Jaramillo - Sensibilidad y Especificidad de Indices Topográficos Table 2. Demographic data PATIENT GROUP Characteristics (median or interquartile range) Group A: Keratoconus (n = 60 eyes) Group B: Keratoconus Suspects (n = 43 eyes) Group C: Normal eyes (n = 45 eyes) p-value Male 21patients, 34 eyes 12 patients, 18 eyes 12 patients, 24 eyes 0.317 Female 18 patients, 26 eyes 15 patients, 25 eyes 11 patients, 21 eyes 0.317 Age (years) 28 (21, 36) 24.0 (18.0, 33.0) 25.0 (23.0, 31.0) 0.232 CCT (μm) 475 (449, 498.5) 485.0 (464.0, 520.0) 552.0 (534.0, 564.0) <0.001 Flat meridian (D) 45.1 (43.5, 47.6) 43.5 (41.5, 45.0) 43.0 (42.5, 44.5) 0.001 Sphere (D) -1.25 (-2.75, 0.0) -0.25 (-2.50, 0.00) 0.25 (-0.25, 0.50) <0.001 Cylinder (D) -3.00 (-4.12, -1.75) -2.00 (-3.00, -1.25) 0.0 (-0.25, 0.0) <0.001 LogMAR 0.30 (0.18, 0.44) 0.097 (0.000, 0.176) 0.0 (0.0, 0.0) <0.001 0.896 (0.696, 1.234) 0.642 (0.455, 0.783) 0.261 (0.215, 0.321) <0.001 Posterior elevation (μm) 85 (59.5, 109.5) 51.0 (41.0, 70.0) 25.0 (21.0, 31.0) <0.001 PPK (%) 99.4 (70.4, 100) 7.7 (1.7, 90.8) 1.0 (0.5, 2.2) <0.001 KPI 59.7 (35.7, 100) 16.7 (5.3, 44.5) 0.0 (0.0, 4.2) <0.001 AER Roush KISA% OrbscanTM KISA% Galilei TM KISA% KeratronTM 160.5 (119, 192) 108 (85, 135) 57 (45, 66) <0.001 2951 (153, 12750) 53.4 (11.0, 205.3) 5.2 (1.86, 8.66) <0.001 1869 (144.9, 14984) 31.2 (10.4, 158.6) 3.0 (1.2, 10.3) <0.001 980 (109.2, 8041) 19.8 (4.9, 174.6) 4.1 (1.5, 8.7) <0.001 CCT: central corneal thickness in parenthesis interquartile range Table 3. Area under the ROC curves AREA UNDER THE ROC CURVE (CI 95%) (Keratoconus + Suspects) vs. normal eyes Keratoconus suspects vs. normal eyes Keratoconus vs. normal eyes AER 0.984 (0.969, 0.998) 0.968 (0.938, 0.997) 0.995 (0.987, 1.000) Highest Posterior Elevation 0.987 (0.974, 0.999) 0.973 (0.947, 0.999) 0.993 (0.984, 1.000) PPK 0.897 (0.849, 0.946) 0.802 (0.708, 0.896) 0.966 (0.931, 1.000) KPI 0.910 (0.866, 0.954) 0.837 (0.753, 0.921) 0.963 (0.928, 0.998) 0.973 (0.951, 0.995) 0.941 (0.892, 0.989) 0.996 (0.990, 1.000) 0.929 (0.889, 0.969) 0.862 (0.782, 0.942) 0.977 (0.945, 1.000) 0.928 (0.889, 0.967) 0.862 (0.784, 0.939) 0.976 (0.949, 1.000) 0.878 (0.824, 0.932) 0.747 (0.641, 0.852) 0.972 (0.941, 1.000) 0.0005 <0.001 0.5330 Indices Roush KISA% Orbscan TM KISA% GalileiTM KISA% Keratron p-value TM 233 Revista SCO Septiembre 2011.indd 233 10/21/11 8:12:32 PM