase reflected another very successful year in national and international applications for competitive peer reviewed grants.

In addition to the significant funding from governments, substantial extra funding is generated from philanthropic sources. Donation income increased by 22 per cent to more than $3.92 million, reflecting increasing recognition of the significance of our outcomes based research. This included a bequest of $1.5 million from the Estate of Joan Roxburgh, a generous and lasting legacy.

Institute board

Patricia Cross rejoined the board in 2005, after a two year absence. Patricia has more than 20 years of experience in international financial services and also serves on the boards of a number of major public companies. In late 2005 we also welcomed Suzi Carp to the board. Suzi has been a key member of our development board for more than two years and provided countless hours of pro bono advice to secure corporate and private support for the institute.

The institute receives invaluable help and guidance from many financial and other professionals, who donate their time and expertise to advisory and

board committees (refer to page 7). It would not be possible to manage the growth and development of the institute without their input, which is all given on a pro bono basis.

I would like to especially thank our patron, Dame Elisabeth Murdoch AC DBE, for her continued personal support throughout the year.

2005 was a year of strong growth and successful research and I look forward with confidence to a continuation of this track record in the years ahead.

Mr Laurence G Cox AO Chairman

Terry Dwyer awarded AO

Terry was awarded an Order of Australia for his service and dedication to medical research, particularly in the field of population health. The prestigious award recognised his important research in the 1990s that led to the prevention of a large proportion of SIDS deaths internationally. In Australia, SIDS deaths decreased from 500 to less than 100 babies per year following Terry’s research group’s finding that sleeping in the prone position increases the risk of SIDS.

board of directors

Directors bring to the board a diverse range of expertise across business and finance, health and research.

1. Chairman

Mr Laurence G Cox AO

Investment banker, director of various public and private companies and community groups

2. Deputy Chairman

Mr WH Hodgson

Formerly executive director and director of various private and public companies

3. Mr Martin Armstrong

Lawyer and a director of various public and private companies and community groups

4. Mr Anthony Beddison AO Chairman of the Royal Children’s Hospital

5. Professor Glenn Bowes

Stevenson Professor of Paediatrics, University of Melbourne

6. Mrs Janet Calvert-Jones AO Chairman of Herald & Weekly Times Pty Ltd, Chairman of the Tapestry Foundation Victoria

7. Mrs Suzi Carp

Director of River Capital, member of MCRI development board and other charitable foundations

8. Ms Patricia Cross

Board director of National Australia Bank and other private and public companies

9. Dr Tony Cull

Chief Executive Officer of The Royal Children’s Hospital

10. Professor Terry Dwyer AO MD MPH Director, Murdoch Childrens Research Institute

11. Ms Jane Fenton AM Director of Fenton Communications, Chair of The Victorian Health Promotion Foundation

12. Mr Peter Griffin

Investment banker and director of various public and private companies and community groups

13. Mrs Judy Paterson Director of Ace Radio Broadcasters

14. Professor Richard Smallwood AO

Chief Medical Officer for the Commonwealth of Australia

15. Professor Geoff Tregear Deputy Director of the Howard Florey Institute

board committees

Audit, Finance & Risk Management Committee

Chairman, Mr WH Hodgson

Mr Martin Armstrong

Mr Laurence Cox AO

Mr David Craig

Ms Anne Cronin

Professor Terry Dwyer AO MD MPH

Commercialisation/IP Committee

Chairman, Professor Geoff Tregear

Mr Martin Armstrong

Mr Andrew Baker

Ms Anne Cronin

Professor Terry Dwyer AO

Mr Ross McKenzie

Ms Sue Michelmore

Mr Bob Moses

Mr George Raitt

Professor George Werther

Genetic Health Services Victoria Board

Chairman, Professor Terry Dwyer

AO MD MPH

Professor Agnes Bankier

Professor Graeme Barnes

Mr Laurence G Cox AO

Mr WH Hodgson

Professor Stephen Holdsworth

Professor Finlay Macrae

Investment Committee

Chairman, Mr Peter Griffin

Mr Laurence G Cox AO

Mr David Craig

Mr Simon Dighton

Mr Ben James

Mr Dominic Leary

Mr Paul Martin

Mr Ian Miller

Mr John Nickson

Remuneration Committee

Mr Laurence G Cox AO

Mr WH Hodgson

Professor Richard Smallwood AO

Research Advisory Committee

Chairman, Professor Geoff Tregear

Professor Glenn Bowes

Dr Emily Banks

Dr Georgia Chenevix-Trench

Ms Anne Cronin

Dr Tony Cull

Professor Terry Dwyer AO

Dr Paul Ekert

Associate Professor Elizabeth Elliott

Professor Chistopher Fairley

Professor Nick Hoogenraad

Professor John Hopper

Professor Frank Oberklaid

Professor Brian Oldenburg

Professor George Patton

Professor Sheena Reilly

Associate Professor Andrew Sinclair

Associate Professor Euan Wallace

DEVELOPMENT BOARD

Provided strategic advice and direction for communications, development and events. Its purpose is to engage a new generation of supporters for MCRI.

More than 1,000 new friends have been introduced to the institute through the development board’s activities over the last few years, which include tours and special events.

In 2005, friendraising and fundraising events included a marquee at the Portsea Polo, a family picnic day at Cruden Farm and an art auction, which was the most successful event to date raising more than $200,000.

Profile raising initiatives included a multi million dollar advertising campaign in The Australian and substantial media coverage of development board events.

Thanks to the hard work and dedication of the development board and event organising committees, more than $500,00 and $1.2 million in pro bono support was leveraged for the institute.

Development Board

1. Chairman, Ms Jane Fenton AM

2. Ms Prue Brown

3. Ms Susannah Calvert-Jones

4. Ms Suzi Carp

5. Mr Antony Catalano

6. Dr Narelle Curtis

7. Ms Aimee Dean-Pritchard

8. Ms Alexandra Lowen

9. Mr Fraser Macvean

10. Ms Sarah Murdoch

11. Mr Jason Newman

12. Mr Ryan O’Hare

13. Mr Sam Patterson

14. Mr Angus Reynolds

DIRECTOR’S REPORT

In my first full year as director, I have continued to be impressed by the high calibre of our research and the passion of our researchers.

I have worked closely with the board and executive to put in place new structures, policies and procedures to ensure the institute contributes world class research to improve the lives of children, both here and internationally.

Organisational restructure

In mid 2005, the institute initiated a major restructure aimed at consolidating our research activities and ensuring we stay globally competitive. Following input from researchers, our research groups (including units, centres and clinical departments that conduct research) were assigned to six themes based largely on pre existing and potential research synergies:

• Critical Care & Neurosciences

• Early Development & Disease

• Healthy Development

• Infection, Immunity & Environment

• Laboratory & Community Genetics

• Musculoskeletal Disorders

The themes increase the critical mass of researchers working on related areas, to stimulate scientific collaboration, cooperation and discussion, and take advantage of the clinical opportunities and insights provided by co location at RCH.

Since restructuring, we have made significant operational improvements, including a new emphasis on performance based allocation of research funding and an increased engagement of clinicians – people who spend the bulk of their time working with patients at RCH, but who now also undertake research.

Executive committee

With the restructure came a new executive committee that includes the six theme directors, who have already made critical contributions. Other key contributors to the executive committee were director of operations, Anne Cronin, our recently appointed head of development, Narelle Curtis, our grants officer Julia Malone and Moira Clay, our new policy advisor whose appointment was a key step in being able to implement the significant changes to the way we work.

I would like to thank the outgoing associate directors Kerr Graham, John Hutson, Frank Oberklaid and George Patton for their exceptional contributions to the institute over the preceding five years.

ExECuTIvE COMMITTEE

Professor Vicki Anderson Critical Care & Neurosciences

A/Professor Andrew Sinclair Early Development & Disease

Professor Sheena Reilly Healthy Development

A/Professor Jonathan Carapetis Infection, Immunity & Environment

Professor Andy Choo Laboratory & Community Genetics

Professor John Bateman Musculoskeletal Disorders

Anne Cronin Chief Operating Officer

INvITED TO ATTEND

Dr Moira Clay Policy Advisor

Dr Narelle Curtis PR & Development Manager

Julia Malone Grants Officer

3. Julia Malone, Grants Officer

The new research building

Much of the work on our new 10-storey research building was completed in 2005. The $50 million project, substantially funded by Atlantic Philanthropies, is key to building and nurturing collaborative links between our researchers and clinicians. The concept behind the building was to bring together a significant part of our clinical, laboratory and public health research teams into close proximity with relevant clinical activities. In today’s world it is vital that clinicians and researchers are encouraged to share knowledge in order to hasten genuine medical progress. The building redevelopment was explicitly designed to achieve this.

Clinical research

Development of clinical research on the RCH campus is an ongoing priority, and maximises our advantage of being co located at the leading Australian pediatric hospital. During the year, each of the research themes actively engaged clinicians on the campus, including those who were already leading research activities and those seeking to develop active research. In addition, we collaborated with RCH and the university of Melbourne’s Department of Pediatrics to develop a model for a clinical research development office (CRDO) and we will recruit an eminent clinical researcher to work in this role in 2006. The new head of CRDO will provide leadership and mentoring to clinical researchers on campus.

Research income and grants

In 2005, our income rose to $52 million, while expenditure was $48.7 million. Our total income from research grants increased to $27 million. We were awarded more than $4.3 million from the National Health and Medical Research Council (NHMRC)

for the funding round for 2006. We were allocated 11 grants from NHMRC for PhD scholarships, the most we have ever received. The Australian Cancer Research Foundation generously awarded us $1 million to fund new laboratories for cancer research. The laboratories are to be located in the new research building so that our researchers will join clinicians caring for cancer patients and ensure we continue to save lives and improve care for very sick children.

Research outcomes

A new performance evaluation framework has been implemented to assess research performance across the institute. As the institute has strengths across the disciplines of laboratory, clinical and public health research, the framework was designed to recognise that research performance indicators will differ, depending on the nature of the research. Research publication output, peer reviewed competitive funding and non traditional indicators such as commercial, clinical and public health outputs of research activity will be assessed. The performance framework will be used by the evaluation committee chaired by Professor Geoff Tregear, to assess research performance across all themes. The committee will meet in 2006 to consider research performance information for 2005. The recommendations and feedback from the evaluation will inform future institute wide and theme based strategies to drive globally competitive research.

The annual report lists 544 peer reviewed publications (journal articles and book chapters), with 21 publications having an impact factor greater than 10 (as measured by the Web of Science Citation Index). This strong result, a substantial increase on last year, provided an early indication that we are moving towards our goal of increasing global competitiveness.

Research highlights

Our researchers continued to make important contributions to knowledge to improve children’s health in 2005. The research outcomes and highlights for each theme are detailed on pages 34–69.

Musculoskeletal Disorders: Achievements of particular note included the discovery of the enzyme that causes cartilage to be degraded in arthritis. This world first discovery was published in the prestigious Nature journal and offers great hope to arthritis sufferers both young and old, as a therapy can now be developed to prevent cartilage destruction.

Critical Care & Neurosciences: We investigated the long term impact of traumatic brain injury on children and found that children who were older at the time of injury recovered better than those who were younger at the time of injury. Our results indicated that residual problems occur in the areas affecting intellectual ability, attention and memory, which could result in academic, social and emotional difficulties.

Infection, Immunity & Environment: We conducted a major trial of a bird flu vaccine, to help prepare the nation against the threat of an influenza pandemic. The vaccine, produced by Australian pharmaceutical company CSL Limited, was tested in 400 healthy adults, aged 18 to 45 and was well tolerated by trial recipients.

Healthy Development: In an effort to help combat the obesity epidemic, we commenced a new program for GPs called Live, Eat & Play, which encourages overweight children and their families to work with GPs to set goals and strategies for a healthier lifestyle.

Early Development & Disease: We undertook a research study on the quality of life of intersex patients treated at RCH. The results showed that the unique holistic multidisciplinary approach used at RCH, including

early surgery, delivers optimal outcomes for these individuals and the approach is now being advocated internationally.

Laboratory & Community Genetics: Our internationally recognised mitochondrial research laboratory continued to act as the Australasian referral centre for the investigation of children’s mitochondrial disease, diagnosing more than 330 children with mitochondrial disease. The success of this laboratory is achieved through the close interaction of diagnostic service delivery and research.

Policy

A new policy advisor role was established and filled by Dr Moira Clay, to focus on developing strategic policies and advocacy activities. This role was vital in facilitating the process of restructuring into themes and developing key policies, including the performance evaluation framework. A new advocacy strategy was established and key principles on how research activities should be integrated into the new hospital developed.

PR & development

Based on an independent report, we reviewed our communications and fundraising programs, which resulted in an integration of fundraising with communications activities, an increased investment in fundraising and a restructure of the department including the employment of more staff. These changes aim to significantly increase income from development over next five years, maintain independent control of fundraising, maximise our unique opportunities and leverage our already well developed relationships.

We began to develop new policies and procedures to make our systems more efficient, to better manage our relationships and maximise results. Our data

management systems and processes were reviewed pro bono by KPMG, to ensure we develop accurate systems for capturing and tracking donation information.

Our development focus in 2005 was on capitalising on current activities, to maintain existing donation income, as well as continuing to introduce new supporters to the institute. We began to increase our focus on obtaining corporate support, through corporate sponsorship, pro bono and cause related marketing activities. We also launched the PuMA Lap, a new fundraising event aimed at the corporate market.

The development board had its most successful fundraising event to date, the Art for Science charity auction, which raised more than $200,000. Thanks to the development board’s contributions, more than $500,000 and $1.2 million in pro bono support was leveraged for the institute. Our ambassador Sarah Murdoch once again demonstrated her commitment through invaluable personal support, which helped to promote the institute and its work.

We produced high quality publications, including the annual report, various brochures and our quarterly newsletters. We liaised with other health, medical and research advocacy organisations, including Research Australia and Australian Society for Medical Research, to make research a higher priority in both the political and public domains.

Profile raising activities were also successful in 2005, with more than 350 news items and features in the media and a new advertising campaign, which was produced pro bono by The Australian and The Council Brand Communications Group.

Our students

In partnership with the university of Melbourne and RCH, we continued our commitment to nurturing

Professor Terry Dwyer AO MD MPH, Director

excellent medical researchers. Our students could one day be world leading medical researchers, so we provided them with the best opportunities for learning and development. We placed a strong emphasis on investing in student potential and encouraged a supportive, innovative and dynamic working environment, where students interact with senior scientists and clinicians, and where international benchmarking is standard practice.

Our postgraduate students association held seminars and retreats to improve the development of our PhD students by encouraging interaction between students and providing them with opportunities to share experiences and develop their academic and professional skills.

I anticipate that the restructure initiative and the plans for redevelopment, will lead to continued growth and success in the future for the Murdoch Childrens Research Institute and I look forward to working with the board, executive and our supporters to ensure our medical research helps children have happy, healthy lives.

Professor Terry Dwyer AO MD MPH Director

Obituaries

Vale Panos Ioannou (1951–2005)

It is still hard to believe that our dear friend and colleague Associate

Professor Panos Ioannou is no longer with us. Panos was a scientist who was dedicated to his research to improve treatment for those suffering from thalassaemia, ataxia and other genetic diseases.

From his childhood in London and Cyprus, he developed a commitment to excellence. After winning First Class Honours and publishing in top journals such as Nature, he moved from London u niversity to Nicosia to set up molecular gene testing for thalassaemia. His work became the model for the World Health Organization.

He was the first to make a human BAC library, used as the foundation for the Human Genome Project. He became head of the Cell and Gene Therapy research group at the Murdoch Institute in 2001 and together with his colleagues, Panos introduced new concepts that had a major impact on our approaches to molecular therapies for genetic diseases.

He was a man of passion, totally committed to his family, his countries (Cyprus, England and Australia) and his science. He is survived by his wife Athina and his children Ioannou, Andreas and Evagoras.

Vale Alan Barry Holt (1940–2005)

Barry began work at the old Royal Children’s Hospital in Carlton in 1957, first as a trainee and then as a qualified medical technologist.

He spent six years at the Adelaide Children’s Hospital as a senior medical laboratory technologist before a six year period in the united States as a research associate at the Johns Hopkins university School of Medicine. Barry came back to Australia in 1972 and loyally returned to the then Royal Children’s Hospital Research Foundation where he worked as chief technologist and then laboratory manager. He was the building and development manager at Murdoch Childrens Research Institute for the past five years.

Barry was a greatly loved staff member who contributed greatly to the social life as well as to work life of the Murdoch Childrens. He was the life of the party and we will all miss his friendliness, his jocularity, his font of knowledge, his warm heartedness and his never ending good humour. Barry’s spare time was filled with activities which saw him generously volunteer his time throughout the community and to his many family members and friends.

He is survived by his wife Margaret and his two sons, Greg and Michael.

Internal committees

CAREER GRANT COMMITTEE

Professor Graham Brown

Chairman

GENDER EquITy COMMITTEE

Dr Peter Farlie

Chairman

INSTITuTIONAL BIO SAFETy COMMITTEE

A/Professor Henrik Dahl

Chairman

MAJOR RESEARCH EquIPMENT COMMITTEE

Professor John Bateman

Chairman

OCCuPATIONAL HEALTH & SAFETy COMMITTEE

Marisa Fielding & Yvette Mueller

Chairs

SPACE COMMITTEE

Anne Cronin

Chairman

TRAINEE RESEARCH SCHOLARSHIP COMMITTEE

Professor Geoff Tregear Chairman

Staff list

DIRECTOR

Professor Terry Dwyer

AO MD MPH

Felicity Hewett

Executive Assistant to Director

Kylie Gilmartin

Executive Assistant to Director

ExECuTIvE

Anne Cronin

Chief Operating Officer

Professor Vicki Anderson

Theme Director

Professor John Bateman

Theme Director

A/Professor Jonathan

Carapetis

Theme Director

Professor Andy Choo

Theme Director

Professor Sheena Reilly

Theme Director

A/Professor Andrew Sinclair

Theme Director

POLICy

Dr Moira Clay

Policy Advisor

Sharon Anuku

Administrative Assistant

PuBLIC RELATIONS & DEvELOPMENT

Dr Narelle Curtis

PR & Development Manager

Alyssa Jones

Communications Coordinator

Tanya Hollis

Public Relations Officer

Helen Raschella

Administrative Assistant

Hana Thompson

Administrative Assistant

O R g ANISATIONAL Ch ART

Members

Stakeholders The Board Chairman Professor Laurence G Cox AO

Director Professor Terry Dwyer AO MD MPH PR & Development

Board Committees

Audit, Finance & Risk Management

Commercialisation & IP Development Board Investment Remuneration Research Advisory

Dr Narelle Curtis Policy

Executive Committee Internal Committees

Clinical Epidemiology & Biostatistics

Australian Paediatric Pharmacology Research Unit

Dr Moira Clay

Early Development & Disease

Theme Director

A/Professor Andrew Sinclair Cancer

Diabetes

Early Determinants of Child Health

Embryology

Genetic Hearing Research

Hormone Research Liver Research

Molecular Development Antisense Therapeutics Ltd

Infection, Immunity & Environment

Theme Director

A/Professor Jonathan Carapetis

Allergy & Immune Disorders

Clinical

Paediatrics & Therapeutics

Enteric viruses

Environmental & Genetic Epidemiology Research

Gut & Liver

Immunisation Research

Infectious Diseases & Microbiology

International Child Health

Intestinal Failure & Clinical Nutrition

Respiratory Diseases

Surgical Research

Musculoskeletal Disorders

Theme Director Professor John Bateman

Arthritis & Rheumatology

Craniofacial Research

Muscular Dystrophy

Oral Health Research

Orthopaedics & Gait Analysis (Gait CCRE)

Skeletal Biology & Disease

Laboratory & Community Genetics

Theme Director Professor Andy Choo

Cell & Gene Therapy

Chromosome & Chromatin

Research

Cytogenetic Research

Genetics

Education & Health Research

Genetic Health Research

Mitochondrial Research

Molecular Diagnostics Research

Public Health Genetics

Ethics

Healthy Development

Theme Director Professor Sheena Reilly

Alcohol & Drug use

Health Services

Healthy Communities

Public Health Hearing

Language & Literacy

Mental Health, Behaviour & Wellbeing

Obesity, Physical Activity & Nutrition

Physical Health & Development

Critical Care & Neurosciences

Theme Director Professor vicki Anderson

Academic Child Psychiatry

Anaesthesia & Pain Management

Child

Neuropsychology

Developmental Disability Research

Emergency Research

Haematology Research

Heart Research

Infant Mental Health

Neonatal Research

Neurorehabilitation research

Neuroscience Research

Otolaryngology

Paediatric Intensive Care

Medical Imaging Research

Chief Operating Officer Anne Cronin

Corporate Services

Building & Scientific Services

Finance

Grants Office

Graphic Design

Human Resources

Information Technology

Payroll

Information Technology

Purchasing

Occupational Health & Safety

Enabling Facilities

Bioinformatics

Disease Models

Tissue Culture

Flow Cytometry & Imaging

corporate report

Corporate services

The introduction of a theme based governance structure gave corporate services and the research enabling facilities an opportunity to review and consider the best means by which to support and improve the services we provide to our researchers.

Highlights

• Launched a web based grants management system designed and developed in house, to comprehensively track grant statistics and performance

• Together with the Bureau of Animal Welfare, IT and the disease model unit developed two web based systems for the mandatory tracking and reporting of animals used in medical research

• Developed and launched an online training module in compliance with the Office of the Gene Technology Regulator

• Introduced super choice

• Adopted international accounting standards

• Awarded employer of choice for women by the Equal Opportunity for Women Agency for the third consecutive year

Finance, payroll & purchasing Grant and other income has increased by more than 20 per cent over the past few years and our

total staff numbers reached 670 at the end of 2005. Our finance team has been required to draw on their skills and competencies in order to ensure that the institute continues to be managed to a high standard in this area. The restructure brought a major revision of our internal management reporting, in line with the establishment of an investment approach to the allocation of internal funding to research themes and groups. The introduction of the Australian equivalents of International Reporting Standards (AIFRS) required our staff to attend training programs to ensure they were fully conversant with the new standards, as the adoption of AIFRS for our large organisation was a substantial task.

Human resources & industrial relations

It was a busy year for the human resources (HR) team as the institute’s restructure necessitated the review of many internal processes. A number of new initiatives were also introduced, including transparent remuneration and a classification and promotion system (relating to both research and general appointments), which aligns with the institute’s new strategy and structure and provides greater clarity and consistency for staff. We continued to establish new policies to streamline standard HR processes, with a view to undertaking more developmental work. Andrea Frigo joined the HR team during the year as HR Officer. For the third consecutive reporting period, the institute was awarded ‘employer of choice for women’ by the

Equal Opportunity for Women Agency. The Agency evaluated the institute’s success in leading and managing diversity, our work life balance initiatives and our staff management practices. Only 116 organisations nationally were given this status.

Grants management

The grants office completed the installation of a new online grants management system. The database was designed in house by the grants office and the IT department to meet the institute’s specific needs of recording grant data, to help track grant statistics and performance. The database has the ability to:

• Highlight current and past grants by researcher, research theme or group

• Provide details of grant submissions per annum and success achieved

• Generate notices to researchers to assist them in meeting the requirements of funding bodies and grant award conditions such as progress and final reports

• Provide notice to the accounts department regarding outstanding invoices and payments required

• Confirm ethics requirements and approvals and completion of projects

The grants office is working closely with the executive committee to coordinate submission of grant applications across themes, assist with grant mentoring and provide additional data regarding research groups. With the proposed changes to the National Health and Medical Research Council’s structure and priorities in 2006, we provided updated information to researchers

concerning the new processes and procedures that will be required.

Information technology

As the institute continued to grow, greater demands were placed on our IT team, who were adept in managing the complexities of the new structure and the broad needs of our operations, research and business. One example was the need to upgrade and expand our network switch configuration, to resolve immediate networking bottlenecks. We also focused on building web based software for grants management and animal research reporting.

Risk management

Progress in the roll out of the risk management program advanced well following the adoption of a revised risk management framework and risk management policy by the Board. The framework provides a formalised and visible process to identify risk exposures and to provide explicit and positive assurance that these exposures are adequately controlled. A risk management steering committee was established to guide the introduction and ongoing refinement of the framework. Our staff received information on this process through the intranet and internal email bulletins. We will develop a risk register through which we expect to address all the risks faced by the institute, and from there move to a risk treatment plan. With the cooperation of the children’s cancer centre a pilot evaluation of group risks was performed, which assisted in the identification and ranking of risks. The next phase of the work will focus on controls and accountability.

1. Occupational Health & Safety, Yvette Muller

2. Commercialisation & Biotechnology, Ross Andrews

were conducted in a manner in which animal welfare was of the highest priority, to meet the principles of reduction, replacement and refinement. A representative from the Bureau of Animal Welfare visited to inspect all aspects of AEC operations, including committee records, investigator records and animal facilities. The representative was impressed by the high standards demonstrated and has recommended renewal of our licenses.

Institutional biosafety committee

The Institutional Biosafety Committee (IBC) continued to ensure that all work with genetically modified organisms was conducted in a manner that complied with the Office of Gene Technology Regulator Gene Technology Act and regulations. An online training module was developed and launched in late 2005 and three new laboratories attained accreditation.

Occupational health & safety

Occupational Health and Safety (OHS) training activities increased in 2005 with the implementation of several new training modules. A comprehensive emergency procedures training session is now presented to all staff at induction, and lab staff must also attend a more in depth safety induction prior to commencing work in the laboratory. Chemical and biological spill management training has been introduced. The number of elected and trained OHS employee representatives increased over the year, resulting in improved consultation in OHS issues, while the self-audit process implemented in 2004 continued to improve recognition of potential safety issues.

Animal ethics committee

In late 2004 MCRI was made responsible for the administration of the Animal Ethics Committee (AEC). In 2005, AEC endeavoured to ensure all projects

Commercialisation & biotechnology

2005 saw MCRI build upon its already impressive patent portfolio and continue to foster commercial collaborations within industry and academia.

Commercial activities

We filed a total of 16 national and international patent applications, an increase of 12 from the previous year. Three international patent applications were granted for commercial opportunities in the area of gene and stem cell research, gene diagnostics and molecular therapeutics. The Institute now manages an impressive portfolio of 11 national and international patents and 53 national and international patent applications in a diverse range of disciplines.

2005 was also a successful year for collaborations. A total of 23 commercial agreements were

finalised, which brought financial reward and further opportunities to expand the institute’s research capabilities. We remained focused in supporting commercial activities within the Institute. A new and improved commercialisation intranet page was launched to assist and educate staff and students on commercial matters. As well, the institute commenced a detailed commercialisation training program, provided by Consulting & Implementation Services. The 10 month training program, which will extend into 2006, provides up and coming researchers with the skills needed to identify, evaluate and develop commercial opportunities for the institute, now and into the future. We also focused on improving the ways we identify and evaluate commercial opportunities. In collaboration with Bio21, we commenced the Bio21 Opportunity Tree program, which, once developed, will provide the institute and others with a tool for assessing and quantifying the commercial potential of projects arising from research activities. We were also pleased to host and present at the Melbourne Commercialisation Professionals meeting in July.

