Pluvicto™ Treatment Information for patients What is Pluvicto™? Pluvicto™ is a medicine used to treat adults with a certain type of prostate cancer. The chemical drug name for Pluvicto™ is Lutetium Lu 177 Vipivotide Tetraxetan. − Pluvicto™ is specially designed to deliver radiation treatment directly to prostate cancer cells − Pluvicto™ targets only prostate cancer cells that have a marker, called PSMA, on the cell surface. − Pluvicto™ attaches to the marker, and is absorbed by the cell − When Pluvicto™ is absorbed, it releases radiation that can damage and kill the PSMA+ cell and other cancer cells in the area − You will have a special PET scan to determine PSMA activity in your prostate cancer cells, and see if you are eligible for Pluvicto™ treatment Because Pluvicto™ treatment uses radiation, you will receive treatment in a private room or semiprivate room. This is to ensure radiation safety procedures are followed. A team of specially trained doctors, nurses, and pharmacists will care for you. The team will also include a Nuclear Medicine clinician and a Radiation Safety Officer who will assist with the infusion. You must also follow radiation safety precautions at home after your treatment, to protect your family and loved ones. We will provide you with specific detailed instructions.
The Pluvicto™ Regimen − − − −
Pluvicto™ is given up to a maximum of 6 infusions, with at least 6 weeks between infusions The treatment takes about 1 hour You will have blood tests 7-14 days before you begin treatment with Pluvicto™ After your first treatment and between cycles, you will have blood work scheduled every two weeks, and prior to your next dose of Pluvicto™ − You will have a scheduled appointment with your oncology provider before each treatment
Pre-treatment preparation Before treatment, we will review your blood work and check that your liver function, kidney function, and blood counts are acceptable and safe for treatment. − You should drink plenty of water to hydrate your body and be able to urinate as soon as possible after your treatment. This helps to clear the radiation from your system and reduce bladder irritation. Pluvicto™ Treatment
YNH000473 (03/2026)