University at Buffalo
2025 Research & Innovation Report
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University at Buffalo
2025 Research & Innovation Report





2025 was defined by the dedication and resilience of the UB community. We advanced research across disciplines and delivered outcomes with lasting global impact.
At the heart of this momentum is the integration of artificial intelligence throughout our departments, decanal units and administrative functions. From exploration and investigation to teaching and learning, AI continues to be a powerful partner, unlocking new approaches and accelerating breakthroughs.
The year was also shaped by a deeper emphasis on emerging technologies. The launch of the UB Quantum Institute, combined with our decades of leadership in AI, position UB among a select group of institutions with deep expertise in these critical fields.
Our combined efforts reaffirm UB’s commitment to advancing discovery for the public good and shaping the future through innovation.
Venu Govindaraju, PhD Senior Vice President for Research, Innovation and Economic Development







Across disciplines, UB faculty are at the forefront of discoveries that have real-world impact.
Researchers are supported throughout their journey to transform lab breakthroughs into life-changing solutions.
Visit the POP Bio website: Read the complete POP Bio case study:




One
reason this type of cancer is so tough is that pancreatic tumors don’t have many blood vessels. That makes it hard to get enough medicine into them. We demonstrate that light-infused chemotherapy can reach these tumors and shrink them.
Jonathan Lovell, PhD Professor, Department of Biomedical Engineering, Jacobs School of Medicine and Biomedical Sciences
Advancing UB innovation to market
Through UB’s Business and Entrepreneur Partnerships, UB spinout POP Biotechnologies (POP BIO) patented and licensed the UB-developed vaccine platform, secured incubator space, research funding and investor support, and forged research partnerships with pharmaceutical companies to commercialize its innovations.
Innovative therapies target devastating diseases
Co-founded by UB researcher Jonathan Lovell, POP BIO is advancing revolutionary therapies for cancer treatment and infectious disease prevention. The company’s mission is to use innovative platforms to fill critical gaps in today’s medical interventions.
Transforming treatment and prevention
Building on discoveries from UB laboratories, POP BIO’s vaccine delivery platform enhances the potency and durability of existing vaccines and opens new possibilities for preventing diseases such as HIV and Alzheimer’s. The company is also pioneering a light-activated chemotherapy system that targets and destroys solid tumors while limiting damage to healthy tissue.




Built on five decades of investment, expertise and leadership in AI, this work at UB is not new. What has changed is the acceleration of innovation, the pace of adoption and the integration of AI across the university. Today, UB is not simply reacting to an evolving landscape. Our more than 200 faculty engaged in over 500 AI-infused projects are shaping the future by advancing AI for the public good.
Learn more about UB’s legacy and innovation in Artificial Intelligence
Outcomes are accelerated thanks to Empire AI
Rohini Srihari is leveraging Empire AI to develop tools to ensure that people with ALS, cerebral palsy and other motor neuron diseases have equal access to AI. To do this, she is working with Jeffrey Higginbotham, professor in the Department of Communicative Disorders and Sciences, and other researchers to enrich augmentative and alternate communication devices with conversational AI.
The $500+ million statewide consortium—which New York Gov. Kathy Hochul announced in 2024, including its supercomputing center located at UB— is harnessing AI for the betterment of society and driving innovation in New York State.

Rohini Srihari, PhD Professor, Department of Computer Science and Engineering, School of Engineering and Applied Sciences; Adjunct Professor, Department of Linguistics, College of Arts and Sciences
Photo: UBNow Staff
At Right: Gov. Kathy Hochul visited UB on September 6, 2025, to receive an update on the university’s artificial intelligence programs. She met with UB leadership, faculty and students while touring the National AI Institute for Exceptional Education and the UB Institute for Artificial Intelligence and Data Science.
Photo: Meredith Forrest Kulwicki
By Cory Nealon
Published March 21, 2025
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This revolutionary project is supported by Empire AI
UB researcher Thomas Grant was awarded $2.18 million from the National Institute of General Medical Sciences, part of the National Institutes of Health, to create a new AI-powered tool that improves the understanding of how proteins move and change shape within the human body.
Called SWAXSFold, this discovery aims to speed up drug development and help scientists design more precise medicine for people suffering from everything from cancer to Alzheimer's disease.
Grant is utilizing Empire AI’s supercomputing center to train and validate SWAXSFold. The “Fold” part of SWAXSFold is a nod to AlphaFold, an AI system that won the 2024 Nobel Prize in Chemistry for using deep learning to predict protein structures.