We continued to develop our strong academic and commercial partnership with the Victorian Infectious Diseases Reference Laboratory (VIDRL). Market intelligence conducted by Teraform Advisory Pty Ltd provided valuable insight into the commercial potential of the Hepatitis B diagnostic technology (virTOL), a technology developed in collaboration with VIDRL and the institute. The institute is now well placed to capitalise on the increased market interest shown in 2005 for this unique monitoring technology.

POSSUM

The progression of the institute’s computer based syndrome diagnostic product POSSUM to a web platform has been very successful. Beta trials are

expected to commence in early 2006 at several sites nationally and internationally. Web Mac users will have access to the POSSUM program for the first time. It is anticipated that POSSUM Web will be launched at the International Congress of Human Genetics in Brisbane in August 2006. It will be available as an annual subscription. Plans are underway to develop a version that can be used on handheld devices.

Antisense Therapeutics Limited

As a founding research partner and leading shareholder of Antisense Therapeutics Limited (ATL), MCRI continued its strong collaboration with the Australian stock exchange listed company. 2005 saw the completion of laboratories and offices in the newly constructed research building and ATL are expected to relocate to these state of the art facilities in early 2006.

New patent applications

• Australian patent for a marker of arthritis

• Two United States patents for a novel treatment of Neuroblastoma

• Three International patent applications for the treatment of psoriasis

• Five International patent applications for the diagnosis of genetic deafness

• Five International patent applications for the diagnosis and treatment of Hepatitis B infection

Research enabling facilities

The research enablers support our research groups and themes by providing expertise in the areas of bioinformatics, disease models, tissue culture, flow cytometry and imaging, biostatistics and clinical trials.

Flow cytometry & imaging

The flow cytometry and imaging facility provides highly specialised cell sorting, analysis and imaging facilities to both internal and external researchers. The facility is equipped with an LSR II analytical flow cytometer and in 2005 purchased Leica TCS SP2 confocal microscope and MoFlo cell sorter. The new cell sorter will allow sorting and purification of specific chromosomes, a service no other laboratory within Australia currently provides. This core facility will be relocated in 2006 to a purpose built laboratory in the new research building, allowing consolidation of all instrumentation.

Disease models

Anne Cronin Chief Operating Officer

The disease model provides mouse models of human ailments for our researchers. State of the art techniques are used to generate and characterise the various mouse strains for studying conditions such as arthritis, deafness, thalassaemia, Friedriech’s ataxia and Parkinson’s disease. With MCRI IT, we worked closely with ADB Computers and the Bureau of Animal Welfare to develop two computer programs for the mandatory tracking and reporting of animals used in medical research. In addition we developed strong ties with Monash University and the Walter and Eliza Hall Institute to help with the care and breeding of mice.

Clinical epidemiology & biostatistics

In 2005 CEBU contributed to more than 150 research projects in 46 groups throughout MCRI and the RCH, with contributions ranging from advice on research methods and statistics, through to large scale collaborations on major community based studies of common health problems in children and adolescents. Our program of short courses attracted 250 attendees across seven courses. Specific research highlights included the commencement of National Health and Medical Research Council funded work on methods for dealing with missing data in large epidemiological studies, collaborative research on how to use twin studies to learn about the effects of the fetal environment on later health and major new collaborations on a range of studies related to childhood obesity, infant sleep problems and early hearing and language development.

Highlights

• Published 32 publications in scientific journals including numerous collaborative studies on paediatric clinical problems and a major review of twin study analysis in the International Journal of Epidemiology

• Recruited two biostatisticians, Obioha Ukoumunne and Polly Hardy, to our team from the UK

• John Carlin spent three months as visiting professor at the University of Bristol UK, where he gave short courses on methods for missing data, worked on data from the Avon Longitudinal Study of Parents and Children and pursued research with colleagues in London and Cambridge

• Made a leading contribution to a World Health Organization workshop held to analyse data from an international study on the value of simple clinical signs for diagnosing severe illness in young babies

• John Carlin was awarded a project grant from NHMRC

Australian Paediatric Pharmacology Research Unit

We perform high quality, timely, clinical diagnosis in children, that complies with local and international good clinical practice guidelines. Our primary focus is always on the quality use of medicines in children. We continued to provide clinical trials services and personnel who are highly experienced in Phase I to Phase IV trials and issues relating to good clinical practice, CRF management and subject recruitment. We also provided clinical pharmacology, research and development, clinical trial design and protocol development, good clinical practice compliance, pharmacokinetic and pharmacodynamic modelling and regulatory affairs strategy.

Highlights

• Collaborated on numerous clinical drug trials, including phase I to phase IV studies, single centre and international multi centre trials and a number of pharmacokinetic, bioequivalence and pharmacodynamic studies

• Successfully developed and piloted a medication in schools policy in 27 primary schools

• Facilitated public and media debate on the use of over the counter analgesics in children

• Developed an international health project on essential medicine list for children in collaboration with the World Health Organization

• Continued early phase studies in children in metabolic disease, skin disease, allergy, vaccines, musculoskeletal and neurological disease

Staff List

CHIEF OPERATING OFFICER

Anne Cronin

Colleen King Personal Assistant

BUILDING & SCIENTIFIC SERVICES

Barry Holt Building & Development Manager

Andrew Grimes Technical Services Manager

Marisa Fielding Purchasing / OH&S Manager

Ross McKenzie Business & Building Development Officer

Yvette Mueller OH&S Coordinator

Mandy ParkinsonBates Assistant Operations Officer

Robert Kimoski Purchasing Officer

FINANCE

Viren Abeyasinghe Finance Manager

Neil Harker Finance Consultant

Joanne Le Accountant

Areta Smith Accountant

Maria Telford Accountant

Rebecca Harford Administrative Assistant

Maria Zarkadoulos Administrative Assistant

Maggie Fu Patient Accounts

Neofita Hajigeorgi Patient Accounts

Christine Keenan Patient Accounts

GRANTS

Julia Malone Grants Officer

Maria Salvatico Administrative Assistant

GRAPHIC DESIGN

Voula Boukouvalas Photographer / Graphic Artist

Michele Winsor Photographer / Graphic Artist

HUMAN

RESOURCES

Kathryn Bellion Human Resources Manager

Nicki Carr Human Resources Officer

Andrea Frigo Human Resources Officer

INFORMATION TECHNOLOGY

George Teng IT Manager

Joe Nuchthapho Network Officer

Jason Elliott Web Administrator

Michael Mariani Support Officer

Jim Ristevski Support Officer

Shilpa Shah Support Officer

Michael Black Computer Programmer

Stanley Ho Computer Programmer

PAYROLL

Debbie Zombolas Payroll Manager

Sandra Nield Senior Payroll Officer

Sharon Dughetti Payroll Officer

Marie-Antoinette van Lunenburg Payroll Officer

RECEPTION

Kimberley Cunningham Receptionist

Vicki Hirt Receptionist / Library Assistant

RESEARCH ENABLING FACILITIES

BIOINFORMATICS

Dr Katrina Bell

Bioinformatics Officer

Daniel Singh Bioinformatics Officer

CLINICAL EPIDEMIOLOGY & BIOSTATISTICS

Professor John Carlin

Group Leader

Dr Sue Skull

Deputy Group Leader

Susan Donath Senior Research Fellow

Dr Obioha Ukoumunne Senior Research Officer

Suzanna Vidmar

Senior Research Assistant

Dr John Galati

Research Officer

Dr Rajalingam Sivakumaran

Research Officer

Tracy Bai

Research Assistant

Claudine Chionh

Research Assistant

Kris Jamsen

Research Assistant

Patty Chondros

PhD Scholar

Donna De Sair

Administrative Officer

Pollyanna Hardy Biostatistician

Jonathon Little

Data Clerk

CLINICAL TRIALS

Dr Noel Cranswick

Group Leader

Dr Sean Beggs

Research Fellow

Susan Davie

Clinical Trial

Coordinator

Shannon Power

Clinical Trial Coordinator

Kathryn Ross

Clinical Trial Coordinator

DISEASE MODELS

Dr Kerry Fowler

Group Leader

Sophie Gazeas

Senior Technical Officer

Amanda Blaik

Technical Assistant

Anna Cawood

Technical Assistant

Shelley McCaig

Technical Assistant

Kylie McMaster

Technical Assistant

Lana Ninkovic

Technical Assistant

Carly Turner

Technical Assistant

FLOW

CYTOMETRY & CONFOCAL

MICROSCOPY

Dr Matt Burton

Flow Cytometry

Manager

TECHNICAL

SUPPORT

Marjorie Crawford

Technical Officer

Josefina (Lucy)

Perez

Technical Officer

Anna Czajko

Technical Assistant

Dino Disint

Technical Assistant

Mark Edmunds

Technical Assistant

Sophie Kotsakidis

Technical Assistant

Paul Lau

Technical Assistant

Zahra Manji

Technical Assistant

our supporters

Murdoch

Childrens

Research Institute has more than 3000 very loyal and regular supporters, including major private donors, trust and foundations and

corporate supporters.

Our supporters

Donation income in 2005 increased to $3.92 million and the institute also had excellent support from government. Several families made major contributions in memory of a child who passed away and we received five large bequests. The development board and our event committees collectively raised more than half a million dollars and secured more than $1.2 million donated in kind.

Essential partnerships

We strengthened our partnership with the Royal Children’s Hospital and University of Melbourne Department of Paediatrics through collaborative initiatives. Some floors of the new joint research building were completed and through greater involvement of RCH clinicians in research, the link between research and patient care was further enhanced. The RCH also supported us through the very successful Good Friday Appeal 2005, which continued its long standing tradition of supporting research on this campus. A substantial portion of Good Friday Appeal funds was directed to MCRI research, allowing us to continue our work to improve child health.

Government

support

The Federal government awarded $4.3 million in 2005 through the National Health & Medical Research Council, as well as significant funding through the Australian Research Council, Criminology Research Council, Department of Health & Aging and Department of Family & Community Services. Federal Treasurer Peter Costello joined Dame Elisabeth Murdoch in July to launch a $2 million centre for clinical research excellence (CCRE) that employs movie and computer game technology to help improve mobility for patients with cerebral palsy, Parkinson’s disease, osteoarthritis, stroke and sporting injuries.

The Honourable Tony Abbott, Minister for Health launched NHMRC’s 10 of the best, an initiative that highlighted successful NHMRC funded research projects, which included MCRI’s project on genetic screening for haemochromatosis.

The Department of Innovation, Industry & Regional Development, Department of Human Services and VicHealth awarded Victorian government funding. The Honourable John Brumby, Minister for Innovation

visited in February to announce a $2.5 million funding boost for an international paediatric magnetic resonance imaging (MRI) research centre, which is to be launched in 2006. The unique centre will provide the most advanced magnetic imaging resonance for children in Australasia, with three MRI machines including Australia’s only three tesla machine for children.

Charitable Foundations

Our research was again generously supported by many charitable organisations including Alcohol Education and Rehabilitation Foundation, Australian Cancer Research Foundation, Beyond Blue, Cystic Fibrosis Australia, Financial Markets for Children, Garnett Passe and Rodney Williams Foundation, Heart Foundation, Helen Macpherson Smith Trust, Hugh Williamson Foundation, Ian Potter Foundation, The Miller Foundation, Jack Brockhoff Foundation, Marion & EH Flack Trust, Perpetual Trustees, Pratt Foundation, Rotary Inner Wheel Australia Inc, Telstra Foundation, Uncle Bob’s Club, Victorian Health Promotion Foundation, William Buckland Foundation and the Windermere Foundation.

1. Rebecca, Abbey & Dan Harford with Tony Abbott

2. Dame Elisabeth Murdoch, Olivia & Paul Evans with Peter Costello 3. Terry Dwyer, Jennifer & Brock Gibson, John Brumby 4. Dame Elisabeth Murdoch & her grandson Sam Calvert-Jones 5. Janet & John Calvert-Jones with Dame Elisabeth Murdoch

6. James & Susannah Calvert-Jones

International funding

Competitively won funding from international sources was maintained at $1.8 million, the same as the previous year. Major support came from the Friedreich Ataxia Foundation USA, Juvenile Diabetes Foundation USA, Muscular Dystrophy Association USA, National Alliance for Research on Schizophrenia and Depression USA, National Childhood Cancer Foundation USA, National Institutes of Health USA, Paediatric Brain Tumor Foundation USA and the World Health Organization.

The Murdoch family

Our patron Dame Elisabeth Murdoch AC DBE and her family generously supported the institute. In April, Dame Elisabeth opened her gardens at Cruden Farm to friends of MCRI, to raise money for research. She also continued her significant financial and personal support, as did her family including daughters Janet Calvert-Jones and Anne Kantor, and grandchildren including Judy Paterson and husband Rowly, Matt Handbury, Julie Kantor, Lachlan Murdoch and wife Sarah, Mark Calvert-Jones and wife Louise, James Calvert Jones and wife Susannah, and David CalvertJones and wife Karina. Janet Calvert-Jones and Judy Paterson served as directors on the board. Sarah Murdoch helped raise our community profile as our celebrity Ambassador and Susannah Calvert-Jones served on the development board.

7. Suzi Carp & Nellie Castan 8. Anne Cronin, Peter Griffin, Julie-Ann Cox 9.Scott Livesey

auctions off the Mimco necklace worn by Suzi Carp

10. Aime Swann, Johnny Clemons, Kati Lansell

11.Bernard Carp, Monica Edwards, George Castan

12. The committee: Narelle Curtis, Terry Dwyer, Suzi Carp, Prue Brown, Mardi Foster, Ion Teska

13. Artist Mark Douglass with Ion Teska

Corporate supporters

We continued to receive support from corporate organisations through employee payroll giving and matched giving schemes, corporate donations, event sponsorships and in kind support.

We greatly appreciated generous support in 2005 from Austereo, AON, The Big Group, Crazy John’s, The Council Brand Communications Group, Deacons, Deloitte, Eclipse, Fenton Communications, Foxtel, The Herald & Weekly Times, JR Group, KPMG, Laiki Bank, Leader Community Newspapers, National Australia Bank, Nellie Castan Gallery, News Limited, Paperlinx, PUMA, Qantas, River Capital, Servcorp and Smorgon Steel, Splitrock, Teska Carson, Village Roadshow.

Special events

Art for Science

More than 50 contemporary Australian artists donated specially commissioned works inspired by the brilliance of scientific discovery and child health. The charity art exhibition and auction hosted by our development board raised more then $200,000. Our special thanks to Nellie Castan Gallery, the contributing artists, generous sponsors, auctioneer Scott Livesey and The Big Group. Project group: Suzi Carp, Prue Brown, Ion Teska, Mardi Foster

Cruden Farm family day

The family fun day held at Dame Elisabeth Murdoch’s Cruden Farm was a great success with more than 800 guests attending to raise $40,000 for MCRI. Children and adults alike enjoyed the enchanted garden theme with fairies and butterflies roaming the gardens. Thank you to our wonderful volunteers and sponsors.

14. The giant butterflies

15. The Colls Family

16. Dorothy the Dinosaur

17. Face painting & fun at Cruden Farm 18. St Kilda footballers Leigh Fisther and Dylan Pfitzner with Wil and Matt 19. Antony and Mimi Catalano, Fraser, Amelie and Chloe Macvean, Narelle Curtis

Project group: Susannah Calvert-Jones , Fraser Macvean, Julia Rockman, Shara Catalano, Bruce Macfarlane, Gwenda Hance

MI7 classic aquarium party

In February 2005, the wonderfully creative and driven group called the MI7 organised a party at the Melbourne Aquarium, which raised $45,000 to fund adolescent health research.

Project group: Amanda Catanach, Jacqui Clark, Amanda Hall, Sue Michelmore , Cathy Ramsden, Rozalba Renzella, Caroline Wilson

Portsea Polo Charity Cup

Sun, sea, food, wine and polo made for an enjoyable day at The Age Portsea Polo Charity Cup in January. MCRI was the appointed charity for the El Questro Lexus Polo team, who presented a cheque of $10,000 after the final chukka. Thanks to David Calvert-Jones, Hamish McLachlan, Antony Catalano and Josh Mantello for their hard work and support, to Daniel Vaughan and Andrew Morrison from the Pantry, and thank you to William Burrell Charitable Trust Foundation and Lexus of Brighton for the prize money.

The PUMA Lap Corporate Challenge

CEOs and staff from some of Australia’s biggest corporations swapped suits and ties for shorts and trainers for The PUMA Lap in September. In Sydney, Melbourne and Brisbane, 910 corporate staff ran laps on treadmills to raise funds for our child health research. Our ambassador Sarah Murdoch hosted the launch in Sydney, while Fox Footy’s Tiffany Cherry hosted the Melbourne launch with Deputy Lord Mayor Gary Singer.

Teams included AON, Deloitte, Foxtel, Middletons Lawyers, Fitness First, KPMG, ING, National Australia Bank, Qantas, St George, HBOS Australia, BankWest and Capital Finance, BOS International, St Andrews Insurance, Motorola and Carey Grammar School. Thanks to our sponsors PUMA, Eclipse, Fitness First, Foxtel Digital, Repco Treadmills, Courier Mail, Herald Sun, Peak Teams, BLS Printing and Supersprint.

Fundraising committees

Valuable friendraising, fundraising and events were also coordinated by the following committees :

Centre for Hormone Research Board

• Fergus Cameron • Anne Cronin • Narelle Curtis

• Phillippa Finney • David N Galbally QC (Chairman)

• David J Galbally • Vincenzo Russo • Andrew Sinclair

• George Werther • Christopher Wraight

Bruce Lefroy Centre Committee

• Alicia Burton • Jonathan Correll • Charlotte Cole

• Rachel Hann • Thea Kogler • Marj Lefroy

• Amy Mitchell • Janet Stewart

Volunteers

• Michelle Goldstein • Lauren Fragapane

Our profile

Making news

A consistently high level of positive media coverage has been maintained since 2000. Just over 350 news and feature articles appeared in print and broadcast and online media in 2005. Major national media coverage was achieved for research news stories on obesity in children, awareness under anaesthesia,

the bird flu vaccine trials, haemochromatosis genetic screening program, the launch of the gait analysis centre and the discovery of a gene that causes cartilage destruction in arthritis. Other key stories included coverage of our fundraising events.

National advertising campaign

Our ambassador Sarah Murdoch unveiled an innovative multi million dollar advertising campaign to raise awareness of world class medical research and to engender public support. The Australian committed more than $1 million worth of advertising space for the campaign, which ran 14 full page colour ads in the second half of 2005.

Development board member Aimee Dean-Pritchard and her partner Adrian Pritchard from The Council Brand Communications Group designed and produced the entire campaign pro bono. The campaign will continue in 2006 and 2007.

Delta wins kids’ hearts

Delta Goodrem paid a special visit to MCRI in November to help celebrate Thank You Day, a Research Australia initiative drawing attention to the work of medical researchers. The singer joined dozens of children, many of whom had been critically or chronically ill and had directly benefited from world class research and care at MCRI and the Royal Children’s Hospital.

donations & s UPP o R t ER s

Thank you to all our generous donors, sponsors and event supporters in 2005

A

James Abbott

Robert Abbott

Justin & Emma Abrahams

Accenture

Cassie Adland

Aitken Walker

Albert St Children’s Market

Alexander, Robertson & Co

L Allen

Matt & Megan Allen

TI Allan

Peter Altidis

American Fund for Charities

S Amos

Stan Andrianopoulos

Antipodean Pharmaceuticals

ANZ Trustees

Artbank

Asia Pacific Building Corporation

Association of Greek & Affiliated

Panhellenic Interests

Ataxia UK

Amanda Atkins

Australia and New Zealand Children’s Heart Research Centre

Australian Children’s Cancer Centre Foundation

B

Bachrach Charitable Fund

Jane Baillieu

Judy Baillieu

Sam Baillieu

Sybil Baillieu

Andrew Baines

M N Balfe

AJ & A Balloch

Banabor Graphics

Bank of Cyprus

Baracon Group

L & I Barbieri

Clem Barker

Tony & Kate Beaconsfield

Mary Beasley

WHA Becke

Beejay Jewellery

Katherine Behrend

Bendigo Truss Plant

C A Bernardi

Sanjay L Bhojwani

Biggin & Scott

Grant & Lindy Blashki

Jo Blunck

Greg Bond

G & LJ Boulter

Bouna Holdings

Nicholas Brand

Lori Brand

Brighton Christmas Market

David & Amanda Briskin

Rod & Vanessa Brott

Tania Brougham

Nick & Prue Brown

M Bunn

Graham & Dana Burrows

Cameron Butts

Buxjune Pty Ltd

CDavid & Karina Calvert-Jones

Calvert-Jones Foundation

James & Susannah Calvert-Jones

John & Janet Calvert-Jones

Mark & Louise Calvert-Jones

C Cameron

J Cameron

Carolyn Cameron

Neil Campbell

Suzanne Camilleri

Barry & Suzi Carp

Bernard & Helen Carp

Brandon & Nicky Carp

Michael & Emma Carp

Sandy Carr

Emily Carroll

FA Carter

S Case

Anita Castan

George Castan Family Trust

George & Freda Castan

Nellie Castan

Antony & Shara Catalano

Amanda Catanach

Catanach’s Jewellers

David Catanach

CFA Cycling Club

Charities Aid Foundation

Charlotte Anderson Memorial Fund

Ric Charlton

Paul Cherny

A & S Chirnside

Wilson & WInnie Chong

Citigroup Community Fund

Jenny Clairs

B Claney

E Clark

J Clark

JS & M Clark

Peter & Jan Clark

Tim Clarke

S Clemenger

Christine Clough

Andrew Cochrane

Grant & Debbie Cohen

Miriam Colless

LE Colley

Chris Connolly FPA

Sandra Cook

Tanya & Simon Cook

Emma Cooper

Faye Cormick

Dora Coroneos

Coulson Group

Caitlin Coventry

Paul Cowan

Laurie & Julie Ann Cox

Prudence Cox

Liz Crosby

C Cunningham

RN Cunningham

Narelle Curtis

Cyprian Greek Community AP

Andreas Sunshine

Cyprus Club Kapouti

Cyprus Club Karavas Zambo

Cyprus House

D

Albert & Debbie Dadon

June Danks

Glen & Adena Davidson

Richard & Danielle Davies

Tony & Trisha Davies

Johnny & Briely Davis

Rohan & Sophie Davis

Richard & Sarah de Crespigny

Ron Dewhurst

M & L Doery

Domain Ramsey

M Downey

E Dillon

J & N Druce

IC Dungey

Terry & Jeanine Dywer

E Earthdance

Nick Edwards & Amanda Hall

Peter & Monica Edwards

Elizabeth Edwards

Elizabeth M Hughes Trust

Elpis Finance Pty Ltd

Embelton Limited

F

D Farfor

Jane Fenton

Amanda Fish

Sam Fletcher

Bennett Foddy

Hamish Foletta

Adriana Forlenza

Mardi Foster

Peter Foster

Grant & Penny Fowler

Rena Frangiodaki

Natalie Frid

Robert Frost

Friedreich Ataxia Association of Victoria

Friedreich Ataxia Research Association

GHelen Gannon

Neilma B Gantner

ADR Garrison

The Geelong College

Sylvia Gelman

Nigel & Leora Givoni

A & L Glavan

Quinton Gleeson

Nick & Jenny Glenning

Louise Gourlay

Hugh Graham

Grosby Family Trust

R & JM Grutzner

James Guest

Goldman Sachs JB Were

Greg Goodman

L Goodman

Phillip H Goodman

J Graves

Graywinter Investments

Andrew Grech

Greek Cypriot Parish & Youth Group Church

AJ Grimwade

FS Grimwade

Michael & Dalia Gross

Grovsenor Settlement

GV Marine & Trailers

H

H & L Hecht Trust

Nicholas Haddad

Michael Haintz

Maurice E Hall

W R Hall

Robert & Gwenda Hance

Matt Handbury

Handweavers & Spinners Guild of Victoria

Vivian Hanna

Judith Harley

C Harold

Colin Harris

Michael & Cassie Harris

Susan Hawthorn

Brian Hay

A Hays

D Hayes & A Blosfe

Sam Hayes

Simon & Jane Hayman

Andrew & Carrie Hayne

Geoffrey E Heeley

Helen Macpherson Smith Trust

Michael & Vanessa Herskope

RM Hiam

AG & LM Highet

Peter Hilderbrandt

Joanna Hill

RT & SA Hinton

Ant Hocking

Hometom Pty Ltd

Tim Hook

Danni Hosking

Charles Hough

Eric Howie

Peter Howie

Paul Howland

Yi Huang & Yu Hao Wu

Ariane Hubay

Christine Hubay

Hudson Pacific Corporation

The Hugh Williamson Foundation

SEK Hulme

FL Humphris

R Hunger & M Hurley

Sam Hunt

Tom Hutchins

IPeter Isaacson Foundation

Judith Ince

Penny Inge

Caroline Ingham

Margaret Inglis

G & V Inserra

JSR Jackson

KMD Jalland

Andrew & Andrea James

Janssen-Cilag

Governor General Michael Jeffrey

David Jenkins

Dean & Shareen Joel

John D & Lyla Harris Charitable Foundation

MS Johnson

Alyssa Jones

Noel Jones

Junee High School (Year 12 2004)

