FLOT & FLOT + Durvalumab Anti-Cancer
Therapy Supportive Care Medications
Medications following Fluorouracil, Leucovorin, Oxaliplatin, & Docetaxel
Please review the following education for supportive care medications to help relieve symptoms of nausea/vomiting and diarrhea after your treatment.
Nausea & Vomiting
Prochlorperazine (Compazine) 10 mg tablets
• Take 1 tablet (10 mg) by mouth every 6 hours as needed for nausea or vomiting
• This medication should be the first medication that you take if you are nauseous after treatment. If you are going home with a chemotherapy pump, this is the medication you may take until your pump is disconnected.
• This medication will take about 30 minutes to start working – take at the first sign of nausea or upset stomach.
• This medication can cause you to feel tired. If you are experiencing this side effect, you may switch to ondansetron on the 3rd day after treatment.
Ondansetron (Zofran) 8 mg disintegrating tablets
• Dissolve 1 tablet (8 mg) under the tongue every 8 hours as needed for nausea or vomiting
• This medication can be taken in addition to prochlorperazine if you are nauseous after treatment, but only on the 3rd day after treatment. It can cause constipation, so be sure to add a stool softener or laxative every day while you are taking this medication if you experience this side effect.
• If you are going home with a pump, this medication should not be used until after the pump is disconnected. You will receive a long-acting version of this medication during your treatment.
• The disintegrating tablets may be swallowed whole if you do not like the taste.
Edema
Dexamethasone (Decadron) 4 mg tablets
• Take 2 tablets (8 mg) by mouth the day before and day after treatment.
• This medication is only prescribed for very specific regimens and specifically to prevent major edema (swelling) from docetaxel
• Take this medication as early in the day as possible. It can cause insomnia and restlessness. This medication can also be used for nausea/vomiting if other medications are not effective