Thomas Grant, PhD Assistant Professor, Department of Structural Biology, Jacobs School of Medicine and Biomedical Sciences
By Dirk Hoffman
Published September 22, 2025
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Catching these neurodevelopmental disorders early is critically important to ensuring that children receive the help they need before their learning and socio-emotional development are negatively impacted.
Venu Govindaraju, PhD Senior Vice President for Research, Innovation and Economic Development; SUNY Distinguished Professor, Department of Computer Science and Engineering, School of Engineering and Applied Sciences; Director and PI, National AI Institute for Exceptional Education
Douglas Levere
By Cory Nealon
Published May 16, 2025
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Building upon previous groundbreaking AI research
A UB-led study outlines how AI-powered handwriting analysis may serve as an early detection tool for dyslexia and dysgraphia among children. The work, presented in the journal SN Computer Science, aims to augment current screening tools that are effective but can be costly, time-consuming and focus on only one condition at a time.
It could eventually help alleviate the nationwide shortage of speech-language pathologists and occupational therapists, who each play a key role in diagnosing dyslexia and dysgraphia.
The work is part of the National AI Institute for Exceptional Education, a UB-led research organization that develops AI systems that identify and assist young children with speech and languageprocessing disorders.
This research builds upon earlier groundbreaking work in handwriting recognition at the University at Buffalo. Decades ago, Govindaraju and colleagues employed machine learning, natural language processing and other forms of AI to analyze handwriting, an advancement the U.S. Postal Service still uses to automate the sorting of mail.
This work demonstrates remarkable accuracy
A powerful clinical AI tool developed by UB biomedical informatics researchers has demonstrated remarkable accuracy on all three parts of the United States Medical Licensing Exam (Step exams), according to a paper published April 22, 2025, in JAMA Network Open.
Achieving higher scores on the USMLE than most physicians and all other AI tools so far, Semantic Clinical Artificial Intelligence (SCAI, pronounced “Sky”) has the potential to become a critical partner for physicians, says lead author Peter L. Elkin.
“Artificial intelligence isn't going to replace doctors, but a doctor who uses AI tools may replace a doctor who does not.”
Peter L. Elkin, MD
Professor and Department Chair, Department of Biomedical Informatics, Jacobs School of Medicine and Biomedical Sciences; Physician, UBMD Internal Medicine
When robots team up
Large language model agents, such as virtual assistants or chatbots, can learn to cooperate with one another, even when they aren’t given any instruction to do so, according to new research from the School of Management.
Generative AI programs focus on creating humanlike text, such as answering questions, explaining ideas or making decisions based on what they have learned. The study examines whether generative AI assistants with different or conflicting goals can choose to cooperate because each recognizes the benefits of collaboration.
The findings show that the virtual assistants demonstrate an innate ability to autonomously establish and discover the advantages of cooperation and actively adapt their strategies.
“This approach allows us to see if a generative AI-powered agent can think on its own, instead of relying on carefully prepared questions or prompts.”
Shaojie Tang, PhD
Professor and Department Chair, Department of Management Science and Systems, Faculty Director, Center for AI Business Innovation, School of Management
By Ellen Goldbaum
Published April 22, 2025
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TRY SCAI
Ask this AI tool
your medical questions:
By Alexandra Richter
Published January 31, 2025
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New creative approach leads to innovative practice
By combining his skills in both the humanities and engineering, Marc Böhlen, professor, Department of Art, College of Arts and Sciences, expresses his creative works through technology.
“I’m an artist-engineer. I think of engineering as an expressive palette that you can use like any traditional medium to comment on the cultural context we live in,” he says.
Böhlen's current work is rooted in culture jamming — using art, installations, books and public engagements to critique and provoke dialogue about technological systems, especially those like AI that subtly shape society. His latest project, Logics of Planetary Computing: Artificial Intelligence and Geography in the Alas Mertajati, explores how satellite imagery and AI interpret unusual landscapes, such as those shaped by sustainable land practices like agroforestry, and examines the complex relationship between AI and geography. The interactive web installation (at right) allows users to engage directly with some of the AI models.

Art professor Marc Böhlen uses AI information and geography to produce images like this mosaic, which includes samples from his bali26 collection of more than 50,000 images. It was created for a recent project called "Return to Bali: critical machine learning practices in the wild."
Photo: Marc Böhlen
By Vicky Santos
Published August 1, 2025
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Experience Böhlen's interactive web installation:

Pharmacy school lab evolving to improve drug development
Murali Ramanathan has used AI since its early days to explore possible treatments for multiple sclerosis and Alzheimer’s disease.
Today, he is expanding his use of AI to analyze complex biomedical data to ultimately improve drug development for many conditions.
Much of this work takes place in UB’s Laboratory for Artificial Intelligence and Clinical Pharmacology. The lab allows his interdisciplinary team to apply AI, deep learning, large language models, pharmacometrics and advanced analytics to real-world health care and biomedical data.
“Our lab brings together experts in disciplines such as neurology and radiology, engineering, computer science and statistics,” Ramanathan says. “This cross-collaboration of skills helps us to tackle complex problems that no one single discipline could solve alone.”
By Laurie Kaiser
Published October 7, 2025
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UB is transforming the biomedical field through research, discovery and development. From pioneering drug discovery to revolutionary medical breakthroughs, researchers are shaping the future of health and technology, pushing the boundaries of knowledge to improve lives and build a healthier world.
Learn more about UB’s leadership in Biotech, Health and Medicine
More than 700,000 Americans experience a stroke each year, with many survivors experiencing longterm motor impairments that limit their ability to perform everyday activities. Access to rehabilitation programs often drops off within a few months after a stroke, leaving patients with minimal support when ongoing practice is still needed.
As a result, many stroke survivors turn to mobile apps for help, but these tools are often created without user input and fail to address real-life challenges.
A UB-developed rehabilitation system is tackling this challenge, with the goal of helping people recover from stroke at home with greater success than traditional approaches.
Researchers were awarded a $750,000 grant from the National Institute on Disability, Independent Living and Rehabilitation Research.

Our purpose is to develop a user-friendly, scalable system that promotes independence and improves the quality of life for stroke survivors while reducing caregiver burden.
Wenyao Xu, PhD
Professor and Director of Research, Department of Computer Science and Engineering, School of Engineering and Applied Sciences
Photo: Douglas Levere
By Kay Torrance and Cory Nealon
Published October 1, 2025
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OneTouch-PAT shows promise in early clinical tests
Breast cancer is among the leading causes of death for women worldwide. Early detection, most commonly through mammograms and ultrasound, has helped save countless lives.
OneTouch-PAT, a new UB-developed breast scan for detecting cancer, takes less than a minute using a system that combines photoacoustic and ultrasound imaging. In tests with four healthy individuals and 61 breast cancer patients, OneTouch-PAT produced clear, AI-powered, 3D images of common breast cancer subtypes such as luminal A, luminal B and triplenegative breast cancer.
Jun Xia stresses that more work is needed before this tool can be used in clinical settings, but OneTouch-PAT has the potential to augment current imaging methods and help fight this terrible disease.

Our system combines advanced imaging, automation and artificial intelligence — all while enhancing patient comfort.
Jun Xia, PhD Professor, Department of Biomedical Engineering, Jacobs School of Medicine and Biomedical Sciences
By Cory Nealon
Published July 16, 2025
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New molecule relieves chronic pain for three weeks
A new molecule developed by UB researchers acts like a local, long-lasting anesthetic, providing robust pain relief for up to three weeks, according to the results of preclinical studies reported in the journal Pain.
Like the numbing sensation that results from being anesthetized at the dentist’s office, the new molecule acts like a local anesthetic, but in a much more targeted way.
“The limitation with local anesthetics is that they aren’t very selective for your pain fibers. They block touch sensation as well, and they don’t last very long,” says Arindam Bhattacharjee. “In our new paper, we showed how our new molecule acts like a local, long-lasting pain-fiber anesthetic. We showed that a single injection locally can relieve chronic pain behavior for three weeks.”

By Ellen Goldbaum
Published June 17, 2025
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Zebrafish have been previously studied for cancer, infectious disease treatment
UB researchers are studying if zebrafish, a popular aquarium fish whose genetic and physiological makeup is similar to humans, might be key to unlocking new treatments for kidney stones and gout.
The tiny fish, named for its horizontal blue stripes, has long been used to study possible treatments for cancer, cardiovascular disease, infectious diseases and more.
After receiving a $1.2 million grant from the International Human Frontier Science Program, a team of researchers, including Viviana Monje, will leverage resources within UB’s Center for Computational Research to examine how zebrafish produce a crystal to adjust their skin pigmentation.
The team will focus on an essential but unexplored structure: the lipid membrane that encloses each crystal inside a cell. This information, Monje says, could lead to new treatments for diseases where abnormal crystallization is a hallmark.

By Peter Murphy
Published July 8, 2025
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Taking physiological approaches to a neurological injury
Active management after concussion is the best way for patients to recover and get back to school and work as quickly as possible, according to a clinical practice paper published in the New England Journal of Medicine. The paper is authored by UB researcher John J. Leddy, whose work over several decades has helped establish that physical activity facilitates faster recovery from sport-related concussion.
“Our work at UB has taken an exercise physiological approach to a neurological injury that has changed clinical treatment from a passive, strict rest approach to a prescribed active rehabilitation approach,” says Leddy.
Once all concussion signs and symptoms are gone, both at rest and with exertion, the patient can advance gradually back to contact sport participation, ideally under supervision of an athletic trainer or coach.
The paper references findings that cognitive activity soon after injury is more effective than prolonged absence from school or work. This is particularly important for adolescents, the group most vulnerable to persisting symptoms after concussion.