K Kafig

Kailis Bros

Kambos Community of Australia

Simon & Zoe Kanat

Anne Kantor

Kaoulla Bros

Saziye Kaya

CF Kelaher and Co

A Kelly

Polly Kerdel

PA Kiel

Jason Kimberley

Kilwinning Trust

Kimberley Foundation

Sheila F Kimpton

M Klemens

DA & TE Kogler

Peter Kudelka

Irene Kyriacou L

Gregory Ladner

Laiki Bank

Karen & David Lambert

Lamont Capital

Lassara Pty Ltd

James Lee & Manjula Ari

Jason & Fran Lefroy

Marj Lefroy

The Lefroy Family

S Leggatt

Simon Lethlean

Rodd Levy & Julia Cox

David Lewis

J & M Lillie

Linskens

John Brian Little

The L & M Price Trust

Bernadette Long

Keren Ludski

AR Lynch

M

Bruce MacFarlane

Patricia Mackinnon

Macquarie Bank Foundation

Fraser & Annika Macvean

J Mahaemoff

Jonathan Manifold

Josh Mantello

The Marian & EH Flack Trust

Bernard Marin

Nick & Anna Marinopoulos

Vas Maroulis

Marshall White

Paul & Simone Martin

Rick & Ros Matear

MBB Holdings

Andrew McCarthy

Stirling McGregor

Anthony McIntosh

Hamish McLachlan

Joy Mein

Melbourne Grammar School, Grimwade

House

Priscilla Mendelson

Angela Metcalfe

Michael & Andrew Buxton Foundation

Mark & Sue Michelmore

D Middleton

WR Middleton

The Miller Foundation

DA Mitchell

Bianca Mitsord-Henry

AE & K Moli

RM Morrison

Morris Family Trust

Marie Morton

Romy & Richard Moshinsky

Bessy Mougos

Dame Elisabeth Murdoch

N

National Australia Bank

National Wealth Management

Neta Needs

Christine Neophitou

Neo Printing

Robert & Gillian Nethercote

P Newton

Kate & Keith Nicolas

Livinia Nixon

Nordia Foundation

Heather Noyes

NRMA Insurance

O

Ryan O’Hare

ME Oldfield

Matthew Oliphant

Nick & Sarah Orloff

P Lane Palmer

Kula & Con Papargiris

Pantazis Family

Parthenon Marble

James & Carrie Paterson

Sam Patterson

Tom Paul

SGL Peake

Angelo Pepe

C Perkin

Corrie Perkins

Pia Perkins

D Permezel

Mif Pescott

Mark Podgornik

Danielle Poli

Irene Ponias

James Porteous

PMP Print

Poster Magazine

The Pratt Foundation

Premier Developments

Adrian Pritchard & Aimee Dean Pritchard

Provincial Press Group

QAdrian Quilter

R

Herme Rabl

A & U Radok

LJ & OM Raphael

Lelde Rita Ramma

Cathy Ramsden

MC Ramsden

Michael Ramsden

Ramtam Pty Ltd

Katrina Raymond

Brendan Redden

Matt Reid

Renma Screens & Blinds

Renn Ta Gardner Pty Ltd

Andrew Rettig

Angus & Lara Reynolds

Mark Rice & Lisa Ainsworth

P Richard

A & R Richards

Mr & Mrs Ritchie

R Michael Trading Co

Emma Robenstone

Annette Roberts

Paul Roberts

Sam Robinson

Matthew & Julia Rockman

Andrew Rogers

BJ Roper

Michael Rose

Paul & Gay Rosen

Candy & Michael Rosenbaum

Emma Rosenberg

JJ & MA Rothfield

The Rotary Club

Royal Children’s Hospital (Health Information Service staff)

Royal Children’s Hospital (Pharmacy staff)

PD & CJ Ryan

Ben Rozenes & Laini Liberman

S Theo Sakell

Daniel Salter

Lydia Schiavello

Marielle Schwerin

Jason Scillio

George Scott

Michelle Seippot

Sheena Reilly

Gardi Seymour

Tom Seymour

Richard & Trine Shelmerdine

Richard Sherman

Georgia Sinclair

ML Sims

B Sommerville

Jack & Robert Smorgon Families Trust

Ricky & Amanda Smorgon

Tony & Jennifer Smorgon

Mark Soutar & Jan Street

Margaret Steffens

MA Stewart

FRG Strickland

F G Stuart

Douglas Stutt

Scanlon Foundation

Style Bureau

T

Erwin & Juliette Tan

Templestowe Valley Primary School

Ion Teska

Susan Thacore

St Thomas Ladies Guild

Andrew Thompson

M L Thompson

P Thompson

Arthur Topalid

Dinos Toumazos

S Tsikkos

Thalassaemia Society of Victoria

Peter & Sharon Thurin

UPatrick Upfold

Uncle Bob’s Club

Ultima Function Centre V Greg Valles

Vermont Cancer Centre

Victor Smorgon Charitable Fund

Vicki Vidor

Andrew Vidor & LJ Ryan

Village Roadshow

De Heer IR P H Vogtlander

WWJ Messurier Family Trust

Henry Walachow

Campbell & Elli Walker

Warrenmang Limited

Watsonia North Primary School

Jenny Webb

Carl Wedding

Phillip & Gaye Weeden

David Weissman & Natalie King

Richard Wenzel

Westribe Investments

Rein & Adri Willems

The William Angliss Charitable Fund

The William Buckland Foundation

The William Burrell Charitable Trust

Foundation

SB & MJ Williams

Caroline Wilson

Michele Winsor

Women of the University Fund Inc

Margaret Wong

Woodfield Investments

Woodmarsh Architecture

Micahel & Susan Wyles

Micahel & Susan Wyles

Y Jane Yule

Yonnie Consulting

David Yunghanns

Z

Paul & Vivien Zimmet

Estates

Estate of Bartholomew Frances Reardon

Estate of Agnes Tait Robertson

Estate of Heather Sybil Smith

Estate of L I Roach

Estate of Joan Roxburgh

In lieu of gifts for Lydia Slonim’s

12th birthday

F Brash & L Faraday Brash

Michael & Beverley Bookman

G Bornstein

Coogee Auto Pty Limited

JH & NP Dessauer

M & K Diamond

B & LB Eizenberg

D & B Fisher

M & A Gledhill

Mark & Yona Igel

MG & RL Loff

A Slonim & L Gibson

My Three Sons Investments

P & D Owen

Mark & Debra Perlow

Dr Henry & Marcia Pinskier

R & E Ptasznik

L Rotstein

O Schneeweiss

A & H Shmerling

Benjamin Slonim

DH & M Slonim

L & F Slonim

MS Slonim

Zamiral Investments Pty Ltd

In lieu of Christmas Gifts

Beaton Consulting

Curtis Family

Deloitte Foundation

John & Joyce Halligan

News Limited

In memory of John Alder

Bob & Jo Bennett

John Brunner

Ian Heffernan

Jane Henry

Dr Keith Neill

Diana Phoenix

Pat Sutton

Mr & Mrs Watson

Nona & Peter Willis

J S Wilson

In memory of Pam Beeching

Glen Katherine Primary School

In memory of Catherine Ester Clark

Mary Nicol & Elsie Hutchieson

In memory of

Demitrious Gikas ‘Jamie’

John & Amelia Efkarpidis

In memory of

Panos Ioannou

G & D & S Alexandrou

S Angelodemou

Mary & Chris Chara

D & A Christodoulou

P & A Constanti

Harry Diacos

Elderly Group of Cyprus Club

Demia Eleftherakis

Costa Elisseou

Federation of Cypriot Community Australia

D & P Florentzos

Desi Gadzhis

The Garivaldis Family

Reno & Con Geogiou

Katrina Georgiou

Georgiou Family

Christina Karabatos

Cindy Karabatsos

Sia Kastoras

D Komodromos

Eva Kouloupas

Laiki Bank

Andreas Merakis

Mr A Meraklis

Mitatsakis Family

Bessy Mougos

Mr & Mrs Patouta

H & D Neoleon

The Nikias Family

The Orfanos Family

Maro & Edward Ostrognay

Jian L Xu & William Quan

N & L Sawa

The Seka Family

Harry Shiamaris

George Skouride

The Socratous Family

A & L Soteriou

T & P Stavrou

Emmanuel Tacticos

Tasoula Tamana

Dinos Toumazos

George & Debbie Toumbakis

Andreas Tziortz

R Villain

Philip Wen

Costa & Rita Yiangou

Steve & Daphne Cheah

In memory of

Shaun Nicholas Martin

Bonnie & Steve Redman

Valerie Walsh

In memory of Indiana Jasmine Orlando

Enzo & Vicki Bergamo

Sandie Beswarick

Mark & Julie Botham-Clarke

Pat Chalmers

The Coote Family

S Delany

Margaret Douglas

Len & Meryl Galloway

Ross & Judy Gardner

Georgie Gardner

Tamara Grigg

B & S Hanly

John & Chris Hanly

Stewart Harries

The Harries Family

Trent Howard

John & Monica Tudhope

Leigh Matheson

Jeanette Miller

J & N Panettie

Steve & Mim Peatling

Henry & Jean Speagle

Sandra Walczynski

In memory of Matthew Paikos

Arthur Paikos

Maria Paikos

In memory of Emma Ritchie

Colin Ritchie

Robyna Calisthenics College

In memory of Liam Suffern

Robyn Bos

Jed & Judy Martin

Beverley Sargeant

Grace Stractan

Daniel & Belinda Suffern

Michelle Suffern

Pennie Suffern

Suzi Wiseman

Mrs Rebecca Watson

Yarrawonga Presbyterian Sunday School

In memory of Sam Toovey

Mr & Mrs Kevin & Beryl Hayes

In memory of Mrs Trinder

J & I Brown

In memory of Charlotte Clare Wendt

Michael & Ursula Wendt

Major pro bono supporters

Abercrombie & Kent

Austereo

The Australian

The Big Group Catering Firm

Cheviot Bridge Limited

The Council Brands Communication Group

Crazy John’s

Deacons

Deloitte

Eclipse

Fenton Communications

John & Agita Haddad

The Herald & Weekly Times

Hub Design Agency

KPMG

Nellie Castan Gallery

News Custom Publishing

News Limited

Nicholas Feuillatte Champagne

Paperlinx

Servcorp

Southern Colour

The Wiggles

Yabby Lake Vineyard

Event sponsors

Aon

Australian Football League

BankWest & Capital Finance

BOS International

Carey Grammar School

Catanach’s Jewellers

Deloitte

Eclipse

Fitness First

Foxtel

HBOS Australia

The Herald & Weekly Times

ING

James Richardson Corporation

Kay & Burton

KPMG

Leader Community Newspapers

Lexus of Brighton

Middletons Lawyers

Motorola

Norton Gledhill Commercial Lawyers

Playgro

PUMA

Qantas

Renzella Group

River Capital

Smorgon Steel

St Andrews Insurance

St George

Star Bank

Terrain Capital

Teska Carson Real Estate

Toll Holdings

Event supporters (pro bono)

45 Degrees North

Australian Football League

Akarba

Bib Stillwell BMW

Bloom Cosmetics

Bonds

Vanessa Brott

Cadbury Schweppes

Café Racer

Chill Designs

Christine Abrahams Gallery

CPL Services

Crown Casino

DJ Dimension

Dr Lewin Cosmetics

Dutch Stationary

Frangelico

Frankston SES

Greentix

Hotel Sorrento

Humour Foundation

Chrissy Japp

Kraft

Lavazza

Linton’s Garden and Home

Marshall White

Mimco

Music Theatre Australia

Natalie King

National Storage

Niagara Galleries

Ocean Spray

The Pantry

Papyrus Design

Passionfoods

Peninsula Horse & Cart Rides

Place Settings

The Promotions Factory

Christina Redlich

Rain, Hayne & Shine Farmyard

San Pellegrino

Scott Livesey Art Dealer

Succulent Designs

Surf Life Saving Victoria

Tims Interior Motives

Town Mouse

Tyabb Wholesale Roses

Victorian Polo Association

Art for Science contributing artists

Emma Abrahams

Kate Beynon

Angela Brennan

Amanda Briskin

David Bromley

Andrew Browne

Jane Burton

Jon Campbell

Karen Casey

Jon Cattapan

Peta Clancy

Emma Davies

Robert Doble

Mark Douglass

Carolyn Fels

Bill Ferguson

Jennifer Goodman

Sharon Green

Deborah Halpern

David Hawley

Trish Heasllip

Tanya Hoddinott

Christine Hubay

Phillip Hunter

Matthew Johnson

Tim Jones

Jason Kimberley

Gregory Ladner

Lara Merrett

Julie Millowick

Vera Moller

Magdalena Moreno

David Naseby

Peter Neilson

Simeon Nelson

Kate Nicolas

Fiona Omeenyo

Sonia Payes

Viki Petherbridge

Stephen Pleban

Lisa Roet

Bill Sampson

Jen Smorgon

Kim Spooner

Jacqueline Stephens

Simon Strong

Darren Sylvester

Wilma Tabacco

Vicki Vidor

Marnie Wark

Carl Warner

John Young

critical care & neurosciences

You have to put your heart and soul into it.

The biggest hearts in the world are often found in the smallest bodies. Children with serious medical conditions are renowned for their bravery and resilience in the face of extreme adversity. We put our heart and soul into research to make them better.

Helping to save lives and improve the long term health and well being of babies and children with serious conditions requiring surgery and acute care, like heart disease, prematurity, brain injury, epilepsy and autism.

This research theme is unique in its capacity to integrate clinical and research activities, taking advantage of the close links between the Royal Children’s Hospital and MCRI.

Many of our researchers play key roles in patient care, so are in an excellent position to identify cutting edge issues and enable rapid translation of research findings into improved care and management of very sick babies, children and their families.

The establishment of this theme facilitated collaborations leading to important new multidisciplinary research programs, which will advance accurate diagnosis and treatment, identify key factors that may improve child health outcomes and expand our knowledge of the long term consequences of childhood illness.

critical care & neurosciences

Enhancing quality of life for children after surgery and for children with brain injury, developmental and behavioural disorders is our focus. We seek to develop, implement and evaluate intervention programs to enhance patient care and maximise medical, educational and psychosocial outcomes for children.

Theme Director: Professor Vicki Anderson vicki.anderson@rch.org.au

Research priorities 2005

One of the institute’s objectives in 2005 was to develop clinical research on the Royal Children’s campus. This theme brought together a number of new clinical research groups with pre-existing groups, to forge collaborations and provide support to clinician researchers.

The primary goal was to conduct cutting edge research of an international standard, to improve both medical and psychosocial outcomes for children and their families and prevent unnecessary secondary problems and complications.

Other priorities included supporting the development of multidisciplinary research collaborations and encouraging the career development of promising new researchers. Many of our team already had international reputations in their specific fieldof expertise.

The theme focused on extending the institute’s reputation for excellence in clinical research in

child health by facilitating more contemporary multidisciplinary research approaches to illness and recovery. Research priorities and projects included:

• Long term consequences of premature birth

• Incidence and timing of neurological abnormalities in children undergoing cardiac surgery

• Incidence and impact of sports concussion in children

• Comparing neurodevelopmental outcomes after spinal vs general anaesthetics in newborns

• Cognitive and emotional outcomes for children with epilepsy

• Trajectories for motor development in children with cerebral palsy

• Genetics of autistic spectrum disorder

• Impact of prenatal diagnosis of heart disease on parent child relationships

• Parent based interventions for problems related to acquired brain injury in children

Investment strategy

The theme was committed to identifying and supporting excellent research relevant to the health and wellbeing of sick children and their families. To this end, our investment strategy was to support research initiatives that fulfilled the following criteria:

1. Cutting edge research of an international standard

2 Provide opportunities for new collaborations within the theme relative to theme priorities

3. Enable the development of promising new researchers

4 Provide infrastructure for the establishment of emerging research groups working in fields relevant to theme priorities

Research groups & leaders

Academic Child Psychiatry

A/Professor Alasdair Vance

Anaesthesia & Pain Management

Dr Andrew Davidson, Dr Chris Bolton

Child Neuropsychology

Professor Vicki Anderson

Developmental Disability Research

A/Professor Dinah Reddihough

Emergency Research

Dr Franz Babl

Haematology Research

A/Professor Paul Monagle

Heart Research

Professor Dan Penny

Infant Mental Health

Dr Brigid Jordan

Neonatal Research

Professor Colin Morley

Neonatal Nursing Research

Professor Linda Johnston

Neuro Rehabilitation Research

Dr Anna Mandalis

Neuroscience Research

A/Professor Andrew Kornberg

Otolaryngology

A/Professor Robert Berkowitz

Paediatric Intensive Care

A/Professor Lara Shekerdemian

Patient Safety Research

Dr Karen Dunn

Medical Imaging Research

Dr Mike Ditchfield, Dr Tim Cain

Victorian Infant Brain Studies

Dr Peter Anderson, Professor Lex Doyle, Dr Rod Hunt

Research Outcomes

• Completed development of the new Children’s MRI Centre

• Published results from MRI studies indicating specific differences in brain structure in very premature babies when compared to full term (very preterm babies had less grey matter and hippocampal volumes were reduced). White matter injury identified in the neonatal period by MRI is the strongest perinatal predictor of developmental delay

• Published results of a study on awareness under anaesthesia that was ranked number one by the Society for Pediatric Anesthesia

• Received institutional review board approval to carry out a drug trial in children who are tracheostomy dependent due to congenital vocal cord paralysis

• The Victorian cerebral palsy register contributed to eight research projects and launched its third report

• Completed a study of thrombophilic mutations as a cause of cerebral palsy

• Evaluated interventions for children with disabilities including saliva control surgery, intrathecal baclofen therapy and an early childhood intervention program

• Refined a depressive subtype of ADHD with distinctive behaviour and cognition

• Refined a single case design metric to assess cognitive and behavioural change in children and the specific neural networks underlying subserving spatial working memory in pre-pubertal children and adolescents

Publications

The theme published 124 peer reviewed papers. Highlights included:

• Rodriguez-Casero MV et al. Neurology 64: 1786-1788 (2005)

• O’Donnell CPF et al. Journal of Pediatrics 147: 698 – 699 (2005)

• Rankins D et al. Diabetes Care 28: 2771-2772 (2005)

• Anderson V et al. Pediatrics 116(6): 1374-1382 (2005)

• Simpson CM et al. Heart (2005)

Awards & achievements

• Andrew Davidson was invited to contribute to a US based think tank on awareness and EEG monitoring in children and was also the first Australian elected to the editorial board of the journal Pediatric Anesthesia

• Chris Bolton was awarded his PhD

• Coordinated an international meeting on child rehabilitation

• Presented invited addresses at both national and international scientific meetings

• Dinah Reddihough was made an honorary member of the Order of Australia

• The accelerated care through the emergency departments program won a Victorian public health care award from the Department of Human Services

Major collaborators

• Children’s Hospital at Westmead

• Columbus Children’s Hospital

• Deakin University

• Harvard University USA

• Howard Florey Institute

• Latrobe University

• Monash Medical Centre

• Scope

• Sydney Children’s Hospital

• Toronto Sick Children’s

• University of Oslo Norway

• University of Queensland

• University of Sydney

• University of Western Sydney

• Victorian Parenting Centre

• Washington University USA

Objectives for 2006

• To coordinate an international multisite randomised controlled trial to determine the long term effects of anaesthesia on the developing brain

• To develop and use a definitive tool to measure exactly how often and when unexpected awakening (awareness) occurs during anaesthesia in children

• To evaluate new drugs or new formulations for preventing vomiting and nausea after anaesthesia in children, and for treating post operative pain in children

• To acquire funding for a six year follow up cohort study to determine the significance of brain injury at birth for very prematurely born children and evolution of brain abnormalities

• To explore the impact of the neonatal intensive care on babies’ long term health and wellbeing

• To further animal studies to increase knowledge of how the brain controls function of the larynx

• To evaluate the optimal management of tonsilitis in young children, in a prospective study

• To complete a randomised trial of botulinum toxin in the management of poor saliva control

• To further refine a depressive subtype of ADHD with a distinct behavioural and cognitive phenotype, and investigate its association with pure depressive disorders and pure ADHD in pre and post pubertal children

• To further refine a single case design metric to assess cognitive and behavioural change in children with ADHD and depressive disorders, and conduct RCTs of specific medication and psychological treatments using this metric to define genuine treatment responsive and non responsive cases

• To further refine the specific neural networks subserving spatial working memory in pre pubertal children and adolescents with ADHD, depressive disorders (dysthymic disorder and major depressive disorder) and obsessive compulsive disorder

• To evaluate outcomes and rehabilitative interventions for children with developmental or acquired neurological deficits, to implement evidence based interventions to help children reach their maximum potential

• To commence a study examining the strengths and vulnerabilities of very preterm children prior to commencing primary school, so that appropriate intervention programs can be devised to minimise learning difficulties

Grants list

NHMRC AWARDS

Project Grants

Peter Anderson

Neonatal Research

$78,500

Vicki Anderson, Alex Collie, Paul McCroy

Child

Neuropsychology

$106, 750

Vicki Anderson, Cathy Catroppa, Susan Morse, Jeffery Rosenfeld

Child

Neuropsychology

$119, 550

Peter Dargaville, John Mills, Colin Morley

Neonatal Research

$60,100

Terrie Inder, Roslyn Boyd, Lex Doyle, Dinah Reddihough

Neonatal Research

$200,750

Terrie Inder

Neonatal Research

$115,250

Susan Jacobs, Colin Morley, Lex Doyle, Terrie Inder, Peter Gluckman

Neonatal Research

$84,500

Fellowships

Peter Anderson

Australian

Clinical Research

Fellowship

Neonatal Research

Cathy Catroppa

Australian

Training Research Fellowship

Child

Neuropsychology

Medical

Postgraduate Scholarships

Karen Dunn

Gehan Roberts

Kate Simpson

David Tingay

Public Health

Postgraduate Scholarships

Alicia Spittle

EXTERNAL GRANTS

Allens Arthurs

Robinson

Alicia Spittle

Neonatal Research

$10,000

Equity Trustees (Grosvenor Settlement)

Dinah Reddihough

Child Development and Rehabilitation

$20,000

Marian & EH Flack

Trust

Dinah Reddihough

Child Development and Rehabilitation

$40,326

Nurses Board of Victoria

Linda Johnston

Neonatal Research

$4,970

Perpetual Trustees

Dinah Reddihough

Child Development and Rehabilitation

$12,486

Scanlan Foundation

Linda Johnston

Neonatal Research

$21,000

Victorian Trauma Foundation

Stuart Lewena Emergency

Medicine

$40,000

MCRI INTERNAL GRANTS

Part Time Career Grants

Elisabeth Northam

Psychological Development

Postgraduate Health Research Scholarships

Anastasia Pellicano

Neonatal Research

Candice Franich-Ray Child

Neuropsychology

Megan Spencer

Smith

Child

Neuropsychology

Project Grants

Roslyn Boyd

Neuroscience Research

Beverley Copnell

Neonatal Research

Dinah Reddihough

Developmental

Disability Research

Alasdair Vance

Academic Child

Psychiatry

Staff list

THEME DIRECTOR

Professor Vicki Anderson

Mary Iliadis Executive Assistant to Theme Director

THEME ADVISORY GROUP

Dr Peter Anderson Group Leader

Dr Franz Babl

Honorary Fellow / Group Leader

A/Professor Robert Berkowitz

Honorary Fellow / Group Leader

Dr Chris Bolton Honorary Fellow / Group Leader

A/Professor Andrew Cochrane Research Affiliate

Dr Karen Dunn Group Leader

A/Professor

Andrew Davidson Honorary Fellow / Group Leader

Dr Michael Ditchfield

Honorary Fellow / Group Leader

Professor Lex Doyle

Honorary Fellow / Group Leader

Alessandra Giannini

Research Assistant

Dr Rod Hunt

Honorary Fellow

Professor Linda Johnston

Honorary Fellow / Group Leader

Dr Brigid Jordan

Honorary Fellow / Group Leader

A/Professor

Andrew Kornberg

Honorary Fellow / Group Leader

Dr Anna Mandalis Group Leader

Professor Paul Monagle

Honorary Fellow / Group Leader

Professor Colin Morley

Honorary Fellow / Group Leader

Professor Dan Penny Group Leader

A/Professor Dinah Reddihough

Honorary Fellow / Group Leader

Sue Reid Senior Research Assistant

A/Professor Lara Shekerdemian

Honorary Fellow / Group Leader

A/Professor Alasdair Vance

Honorary Fellow / Group Leader

THEME MEMBERS

Dr Elizabeth Algar Honorary Fellow

Dr Giuliana Antolovich Research Affiliate

Dr Gordon Baikie

Honorary Fellow

Dr Chris Barnes Research Affiliate

Dr Peter Barnett

Research Affiliate

Merilyn Bear Research Affiliate

Robert Bourke

Research Affiliate

Deborah Boyce

Research Assistant

Dr Roslyn Boyd Postdoctoral Fellow

Dr Lesley Bretherton Honorary Fellow

Dr Christian Brizard

Research Affiliate

Jo Brooks

Research Affiliate

Dr Kester Brown Research Affiliate

Nisha Brown

Research Affiliate

Sandra Brown Research Assistant

Dr Cathy Catroppa

Research Psychologist

Dr George Chalkiadis

Research Affiliate

Dr Michael Cheung

Research Affiliate

Emma Couper

Research Affiliate

Dr Beverley Copnell Research Fellow

Louise Crowe Research Assistant

Dr Karen Dally Research Affiliate

Dr Peter Dargaville Associate Fellow

Dr Ben Davies

Clinical Research Fellow

Dr Andrew Davis Honorary Fellow

Eleanor Death Research Affiliate

Ben Deery Research Affiliate

Cinzia De Luca Research Assistant

Carmel Delzoppo Research Coordinator

Bernice Dodds Research Affiliate

Julian Dooley Research Assistant

A/Professor Yves d’Udekem Research Affiliate

Dr Paul Dudgeon Research Affiliate

A/Professor Gary Egan Research Affiliate

Senem Eren Research Assistant

Cheryl Evans Research Assistant

Dr Rob Eyres Research Affiliate

Atika Farooqui Research Officer

Carmel FerrettiBegagna Research Affiliate

Dr Peter Filan Clinical Research Fellow

Lorraine Fitzgerald Research Affiliate

Candice

Franich-Ray Doctoral Student

Dr Geoff Frawley Research Affiliate

Dr Jeremy Freeman Honorary Fellow

Celia Godfrey Research Officer

Dr Linda Gonzalez Research Affiliate

Mardee Greenham

Research Assistant

Dr Joanne Grindlay Research Affiliate

Dr Simon Harvey Honorary Fellow

Dr Denise Harrison Research Affiliate

Katie Hazard Research Assistant

Dr Peter Hewson Associate Fellow

Kelly Howard PhD Scholar

Dr Vera Ignjatovic Senior Research Officer

Professor Terrie Inder

Associate Fellow

Dr Craig Ironfield

Research Assistant

Dr Rani Jacobs Honorary Fellow

Kelly Johnson Research Psychologist

Ingrid King Data Manager

Anna Kouselas Administrative Assistant

Tiffany Kwok Research Affiliate

Anna Lanigan Research Assistant

Shelly Lavery Research Affiliate

Dr Rick Leventer Honorary Fellow

Brian Long Research Affiliate

Connie Louizos

Research Assistant

Greta Ludwig Research Assistant

Dr Mark Mackay

Research Affiliate

Niloufar Mahdavi Research Assistant

Dr Catherine Marraffa Research Affiliate

Rosalie Maxted Research Affiliate

Dr Ian McKenzie Research Affiliate

Anne Marie McVeigh-Dowd Research Assistant

A/Professor

Samuel Menahem Research Affiliate

Silvana Micallef

Research Affiliate

Dr John Mills Research Affiliate

Carly Molloy PhD Scholar

Anne Moodie

Research

Physiotherapist

Sue Morse

Research Affiliate

Frank Muscara Doctoral Student

Jonathan Mynard

Research Assistant

Jennifer Neale Research Assistant

Fiona Newall

Research Affiliate

Dr Carol Newnham Research Affiliate

Bridget O’Connor

Research

Physiotherapist

Dr Christine Olesch Honorary Fellow

Jane Orton

Research

Physiotherapist

Dr Greta Palmer

Research Affiliate

A/Professor

Campbell Paul

Research Affiliate

Tamis Pin

Group Member

Dr Philip Ragg

Research Affiliate

Dr Marnie

Robinson

Research Affiliate

Dr Margaret Rowell

Research Affiliate

Melinda Randall PhD Scholar

Dr Debbie Rankins

Research Officer

Larissa Reavey

Office Manager

Dr Anne Rickards

Research

Psychologist

Dr Gehan Roberts

PhD Scholar

Dr Marnie

Robinson

Research Affiliate

Mia Rowe

Research Assistant

Dr Margaret Rowell

Research Affiliate

Dr Alan Sandford

Group Member

Professor Ingrid Scheffer

Honorary Fellow

Hilary Sellars

Research

Physiotherapist

Dr Divyen Shah

Research Affiliate

Dr Lloyd Shield

Research Affiliate

Dr Kate Simpson

Trainee Research Scholar

A/Professor Joe Smolich

Research Fellow

Megan Spencer-Smith

Research Assistant

Maureen Spicer Research Officer

Alicia Spittle

Research

Physiotherapist

Michele Spreckley Research Affiliate

Robyn Stargatt

Honorary Fellow

Dr Matthew Stevens

Group Member

Dr Amanda Stock Research Affiliate

Robyn

Summerhayes

Research Assistant

Olga Szymanska

Research Affiliate

Dr Leone Thiele

Group Member

Deanne Thompson Research Affiliate

Dr Frances

Thomson Salo

Research Affiliate

A/Professor

James Tibballs

Honorary Fellow

Dr David Tingay

PhD Scholar

Janet Walstab Research Assistant

Dr Hong Wang

Research Affiliate

Beverley Weate

Research Assistant

Dr Robert Weintraub Honorary Fellow

Christine Westbury

Research Assistant

Elisabeth Westrupp Research Affiliate

Michelle Wilson-Ching PhD Scholar

Connie Wong Research Assistant

Dr Amanda Wood

Honorary Fellow

Jacquie Wrennall Research Affiliate

Dr Simon Young

Research Affiliate

Dr Helena Zdolsek Research Affiliate

Early D E v E lopm E nt & D is E as E

Remember the first time you heard your favourite song?

Music is a joy many of us take for granted. But without the gift of hearing, a child may never learn their favourite song. We hope to understand how genes influence not just hearing but other developmental processes in children.

Improving understanding and care for children by identifying the role of genes in the developing embryo and in conditions like cancer, diabetes, intersex conditions, deafness and liver diseases.

This theme of research is based on the premise that many childhood diseases have their origins in early development.

In this context, development may refer to the change from a non-specialised to a specialised cell or the sort of extraordinary development that occurs in a growing human embryo and foetus during pregnancy.

If there are faults in the genes that regulate these developmental processes, in combination with environmental insults, then normal development may go awry resulting in a variety of childhood diseases.

Early D E v E lopm E nt & Dis E as E

Our research is focused on understanding childhood conditions such as cancer, diabetes, hearing loss, liver disorders, testis/ovary dysfunction and pituitary disease, leading to improved outcomes for affected children.

Theme Director: A/Professor Andrew Sinclair andrew.sinclair@mcri.edu.au

Research priorities 2005

Our first priority was to strategically structure our research effort to maximise health benefits for affected children. To this end, we created greater synergies between the existing research groups and identified common research themes such as cell and embryonic development, controlled cell death (apoptosis), epigenetics and gene/ environment effects on disease.

Another priority was to recruit people with complementary expertise, to help find answers to childhood diseases. We appointed Paul Ekert, who brings expertise in apoptosis and its role in cancer and adds another dimension to research groups such embryology and pituitary research. We also supported the appointment of Matt Sabin from the UK, who will set up a new research program on childhood obesity to determine which types of dietary fats are responsible. Childhood obesity is reaching epidemic proportions, yet little is known about its underlying causes.

We also created a new research group with expertise in epigenetics, a relatively new area of research that impacts on a wide range of childhood diseases and on many research groups in our theme and beyond. This group rapidly became involved with a range of research projects in cancer, early determinants of health, embryology and molecular development.

The molecular development group began a large scale trial of new gene chip technology, in an effort to identify the genetic lesions underlying gonad failure in intersex patients. This technology has the potential for widespread application and diagnosis across a range of childhood conditions.

Investment strategy

• Funded a three year fellowship for David Ashley, head of the Children’s Cancer Centre, to allow a 50 per cent time commitment to cancer research

• Supported the appointment and establishment of Paul Ekert, Matt Sabin, Jeff Craig and Richard Saffery

• Established a molecular medicine seminar series, attracting high profile national and international speakers, including 2005 Nobel Prize winner Professor Barry J Marshall

• Shared use and costs of large equipment with other themes

• Completed the fit out and bought equipment for new third floor laboratories

Research groups & leaders

Antisense Therapeutics (ATL)

Dr Lynne Atley

Cancer

A/Professor David Ashley

Diabetes

A/Professor Fergus Cameron

Embryology

Dr Don Newgreen

Early Determinants of Child Health

Dr Ruth Morley

Genetic Hearing Research

A/Professor Henrik Dahl

Hormone Research

Professor George Werther

Liver Research

Dr Katie Allen

Molecular Development

A/Professor Andrew Sinclair

Pituitary Development & Disease

Dr Paul Thomas

Research outcomes

• Completed stage one redevelopment of the Children’s Cancer Centre and aligned clinical research capacity with the Monash Medical Centre through the paediatric integrated cancer service

• Established a psycho-oncology research program and committee and a patient care research committee (nursing)

• ATL tested its antisense cream on patients with psoriasis and a clinical assessment showed improvement

• Identified a possible role for epithelialmesenchymal transition in cancer invasion and metastasis

• Some light skinned Australian women are Vitamin D deficient during pregnancy. Vitamin D is a potent natural hormone, produced when skin is exposed to sunlight. We found evidence that some of these women’s babies have reduced long bone growth

• Identified genes that, when mutated, are responsible for deafness and worked towards improved understanding of human deafness and therapies for hearing loss

• Developed a system to deliver stem cells to the inner ear

• Demonstrated that the insulin like growth factor system has multiple functions in the brain

• Haemscreen was selected in the “10 of the best” NHMRC funded health and medical research successes – the project demonstrated that screening can be used to prevent problems associated with

haemochromatosis, a liver disorder associated with iron overload

• Began development of world class cell therapeutics for the treatment of liver disease and optimising conditions for liver cell repopulation after liver cell transplantation

• Developed gene chip technology to identify gene defects in patients with testis/ovary dysfunction

• The ARC reviewed our Centre of Excellence and gave it one of the highest national rankings

• Growth hormone deficiency is a significant clinical problem in children – we identified a cell type within the pituitary that can be coaxed to produce growth hormone, which could be transplanted into patients with this condition

Publications

The theme published 67 peer reviewed papers. Highlights were:

• Delatycki MB et al. Lancet 366: 314-316 (2005)

• Silke J et al. Proceedings of the National Academy of Sciences USA 102: 16182-16187 (2005)

• Snoeckx RL et al. American Journal of Human Genetics 77: 945-957 (2005)

• Russo VC et al. Endocrine Reviews 26: 916-943 (2005)

• Ashley DM et al. Cancer 104:1487-96 (2005)

Awards & achievements

• Andrew Sinclair was appointed by the Federal Minister of Health to the Australian Biotechnology Advisory Council, which provides direct high level independent advice

• David Ashley was appointed leader of the international pediatric brain tumour consortium

• Don Newgreen was the invited speaker at the international conference on epithelialmesenchyme transition, Vancouver, Canada

• Don Newgreen was invited to write an article for Cancer Research on the important and controversial subject of EMT and its role in cancer invasion

• Elisabeth Northam, Fergus Cameron and Debbie Rankins were invited to write a review on the impact of type-1 diabetes on brain development for Nature Clinical Practice Neurology

• Fergus Cameron was the only Australian invited to join the international consensus guidelines group on the use of the insulin pump therapy for children and adolescents with diabetes

• Garry Warne was awarded a highly prestigious medal for services to child health over 10 years by the Government of Vietnam

• George Werther was appointed chairman of biotech Neuren’s scientific advisory committee (SAC) and a member of the SAC of Tercica, a US based biotech company.

• Katie Allen was awarded a Career Development Award from NHMRC

• Quanah Hudson was awarded his PhD and a postdoctoral fellowship by the prestigious US based Jackson Laboratories

• The theme organised a very successful national symposium on epigenetics and disease

Major collaborators

• Australian Phenomics Facility

• Children’s Oncology Group USA

• Isis Pharmaceuticals Inc USA

• Walter and Eliza Hall Institute

Major sponsors

• Australian Cancer Research Fund

• Bluey Day

• Brain Foundation

• Cancer in Kids Auxillary

• Children’s Oncology Group

• Children’s Cancer Centre Foundation

• Inner Wheel Australia

• Janet and John Calvert Jones

• Leukaemia Auxiliary RCH

• Leukemia Research Fund

• My Room

• Novo Nordisk

• Pediatric Brain Tumour Foundation

• Pfizer Australia

• SciGen

• Serono

• Swiss Vitamins

Objectives for 2006

• To review and assess performance of new initiatives to maximise health outcomes for children

• To encourage new groups in apoptosis, epigenetics and obesity to focus on specific problems related to childhood disease

• To improve synergies between the laboratory based, clinical and public health research groups

• To oversee grant submissions in order to improve success rates

• To monitor progress and suggest new strategic directions through theme workshops

• To encourage greater cross theme collaborations where appropriate

• To develop appropriate strategies to increase critical mass of research groups

• To ensure appropriate laboratory and office space is available for all research groups

• To position groups to be competitive for larger funding opportunities such as NHMRC programs, ARC centre of excellence, National Institutes of Health USA and EU funding opportunities

• To establish a new and exciting seminar program with high profile speakers

Grants list

NHMRC AWARDS

Project Grants

Fergus Cameron, Terrie Inder, Elisabeth Northam, Mark Wellard, George Werther

Diabetes

$135,150

Henrik Dahl, Shehnaaz Manji

Genetic Hearing Research

$186,250

Christine Hawkins Cancer

$83,250

John Heath, Vicki Anderson Cancer

$29,863

Don Newgreen Embryology

$120,000

Paul Thomas, Diana Lepore, Iain Robinson, Chen Chen, Kenneth Knight

Pituitary Development and Disease

$154,250

Paul Thomas Pituitary Development and Disease

$105,125 Career Development Awards

Paul Ekert Neonatal Research

Christine Hawkins Cancer

Paul Thomas Pituitary Development and Disease

Fellowships

Henrik Dahl

Senior Research Fellowship

John Heath

Health Professional Research Fellowship Cancer Heart Foundation

Dora Lush Biomedical Postgraduate Research

Scholarships Dinh Nguyen

EXTERNAL GRANTS

Australia and New Zealand Children’s Haematology/ Oncolology

Ngaire Elwood Cancer

$15,000

Australian Cancer Research Foundation

David Ashley Cancer

$500,000 Cancer Council

Australia

John Heath Cancer

$40,000

Diabetes Australia Research Trust

George Werther Hormone Research

$45,000

Garnett Passe and Rodney Williams Memorial Foundation

Henrik Dahl

Genetic Hearing Research

$86,280

Heart Foundation

Ruth Morley and

Melissa Wake

Early Determinants of Health

$37,010

Helen Macpherson

Smith Trust

Andrew Sinclair Molecular Development

$100,000

Juvenile Diabetes Research Foundation

International (USA)

Elisabeth Northam Diabetes

$147,444

Juvenile Diabetes Research Foundation

International (USA)

Fergus Cameron Diabetes

$38,658

Juvenile Diabetes Research Foundation

International (USA)

George Werther/ Vince Russo Hormone Research

$155,723

National Childhood Cancer Foundation (CureSearch)

John Heath/David Ashley Cancer

$26,260

Paediatric Brain

Tumor Foundation of the United States

David Ashley Cancer

$66,666

Pfizer Australia

George Werther

Hormone Research

$80,000

Rotary Inner Wheel

Australia Inc Ngaire Elwood Cancer

$65,000

MCRI INTERNAL GRANTS

Part Time Career Grants

George Werther Hormone Research

Project Grants

Katie Allen Allergy and Immune Disorders

Lee Parry

Genetic Hearing Research

Richard Saffery Epigenetics Research

Craig Smith Molecular Development

Paul Thomas Pituitary Research

Staff list

THEME DIRECTOR

A/Professor Andrew Sinclair

Nicky Woods Executive Assistant to Theme Director

THEME ADVISORY

GROUP

Dr Katie Allen Group Leader

A/Professor David M Ashley Group Leader

Dr Lynne Atley Group Leader

A/Professor Fergus Cameron Group Leader

A/Professor Henrik Dahl Group Leader

Dr Ruth Morley Honorary Fellow / Group Leader

Dr Don Newgreen Group Leader

Dr Paul Thomas Group Leader

Professor George Werther Honorary Fellow / Group Leader

THEME MEMBERS

Frank

Anastasopoulos Research Affiliate

Elena Andaloro Research Assistant

Lotte Andreasen Research Affiliate

A/Professor Leon Bach Research Affiliate

Dr Anurag Bajpai Senior Clinical Fellow

Andrew Boucher Research Affiliate

Inigo Brinas Honours Student

Dr Nicole Buck Postdoctoral Fellow

Dr Denise Caruso Senior Research Officer

Anna Cawood Technical Assistant

Daphne Cheah Research Officer

Linda Chilcott

CBB Clinical Coordinator

Lesley Chow Research Assistant

Anna Crack Research Affiliate

Vinod Dagar

Research Assistant

Hinda Daggag

PhD Scholar

Dr Michelle de Silva Research Fellow

Dr Tam Dieu PhD Scholar

Karen Egan Research Affiliate

Dr Ngaire Elwood Group Leader

Melissa Ferguson Research Assistant

Jenny Forrester CBB Clinical Coordinator

Samantha Francis-Pester Research Affiliate

Sarah Fraser

Research Assistant

Marlena Galczewski Honours Student

Rebecca Gebert

Research Affiliate

Dr Heather Gilbertson Research Affiliate

Sonja Gustin Research Officer

Dr Winita Hardikar Research Affiliate

Dr Christine Hawkins Group Leader

Dr John Heath Senior Research Fellow

Sandra Higgins Honours Student

Michael Hildebrand Research Affiliate

Po-ki Ho

PhD Scholar

Jennifer Houlihan Research Affiliate

Quanah Hudson PhD Scholar

Dr Honor Hugo Postdoctoral Fellow

Rebecca Humphreys Research Affiliate

Wendy Hutchison Scientific Officer

Dr Anissa Jabbour Research Officer

Lee-Ann Jones Administrative Assistant

Eric Joo Honours Student

Sue Kantor

Research Affiliate

Jane Kaye CBB Clinical Coordinator

Bronwyn Kitchingman CBB Clinical Coordinator

Dr Maria Kokkinos Visiting Postdoctoral Fellow

Katherine Kolk

Research Nurse

Dr Ildi Koves

Research Affiliate

Lisa Kropf

CBB Clinical Coordinator

Rita Krouskos Honours Student

Dr Diana Lepore Postdoctoral Fellow

Shan Li

Research Assistant

Dr Ruili Li

Senior Research Officer

Elizabeth Loughlin Research Affiliate

Dr Shehnaaz Manji Research Fellow

Dr Peter McClive

Postdoctoral Fellow

Sally Morrissy

CBB Clinical Coordinator

Andrea Muscat Research Assistant

Li Yong Ng

Research Affiliate

Tam Nguyen PhD Scholar

A/Professor

Elisabeth Northam

Research Affiliate

Dr Michele O’Connell Clinical Research Fellow

Marisel Peverelli PhD Scholar

Susan Pongrac

CBB Scientist

Dr Preamrudee Poomthavorn

Research Affiliate

Dr Supriya Raj Research Affiliate

Anne Reilly Research Affiliate

Chris Riffkin

Research Assistant

Jeanette Ripper CBB Production Manager

Ashley Robertson Research Assistant

Kelly Roeszler Research Assistant

Jacqui Rosen Research Affiliate

Dr Vincenzo Russo

Senior Scientist

Emma Schouteten

Technical Assistant

Maria Siboe

AMS Scholar

Michelle Sichlau Honours Student

Dr John Silke

Research Affiliate

Dr Peter Simm Clinical Research Fellow

Dr Matthew Simpson Postdoctoral Fellow

Dr Craig Smith

Honorary Fellow

Dr Julieta Solis Clinical Research Fellow

Kally Theodore Research Assistant

Elesha Tournier Group Member

Shilpa Trevedi Research Affiliate

Jocelyn van den Bergen

Research Assistant

Joseph Wagner PhD Scholar

Professor Garry Warne Honorary Fellow

Dr Patrick Western Postdoctoral Fellow

Marguerite Wijetunge Research Affiliate

Fee Yee Wong Research Affiliate

Dr Christopher Wraight Honorary Fellow

Susie Ymer Senior Research Officer

Dr Margaret Zacharin

Research Affiliate

Dr Sally Zeunert

Research Affiliate

Dong Zhang

Research Assistant

Healt H y development

You’ve given her something to smile about. It’s not just physical illness that affects children. Other things make a big difference to a child’s development and behaviour. With your support, our research helps give children a healthier start in life for a happier future.

Giving children and young people the best start in life by preventing poor health, enhancing wellbeing and investigating common problems like obesity, minimising risk, depression, alcohol and drug abuse, hearing, language and literacy.

Our research examines the physical, social and environmental factors that shape the health of children and young people. We aim to improve their quality of life by informing public policy, service systems and professional practice in clinical and community settings, including family focused programs.

Our theme encompasses the majority of public health research undertaken on the campus and comprises the centre for adolescent health and the centre for community child health, together with other research groups using similar methodologies and approaches.

healthy development

We focus on pathways to good health in children and young people by addressing common problems including alcohol and drug use, obesity, physical activity, nutrition, language and literacy, hearing, development, mental health, behaviour and wellbeing.

Theme Director: Professor Sheena Reilly sheena.reilly@mcri.edu.au

Research priorities 2005

Our priorities focused on common problems affecting children, young people and their families. The prevalence of obesity in children has doubled over the past decade, which has serious long term health and psychosocial consequences. Obese children are significantly more likely to become obese adults. Because established obesity is very difficult to treat, our efforts were directed to preventing problems through education, physical activity and nutrition programs.

Hearing impairment is one of the most common disabilities worldwide. Despite major advances, including the cochlear implant, many hearing impaired school leavers have poor language and literacy skills. Our research determined the prevalence and impact of milder hearing losses in order to understand why children with apparently identical deafness do well or do badly at school, and to understand what it is like to be a deaf child or adolescent in today’s world.

Difficulties with language, literacy and learning have lifelong implications and can significantly compromise levels of achievement and quality of life. We conducted research to better understand the causal pathways that lead to these problems, and to develop more reliable methods of early identification.

Approximately 15 per cent of Australian children are affected by chronic physical illness or disability or have chronic mental, emotional or cognitive disorders. Our research explored the impact of chronic conditions on children, young people and their families, and investigated how the experience changes as children mature through childhood into adolescence and adult life.

Alcohol and drug use in young people is prevalent. It can threaten their health and have long term adverse consequences. Adolescent habits tend to continue into adulthood and impact on future generations. We contributed to knowledge of how to reduce the risk of alcohol and drug use and successfully developed and evaluated effective prevention approaches.

We were also concerned with common problems that occur in infants and young people, such as

crying, sleeping and behavioural problems and adolescent issues such as depression. Our work was targeted at understanding the causal pathways and complex biological and environmental interactions that lead to these problems. We also developed and trialled effective management strategies to be employed in schools and community settings.

We explored and promoted the role of the community and social environment in enhancing children’s healthy development. This included research that focused on community development, the physical and social environment and promoting changes to the school environment and service infrastructure. We also studied the organisation, delivery, effectiveness and financing of health services that impact on children, young people and their families.

Investment strategy

Our investment strategy is to strengthen and grow the research of our eight groups by supporting innovative projects that will enhance the scale and focus of our research interests. Investing in people is a key strategy and includes:

1. Attracting outstanding researchers to work in the theme from other organisations, both nationally and internationally

2. Investing in our own talented and dedicated staff

3. Supporting specific expertise that will give us a competitive edge

We have also invested in infrastructure that is key to enhancing our theme’s research activity and outcomes.

Research groups

Alcohol & Drug Use

Health Services

Healthy Communities

Public Health Hearing

Language & Literacy

Mental Health, Behaviour & Wellbeing

Obesity, Physical Activity & Nutrition

Physical Health & Development

Research outcomes

• Citation of our research on the impact of cannabis on mental health in large national campaigns in the USA, which encouraged a more assertive policy to be developed in Australia

• Noted high rates of Australian adolescent alcohol in international research comparing Australian trends to USA trends

• Contributed to an international publication summarising current research literature on the prevention of substance abuse

• Continued the Beyond Blue school research initiative, a national randomised controlled trial to prevent depression in secondary school students

• 10 years of hearing research and advocacy culminated in the Victorian infant hearing screening program commencing state funded universal newborn hearing screening at six metropolitan sites

• Presented findings from the Hearing in Schools program across the USA

• Commenced an obesity prevention and intervention initiative Live, Eat And Play, a program to help general practitioners and families manage obese primary school aged children

• Found that obese children have a dramatic decrease in quality of life and are more likely to suffer self esteem and social acceptance issues than other children

• Furthered application and validation of diverse time use methodologies as a tool for researching obesity

• Launched Let’s Read, a national program to encourage reading by young children

• Continued a longitudinal study on the natural history of language development

• Completed a primary care program to prevent externalising behaviour problems in toddlers, which attracted international interest

• Disseminated the Gatehouse Project to more than 150 schools

• Piloted a joint project with the University of Calgary to implement the Gatehouse Project. A broad scale trial is planned for 2008

• Trialled the Australian Early Development Index on more than 30,000 children at school entry in 60 communities across Australia

• Trialled the Healthy Neighbourhoods project in 30 communities, focusing on adolescent perceptions of the community

• Replication of our Toddlers Without Tears research program by the New Zealand government

• Showed that a simple primary care behavioural intervention can improve infant sleep and maternal wellbeing

Publications

We published 55 papers in 2005. Highlights were:

• Mann JJ et al. Journal of the American Medical Association 294: 2064-2074 (2005)

• Olsson CA et al. Molecular Psychiatry 10: 868-876 (2005)

• Sawyer SM et al. Thorax 60: 326-330 (2005)

• Williams J. Journal of the American Medical Association 293: 70-76 (2005)

• Yeo M et al. British Medical Journal 330: 721-723 (2005)

Awards & achievements

• Lyndal Bond invited to consult on the whole school approach to health promotion at Case Western Reserve University, USA

• Sarah Drew appointed as a Windermere Fellow

• Katherine Frayman awarded a high distinction for her thesis

• Angela Hassett awarded an APA scholarship from the University of Melbourne and an MCRI research scholarship

• Angela Morgan was awarded a clinical research fellowship from NHMRC

• Frank Oberklaid was appointed to the Victorian Children’s Council

• Craig Olsson was awarded a VicHealth Fellowship

• George Patton was appointed to a top level advisory group of five experts to advise the government on the links between cannabis and mental illness

• George Patton was awarded the Iris Litt Visiting Professorship in adolescent health research

• Sophie Reid won the National Fresh Innovation award from the British Council and the Department of Industry, Innovation and Regional Development

• Susan Sawyer appointed to the national advisory group on smoking and pregnancy

• Melissa Wake appointed to the expert panel advising the Victorian Department of Human Services on the best ways to prevent and manage child and adolescent obesity

Major collaborators

• Institute of Child Health UK

• Institute of Psychiatry UK

• International Collaboration for Complex Interventions

• McMaster University Canada

• National Drug and Alcohol Research Centre

• National Drug Research Institute

• Telethon Institute for Child Health Research

• The Smith Family

• University of Arizona USA

• University of Melbourne

• University of New England

• University of South Australia

• University of Washington USA

Major sponsors

• Alcohol Education and Rehabilitation Fund

• Australian Research Council

• Colonial Foundation

• Criminology Research Council

• Equity Trustees

• Federal Department of Family and Community Services and Indigenous Affairs

• Federal Department of Health and Ageing

• Financial Markets

• Geoff Handbury

• Dame Elisabeth Murdoch

• National Institute of Health

• Judy & Rowly Paterson

• Perpetual Trustees

• Philip S Myer

• Pratt Foundation

• RE Ross Trust

• Sarah and Baillieu Myer Family Foundation

• Shell Australia

• Telstra Foundation

• VicHealth

• Victorian Department of Human Services

• Windermere Foundation

Objectives for 2006

In 2006 we aim to increase both the quantity and quality of our theme’s research activity by increasing the funding awarded and maintaining our publishing rates through:

• Examining how we can further focus the research direction of the theme

• Increasing the number of staff able to win competitive grants

• Building an environment that supports the growth and wellbeing of our researchers and attracting current and future high achievers

Grants list

NHMRC AWARDS

Project Grants

Harriet Hiscock, Melissa Wake

Community Child Health

$60,000

George Patton, John Carlin, Carolyn Coffey

Adolescent Health

$222,950

Sheena Reilly, Edith Bavin, Margot Prior, Melissa Wake, Joanne Williams

Language and Literacy

$75,000

Melissa Wake, Michael Bittman, Michael Sawyer, John Carlin

Community Child Health

$64,500

Melissa Wake, George Patton, Elisabeth Waters, Joanne Williams, Kylie Hesketh, Timothy Olds Community Child Health

$218,000

Melissa Wake, Jane Gunn, Louise Baur, Zoe McCallum, Kay Gibbons

Community Child Health

$255,850

Joanne Williams, Melissa Wake

Community Child Health

$69,300

Joanne Williams, John Toumbourou, Ross Homel, George Patton Community Child Health

$188,350 Career Development Awards

Melissa Wake

Community Child Health

Public Health

Postgraduate Scholarships

Michele Campbell

Julie Green

Michelle Seipolt

Postgraduate Scholarships in Palliative Care

Jenny Hynson

EXTERNAL GRANTS

Alcohol Education and Rehabilitation Foundation Ltd

George Patton

Adolescent Health

$146,163

Alcohol Education and Rehabilitation Foundation Ltd

Sophie Reid

Adolescent Health

$19,760

Beyond Blue

Sophie Reid

Adolescent Health

$70,000

Cystic Fibrosis

Australia

Susan Sawyer

Adolescent Health

$23,745

Dept of Family and Community Services

Frank Oberklaid Community Child Health

$179,000

Equity Trustees (Grosvenor Settlement)

John Bamberg

Adolescent Health

$20,000

Financial Markets

For Children

Melissa Wake

Community Child Health

$50,000

Helen Macpherson

Smith Trust

Frank Oberklaid

Community Child Health

$55,000

National Alliance for Research on Schizophrenia and Depression

Craig Olsson

Adolescent Health

$38,971

National Institutes of Health

John Toumbourou

Adolescent Health

$189,834

Perpetual Trustees

Craig Olsson

Adolescent Health

$50,070

Perpetual Trustees

Sheena Reilly

Language and Literacy

$38,470

Perpetual Trustees

Cathy Crock

Adolescent Health

$23,000

RE Ross Trust

Craig Olsson

Adolescent Health

$18,750

Telstra Foundation

Harriet Hiscock

Community Child Health

$50,000

Telstra Foundation

Sophie Reid

Adolescent Health

$50,000

Victorian Health Promotion Foundation

George Patton

Adolescent Health

$100,000

Victorian Health Promotion Foundation

George Patton

Adolescent Health

$47,000

William Buckland Foundation (ANZ Charitable Services)

Craig Olsson

Adolescent Health

$24,094

William Buckland Foundation (ANZ Charitable Services)

Jenny Hynson

Palliative Care Research

$27,947

MCRI INTERNAL GRANTS

Part Time Career Grants

Harriet Hiscock

Community Child Health

Postgraduate Health Research Scholarships

Deirdre Gartland

Mental Health, Behaviour and Wellbeing

Kerry Ttofari Eecen

Speech Pathology

Staff list

THEME DIRECTOR

Professor Sheena Reilly

Kylie Gilmartin

Executive Assistant to Theme Director

THEME ADVISORY GROUP

Dr Lyndal Bond Honorary Fellow

Dr Kay Gibbons Honorary Fellow

Dr Sharon Goldfeld Honorary Fellow

Professor Frank Oberklaid Honorary Fellow

Professor George Patton

Group Leader

A/Professor Susan Sawyer Honorary Fellow

A/Professor John Toumbourou Honorary Fellow

A/Professor

Melissa Wake

Group Leader

THEME MEMBERS

Donna Anderson

Training Project Officer

Kate Anderson Visiting Student

Dr Richard Anney Research Fellow

John Bamberg Project Manager

Melinda Barker Research Officer

Yin Barrett Research Assistant

Amy Basile Research Assistant

Dr Jordana Bayer Postdoctoral Fellow

Frances Biffin Research Assistant

Melanie Bissett Research Affiliate

Catherine Bolzonello

Research Assistant

Jessica Butler Research Assistant

Sarah Butler Administrative Assistant

Helen Butler Project Coordinator

Petrea Cahir

Administrative Assistant

Dr Michele Campbell PhD Scholar

Louise Canterford Research Assistant

Rianna Chapman Research Assistant

Dr Isabelle Chossis Masters Scholar

Eileen Cini Research Assistant

Dr Carolyn Coffey Associate Fellow

Dr Melissa Coutts Project Officer

Diana Crocker Administrative Assistant

Catherine Croft Project Officer

Belinda Davey Research Assistant

Judy Davey Research Affiliate

Natalie de Bono Project Coordinator

Hilary Dent Research Assistant

Sarah Drew Research Affiliate

Amanda D’Souza Project Officer

Dr Patricia Eadie Honorary Fellow

Dr Daryl Efron Research Affiliate

Dr Tracy Evans-Whipp Research Officer

Fides Ferlin Research Affiliate

Maria Fong Project Officer

Lucianne Foy Research Affiliate

Dr Alexandra Fraser

Project Officer

Philippa Garrard Group Member

Deirdre Gartland Research Assistant

Bibi Gerner Research Assistant

Julie Green Research Fellow

Philip Greenwood Research Assistant

Adina Grossman Research Assistant

Dr Sonia Grover Honorary Fellow

Eva Grunden Co-ordinator / Evaluator

Dr Dagmar Haller-Hester PhD Scholar

Ann Hampton Research Assistant

John Hargreaves Research Officer

Angela Hassett PhD Scholar

Dr Sheryl Hemphill Project Manager

Philippa Hillman Visiting Student

Trina Hinkley Research Assistant

Dr Harriet Hiscock Senior Postdoctoral Fellow

Tessa Hughes Senior Project Officer

Dr Jenny Hynson Research Affiliate

Hasherah Ibrahim PhD Scholar

Christine Imms PhD Scholar

Victoria Jolley PhD Scholar

Stephanie Jones PhD Scholar

Richard Kaa Research Assistant

Sylvia Kauer

Research Assistant

Andrea Krelle Project Manager

Kylie Lee

Masters Scholar

Penny Levickis Research Assistant

Dr Martha Lide Research Affiliate

Dr Andy Lovett PhD Scholar

Megan Mathers Research Assistant

Dr Zoe McCallum Senior Research Officer

Rachel McConaghy Manager

Communication & Translation

June McLoughlin

Research Assistant

Dr Tim Moore

Senior Research Fellow

Elise Morton-Allen

Research Assistant

Kate Naish Project Officer

Jennifer Nazareth Research Affiliate

Shannon Newman Senior Project Officer

Ruth Nicholls PhD Scholar

Matt O’Brien Project Manager

Dr Craig Olsson Postdoctoral Fellow

Dr Zeffie Poulakis Research Officer

Elke Power

Research Assistant

Dr Jenny Proimos Medical Scientist

Melinda Randall

PhD Scholar

Julie Reid PhD Scholar

Dr Sophie Reid Research Officer

Lucy Rogers Research Assistant

Dr Katherine Rowe Honorary Fellow

Charmaine Sambathkumar Research Affiliate

Dr Lena Sanci Honorary Fellow

Professor Ann Sanson

Research Affiliate

Mary Sayers Senior Project Officer

Melinda Schambre

PhD Scholar

Emma Sciberras

Research Assistant

Dr Jillian Sewell Honorary Fellow

Alice Shaw Research Assistant

Jane Sheehan Research Assistant

Helen Shoemark Honorary Fellow

Dr Alison Shortt Research Affiliate

Dr Jemma Skeat Research Assistant

Katherine Smith Research Assistant

Rachel Smith

Research Assistant

Libby Smith Research Assistant

Denice Spence

Administrative Coordinator

Kezia Stokes

Masters Scholar

Daniel Strachan Project Officer

Sherryn Tobin Research Assistant

Michelle Tollit Research Assistant

Lea Trafford Project Officer

Kerry Ttofari Eecen

PhD Scholar

Dr Friederike Veit

Honorary Fellow

Carly Veness Research Assistant

Jacinta Wainwright Project Officer

Amy Watts Visiting Researcher

Samuel Wills

Group Member

Aisha Williams

Administrative Assistant

Debra Williams

Administrative Assistant

Ian Williams Research Officer

Dr Joanne Williams

Senior Research Fellow

Dr Michele Yeo Research Fellow

Infect I on, I mmun I ty & env I ronment

Thanks to you, the local U15s have their pitcher. Being sidelined by asthma or other common allergic and infectious diseases isn’t fun when you’re young and full of life. Research helps keep young people where they belong – out amongst it, playing, living, loving every minute.

Our research addresses common infections, immune conditions, allergies and immunisation and also aims to solve severe health problems that affect many children living in settings of poverty.

We have a strong emphasis on translating our research findings into practical interventions to reduce death and disease and prevent conditions such as asthma, allergies, gastrointestinal diseases, Crohn’s disease and staphylococcal and streptococcal infections.

Vaccine development forms a large part of our research, to enable us to prevent rather than just treat disease. Much of our research aims to improve the lives of indigenous Australians living in remote Northern Territory communities and children in developing countries, especially in the Asia-Pacific region.

We have some of the best laboratory scientists and public health researchers in Australia and the prominence of clinicians in our theme allows us to maintain direct contact with the beneficiaries of our research: people.

Infect I on, Immun I ty & e nv I ronment

Our research deals with the interaction of people (particularly the immune system and the gut) with the outside world (particularly infectious agents and allergens).

Theme Director: A/Professor Jonathan Carapetis jonathan.carapetis@rch.org.au

Research priorities 2005

We are developing and testing a vaccine to protect children both in Australia and around the world against a number of diseases. In 2005 we made progress on a new vaccine to prevent gastroenteritis caused by rotavirus. Vaccines being produced elsewhere will be too expensive for all but the richest countries, so we were able to secure funding and international interest to develop an Australian vaccine that will benefit those living in developing countries.

We expanded our research program in Fiji, which explores cheaper and more flexible ways to combine the new conjugate and older style polysaccharide vaccines for pneumococcal infections, the major cause of child death due to bacterial infection in the world. We were part of an international consortium that demonstrated a vaccine to prevent human papilloma virus, the cause of most cervical cancer, is safe and effective. We also led the Australian human trials of a pandemic avian influenza vaccine.

We are collaboraing in the development of a vaccine for rheumatic fever and other group A streptococcal infections, to prevent this major cause of disease in Aboriginal people and developing countries. Using the latest microarray technology to profile the human immune response to infection, sleep and other stimuli, we investigated how rheumatic fever is caused by streptococcal infections.

Further development of our immunisation research will progress through the new NHMRC funded Centre for Clinical Research Excellence in child and adolescent immunisation that aims to conduct practical vaccine related research and train the immunisation researchers of the future.

We continued to expand a large collaborative project in the Northern Territory, which aims to demonstrate how community control of skin infections will have far reaching benefits for health in remote Aboriginal communities.

We commenced large and long term studies to investigate the complex interplay of early childhood factors (for example, exposure to infections, number of siblings, infant care

practices) on diseases such as asthma, allergy and multiple sclerosis.

We further developed our studies into important gut and liver conditions affecting children, including Crohn’s disease, constipation, chronic pancreatitis, end stage liver disease and bowel dysmotility.

Investment strategy

Our funds are used to support research with the greatest potential to improve child health or health-related practices, particularly in settings of poverty. Some of these are expansions of existing programs, (rotavirus vaccine and food allergy research) and others are new (environmental and genetic epidemiology research). We are focused on supporting the emerging research leaders of the future and funding the occasional high risk area that, if successful, could produce major findings with important health benefits.

Research groups & leaders

Allergy & Immune Disorders

A/Professor Mimi Tang

Clinical Paediatrics & Therapeutics

A/Professor Mike South

Enteric Viruses

Dr Carl Kirkwood

Environmental & Genetic Epidemiology Research

Professor Anne-Louise Ponsonby

Gut & Liver

Professor Tony Catto-Smith

Immunisation Research

Professor Terry Nolan

Infectious Diseases & Microbiology

A/Professor Nigel Curtis

Professor Roy Robins-Browne

International Child Health

A/Professor Jonathan Carapetis

Intestinal Failure & Clinical Nutrition

A/Professor Julie Bines

Respiratory Diseases

Professor Colin Robertson

Surgical Research

Dr Bridget Southwell

Research outcomes

• The centre for international child health was designated as a World Health Organization Collaborating Centre for Child and Neonatal Research and Training

• Demonstrated the success of interventions to reduce scabies and skin sores in remote Aboriginal communities

• Identified significant changes in rotavirus strains causing gastroenteritis in Australian children

• Led the development of Australian national best practice guidelines for the diagnosis and

management of rheumatic fever and rheumatic heart disease

• Constructed Australia’s first purpose built facility for performing early stage drug trials in children

• Progressed with the RV3 rotavirus vaccine candidate, with agreements to manufacture vaccine for human trials during 2006

• Used new methods to demonstrate that chronic constipation in children is a collection of different disorders and highlighted the importance of slow transit constipation

• Investigated the link between vitamin D status and autoimmune disorders such as diabetes. Demonstrated that a low cost vitamin D supplement is effective and acceptable in African refugees

• Participated in international vaccine studies demonstrating the effectiveness of Hib vaccine in eliminating serious bacterial infection in the Gambia. Also demonstrated that Hib is an important cause of pneumonia and meningitis in Indonesian children

• Found that a purpose designed meningococcal group B vaccine has the potential to stop a long term outbreak in New Zealand

• Expanded the laboratory capacity to measure immune responses to pneumococcal vaccines, as part of the Fiji Pneumococcal Program

• Established collaborations to look at the causes of Crohn’s disease, including the early life factors that influence its later development

• Developed a mouse model to measure the efficacy of active and passive immunity to bacteria, such as H pylori

• Commenced a collaborative study to investigate the various aspects of tuberculosis, including the human immune response to infection and the use of new diagnostic tests

• Developed and validated a clinical case definition for intussusception in association with the World Health Organization. Identified risk factors for intussusception in infants in Vietnam and Australia

• Embarked on a study of probiotics, given to mothers to prevent allergic disease in their children

• Researched the physiology of descent of the testis, demonstrating two stage descent

• Produced and distributed a DVD and training booklet on management of children with serious illness in developing countries

• Established a pilot program to introduce community ante natal screening for cystic fibrosis

Publications

We published 128 papers in 2005. Our top five publications were:

• Ponsonby AL et al. Journal of the American Medical Association 293: 463-469 (2005)

• Carapetis JR et al. The Lancet Infectious Diseases 5(11): 685-694 (2005)

• Buttery JP et al. Journal of the American Medical Association 293: 1751-1758 (2005)

• Robins-Browne RM et al. Infection and Immunity 73(5): 3063-3071 (2005)

• Griffiths A et al. American Journal of Respiratory and Critical Care Medicine 2005: (171) 1020-1025

Awards & achievements

• Jonathan Carapetis was appointed Director of the Menzies School of Health Research, Darwin

• Terry Nolan was appointed head, and Ann Kempe and Sue Skull were appointed members of the Australian Technical Advisory Group on Immunisation

• Terry Nolan presented the results of a successful trial of HPV vaccine on behalf of an international consortium at the major European infectious diseases conference

• Kim Mulholland was appointed Chair of Vaccinology at the London School of Hygiene and Tropical Medicine

• Bridget Southwell received an award from the International Foundation for Functional Gastrointestinal Disorders

Major collaborations

• Australian National University

• Cooperative Research Centre for Aboriginal Health

• Fiji Ministry of Health

• Fiji School of Medicine

• Menzies Research Institute

• Menzies School of Health Research

• University of Gadjah Mada Indonesia

• World Health Organization

Major sponsors

• All Bowel Conditions Auxiliary

• Australian Research Council

• CASS Foundation

• CSL

• Department of Health and Ageing

• Edythe and Eli Broad Foundation

• Glaxo SmithKline

• Gotta Get a Life Foundation

• Ian Potter Foundation

• International Foundation for Functional Gastrointestinal Disorders

• Lions Club

• National Heart Foundation of Australia

• National Institutes of Health USA

• Rio Tinto Aboriginal Foundation

• World Health Organization

Objectives for 2006

• To begin human trials of the RV3 rotavirus vaccine

• To commence and continue vaccine trials for pandemic influenza, pneumococcal infections in developing countries, pneumococcal infections in Aboriginal mothers and babies, rheumatic fever and group A streptococcal diseases, herpes simplex virus infections, bacterial meningitis, children following cancer chemotherapy and asplenic children and adults

• To further establish an international consortium which aims to pool existing child cohort data to examine the causes of rare diseases such as leukaemia

• To build on our past work on the early life environmental determinants of asthma and multiple sclerosis

• To determine the cause of Crohn’s disease and identify the factors that affect its severity

• To form Australia’s first small bowel transplant unit and intestinal failure centre of excellence

• To translate findings about chronic constipation into therapeutic interventions

• To determine the burden of food allergy and its role in conditions such as infantile reflux

• To determine the role of maternal probiotics in preventing allergy in children

• To expand mathematical modelling capacity as a tool in preventing and controlling infectious diseases

Grants list

NHMRC AWARDS

Project Grants

John Hutson

Surgical Research

$111,250

Career Development Awards

Jonathan Carapetis

International Child Health

Carl Kirkwood

Enteric Viruses

Kumar Visvanathan

Infectious Diseases and Microbiology

Fellowships

Julie Bines

Practitioner

Fellowship

Intestinal Failure and Clinical

Nutrition

EXTERNAL GRANTS

Baxter Health Care

Julie Bines

Intestinal Failure and Clinical

Nutrition

$32,500

Cass Foundation

Carl Kirkwood

Enteric Viruses

$35,000

Cystic Fibrosis

Australia

Phil Robinson

Respiratory Diseases

$70,000

Geoffrey Gardiner

Dairy Foundation

Ltd

Carl Kirkwood

Enteric Viruses

$11,500

GlaxoSmithKline

Julie Bines

Intestinal Failure and Clinical

Nutrition

$30,000

GlaxoSmithKline

Julie Bines

Intestinal Failure and Clinical Nutrition

$10,000

Heart Foundation

Nigel Curtis

Infectious Diseases and Microbiology

$50,000

Ian Potter Foundation

Jonathan Carapetis International Child Health

$125,000

Jack Brockhoff Foundation

Mimi Tang

Allergy and Immune Disorders

$69,566

Jack Brockhoff Foundation

Peter Vuillerman Respiratory Diseases

$100,000

Perpetual Trustees

Peter Vuillerman Respiratory Diseases

$8,200

World Health Organisation

Fiona Russell

International Child Health

$5,000

World Health

Organization

Julie Bines

Intestinal Failure and Clinical Nutrition

$28,167

MCRI INTERNAL GRANTS

Part-Time Career Grants

Graeme Barnes

Enteric Viruses

John Hutson

Surgical Research

Mimi Tang

Allergy and Immune Disorders

Postgraduate Health Research Scholarships

Annette Webb Gut & Liver Research

Peter Vuillerman Respiratory Medicine

Project Grants

Julie Bines Intestinal Failure and Clinical Nutrition

Jim Buttery Immunisation Research (VIRGO/ CCRE)

Kumar Visvanathan Infectious Diseases and Microbiology

Peter Vuillerman Respiratory Medicine

Staff list

THEME DIRECTOR

A/Professor

Jonathan Carapetis

THEME ADVISORY GROUP

A/Professor Julie Bines Group Leader

Professor Tony Catto-Smith

Honorary Fellow / Group Leader

A/Professor Noel Cranswick

Honorary Fellow / Group Leader

A/Professor Nigel Curtis

Honorary Fellow / Group Leader

Dr Carl Kirkwood Group Leader

Professor Terry Nolan Group Leader

Professor AnneLouise Ponsonby Group Leader

Professor Colin Robertson

Honorary Fellow / Group Leader

Professor Roy Robins-Browne

Honorary Fellow / Group Leader

A/Professor Mike South

Honorary Fellow / Group Leader

Dr Bridget Southwell Group Leader

A/Professor Mimi Tang

Group Leader

THEME MEMBERS

Louise Adams

Research Assistant

Dr George Alex

Research Affiliate

Dr Katie Allen

Group Leader

Dr Yasir Alshareef

Research Affiliate

Dr Ross Andrews Senior Research Fellow

Christine Axelrad

Research Assistant

Kristy Azzopardi Honours Student

Leonie Baker

Research Assistant

Dr Debbie Baldi Research Officer

Dr Anne Balloch Research Officer

Professor Graeme Barnes Group Leader

John Bashour

Group Member

Dr Aleya Begum

Casual Study Doctor

Dr David Ben Meir

Research Affiliate

Dr Vicki BennettWood

Research Affiliate

Andrea Bigham

Research Assistant

Professor Ruth Bishop Group Leader

Nada BogdanovicSakran

Research Assistant

Michelle Boglis

Group Member

Karen Boniface

Research Assistant

Dr Bob Boyle

Research Fellow

Janet Briggs

Research Assistant

Clare Brophy

Research Assistant

Dr Penelope Bryant PhD Scholar

Maria Bufalino

Research Affiliate

Dr Jim Buttery

Senior Research Officer

Dr Don Cameron

Research Affiliate

David Cannan

Research Assistant

Kylie Carville

Research Coordinator

Rosemary Carzino

Research Assistant

Rebecca Cerbu

Administrative

Assistant

Dr Ian Chao

Casual Study Doctor

Dr Ho Chow

Research Affiliate

Hsu En Chung

Research Affiliate

Dr Melanie Clarke

Research Affiliate

Danielle Clucas

Research Affiliate

Samantha Colquhoun

Research Coordinator

Dr Robert Commons

Research Affiliate

Lucy Cosentino

Research Assistant

Lyn Crellin

Research Affiliate

Jenny Cuxson

Research Affiliate

Dr Gabriel

Dabscheck

Casual Study Doctor

Dr Andrew Daley

Research Affiliate

Dr Margaret Danchin

Research Affiliate

Siobhan Davenport

Administrative Assistant

Monique Decortis

Research Assistant

Dr David Delaney

Research Affiliate

Nicole Donker

Honours Student

Dr Trevor Duke

Honorary Fellow

Paige Fahey

Honours Student

Pam Farmer

Research Assistant

Margaret Flood

Research Midwife

Geoffrey Gardiner

Research Affiliate

Dr Suzanne Garland

Honorary Fellow

Deborah Gercovich

Research Assistant

Susie Germano

Research Affiliate

Jane Gibson

Research Assistant

Judith Glazner

PhD Scholar

Rebecca Gorrell

PhD Scholar

Dr Gaudi Hafen

Research Affiliate

Dr Winita Hardikar

Research Affiliate

Dr Efrant Junior

Harnaen

Research Affiliate

Andrea Harrington

PhD Scholar

Dr Jo Harrison

AMS Scholar

Dr Emily Hart

Research Affiliate

Dawn Harwood

Research Affiliate

Margaret Heffernan

PhD Scholar

Dr Ralf Heine

Honorary Fellow

Dr Mary Herzig

Research Affiliate

Dr David Hill

Research Affiliate

Dr Dianna Hocking

Research Affiliate

Dr Lana Horng

Casual Study Doctor

Seong Jin Ang

Research Affiliate

Professor John Hutson

Group Leader

Julie Jones

Group Member

Fran Justice

Research Assistant

Johanna Kappers

Research Affiliate

Marita Kefford

Study Co-ordinator

Julian Kelly

Research Affiliate

Loraine Kelpie

Research Assistant

Ann Kempe

Research

Coordinator

Dr Sebastian King

PhD Scholar

Dr Danijela Krmek

Research Affiliate

Sampo Lahtinen

Research Affiliate

Ruth Lawrence Research Assistant

Melissa Lee

Honours Student

Stephanie Lenko

Research Assistant

Paul Licciardi

Research Assistant

Betty Lim

Research Assistant

Dr Barry Linane

Research Affiliate

Catherine LloydJohnsen Administrative Assistant

Dr Elliot Long Medical Co-ordinator

Ethna Macken

Research Assistant

Professor John Mathews

Senior Research Fellow

Dr Carolyn Maclennan

Research Affiliate

Danielle Marazzato

Research Affiliate

Dr John Massie

Honorary Fellow

Dr James McCaw

Honorary Fellow

AnnMarie McEvoy

Research Assistant

Elizabeth McGrath

Research Assistant

Dr Jodie McVernon

Honorary Fellow

Rebecca Miao

Research Affiliate

Sarah Moberley

PhD Scholar

Professor Kim

Mulholland

Honorary Fellow

Brian Muller

Research Affiliate

Dr Angelika Na

Research Affiliate

Paula Nathan

Research Assistant

Jane Nelson

Study Co-ordinator

Dr Sophie Nightingale

Visiting Research Fellow

Sara Noonan

Research Affiliate

Dr Andy Nydegger

Research Assistant

Amanda O’Brien

Administrative Officer

Nyree O’Connor

Research Affiliate

Dr Shane O’Dea

Casual Study Doctor

Kerry-Ann O’Grady

Senior Research Officer

Paula O’Malley

Executive Assistant to Theme Director

A/Professor Mark

Oliver

Honorary Fellow

Sim Ong

Group Member

Frances Oppedisano

Research Assistant

Dr Monique Paris

Honorary Fellow

Ruth Patterson

Research Affiliate

Cristal Peck

Honours Student

Dr Prue Pereira

Research Officer

Angela Pezic

Research Assistant

Marisol Pineiro

Research Affiliate

Dr Briony Price

Casual Study Doctor

Dr Sarath

Ranganathan

Research Affiliate

Mary Roberts

Research Affiliate

Dr Ric Roberts

Research Affiliate

Dr Phil Robinson

Honorary Fellow

Susi Rogers

Research Assistant

Dr Nicole Rose

Casual Study Doctor

Dr Simon Royce

Postdoctoral Fellow

Dr Fiona Russell

Research Affiliate

Jane Ryrie

Research Assistant

Charan Sandhu

Research Assistant

Deborah Saunders

Research Assistant

Catherine Satzke

Research Affiliate

Dr Clare Savage

Research Affiliate

Dr Vered Schildkraut

Research Assistant

Kate Scott

Group Member

Gowri Selvaraj

Research Assistant

Sally Sheridan

Research Affiliate

Barbra Sherry

Research Assistant

Winnie Sim

Honours Student

Serena Simms

Research Assistant

Di Simpson

Research Affiliate

Dr Joanne Smart

Research Affiliate

Dr Arnold Smith

Research Affiliate

Julie Smith

Research Assistant

Jacinta Sonego

Research Assistant

Magdy Sourial

Research Affiliate

Patricia Staig

Group Member

Dr Andrew Steer

Research Affiliate

Dr Matthew Stevens

Group Member

Dr Rick Streitberg

Honours Student

Dr John Sutcliffe

Research Affiliate

Ingrid Sutherland

Research Assistant

Dayna Swiatek

PhD Scholar

Dr Sepehr Tabrizi

Research Affiliate

Liling Tan

AMS Scholar

Dr Marija Tauschek

Research Affiliate

Louise Taylor

PhD Scholar

Dr Sharon Tennant

Research Affiliate

Dr Leone Thiele

Group Member

Loretta Thorn

Senior Research Fellow

Dr Jacinta Tobin

Research Affiliate

Eve Urban

Group Member

Sarah Vaughan

Research Assistant

Dr Claire Veith

Casual Study Doctor

Dr Kumar Visvanathan

Group Leader

Peter Vuillerman

Research Affiliate

Sandra Walker

Group Member

Dr Annette Webb

Research Affiliate

Evan Willis

Administrative

Assistant

Dr Victor Wong

Research Affiliate

Dr Ji Yang

Research Affiliate

Tiam Yap

Research Assistant

Xian Yong

Group Member

Laboratory &

Community Gen e ti C s

It’s not easy finding the right genes. You can’t choose your family and you can’t choose your genes. Everyone knows families share genes, making us look and act the same and bonding us together. But a tiny change in a single gene can be devastating. We study genetics to ensure future generations are healthier.

Discovering the genetic basis of disease and improving the prevention and management of genetic conditions including ataxia, haemochromatosis, thalassaemia, muscular dystrophy and mitochondrial disorders.

We are in a strong position to achieve our mission as we have excellent expertise and track record in molecular genetics, epigenetics, cytogenetics, clinical genetics, epidemiology, muscular dystrophy, mitochondrial and chromosomal disorders.

The new theme structure and incentives will strengthen key collaborations for our researchers, who share a common interest in different aspects of laboratory, clinical, educational and community genetics. We aim to develop a strategic vision and identify priority research areas that will build on the unique strengths and collective talents of the theme.

To facilitate this, we have begun to establish important conceptual and operational policies to achieve better outcomes in research, publications, policy development, fund raising and grant success.

Laboratory & Community Geneti C s

Our mission is to undertake world class research to advance our understanding of the causes of major health problems for which a genetic or epigenetic basis exists or is suspected, and to develop measures to better detect, inform, prevent or correct these conditions.

Theme Director: Professor Andy Choo andy.choo@mcri.edu.au

Research priorities 2005

The formation of this theme brought together eight research groups with an underlying interest in human genetics. Despite this common interest, a quick overview indicated that the different groups, by and large, work on disparate research areas and that most groups lacked sufficient critical mass to be globally competitive. An important goal was to find ways to capitalise on our diverse expertise and to turn what might be a potential weakness, due to too much breadth and insufficient critical mass, into a unified strength in genetic research.

Two publications in 2005 highlighted how this goal was attained. A paper published in the medical journal Lancet described the use of community genetic screening to prevent the iron overload

disorder haemochromatosis. This work was made possible by drawing on the expertise of four groups: genetic health, genetics education, molecular diagnostics and public health genetics.

Another example was the successful collaboration between cytogenetics and chromosome research, through which important proof of principle data was published in the American Journal of Human Genetics on a new method using cutting edge microarray technology for the detection of submicroscopic chromosomal deletions and duplications in patient cells.

Several strategic changes took place, aimed at maximising research synergy and addressing the critical mass issue. We successfully brought together the laboratory and clinical arms of the Friedreich’s ataxia research, previously working separately, and made a new appointment to head up a clinical genetics research group, drawing on the huge amount of useful clinical materials

and research interests within Genetics Health Services Victoria.

Much effort was put in by research group leaders to gain a greater understanding of, as well as help improve, each other’s research through timely workshops and formal and informal discussions. We also instigated research discussion forums, theme seminar series and more in depth regular research discussions for smaller groups. Through such discussions, we aim to begin to better define our key research priority areas.

Investment strategy

Our investment strategy will ultimately reflect our vision and research priorities. Our first round of theme funding allocated for 2006 was based on project proposals from the different groups. Most of those submitted were extensions of existing work. While it is important to continue to foster key existing projects, which arguably should be of the caliber to eventually attract external funding and be self funding, future investment should see an increasing emphasis on high impact new research initiatives and strategic new recruitments that require substantial seed funding to kick off.

Research groups & leaders

Cell & Gene Therapy

Dr Jim Vadolas, Dr Heidi Peters

Chromosome & Chromatin Research

Professor Andy Choo

Cytogenetic Research

Dr Howard Slater

Genetic Health Research (Bruce Lefroy Centre)

A/Professor Martin Delatycki

Genetics Education & Health Research

Dr Sylvia Metcalfe, Dr MaryAnne Aitkin

Mitochondrial Research

Dr David Thorburn

Molecular Diagnostics Research

Dr Desiree du Sart

Public Health Genetics

Dr Jane Halliday

Research outcomes

• Awarded total new external funding of more than $2.5 million, including two NHMRC projct grants and more than 10 grants from other sources

• Identified three new gene mutations in mitochondrial functions that cause serious childhood diseases: two result in seizures and liver failure in young children caused by loss of mitochondrial DNA and inadequate energy generation; one causes severe growth failure in Polynesian children due to inability to utilise the vitamin biotin

• Completed major projects discovering novel mechanisms for regulating centromere structure and function, which are expected to reach high impact journals

• Published a mouse model carrying a human artificial chromosome that we aim to further develop into a novel tool for gene therapy

• Increased our understanding of the role of PACRG gene in Parkinson disease and infertility

• Produced a number of useful and novel mouse models to assist in studies aimed at developing innovative strategies to correct thalassaemia, Friedreich’s ataxia and methyl malonic aciduria

• Improved chromosome analysis using SNP microarrays and subtelomere testing. This translated into improvements in diagnostic practice

• Improved our research output aimed at formulating guidelines and evidence based information to influence and improve the health professionals’ practice of genetic counselling and genetic medicine

• Characterised complexities involved in population screening for spinal muscular atrophy

• Collaborative projects are identifying new mechanisms causing colon cancer, including somatic cell mosaicism and epigenetic factors impacting on the APC gene function, and examining a new gene that may have a role in causing epilepsy

• Completed the first stage of a study to test the effectiveness of a decision aid for prenatal testing of fetal abnormalities in improving women’s informed decision making

• HaemScreen was featured among the “10 of the best” projects by Federal Health Minister Tony Abbott

Publications

We published more than 65 papers in 2005. All groups contributed strongly to this achievement. We published a landmark paper in Lancet reporting the community acceptance and importance of the use of community genetic screening to prevent the ill

effects of haemochromatosis. Highlights were:

• Delatycki MB et al. Lancet 366: 314-316 (2005)

• Slater HR et al. American Journal of Human Genetics 77: 709-726 (2005)

• Davidzon G et al. Annals of Neurology 57: 921-924 (2005)

• Irvine DV et al. Trends in Biotechnology 23(12): 575-83 (2005)

• Wong LH et al. Journal of Biological Chemistry 280: 3954-3962 (2005)

Awards & achievements

• Alexandra Gason and Anna Flouris were awarded their PhDs

• Alice Jaques was awarded her PhD for evaluating prenatal screening in Victoria

• Belinda Dawson was awarded first class Honours

• Dani Irvine was awarded a CJ Martin Fellowship from NHMRC

• Emma Northrop and Gaby Wilson were awarded Dora Lush Scholarships from NHMRC

• Jim Vadolas was awarded the inaugural Panos Ioannou Fellowship

• Lee Wong was awarded an RD Wright Fellowship from NHMRC

• Robyn Matthews received first class Honours for a project on genetic testing in asthma

• Rony Duncan completed her PhD

• The 600th person was recruited to the Spina Bifida Information Network

Major collaborators

• Affymetrix Inc USA

• Biotechnology Australia

• Department of Human Services: Perinatal Data Collection Unit and Birth Defects Register

• Fragile X Alliance

• Gene Technology Access Centre

• Genetic Health Services Victoria

• La Trobe University

• Mayo Clinic USA

• Monash Institute of Medical Research

• Monash, Melbourne and Mercy IVF clinics

• National Taiwan University Hospital

• Prince of Wales Medical Research Institute

• Royal Children’s Hospital

• Royal North Shore Hospital

• Spina Bifida Foundation

• Swinburne University

• UCLA USA

• University of Melbourne

• University of Queensland

• Walter and Eliza Hall Institute

Major sponsors

• Biotechnology Australia

• Department of Human Services

• Friedreich’s Ataxia Research Alliance

• Friedreich’s Ataxia Research Association USA

• Laiki Bank

• Lefroy family and friends

• Muscular Dystrophy Association USA

• National Institutes of Health USA

• St George Kapouti Club

• Thalassaemia Society of New South Wales

• Thalassaemia Society of Victoria

• The Greek Conference

Objectives for 2006

We aim to further define research and investment priorities for the theme and develop the multidisciplinary research within the theme.

In addition, group specific objectives continue, only a small number of which are highlighted here:

• To commence a clinical trial of mitoquinone for Friedreich’s ataxia

• To identify further novel genes causing childhood energy generation disorders to improve diagnosis and prevention

• To continue development of microarrays for high resolution chromosome analysis

• To correlate genotype-phenotype in cardiac arrhythmia disorders

• To develop guidelines for health professionals for the communication of genetic information in families and to influence health professionals’ practice of genetic medicine

• To further develop human artificial chromosomes as a gene therapy tool and to identify the molecular causes for Robertsonian translocations and Down syndrome

• To further develop skills in questionnaire development for evaluation of genetic testing, including psychosocial measures and long term child health and development

• To identify compounds that act as fetal haemoglobin inducers, and investigate the use of antisense oligonucleotides to prevent aberrant splicing in b-thalassaemia, as potential treatments for thalassaemia

Grants List

NHMRC AWARDS

Project Grants

Andy Choo, Paul Kalitsis Chromosome Research

$217,500

Jeff Craig, Andy Choo Chromosome Research

$99,750

Jane Halliday

Public Health

Genetics

$75,000

Paul Lockhart

Genetic Health Research (Bruce Lefroy Centre)

$91,528

David Thorburn, Michael Ryan

Mitochondrial Research

$172,500

Lee Wong, Andy Choo

Chromosome Research

$170,500

Career Development Awards

Jeff Craig

Chromosome Research

Jane Halliday

Public Health

Genetics

Paul Lockhart

Genetic Health Research (Bruce Lefroy Centre)

Richard Saffery Chromosome Research

Jim Vadolas Cell & Gene Therapy

Fellowships

Andy Choo

Senior Research

Principal Research

Fellowship

Martin Delatycki Practitioner Fellowship

Genetic Health Research (Bruce Lefroy Centre)

Denise Kirby

CJ Martin Fellowship

Mitochondrial Research

Heidi Peters Health

Professional Research Fellowship Cell & Gene Therapy

David Thorburn

Senior Research

Fellowship

Mitochondrial Research

Medical Postgraduate Scholarships

Michael Fahey

EXTERNAL GRANTS

ANZ Medical Trusts

Heidi Peters Cell & Gene Therapy

$15,000

Heart Foundation

Veronica Collins

Public Health

Genetics

$38,218

Muscular Dystrophy Association US

David Thorburn

Mitochondrial Research

$127,395

Muscular Dystrophy Association US

Panos Ioannou

Cell & Gene Therapy

$133,333

National Institutes of Health

Andy Choo

Chromosome Research

$257,207

National Stem Cell Centre

Bennett Foddy Ethics

$25,500

Royal Australasian College of Physicians

Heidi Peters Cell & Gene Therapy

$30,000

STI Public Education and Awareness Grants Program

Sarah Chan Ethics

$8,000

William Buckland Foundation (ANZ Charitable Services)

Jane Halliday Public Health

Genetics

$35,680

MCRI INTERNAL GRANTS

Project Grants

Sharon Lewis Public Health Genetics

Sylvia Metcalfe Genetics Education and Health Research

Jim Vadolas Cell & Gene Therapy

Staff List

THEME DIRECTOR

Professor Andy Choo

Vivienne Gorman

Executive Assistant to Theme Director

THEME ADVISORY

GROUP

Dr MaryAnne Aitken Group Leader

A/Professor

Martin Delatycki Group Leader

Dr Desiree du Sart Group Leader

A/Professor Jane Halliday Group Leader

A/Professor Sylvia Metcalfe

Honorary Fellow / Group Leader

Dr Howard Slater Group Leader

Dr Heidi Peters Group Leader

Dr David Thorburn Group Leader

Dr Jim Vadolas Group Leader

THEME MEMBERS

Jane Adams

Administrative Assistant

Melissa Anderson Research Assistant

Alison Archibald Masters Scholar

Alison Arvaj Medical Scientist Varlli Beetham Research Assistant

Michelle Bishop PhD Scholar

Dr Avihu Boneh Metabolic Physician

Kate Brody Research Assistant

Damien Bruno PhD Scholar

Yasmin Bylstra Project Officer

Paul Canham Research Assistant

Breana Cham Masters Scholar

Kasey Chan Group Member

Lyn Chan PhD Scholar

Sherry Chang PhD Scholar

Dr Belinda Chong Senior Medical Scientist

Anderly Chueh PhD Scholar

Dr Veronica Collins Senior Research Officer

Louise Corben Clinical Research Coordinator

Dr Jeff Craig Research Fellow

Ailsa Cranfield Medical Scientist

Greg Cranston Research Assistant

Michael Cronin

Group Member

Debbie Davis

Administrative Assistant

Belinda Dawson Research Assistant

Dr Lesley Donelan Research Assistant

Dr Rony Duncan Research Officer

Elizabeth Earle Research Officer

Dr Michael Fahey PhD Scholar

Susan Fawcett

Genetic Counsellor

Bennett Foddy PhD Scholar

Anna Flouris PhD Scholar

Laura Forrest PhD Scholar

Lydia Gaffney Administrative Officer

Dr Anne Glynn Project Officer

Melanie Gow Research Assistant

Dr David Grubb Research Fellow

Dr Anna Henry Project Officer

Chriselle Hickerton Masters Scholar

Jan Hodgson PhD Scholar

Timothy Holloway Research Assistant

Sara Howden PhD Scholar

Dr Alice Jaques Research Officer

Dr Paul Kalitsis Senior Research Officer

Oudavanh

Khammy Group Member

Dr Mahmoud Khaniani PhD Scholar

Denise Kirby Scientific Officer

Jenny Kozlovski Honours Student

Adrienne

Laskowski Research Assistant

Dr Sharon Lewis Research Officer

Lingli Li Research Officer

Dr Paul Lockhart Senior Research Fellow

Stefanie Lou AMS Scholar

Preeyachan Lourthai Research Affiliate

Dr Sima

Mansooriderakhshan PhD Scholar

Owen Marshall PhD Scholar

James McGhie Honours Student

Evelyne Muggli Research Officer

Catherine Nagle PhD Scholar

Steven Nasioulas Senior Medical Scientist

Amy Nisselle PhD Scholar

Emma Northrop Research Assistant

Dr Jun Okabe Visiting PhD Scholar

Erin Oldaker Research Assistant

Mark Pertile Senior Medical Scientist

Novita Puspasari PhD Scholar

Maysa Qazag Group Member

Julie Quach Research Assistant

Dr Hua Ren Postdoctoral Fellow

Sheena Rigby Research Assistant

Dr Felicity Rodda Research Affiliate

Dr Richard Saffery Senior Research Fellow

Dr Renato Salemi Research Fellow

Dr Joseph Sarsero Research Fellow

Adrienne Sexton Masters Scholar

Margaret Shaw PhD Scholar

Marcus Sim Honours Student

Melanie Smith Group Member

Dr Merle Spriggs Postdoctoral Fellow

Nicklas Staunstrup Visiting Scholar

Canny Sugiana PhD Scholar

Dr Juliet Taylor Research Fellow

Simone Tregoning Research Assistant

Dr Kaye Trembath Clinical Research Coordinator

Michiel van Werkhoven Research Assistant

Joanna Voon PhD Scholar

Lucille Voullaire Medical Scientist

Hady Wardan Research Officer

Evan Williams Research Assistant

Gabrielle Wilson Research Assistant

Dr Lee Wong Senior Research Officer

Dr Jacqueline Wong

Research Affiliate

Dr Nicholas Wong Postdoctoral Fellow

Leonie Wood Research Assistant

Mary-Anne Young Masters Scholar

musculoskeletal disorders

All I want to do is play.

Face it, a trip to the park is much more fun when you can play with your best friend. Our research gives life as it helps children take small steps forward: walking for the first time, throwing a ball, riding a bike, playing hide and seek, all become possible.

Improving the health and wellbeing of children with arthritis, bone dysplasias, craniofacial abnormalities, muscular dystrophy and cerebral palsy by understanding cartilage and bone formation and developing better treatment options.

By studying the developmental pathways of cartilage, bone and craniofacial formation and the causes of inherited and acquired musculoskeletal, craniofacial and oral disorders, we will be able to provide new and improved preventative and treatment strategies. We have an exciting synergy between laboratory, clinical and public health researchers, which will lead to further improvements in the lives of children and families affected by these conditions.

Musculoskeletal Disor D ers

Our research into debilitating disorders such as arthritis, bone dysplasias, craniofacial abnormalities, cerebral palsy and muscular dystrophy will improve diagnosis, develop new therapies including tissue regeneration, to improve patient care.

Theme Director: Professor John Bateman john.bateman@mcri.edu.au

Research priorities 2005

Arthritis affects not only the elderly, but one in 4000 children. We conducted research to better understand how arthritis is caused and found the enzyme responsible for degrading cartilage. This information is critical to develop new therapies to treat and prevent arthritis. Our research was also focused on determining outcomes and best clinical practice for children with arthritis.

We characterised gene mutations that cause inherited craniofacial, bone, cartilage and muscle diseases, to determine how these mutations affect normal tissue structure and function. This knowledge is important for diagnosis and the development of treatments, including biomaterial and tissue engineering approaches.

Our research also focused on understanding normal craniofacial development and the causes of craniofacial birth defects such as cleft lip and palate. We assessed how these abnormalities affect children, their families and their quality of life, to measure the effectiveness of treatments and care.

Gait analysis was used to understand the biomechanics and walking patterns of children with musculoskeletal injury or disease. These studies, on diseases such as cerebral palsy, helped improve clinical decision making and brought together genetics, gait analysis and surgical correction for children with skeletal dysplasias, to provide better patient care.

We were also concerned with improving the oral health of children and conducted research to understand the developmental defects of teeth. We also explored early childhood caries and the socio-cultural determinants of public dental health.

Investment strategy

Our theme investment strategy leveraged grant funding and allocated internal resources in four key areas:

1. Strategic investment in important equipment, technologies and core facilities, which in 2005 included a musculoskeletal genetic testing laboratory

2. Internal project grants for pilot studies

3. Short term funding to enhance the career stability and opportunities for young researchers and attract high quality researchers to develop work in priority areas

4. Establishment of the molecular medicine lecture series in conjunction with other themes to disseminate and raise the profile of our research findings

Research groups & leaders

Arthritis and Rheumatology

A/Professor Amanda Fosang

Clinical Genetics

A/Professor Ravi Savarirayan

Craniofacial Research

Dr Peter Farlie

Oral Health Research

A/Professor Nicky Kilpatrick

Orthopaedics and Gait Research

Mr Leo Donnan and Professor Kerr Graham

Muscular Dystrophy

Dr Shireen Lamandé

Skeletal Biology and Disease

Professor John Bateman

Research outcomes

• Discovered the key enzyme (ADAMTS-5), which is responsible for destroying joint cartilage in arthritis. This work was published in Nature and received national and international media interest

• Developed and patented a monoclonal antibody for the early detection and monitoring of cartilage destruction in arthritis

• Discovered a new cartilage matrix protein and characterised how it interacts with the scaffolding of extracellular matrix of articular cartilage

• Used gene chip (microarray) strategies to determine the genes involved in the maturation of cartilage and transition to bone, which will underpin new disease studies

• Identified the function of key genes involved in the regulation of craniofacial development

• Demonstrated the role of Sox10 in generating neural crest stem cells and maintaining them in an undifferentiated state

• Identified the Dlx2 gene as a key regulator of the shape of facial bones

• Characterised and analysed the gene mutations involved in causing muscular dystrophy

• Improved understanding of the cell biology and mechanisms of how mutations in inherited cartilage disease cause tissue pathology

• Defined how all 45,000 genes are switched up and down during cartilage development and bone formation, which will underpin new disease studies

• Established the $2 million NHMRC funded gait centre for clinical research excellence with other Melbourne gait analysis services, to set the foundations for major advances in gait analysis

• Developed multimedia packages for patients

• Established a clinical outcomes database and integration of high quality animated informed consent modules into standard practice and clinical trials

• Established the craniofacial sciences consortium cleft registry

• Identified the relationship between skull malformation and deficits in brain function of young children with craniosynostosis

• Developed culturally appropriate community based oral health promotion interventions for rural, indigenous and new immigrant child populations

• Characterised development defects and inherited disorders of teeth

• Completed the first 12 months of follow up data collection from the largest Australian cohort study of oral health promotion in pre school aged children. This work will inform future interventions to reduce the inequalities in dental caries experience in very young children

Publications

The theme published 50 peer reviewed papers. Highlights were:

• Stanton H et al. Nature 434: 648-652 (2005)

• Wilson R et al. Journal of Biological Chemistry 280: 15544-15552 (2005)

• Wright JG et al. Lancet 365: 1153-1158 (2005)

• Baker NL et al. Human Molecular Genetics 14: 279-293 (2005)

• Little CB et al. Molecular and Cellular Biology 25: 3388-3399 (2005)

Awards & achievements

• John Bateman was awarded a Leverhulme traveling fellowship

• John Bateman was reappointed a Senior Principal Research Fellow

• John Bateman was reappointed to the NHMRC Program Grants Committee.

• Peter Farlie was awarded a Career Development Award from NHMRC

• Amanda Fosang was appointed to the editorial board of the Journal of Biological Chemistry

• Shireen Lamande was awarded the Solander Fellowship by the University of Melbourne

• Shireen Lamande was elected vice-president of the Matrix Biology Society of Australia and New Zealand

• Jane Munro was awarded The Windermere Foundation Health Services Fellowship

• PhD degrees were awarded to Justin Allen, Naomi Baker, Annette Da Costa, Chris Poon, Sonja McKeown and Julie Reid

• Ravi Savarirayan as an invited member of an International working group on constitutional diseases of bone and a case manager of the European Skeletal Dysplasia Network

• Ravi Savarirayan was appointed to the editorial board of the Journal of Medical Genetics

Major collaborations

• Caltech USA

• Deakin University

• Lund University Sweden

• Shriner’s Hospital for Children USA

• The Children’s Hospital at Westmead

• University of Melbourne

• University of Sydney

Major sponsors

• Allergan

• Arthritis Australia

• Australian Research Council

• Australian Stem Cell Centre

• Johnson & Johnson

• Hugh Williamson Foundation

• LifeCell Corporation USA

• Pfizer Inc USA

• Vicon Peak UK

• Wyeth

Objectives for 2006

• To develop strategies to support and enhance our ongoing research performance

• To foster new initiatives to help us achieve our mission of conducting world class research into musculoskeletal and craniofacial development and disease

• To translate our research into improved diagnosis, prevention and patient care

• To encourage research interactions, discussions and collaborations between our researchers, to maximise our strategic advantages and increase our impact on child health

• To provide pilot project funding and grant mentoring strategies to significantly increase our external competitive grant funding

• To increase our involvement in cross theme collaborations

Grants list

NHMRC AWARDS

Project Grants

John Bateman, Jamie Fitzgerald Skeletal Biology and Disease

$168,500

Peter Farlie, Don Newgreen Craniofacial Research

$115,000

Stuart Hooper, Amanda Fosang Cell & Matrix Biology

$83,000

Shireen Lamande, John Bateman, Kathryn North Muscular Dystrophy

$188,375

Career Development Awards

Peter Farlie Craniofacial Research

Nicky Kilpatrick Oral Health Research

Fellowships

Roslyn Boyd

Health Professional Fellowship

Orthopaedics and Gait Analysis

Anthony Schache

Health Professional Fellowship

Orthopaedics and Gait Analysis

Dental

Postgraduate Research Scholarship

Kar Mun Chan

Negar Jamshidi

EXTERNAL GRANTS

Arthritis Foundation

Stephanie Gauci Arthritis

$18,000

Hugh Williamson Foundation Kerr Graham

Orthopaedics and Gait Analysis

$100,000

Macquarie Bank Foundation

Roslyn Boyd

Orthopaedics and Gait Analysis

$20,000

Australian Stem Cell Centre

John Bateman

Skeletal Biology and Disease

$150,687

Telstra Foundation

Roslyn Boyd

Orthopaedics and Gait Analysis

$63,000

Windermere Foundation

Limited

Jane Munro

Rheumatology

$56,850

MCRI INTERNAL GRANTS

Postgraduate Health Research Scholarships

Tam Nguyen Gait Laboratory

Project Grants

John Bateman

Skeletal Biology and Disease

Shireen Lamande Muscular Dystrophy

Anthony Schache

Orthopaedics and Gait Analysis

Richard Wilson Skeletal Biology and Disease

Staff list

THEME

DIRECTOR

Professor John Bateman

Shirley D’Cruz

Executive Assistant to Theme Director

THEME ADVISORY

GROUP

Dr Roger Allen Honorary Fellow

Mr Leo Donnan Honorary Fellow / Group Leader

Dr Peter Farlie Group Leader

A/Professor

Amanda Fosang

Honorary Fellow / Group Leader

Professor Kerr

Graham

Honorary Fellow / Group Leader

A/Professor Nicky Kilpatrick Honorary Fellow / Group Leader

Dr Shireen Lamande Group Leader

A/Professor

John Meara Honorary Fellow

A/Professor Ravi Savarirayan Group Leader

THEME MEMBERS

Dr Justin Allen Postdoctoral Fellow

Dr Firas Alsoleihat PhD Student

Naomi Adams Research Assistant

Anne Augustine Nurse Educator

Dr Naomi Baker Postdoctoral Fellow

Dr Richard Baker Gait Analysis Service Manager

Dr Jitendra Balakumar Research Affiliate

Dr Edward Bastow Postdoctoral Fellow

Dr Daniele Belluoccio Postdoctoral Fellow

Bianca Bernardo PhD Scholar

Dr Andrea Bialocerkowski Honorary Fellow

Cvetanka Bogoeska Research Affiliate

Dr Bent Brachvogel Visiting Postdoctoral Fellow

Dr Kristian Bundgaard PhD Scholar

Glen Burke Research Affiliate

Trevor Cameron PhD Scholar

Dr Kar Mun Chan

PhD Scholar

Dr Ajay Chauhan Masters Scholar

Alan Corral

Technical Assistant

Dr Annette Da Costa Honorary Fellow

Simon Degen Research Assistant

Marie-Anne DePetro Research Affiliate

Cheryl Dingey Research Affiliate

Fiona Dobson

PhD Scholar

Charlotte East PhD Scholar

Dr Bev Eldridge Research Affiliate

Jessica Faggian PhD Scholar

Dr Jamie Fitzgerald Postdoctoral Fellow

Adrienne Fosang Research Affiliate

Susanna Freddi Research Assistant

Avinash Ganesan Technical Assistant

Stephanie Gauci PhD Scholar

Dr Juliette Gentle Research Affiliate

Suzanne Golub Research Assistant

Christopher Gordon Postdoctoral Fellow

Irma Gresshoff PhD Scholar

Dr Mark Gussy PhD Scholar

Adrienne Harvey Research Affiliate

Dr Tandy Hastings-Ison Research Affiliate

Dr Michael Hubbard Honorary Fellow

Dr Rachael Hutchinson

Research Affiliate

Dr Negar Jamshidi PhD Scholar

Mr Michael Johnson Research Affiliate

Dr Peter Kannu Clinical Geneticist

Dr Richard Kjar

Research Affiliate

Leonie Kurth

Technical Assistant

Friederike Kremer

PhD Scholar

Karena Last Research Assistant

Dr Susan Liew

Research Affiliate

A/Professor

Chris Little

Associate Fellow

Dr Francis Ma

Research Affiliate

Dr Dan McCulloch Postdoctoral Fellow

Dr Jennifer McGinley Postdoctoral Fellow

Robyn McNeill

Research Assistant

Clare Meeker Research Assistant

Professor

Meg Morris Honorary Fellow

Dr Jane Munro Honorary Fellow

Mr Gary Nattrass Honorary Fellow

Tam C Nguyen PhD Scholar

Mark O’Sullivan Research Affiliate

Rishika Pace PhD Scholar

Alana Peters

Research Affiliate

Christopher Poon PhD Scholar

Gullveig Reed

Research Assistant

Sylvie Rockel Visiting Scholar

Jill Rodda

Research Affiliate

Dr John Rogers

Clinical Geneticist

Dr Fraser

Rogerson

Postdoctoral Fellow

Dr Anthony Schache

Postdoctoral Fellow

Dr Paulo Selber

Research Affiliate

Mary Sheedy Research Affiliate

Katrina Simms Data Manager

Dr Brendan Soo Research Officer

Dr Heather Stanton Postdoctoral Fellow

Joan Stevens

Research Affiliate

Dr Guan Tay Research Affiliate

Dr Kate Taylor

Research Psychologist

Pam Thomason Senior Research Officer

Dr Oren Tirosh Postdoctoral Fellow

Mr Ian Torode Research Affiliate

Sharon Vladusic Research Affiliate

Rachel Ward

Research Assistant

Prue Weigall Research Affiliate

Tria Williams

Project Officer

Dr Richard Wilson Postdoctoral Fellow

Malrorzata Zeiba Research Assistant

Publications

Acerini CL and Cameron FJ. The paradigm of pediatric diabetes: art vs.science. Pediatric Diabetes 6: 230-233 (2005)

Adegbola RA, Secka O, Lahai G, Lloyd-Evens N, Nije A, Usen S, Oluwalana C, Obaro S, Weber M, Corrah T, Mulholland K, McAdam K, Greenwood B and Milligan PJM. Elimination of Haemophilus influenzae type b (Hib) disease from The Gambia after the introduction of routine immunisation with Hib conjugate vaccine: a prospective study. Lancet 366: 144-50 (2005)

Al-Hasani K, Vadolas J, Knaupp AS, Wardan H, Voullaire L, Williamson R and Ioannou PA. A 191-kb genomic fragment containing the human alpha-globin locus can rescue alpha-thalassemic mice. Mammalian genome: official journal of the International Mammalian Genome Society 16(11): 847-853 (2005)

Allen KJ, Buck NE and Williamson R. Stem cells for the treatment of liver disease. Transplant Immunology 15: 99-112 (2005)

Altunaiji S, Kukuruzovic R, Curtis N and Massie J. Antibiotics for whooping cough (pertussis). The Cochrane Database of Systematic Reviews (2005)

Altuntas AO, Balakumar J, Howells RJ and Graham HK. Posterior divergent dislocation of the elbow in children and adolescents. Journal of Pediatric Orthopedics 25: 317-321 (2005)

Amor DJ, Voullaire L, Bentley K, Savarirayan R and Choo KHA. Mosaic monosomy of a neocentric ring chromosome maps brachyphalangy and growth hormone deficiency to 13q31.1-13q32.3. American Journal of Medical Genetics 133A: 151-157 (2005)

Anderson B and Cranswick N. The placebo (I shall please) - is it so pleasing in children?

Paediatric Anaesthesia 15: 809-813 (2005)

Anderson V and Catroppa C. Recovery of executive skills following paediatric brain injury (TBI): a 2 year follow-up. Brain Injury 19(6): 459-470 (2005)

Anderson V, Catroppa C, Haritou F, Morse S and Rosenfeld J. Identifying factors contributing to child and family outcome 30 months after traumatic brain injury in children. Journal of Neurology, Neurosurgery and Psychiatry 76: 401-408 (2005)

Anderson V, Catroppa C, Morse S, Haritou F and Rosenfeld J. Attentional and processing skills following traumatic brain injury in early childhood. Brain Injury 19(9): 699-710 (2005)

Anderson V, Catroppa C, Morse S, Haritou F and Rosenfeld J. Functional plasticity or vulnerability after early brain injury? Pediatrics 116(6): 1374 - 1382 (2005)

Anderson V, Jacobs R and Harvey AS. Prefrontal lesions and attentional skills in childhood. Journal of the International Neuropsychological Society 11: 817-831 (2005)

Andreasyan K, Ponsonby AL, Dwyer T, Kemp A, Dear K, Cochrane J and Carmichael A. A differing pattern of association between dietary fish and allergen-specific subgroups of atopy. Allergy 60: 671-677 (2005)

Andrews RM, Skull SA, Byrnes GB, Campbell DA, Turner JL, McIntyre PB and Kelly HA. Influenza and pneumococcal vaccine coverage among a random sample of hospitalised persons aged 65 years or more, Victoria. Communicable Diseases Intelligence 29(3): 283-288 (2005)

Andrews RM. Assessment of vaccine coverage following the introduction of a publicly funded pneumococcal vaccine program for the elderly in Victoria, Australia. Vaccine 23: 2756-2761 (2005)

Angker L, Swain M and Kilpatrick N. Characterising the micromechanical behaviour of carious primary dentine using an ultramicro-indentation system (UMIS). Journal of Biomechanics 38: 1535-1542 (2005)

Armstrong DS, Hook SM, Jamsen KM, Nixon GM, Carzino R, Carlin JB, Robertson CF and Grimwood K. Lower airway inflammation in infants with cystic fibrosis detected by newborn screening. Pediatric Pulmonology 40: 500-510 (2005)

Ashley DM, Riffkin CD, Muscat AM, Knight MJ, Kaye AH, Novak U and Hawkins CJ. Caspase 8 is absent or low in many ex vivo gliomas. Cancer 104(7): 1487-1496 (2005)

Aziz AA, Coleman L, Morokoff A and Maixner W. Diffuse choroid plexus hyperplasia: an underdiagnosed cause of hydrocephalus in children? Pediatric Radiology 35(8): 815-818 (2005)

Babl FE, Borland M, Ngo P, Acworth J, Krieser D, Pandit S, Pitt R, Cotterell E and Jamison S. Paediatric Research in Emergency Departments International Collaborative (PREDICT). Journal of Paediatrics and Child Health 41: 614-615 (2005)

Babl FE, Puspitadewi A, Barnett P, Oakley E and Spicer M. Preprocedural fasting state and adverse events in children receiving nitrous oxide for procedural sedation and analgesia. Pediatric Emergency Care 21: 736-743 (2005)

Baikie G, South MJ, Reddihough DS, Cook DJ, Cameron DJS, Olinsky A and Ferguson EB. Agreement between tests of aspiration in children with severe cerebral palsy using barium video-fluoroscopy, milk scan and salivagram. Developmental Medicine and Child Neurology 47: 86-93 (2005)

Baker NL, Morgelin M, Peat R, Goemans N, North KN, Bateman JF and Lamande SR. Dominant collagen VI mutations are a common cause of Ullrich congenital muscular dystrophy. Human Molecular Genetics 14: 279-293 (2005)

Barnes C, Newall F, Ignjatovic V, Wong P, Cameron FJ, Jones G and Monagle P. Reduced bone density in children on long-term warfarin. Pediatric Research 57(4): 578-581 (2005)

Barnett P. Propofol for pediatric sedation. Pediatric Emergency Care 21: 111-114 (2005)

Barnett R, Maruff P and Vance A. An investigation of visuospatial memory impairment in children with attention deficit hyperactivity disorder (ADHD), combined type. Psychological Medicine 35: 1433-1443 (2005)

Bateman JF, Wilson R, Freddi S, Lamande SR and Savarirayan R. Mutations of COL10A1 in Schmid metaphyseal chondrodysplasia. Human Mutation 25: 525-534 (2005)

Bateman JF. Genetic aspects of osteoarthritis. Seminars in Arthritis and Rheumatism 34: 15-18 (2005)

Bauld C, Toumbourou JW, Anderson V, Coffey C and Olsson CA. Health-risk behaviours among adolescent survivors of childhood cancer. Pediatric Blood and Cancer 45: 706-715 (2005)

Becker NG, Li Z, Hsu E, Andrews RM and Lambert SB. Monitoring measles elimination in Victoria. Australian and New Zealand Journal of Public Health 29: 58-63 (2005)

Beggs S, Sewell J, Efron D and Orkin C. Developmental assessment of children: A survey of Australian and New Zealand paediatricians. Journal of Paediatrics and Child Health 41: 444-448 (2005)

Beggs SA, Cranswick NE and Reed MD. Improving drug use for children in the developing world. Archives of Disease in Childhood 90: 1091-1093 (2005)

Bellgrove MA, Chambers CD, Vance A, Hall N, Karamitsios M and Bradshaw JL. Lateralised deficity in response inhibition in early-onset schizophrenia. Psychological Medicine 12: 1-11 (2005)

Ben-Meir D and Hutson JM. The anatomy of the caudal vas deferens in patients with genital anomaly. Journal of Pediatric Urology 1: 349-354 (2005)

Ben-Meir D, Yin M, Chow CW and Hutson JM. Urethral polyps in prepubertal girls. The Journal of Urology 174(4 Pt 1): 1443-1444 (2005)

Bergman PB, Moravski CJ, Edmondson SR, Russo VC, Bach LA, Wilkinson-Berka JL and Werther GA. Expression of the IGF system in normal and diabetic transgenic (mRen-2)27 rat eye. Investigative Opthamology and Visual Science 46: 2708-2715 (2005)

Berkowitz RG, Sun QJ and Pilowsky PM. Congenital bilateral vocal cord paralysis and the role of glycine. Annals Otology Rhinology Laryngology 114: 494-498 (2005)

Berkowitz RG, Sun QJ, Goodchild AK and Pilowsky PM. Serotonin inputs to laryngeal constricto motoneurons in the rat. Laryngoscope 115: 105-109 (2005)

Berzins SP, Cochrane AD, Pellicci DG, Smyth MJ and Godfrey DI. Limited correlation between human thymus and blood NKT cell content revealed by an ontogeny study of paired tissue samples. European Journal of Immunology 35: 1399-1407 (2005)

Beyers JM, Evans-Whipp T, Mathers M, Toumbourou JW and Catalano RF. A crossnational comparison of school drug policy environments in Washington State, USA and Victoria, Australia. Journal of School Health 75(4): 134-140 (2005)

Bialocerkowski AE, Vladusic SL and Howell SM. Conservative interventions for positional plagiocephaly: a systematic review. Developmental Medicine and Child Neurology 47: 563-570 (2005)

Bidarkar SS and Hutson JM. Evaluation and management of the abnormal gonad. Seminars in Pediatric Surgery 14(2): 118-123 (2005)

Biggin A, Henke R, Bennetts B, Thorburn DR and Christodoulou J. Mutation screening of the mitochondrial genome using denaturing highperformance liquid chromatography. Molecular Genetics and Metabolism 84: 61-74 (2005)

Bines JE and Heine RG. Starvation and fasting: biochemical aspects. In: Cabellero B, Prentice A and Allen L (eds). Encyclopedia of Human Nutrition. Elsevier (2005)

Bines JE, Truby HD, Armstrong DS, Carzino R and Grimwood K. Vitamin A and E deficiency and lung disease in infants with cystic fibrosis. Journal of Paediatrics and Child Health 41: 663-668 (2005)

Bines JE. Rotavirus vaccines and intussusception risk. Current Opinion in Gastroenterology 21(1): 20-25 (2005)

Birch CJ, Clothier HJ, Seccull A, Tran T, Catton MC, Lambert SB and Druce JD. Human coronavirus OC43 causes influenza-like illness in residents and staff of aged-care facilities in Melbourne, Australia. Epidemiology and Infection 133: 273-277 (2005)

Bond L, Toumbourou JW, Thomas L, Catalano R and Patton GC. Individual, family, school and community risk and protective factors for depressive symptoms in adolescents: a comparison of risk profiles for substance use and depressive symptoms. Prevention Science 6: 73-88 (2005)

Boneh A, Korman SH, Sato K, Kanno J, Matsubara Y, Lerer I, Ben-Neriah Z and Kure S. A single nucleotide substitution that abolishes the initiator methionine codon of the GLDC gene is prevalent among patients with glycine encephalopathy in Jerusalem. Journal of Human Genetics 50(5): 230-234 (2005)

Bonomo Y and Proimos J. Substance misuse: alcohol, tobacco, inhalants and other drugs. In: Viner R (eds). ABC of Adolescence. Blackwell Publishing (2005)

Boyle RJ, Hardikar W and Tang ML. The development of food allergy after liver transplantation. Liver Transplantation 11(3): 326-330 (2005)

Boyle RJ, Nikpour M and Tang ML. Hereditary angio-oedema in children: a management guideline. Pediatric Allergy and Immunology: official publication of the European Society of Pediatric Allergy and Immunology 16(4): 288-294 (2005)

Brewer W, Francey S, Woods S, Jackson H, Pantelis C, Phillips L, Yung A, Anderson V and McGorry P. Memory impairments identified in people at ultra-high risk for psychosis who later develop first-episode psychosis. American Journal of Psychiatry 162: 71-78 (2005)

Brizard CP. Congenital anomalies of the mitral valve. In: Franck S (eds). Sabiston and Spencer, Surgery of the Chest, Elsevier Saunders (2005)

Brodnicki TC, Fletcher AL, Pellicci DG, Berzins SP, McClive P, Quirk F, Webster KE, Scott HS, Boyd RL, Godfrey DI and Morahan G. Localization of IDD11 is not associated with thymus and NKT cell abnormalities in NOD mice. Diabetes 54: 3453-3457 (2005)

Brown JJ and Nanayakkara CS. Acetone-free nail polish removers: are they safe? Clinical Toxicology 43(5): 297-299 (2005)

Brown JJ and Zacharin M. An attempted randomised controlled trial of pamidronate versus calcium and calcitriol supplements for management of steroid-induced osteoporosis in children and adolescents. Journal of Paediatrics and Child Health 41: 580-582 (2005)

Brown JJ and Zacharin MR. Proposals for prevention and management of steroidinduced osteoporosis in children and adolescents. Journal of Paediatrics and Child Health 41: 553-557 (2005)

Bryant P. None so naive as the well meaning. British Medical Journal 330: 263 (2005)

Burns J, Dudley M, Hazell P and Patton GC. The clinical management of deliberate self-harm in young people: the need for evidence-based approaches to reduce repetition. Australian and New Zealand Journal of Psychiatry 39: 121-128 (2005)

Burri L, Strahm Y, Hawkins CJ, Gentle IE, Puryer MA, Verhagen A, Callus B, Vaux D and Lithgow T. Mature DIABLO/Smac is produced by the IMP protease complex on the mitochondrial inner membrane. Diabetes Care 28: 2771-2773 (2005)

Buttery J. Pneumococcal conjugate vaccine: an Australian perspective. Medicine Today (2005)

Buttery JP, Riddell A, Mevernon J, Chantler T and Lane L. Immunogenicity and safety of a combination pneumococcal-meningococcal in infants - a randomized controlled trail. Journal of the American Medical Association 293: 1751-1758 (2005)

Caciotti A, Donati MA, Boneh A, D’Azzo A, Federico A, Parini R, Antuzzi D, Bardelli T, Nosi D, Kimonis V, Zammarchi E and Morrone A. Role of beta-galactosidase and elastin binding protein in lysosomal and nonlysosomal complexes of patients with GM1-gangliosidosis. Human Mutation 25(3): 285-292 (2005)

Cameron FJ and Northam EA. Childhood precursors of adolescent outcomes in type 1 diabetes. Journal of Pediatric Endocrinology and Metabolism 18: 223-234 (2005)

Cameron FJ, Kean MJ, Wellard RM, Werther GA, Neil JJ and Inder TE. Insights into the acute cerebral lesion of childhood diabetes. Diabetic Medicine 22: 648-653 (2005)

Cameron FJ. Pediatric endocrinology: the requisites in paediatrics. Journal of Paediatrics and Child Health 41(4): 233-234 (2005)

Carapetis JR, Steer AC, Mulholland EK and Weber M. The global burden of group A streptococcal diseases. The Lancet Infectious Diseases 5(11): 685-694 (2005)

Carboon I, Anderson VA, Pollard A, Szer J and Seymour JF. Global meaning, post-traumatic growth and emotional adjustment to a recent cancer diagnosis. Traumatology 11: 269-283 (2005)

Carlin JB and Doyle LW. 8: Non-parametric methods for continuous or ordered data. Journal of Paediatrics and Child Health 39(4): 309-311 (2005)

Carter BG and Butt W. A prospective study of outcome predictors after severe brain injury in children. Intensive Care Medicine 31(6): 840-845 (2005)

Carter BG and Butt W. Are somatosensory evoked potentials the best predictor of outcome after severe brain injury? A systematic review. Intensive Care Medicine 31(6): 765-775 (2005)

Carter BG, Fairbank B, Tibballs J, Hochmann M and Osborne A. Oxygen delivery using self-inflating resuscitation bags. Pediatric Critical Care Medicine: a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 6(2): 125-128 (2005)

Caruso DA, Orme LM, Amor GM, Radcliff FJ, Downie P, Tang MLK and Ashley DM. Results of a phase I study utilizing monoctye derived dendritic cells pulsed with tumor RNA in children with stage 4 neuroblastoma. Cancer 103: 1280-1291 (2005)

Catroppa C and Anderson V. A prospective study of the recovery of attention from acute to 2 years following pediatric traumatic brain injury. Journal of the International Neuropsychological Society 11: 84-98 (2005)

Catto-Smith AG. Constipation and toileting issues in children. The Medical Journal of Australia 182(5): 242-246 (2005)

Chalkiadis GA, Anderson BJ, Tay M, Bjorksten A and Kelly JJ. Pharmacokinetics of levobupivacaine after caudal epidural administration in infants less than 3 months of age. British Journal of Anaesthesia 95(4): 524-529 (2005)

Chan K, King N and Kilpatrick N. Do infants catch caries? A review of the current evidence on the infectious nature of dental caries in infants. New Zealand Dental Journal 101: 4-11 (2005)

Chan S, Fowler KJ, Choo KHA and Kalitsis P. Spef1, a conserved novel testis protein found in mouse sperm flagella. Gene 353: 189-199 (2005)

Charman T, Neilson TCS, Mash V, Archer H, Gardiner MT, Knudsen GPS, McDonnell A, Perry J, Whatley SD, Bunyan DJ, Ravn K, Hulten M, Orstavik KH, Reilly S, Cass H, Clarke A, Kerr A and Bailey MES. Dimensional phenotypic analysis and functional categorisation of mutations reveal novel genotype-phenotype associations in Rett syndrome (advance online publication). European Journal of Human Genetics (2005)

Chase J, Robertson J, Southwell BR, Hutson JM and Gibb S. Pilot study using transcutaneous electrical stimulation (interferential current) to treat chronic treatment-resistant constipation and soiling in children. Journal of Gastroenterology and Hepatology 20: 10541061 (2005)

Cherian T, Mulholland EK, Carlin JB, Ostensen H and Amin R. Standardized interpretation of paediatric chest radiographs for the diagnosis of pneumonia in epidemiological studies. Bulletin of the World Health Organization 83: 353-359 (2005)

Chew G and Hutson JM. Incidence of cryptorchidism and ascending testes in Trisomy 21: a 10-year retrospective review. Pediatric Surgery International 20: 744-747 (2005)

Chin TYP, Duncan JA, Johnstone BR and Graham HK. Management of the upper limb in cerebral palsy. Journal of Pediatric Orthopaedics-B 14: 389-404 (2005)

Chin TYP, Nattrass GR, Selber P and Graham HK. Accuracy of intramuscular injection of Botulinum toxin A in juvenile cerebral palsy - a comparison between manual needle placement and placement guided by electrical stimulation. Journal of Pediatric Orthopaedics 25: 286-291 (2005)

Chueh AC, Wong LH, Wong N and Choo KHA. Variable and hierarchical size distribution of L1retroelement-enriched CENP-A clusters within a functional human neocentromere. Human Molecular Genetics 14: 85-93 (2005)

Clarke A, Richards M, Kerzin-Storrar L, Halliday J, Young MA, Simpson SA, Featherstone K, Forrest K, Lucassen A, Morrison PJ, Quarrell OWJ and Stewart H. Genetic professionals’ reports of nondisclosure of genetic risk information within families. European Journal of Human Genetics 13: 556-562 (2005)

Clausen H, McCrory P and Anderson V. The risk of chronic traumatic brain injury in professional boxing: change in exposure variables over the past century. British Journal of Sports Medicine 39: 661-664 (2005)

Cohn AC, Kearns LS, Savarirayan R, Ryan J, Craig JE and Mackey DA. Chromosomal abnormalities and glaucoma: a case of congenital glaucoma with trisomy 8q22-qter/ monosomy 9p23-pter. Opthalmic Genetics 26(1): 45-53 (2005)

Cohn AC, Kotschet K, Veitch A, Delatycki MB and McCombe MF. Novel ophthalmological features in hereditary endotheliopathy with retinopathy, nephropathy and stroke syndrome. Clinical and Experimental Ophthalmology 33: 181-183 (2005)

Collins V, Meiser B, Gaff C, St John DJB and Halliday J. Screening and preventive behaviors one year following predictive genetic testing for hereditary nonpolyposis colorectal cancer. Cancer 104: 273-281 (2005)

Connell T and Curtis N. How to interpret a CSFthe art and science. Hot Topics in Infection and Immunity in Children 2 568: 199-216 (2005)

Cook BJ and Berkowitz RG. Tracheostomy in children with nemaline core myopathy. International Journal of Pediatric Otorhinolaryngology 69(2): 263-266 (2005)

Cook BJ, Lim E, Cook D, Hughes J, Chow CW, Stanton MP, Bidarkar SS, Southwell BR and Hutson JM. Radionuclear transit to assess sites of delay in large bowel transit in children with chronic idiopathic constipation. Journal of Pediatric Surgery 40(3): 478-483 (2005)

Cook JL, Ptazsnik R, Kiss ZS, Malliaras P, Morris ME and De Luca J. High reproducibility of patellar tendon vascularity assessed by colour Doppler ultrasonography: a reliable measurement tool for quantifying tendon pathology. British Journal of Sports Medicine 39(10): 700-703 (2005)

Copnell B. Death in the pediatric ICU: caring for children and families at the end of life. Critical Care Nursing Clinics of North America 17: 349-360 (2005)

Copnell B. Endotracheal suction in children and neonates: towards an evidence-based technique. Pediatric Intensive Care Nursing 6: 14-19 (2005)

Copnell B. Trials and tribulations of ‘doing’ poststructural research: a tale from the frontline. Qualitative Research Journal 5: 98-113 (2005)

Craig JM and Choo KHA. Kiss and break up - a safe passage to anaphase in mitosis and meiosis. Chromosome 13: 1-11 (2005)

Craig JM, Dow R and Aitken M. Harry Potter and the recessive allele. Nature 436: 776 (2005)

Craig JM. Heterochromatin - many flavours, common themes. BioEssays 27: 17-28 (2005)

Cranswick N and Mulholland K. Isoniazid treatment of children: can genetics help guide treatment? Archives of Disease in Childhood 90(6): 551-553 (2005)

Cranswick N, Turzikova J, Fuchs M and Hulhoven R. Levocetirizine in 1-2 year old children: pharmacokinetic and pharmacodynamic profile. International Journal of Clinical Pharmacology and Therapeutics 43(4): 172-177 (2005)

Curtis N, Chau L, Garland S, Tabrizi S, Alexander R and Morley CJ. Cytomegalovirus remains viable in naturally infected breast milk despite freezing for ten days. Archives of Disease in Childhood 90: 529-530 (2005)

Da Costa AC, Savarirayan R, Wrennall JA, Walters I, Gardiner N, Tucker A, Anderson V and Meara JG. Neuropsychological diversity in Apert syndrome: a comparison of cognitive profiles. Annals of Plastic Surgery 54(4): 450-455 (2005)

Danchin MH, Carlin JB, Devenish W, Nolan TM and Carapetis JR. New normal ranges of antistreptolysin O and antideoxyribonuclease B titres for Australian children. Journal of Paediatrics and Child Health 41: 583-586 (2005)

Davidson AJ, Huang GH, Czarnecki C, Gibson M, Stewart SA, Jamsen K and Stargatt R. Awareness during anesthesia in children: a prospective cohort study. Anesthesia and Analgesia 100: 653-661 (2005)

Davidson AJ, Huang GH, Rebmann CS and Ellery C. Performance of entropy and bispectral index as measures of anaesthesia effect in children of different ages. British Journal of Anaesthesia 95(5): 674-679 (2005)

Davidson N, King J, Riley M and Halliday J. Influence of prenatal diagnosis and pregnancy termination of fetuses with birth defects on the perinatal mortality rate in Victoria, Australia. Paediatric and Perinatal Epidemiology 19: 50-55 (2005)

Davidzon G, Mancuso M, Ferraris S, Qunizii C, Hirano M, Peters HL, Kirby DM, Thorburn DR and Dimauro S. POLG mutations and Alpers syndrome. Annals of Neurology 57: 921-924 (2005)

Davis E, Waters E, Wake M, Goldfeld S, Williams J, Mehmet-Radji O and Oberklaid F. Population health and wellbeing: identifying priority areas for Victorian children. Australia and New Zealand Health Policy 2: 16 (2005)

Davis P, Koottayi S, Taylor A and Butt W. Comparison of indirect methods of measuring intra-abdominal pressure in children. Intensive Care Medicine 31: 471-475 (2005)

De Paoli AG, Lau R, Davis PG and Morley CJ. Pharyngeal pressure in preterm infants on nasal CPAP. Archives of Disease in Childhood Fetal and Neonatal Edition 90: 79-81 (2005)

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Skinner NA, Macisaac CM, Hamilton JA and Visvanathan K. Regulation of Toll-like receptor (TLR)2 and TLR4 on CD14dimCD16+ monocytes in response to sepsis-related antigens. Clinical and Experimental Immunology 141(2): 270-278 (2005)

Slater HR, Bailey DK, Ren H, Qui M, Bell K, Henke R, Choo KHA and Kennedy GC. High-resolution identification of chromosomal abnormalities using oligonucleotide arrays containing 116,204 SNPs. American Journal of Human Genetics 77: 709-726 (2005)

Smith CA, Hudson QJ and Sinclair AH. Molecular genetics of gonadal sex differentiation and the analysis of candidate sex-determining genes. Second report on chicken genes and chromosomes. Cytogenetics and Genome Research 109(4): 415-479 (2005)

Smith CA, McClive PJ and Sinclair AH. Temporal and spatial expression profile of the novel armadillo-related gene, Alex2, during testicular differentiation in the mouse embryo. Developmental Dynamics 233(1): 188-193 (2005)

Smith CA, McClive PJ, Hudson Q and Sinclair AH. Male-specific cell migration into the developing gonad is a conserved process involving PDGF signalling. Developmental Biology 284(2): 337-350 (2005)

Smith JAS and Efron D. Early case conferences shorten length of stay in children admitted to hospital with suspected child abuse. Journal of Paediatrics and Child Health 41: 513-517 (2005)

South M, Ozonoff S and McMahon WM. Repetitive behaviour profiles in Asperger syndrome and high-functioning autism. Journal of Autism and Developmental Disorders 35: 145-158 (2005)

Southey MC, Jenkins MA, Mead L, Whitty J, Trivett M, Tesoriero AA, Smith LD, Jennings K, Grubb G, Royce SG, Walsh MD, Barker MA, Young JP, Jass JR, St John DJ, Macrae FA, Giles GG and Hopper JL. Use of molecular tumor characteristics to prioritize mismatch repair gene testing in early-onset colorectal cancer. Journal of Clinical Oncology: official journal of the American Society of Clinical Oncology 23(27): 6524-6532 (2005)

Southwell BR, King SK and Hutson JM. Chronic constipation in children: organic disorders are a major cause. Journal of Paediatrics and Child Health 41(1-2): 1-15 (2005)

Spence S, Burns J, Boucher S, Glover S, Graetz B, Kay D, Patton GC and Sawyer M. The beyond Blue schools research initiative: conceptual framework and intervention. Australasian Psychiatry 13(2): 159-164 (2005)

Spriggs M. Autonomy and patients’ decisions. Lexington Books (2005)

Stanton H, Rogerson FM, East CJ, Golub SB, Lawlor KE, Meeker CT, Little CB, Last K, Farmer PJ, Campbell IK, Fourie AM and Fosang AJ. ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vivtro. Nature 434: 648-652 (2005)

Stanton MP, Hutson JM, Simpson D, Oliver MR, Southwell BR, Dinning P, Cook I and Catto-Smith AG. Colonic manometry via appendicostomy shows reduced frequency, amplitude and length of propagating sequences in children with slow-transit constipation. Journal of Pediatric Surgery 40: 1138-1145 (2005)

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Stockwell T, Gruenewald PJ, Toumbourou JW and Loxley W. Preventing risky drug use and related harms: the need for a synthesis of new knowledge. In: Stockwell T, Gruenewald PJ, Toumbourou JW and Loxley W (eds). Preventing Harmful Substance Use: The Evidence Base for Policy and Practice. John Wiley and Sons Ltd (2005)

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Tan TY, Bankier A, Slater HR, Northrop EL, Zacharin M and Savarirayan R. A patient with monosomy 1p36, atypical features and phenotypic similarities with Cantu syndrome. American Journal of Medical Genetics Part A 139(3): 216-220 (2005)

Tan TY, McGillivray G, Goergen SK and White SM. Prenatal magnetic resonance imaging in Gomez-Lopez-Hernandez syndrome and review of the literature. American Journal of Medical Genetics Part A 138A: 369-373 (2005)

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Tassicker RJ. Psychodynamic theory and counseling in predictive testing for Huntington’s disease. Journal of Genetic Counseling 14: 99-107 (2005)

Teesson M, Degenhardt L, Lynskey M, Toumbourou JW and Patton GC. Substance use and mental health in longitudinal perspective. In: Stockwell T, Gruenewald PJ, Toumbourou JW and Loxley W (eds). Preventing Harmful Substance Use: The Evidence Base for Policy and Practice. John Wiley and Sons Ltd (2005)

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Ting AY, Huynh J, Farmer P, Yong EX, Hasthorpe S, Fosang AJ, King S, Deshpande A and Hutson J. The role of hepatocyte growth factor in the humoral regulation of inguinal hernia closure. Journal of Pediatric Surgery 40(12): 1865-1868 (2005)

Tingay DG, Stewart MJ and Morley CJ. End-tidal carbon dioxide and transcutaneous carbon dioxide monitoring during neonatal transport. Archives of Disease in Childhood Fetal and Neonatal Edition 90: 523-526 (2005)

Titchen T, Cranswick N and Beggs S. Adverse drug reactions to nonsteroidal antiinflammatory drugs, COX-2 inhibitors and paracetamol in a paediatric hospital. British Journal of Clinical Pharmacology 59(6): 718-723 (2005)

Toda Y, Duke T and Scekerdemian L. Prime solution and age influence lactate levels in children early after cardiac surgery. Critical Care and Resuscitation 7: 87-91 (2005)

Tomiyama H and Hutson JM. Contractility of rat gubernacula affected by calcitonin generelated peptide and beta-agonist. Journal of Pediatric Surgery 40(4): 683-687 (2005)

Tormiyama H, Sasaki Y, Huynh J, Yong E, Ting A and Hutson JM. Testicular descent, cryptorchidism and inguinal hernia: the Melbourne perspective. Journal of Pediatric Urology 1: 11-25 (2005)

Toumbourou JW, Beyers JM, Catalano RF, Hawkins JD, Arthur MW, Evans-Whipp T, Bond L and Patton GC. Youth alcohol and other drug use in the United States and Australia: a cross-national comparison of three state-wide samples. Drug and Alcohol Review 24(6): 515-523 (2005)

Toumbourou JW, Beyers JM, Catalano RF, Hawkins JD, Arthur MW, Evans-Whipp T, Bond L and Patton GC. Youth alcohol and other drug use in the United States and Australia: a cross-national comparison of three state-wide samples. Drug and Alcohol Review 24: 515-523 (2005)

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Trajanovska M and Catto-Smith AG. Quality of life measures for fecal incontinence and their use in children. Journal of Gastroenterology and Hepatology 20(6): 919-928 (2005)

Trevillian LF, Ponsonby AL, Dwyer T, Kemp A, Cochrane J, Lim LLY and Carmichael A. Infant sleeping environment and asthma at 7 years: a prospective cohort study. American Journal of Public Health 95: 2238-2245 (2005)

Turner A and Robinson P. Respiratory and gastronintestinal complications of caustic ingestion in children. Emergency Medicine Journal 22: 359-361 (2005)

Uuahwatanasakul W and Carapetis JR. Frequently asked questions about varicella vaccine. Australian Prescriber 28: 2-5 (2005)

Vadolas J, Wardan H, Bosman M, Zaibak F, Jamsai D, Voullaire L, Williamson R and Ioannou PA. Transgene copy numberdependent rescue of murine beta-globin knockout mice carrying a 183 kb human betaglobin BAC genomic fragment. Biochimica et Biophysica Acta-Gene Structure and Expression 1728: 150-162 (2005)

Valianpour F, Mitsakos V, Schlemmer D, Towbin J, Taylor JM, Ekert PG, Thorburn DR, Munnich A, Wanders RJA, Barth PG and Vaz FM. Monolysocardiolipins accumulate in Barth syndrome but do not lead to enhanced apoptosis. Journal of Lipid Research 46: 11821195 (2005)

Vance A, Arduca Y and Sanders M. The associations of oppositional defiant behaviour in children with Attention Deficit Hyperactivity Disorder, combine type (ACHD-CT). Journal of Affective Disorders 86: 329-333 (2005)

Venter DJ, Ramus SJ, Hammet FM, Desilva M, Hutchins AM, Petrovic V, Price G and Armes JE. Complex CGH alterations on chromosome 8p at candidate tumor suppressor gene loci in breast cancer. Cancer Genetics and Cytogenetics 160(2): 134-140 (2005)

Vinton A, Fahey MC, O’Brien TJ, Shaw JH, Storey E, Gardner RJM, Mitchell PJ, Du Sart D and King JO. Dentatorubral-pallidoluysian atrophy in three generations, with clinical courses from nearly asymptomatic elderly to severe juvenile, in an Australian family of Macedonian descent. American Journal of Medical Genetics 136A: 201-204 (2005)

Vinton A, Kornberg AJ, Cowley M, Matkovic Z, Kilpatrick C and O’Brien TJ. Tiagabine-induced generalised non convulsive status epilepticus in patients with lesional focal epilepsy. Journal of Clinical Neuroscience 12: 128-133 (2005)

Wake M, Gerner B and Gallagher S. Does Parents’ Evaluation of Developmental Status (PEDS) at school entry predict language, achievement and quality of life two years later?

Ambulatory Pediatrics 5(3): 143-149 (2005)

Wake M, Poulakis Z, Hughes EK, CareySargeant C and Rickards FW. Hearing impairment: a population study of age at diagnosis, severity, and language outcomes at 7-8 years. Archives of Disease in Childhood 90: 238-244 (2005)

Wakui K, Gregato G, Ballif BC, Glotzbach CD, Baily KA, Kuo PL, Sue WC, Sheffield LJ, Irons M, Gomez EG, Hecht JT, Potocki L and Shaffer LG. Construction of a natural panel of 11p11.2 deletions and further delineation of the critical region involved in Potocki-Shaffer syndrome. European Journal of Human Genetics 13: 528-540 (2005)

Walls RS, Heddle R, Tang MLK, Basger BJ, Solley GO and Yeo GT. Optimising the management of allergic rhinitis: an Australian perspective. Medical Journal of Australia 182: 28-33 (2005)

Wandi F, Kiagi G and Duke T. Long-term outcome for children with bacterial meningitis in Papua New Guinea. Journal of tropical paediatrics 51: 51-53 (2005)

Warne GL, Grover S and Zajac JD. Hormonal therapies for individuals with intersex conditions protocol for use. Treatments in Endocrinology 4(1): 19-29 (2005)

Warne GL, Grover S, Hutson J, Sinclair AH, Metcalfe S, Northam E, Freeman J, Loughlin E, Rillstone M, Anderson P, Hughes E, Hooper J, Todd S, Zajac JD and Savulescu J. A long-term outcome study of intersex conditions. Journal of Pediatric Endocrinology and Metabolism 18: 555-567 (2005)

Waters E, Davis E, Reddihough DS, Graham HK, Mackinnon A, Wolfe R, Stevenson R, Bjornsen K, Blair E, Hoare P, Ravens-Sieberer U and Boyd R. A new condition-specific quality of life scale for children with cerebral palsy. Patient Reported Outcomes 35: 10-12 (2005)

Waters E, Maher E, Salmon L, Reddihough DS and Boyd RN. Development of a conditionspecific measure of quality of life for children with cerebral palsy: empirical thematic data reported by parents and children. Child: Care, Health and Development 31(2): 127-135 (2005)

Webb AN, Hardikar W, Cranswick N and Somers G. Probable herbal medication induced fulminant hepatic failure. Journal of Pediatric Health Care 41: 530-531 (2005)

Webb AN, Kukuruzovic RH, Catto-Smith AG and Sawyer SM. Hypnotherapy for treatment of irritable bowel syndrome. The Cochrane Database of Systematic Reviews e-pub: (2005)

Webster KE, O Bryan MK, Fletcher S, Crewther PE, Aapola U, Craig J, Harrison DK, Aung H, Phutikanit N, Lyle R, Meachem SJ, Antonarakis SE, De Kretser DM, Hedger MP, Peterson P, Carroll BJ and Scott HS. Meiotic and epigenetic defects in Dnmt3L-knockout mouse spermatogenesis. Proceedings of the National Academy of Sciences USA 102(11): 4068-4073 (2005)

Western PS, Maldonado-Saldivia J, Van Den Bergen J, Hajkova P, Saitou M, Barton SC and Surani MA. Analysis of Esg1 expression in pluripotent cells and the germline reveals similarities with Oct4 and Sox2 and differences between human pluripotent cell lines. Stem Cells (Dayton, Ohio) 23: 1436-1442 (2005)

White SM, Graham JM, Kerr B, Gripp K, Weksberg R, Cytrynbaum C, Reeder JL, Stewart FJ, Edwards M, Wilson M and Bankier A. The adult phenotype in Costello syndrome. American Journal of Medical Genetics 136A: 128-135 (2005)

Wieck G, Leventer RJ, Squier WM, Jansen A, Andermann E, Dubeau F, Ramazzotti A, Guerrini R and Dobyns WB. Periventricular nodular heterotopia with overlying polymicrogyria. Brain 128: 2811-2821 (2005)

Wilcox G, Strauss BJ, Francis DE, Upton H and Boneh A. Body composition in young adults with inborn errors of protein metabolism-A pilot study. Journal of Inherited Metabolic Disease 28(5): 613-626 (2005)

Williams EN, Carroll SG, Reddihough DS, Phillips BA and Galea MP. An investigation of the timed up and go test in children. Developmental Medicine and Child Neurology 47: 518-524 (2005)

Williams G, Robertson V, Greenwood K, Goldie P and Morris ME. The high-level mobility assessment tool (HiMAT) for traumatic brain injury. Part 1: item generation. Brain Injury 19(11): 925-932 (2005)

Williams GP, Robertson V, Greenwood KM, Goldie PA and Morris ME. The high-level mobility assessment tool (HiMAT) for traumatic brain injury. Part 2: content validity and discriminability. Brain Injury 19(10): 833-843 (2005)

Williams J, Toumbourou JW, McDonald M, Jones S and Moore T. A sea change on the island continent: frameworks for risk assessment, prevention and intervention in child health in Australia. Children and Society (2005)

Williams J, Wake M, Hesketh K, Maher E and Waters E. Health-related quality of life of overweight and obese children. Journal of the American Medical Association 293(1): 70-76 (2005)

Williams LH, McClive PJ, Van Den Bergen JA and Sinclair AH. Annexin XI co-localises with calcyclin in proliferating cells of the embryonic mouse testis. Developmental Dynamics 234(2): 432-437 (2005)

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gENETIC HEALTH SERVICES VICTORIA & VCgS pATHOLOgY

We aim to reduce the burden of birth defects and genetic disorders through timely provision of accurate and appropriate clinical genetic services.

We assist people in coming to terms with their genetic issues through education and counselling, to facilitate the making of informed and appropriate personal choices about genetic issues affecting individuals and their families.

We engage in clinical, laboratory and public health research to contribute to knowledge of the causes of and prevention of genetic disorders and we contribute to professional and public education about genetic disorders and related ethical issues.

Genetic Healt H Service S v ictoria & vc GS Pat H olo G y

Providing a fully integrated and accessible clinical and diagnostic genetics service, with a commitment to research, education and client services of the highest standard.

Director: Professor Agnes Bankier agnes.bankier@ghsv.org.au

Director’s Report

Leading

practice status

Quality matters occupied much of our time in the first half of 2005, as Genetic Health Services Victoria (GHSV) prepared for the first formal accreditation of the clinical genetics services by the Quality Improvement and Community Services Accreditation (QICSA). The accreditation involved the systematic documentation of all our policies, procedures and standards, as well as a major audit of our record keeping practices.

The two day review led to GHSV being recommended for full accreditation and ‘Leading Practice status’ in two categories. A big thank you to all who contributed to this success! Following on from this process, we developed a joint work plan with the Genetic Support Network of Victoria (GSNV) and a quality work plan monitored by our quality committee and clinical management.

Clinical & laboratory services

It was a busy year for our clinical and laboratory services. Within The Royal Children’s Hospital we increased our collaborations with other clinical departments to provide joint services in specialised areas of genetics. Service delivery to regional Victoria increased, particularly in the field of familial cancer, where consultations doubled in the past year. By re-prioritising we were able to commence a much needed service in cardiac genetics, aimed at people who have a family history of sudden cardiac death or other heart conditions.

Diagnostic laboratories

Our diagnostic laboratories are now known as VCGS Pathology. The name and new look will strengthen the collective identity of the individual laboratory services, which are already highly regarded nationally and internationally.

Newborn screening committee

We welcomed the establishment of the Newborn

Screening Advisory Committee. Whilst a national approach to the provision of newborn screening and the management of newborn screening cards is being developed, it is very helpful to have the advice and support of the committee on screening card access issues.

Genetic testing funding

An ongoing challenge is the provision of genetic tests that are not currently funded by state or federal governments. An inequity has risen, in that testing for some conditions is provided to families free of charge, whilst other families are required to pay because genetic testing is not funded for their particular condition. A multi pronged approach is being used to address this inequity at both state and federal levels, but progress to date has been slower than hoped.

New genetic testing services

Funds raised from private sources have enabled us, in collaboration with the RCH cardiology department, to start setting up genetic testing for heart conduction

defects that can cause sudden death. New funding for haemophilia gene testing has been obtained from the state government, a resource that was welcomed by families with this condition.

With the support of Cystic Fibrosis Victoria we commenced offering community genetic testing for cystic fibrosis on a user pays basis. Testing is aimed at detecting carriers of cystic fibrosis and is being offered as a pilot program to pregnant women and women planning a pregnancy.

Education

We placed a high value on continuing education on genetic issues. Education is vital not only for the professional development of our own staff, but also for our colleagues in other health disciplines, to ensure that they can facilitate appropriate use of our services by all

Executive committee

1. Professor Agnes Bankier 2. Ms Anne Cronin

3. Dr Howard Slater 4. Dr James Pitt 5. Dr David Amor

6. A/Professor Martin Delatycki 7. Dr Samantha Wake

Victorians. In 2005 the joint Monash Melbourne Genetic Curriculum Advisory Committee was established.

The collaboration between GHSV and the Monash and Melbourne University Medical Schools, aims to ensure genetic literacy and competence for all medical graduates. An education officer is now developing recommendations for core curriculum and core competencies in genetics and their implementation and evaluation.

Through our research activities we are a significant contributor both locally and internationally, to the cutting edge of genetic knowledge across the range of fields in which we work. In recognition of the substantial research contribution made by GHSV, the focus of this year’s annual report is on some of the recent research contributions made by our staff. For details of our services please visit

our website www.genetichealthvic.net.au and www.vcgspathology.com.au

Professor Agnes Bankier

Director

Executive committee

Professor Agnes Bankier

Ms Anne Cronin

Dr Howard Slater

Dr James Pitt

Dr David Amor

A/Professor Martin Delatycki

Dr Samantha Wake

Dr Howard Slater

Howard Slater was appointed head of cytogenetics at the Victorian Clinical Genetics Service in Melbourne in 1990, after obtaining his PhD in Glasgow. Under his direction the cytogenetics laboratory has expanded to become the largest in Australasia.

Clinical cytogenetics is concerned with the detection of clinically significant chromosome abnormalities. Microscopy is the main technique used and although there have been gradual improvements in resolution there has essentially been little change for the last 35 years. Under Howard’s leadership, the laboratory has embraced DNA technology for improvements in cytogenetic diagnosis and aspires to be a leader in this area. His promising developmental research techniques are hoped to transform cytogenetic practice.

Research has focused on the need to develop techniques that will detect chromosome abnormalities at a submicroscopic level. In 2005 there was significant progress in subtelomere testing and SNP microarrays. Most recently, MLPA was used for detection of abnormalities at the ends of chromosomes, called subtelomeres, seen in approximately five per cent of patients with unexplained mental retardation. The MLPA test is cost effective and more sensitive than other techniques. The subtelomere test is now being assessed in a clinical setting. Research in micro arrays “proof of principle” has been published.

Dr Heidi Peters

Heidi Peters, a medical graduate and qualified paediatrician, joined GHSV in 1996 and completed her PhD in 2003. She has gained international recognition as a leader in working with the metabolic disorder Methylmalonic Aciduria (MMA) and now heads a clinic for patients with lysosomal MPS disorders.

Heidi has developed the first animal models for MMA. These mouse models are unique as they accurately recapitulate the human disorder at both a molecular and phenotypic level. This has enabled a better understanding and an ability to investigate the underlying pathophysiological basis of MMA and its numerous complications.

Genomic reporter assays have also been developed using the MMA genomic locus, to enable the identification of drugs that can modify levels of gene expression in a therapeutically relevant manner. These identified compounds will be tested in developed animal models prior to potential clinical application.

In collaboration with MCRI liver cell research, Heidi is investigating the role of cell transplantation for this disorder, particularly liver cells. Results obtained from this work will be more broadly applicable to a number of other inborn errors of metabolism. It is anticipated that this could potentially lead to direct clinical benefits to those affected by these disorders. A recently established collaboration with the Adelaide Women’s and Children’s Hospital will enable the investigation of viral gene therapy approaches for this condition.

Dr David Amor

David Amor joined GHSV in 2000 and has a special interest in chromosome disorders and the genetic causes of intellectual disability. He is active in the provision of clinical genetics services at The Royal Children’s Hospital and in regional Victoria and Tasmania.

David’s research, for which he was awarded an NHMRC Medical Postgraduate Scholarship, involves studying the structure and function of a specialised part of the chromosome called the centromere. The centromere is present once on each chromosome and is responsible for orchestrating the separation of chromosomes at every cell division. The centromere performs this task with great accuracy, yet is prone to occasional errors that can ultimately lead to birth defects, intellectual disability, cancer and reproductive failure.

The location of the centromere on each human chromosome has been fixed for millions of years. However on rare occasions new centromeres appear at different locations within the chromosome. These variant centromeres are called neocentromeres, and typically arise in association with other chromosome rearrangements that are detrimental to human health.

During his PhD, David investigated the contribution of neocentromeres to various human diseases and identified a number of different neocentromeres in children and adults with a range of health problems, including birth defects, intellectual disability, leukaemia and liposarcoma. Further investigation has provided a greater understanding of how neocentromeres and the chromosome rearrangements that typically accompany them result in this diverse group of health problems.

A/Professor Martin Delatycki

Martin Delatycki is the head of the Bruce Lefroy Centre for genetic health research and is also a clinical geneticist. Martin’s clinical and research interests relate to neurogenetics and community genetics. He is an National Health and Medical Research Council Practitioner Fellow.

HaemScreen was a collaborative research project by GHSV and the Murdoch Childrens Research Institute. More than 11,000 individuals were screened for their genetic risk of developing the iron overload condition, haemochromatosis. Around one in 200 Caucasians are at risk of developing haemochromatosis which if untreated, can result in liver cirrhosis, heart failure, diabetes, chronic fatigue, arthritis and infertility. It is entirely preventable by keeping iron levels in the normal range by donating blood regularly.

In response to concerns regarding insurance, a world first agreement was negotiated with the Australian insurance industry, to ensure that those found to be at risk of developing haemochromatosis would not be inappropriately discriminated against.

Testing for the gene changes was by a cheek-brush sample. Fifty-one individuals were identified as having the genetic predisposition to haemochromatosis and two of these people had severe iron overload with evidence of liver damage.

A health economic evaluation of the program is currently being conducted in conjunction with Professor Jane Hall and Dr Robert Anderson from the Centre for Health Economics Research Evaluation at the University of Technology, Sydney.

Staff list

Director

Professor Agnes

Bankier

Personal Assistant to Director

Alison van Bree

Clinical Geneticists

Dr David Amor

Professor Agnes

Bankier

A/Professor Martin

Delatycki

Dr Mac Gardner

Dr Marion Harris

Dr Peter Kannu

Dr George

McGillivray

Dr Heidi Peters

Dr John Rogers

A/Professor Ravi

Savarirayan

A/Professor Les Sheffield

Dr Sue White

Professor Ingrid Winship

Metabolic

Physicians

Dr Avihu Boneh

Dr Heidi Peters

Clinical Genetics

Fellows

Dr Peter Kannu

Dr Nicholas Pachter

Dr Tiong Yang Tan

Metabolic Fellows

Dr Joy Yapilto-Lee

POSSUM Project

Professor Agnes

Bankier

Dr Catherine Rose

Mr Michael Black

Principal Genetic Counsellor/ Privacy

Dr Samantha Wake

Clinical Services

Coordinator

Robin Forbes

Genetic Counsellors

Sonja Bacic

Dr Jo Burke

Lisette Curnow

Susan Fawcett

Lisa Gordon

Lucinda Hossack

Ivan Macciocca

Margaret Ross

Michelle Sproule

Alison Thornton

Associate Genetic Counsellors

Tarli Bogtstra

Sophie Devery

Renee Dow

Nikki Gelfand

Jacqueline

Greenberg

Vicki Petrou

Katherine

Ruivenkamp

Helen Upton

Jane Wallace

Tay Sachs Educator

Vicki Petrou

Senior Social

Worker

Margaret Sahhar

Social Workers

Flora Pearce

Ross Tassicker

Metabolic Dieticians

Maureen Humphrey

Dorothy Frances

Metabolic Nurse

Helen Upton

Laboratory Quality Assurance Officer

Anne Robertson

Education Project Officer

Dr Wiji Nadesapillai

Clinical Administration

Manager/Quality

David Blake

Clinical

Administrative Assistants

Debbie Davis

Sharon Grosvenor

Sue Hilton

Liz Kanellos

Katherine MacDonald

Tammi O’Connor

Maureen Ralph

Meg Ruttledge

James Shaw

Lucy Shaw

Helen Smith

Nikki Weekes

Maria Zarkadoulas

Receptionists

Kim Cunningham

Vicki Hirt

VCGS

PATHOLOGY

CYTOGENETICS

LABORATORY

Head

Dr Howard Slater

Deputy Head

Mark Pertile

Section Leaders

Trent Burgess

David Francis

Fiona Norris

Administration

Fiona Keltie

Rebecca Manser

Emma Payne

Scientists

Ailsa Cranfield

Alison Blackstock

Alley Arvaj

Amber Boys

Con Ngo

Damien Bruno

Dao Xuon Nguyen

Essra Bartlett

Helen Jackson

Ian Brooks

Jackie Challis

Julie Hammer

Kathy Butler

Lan Ta

Lily Gowans

Louise Hills

Lynda Phillips

Michael Cronin

Olivia Giouzeppos

Paula Lall

Phung La

Dr Prabhakara

Krishnamurthy

Dr Priya Padman

Ralph Oertel

Sam Connors

Sara Nouri

Selga Cirulis

Sylvea Corrie

Dr Tie Lan Han

Vida Petrovic

Wali Drummond

Wendy Francis

Laboratory

Technicians

Bronwyn Kenney

Julie Brown

Students

Damien Bruno

James McGhie

Oudra Khamy

Dr Mamoud

Khaniani

NEWBORN SCREENING

Head

James Pitt

Section Leaders

Nick Tzanakos

Ivan Francis (IT)

Scientists

Thanh Nguyen

Manal Ibrahim

Lan Trieu

Laboratory

Technicians

Jo Karlecik

Students

MATERNAL SERUM SCREENING

Head

Programming:

Ivan Francis

Laboratory:

Leonard Bonacquisto

Administration

Robin Forbes

Sara Grant

Yssa Reyes

Scientists

Gregoria Luna

Stephen Dobie

Vicki Katsonis

Vivienne Iaschi

Laboratory

Technicians

Ian Burns

Marina

Nakonechnaya

Monique Te-Haara

Jacquie Spazevski

Rina Marinucci

Helen Hunter

Patricia Snell

METABOLIC SCREENING

Head

James Pitt

Section Leader

Mary Eggington

Scientists

Avantika Mishra

Michiel van Werkhoven

MOLECULAR GENETICS

Head

Dr Desiree du Sart

Senior Scientists

Belinda Chong

Steven Nasioulas

Melanie Smith

Administration

Fiona Keltie

Scientists

Vanessa Calabro

Shannon Cowie

Nicole Gardiner

Maria Kaps

Sarah Pantaleo

Dean Phelan

Anna Richie

Laboratory

Technicians

Angela De Marco

Tom Milovac

Students

Nicole Austin

GENETIC

SUPPORT

NETWORK

VICTORIA

Leah Lonsdale

Claire Weigall

financial report

Murdoch Childrens Research Institute and its controlled entities

i ncome Statement for the year ended 31 d ecember 2005

Murdoch Childrens Research Institute and its controlled entities

balance Sheet aS at 31 december 2005

Murdoch Childrens Research Institute and its controlled entities

Statement of caSh flowS for the year ended 31 december 2005

FLOWS

2005 TOTAL STAFF AND STUDENTS 666 (+18% from 2004) STAFF 600 (+19% from 2004) STUDENTS 66 (+8% from 2004)

Thanks to the generosity of the following organisations who assisted in the production of this report.

Murdoch Childrens Research Institute

Royal Children’s Hospital

Flemington Road, Parkville

Victoria 3052 Australia

Phone: 1300 766 439 Fax: 61 3 9348 1391

www.mcri.edu.au

Edited by Dr Narelle Curtis and Alyssa Jones (pr@mcri.edu.au)

Cover image R. Schmidt, Kronberg, Germany (www.club-pac.de)