By Ellen Goldbaum
Published January 30, 2025
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UB is driving advancements in semiconductor development and production, powering an entrepreneurial ecosystem across the state and beyond. As a leading industry advocate, the university accelerates innovation, expands career pathways and generates high-impact employment opportunities throughout the region.
Learn more about UB’s leadership in Semiconductors, Robotics and Advanced Materials
Next-generation semiconductor innovation
UB and the three other SUNY university centers will be key players in the new SUNY-NY Creates Technology Innovation Institute (TII) that will advance semiconductor research and workforce development in New York State.
The initiative, announced by Chancellor John B. King Jr., will support the state’s leadership in next-generation semiconductor innovation by leveraging the worldclass infrastructure at NY Creates’ Albany NanoTech Complex, allowing leading faculty researchers at UB, Stony Brook University, Binghamton University and the University at Albany to connect directly with experts from the industry consortia partners on-site.
SUNY-NY Creates TII will address high-impact, industry-relevant challenges by fostering academicindustry collaboration, facilitating recruitment of top faculty researchers and cultivating a pipeline of skilled talent graduating from SUNY academic programs.
“The SUNY-NY Creates Technology Innovation Institute will bring the best in higher education and industry together to help inspire the next generation of researchers and professionals,” says John B. King, Jr. “The institute will benefit industry leaders who make New York their home, as well as our extraordinary faculty who are leading groundbreaking research and preparing the next generation of researchers and entrepreneurs.”

By UBNow Staff
Published October 31, 2025
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Improving the efficiency and power of everyday devices
Nanoelectronics deal with extremely small electronic components: transistors, sensors and circuits that can fit on the tip of a needle. This technology powers our everyday lives through devices such as computers, smartphones and medical tools.
To improve the efficiency, and power, of these devices, scientists are searching for alternative materials to replace standard silicon-based semiconductors.
A UB-led study explores how mixing two-dimensional materials with silicon might achieve this goal.
Published in the January 6, 2025, issue of the American Chemical Society journal ACS Nano, the article suggests a better way to inject and transport electric charges, an advancement that showcases the significant potential of 2D materials in advancing future semiconductor technologies.
"This collaboration highlights UB’s leadership in cutting-edge semiconductor research and its ability to foster impactful international and interdisciplinary partnerships,” Fei Yao says.



Huamin Li, PhD
Professor, Department of Electrical Engineering, School of Engineering and Applied Sciences
Top Photo: Douglas Levere
Vasili Perebeinos, PhD
Professor, Department of Electrical Engineering, School of Engineering and Applied Sciences
Bottom Left Photo: Heather Bellini Photography
Fei Yao, PhD
Assistant Professor, Department of Materials Design and Innovation, School of Engineering and Applied Sciences
By Laurie Kaiser
Published January 30, 2025
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More than 150 leaders from industry, government and academia gathered at the University at Buffalo in July 2025 for “Bridging the Gap: Activating the Semiconductor Supply Chain Network.”
Hosted by the School of Management’s Center for Supply Chain Analytics and the NY SMART I-Corridor Tech Hub, this event focused on building a stronger, more coordinated semiconductor ecosystem across New York State.
The conference tackled urgent questions facing U.S. semiconductor manufacturing. Through keynotes, expert panels and research presentations, attendees shared insights on workforce development, infrastructure needs, supply chain logistics and public policy.
By Emily Gac
Published July 30, 2025
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The NY SMART I-Corridor, spanning Buffalo, Rochester and Syracuse, received $40 million in federal funding in 2024 to accelerate semiconductor development. This conference helped translate that investment into clear next steps.
“Semiconductors are foundational, but their supply chains are fragile,” says Jennifer Flagg. “We created a space where leaders could connect industry goals, research capabilities and policy incentives.”

Connecting UB globally
UB has officially joined SEMI, a leading global industry association representing the semiconductor and electronics manufacturing supply chain.
The move, sponsored by the Center for Supply Chain Analytics in the School of Management and the Center for Advanced Semiconductor Technology in the School of Engineering and Applied Sciences, connects UB directly to a powerful international network.
By Emily Gac
Published October 27, 2025
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For UB, the timing is significant. New York has become a key player in the national effort to expand semiconductor manufacturing, fueled by large-scale investments and workforce development initiatives. Access to SEMI’s resources helps UB contribute directly to that momentum — linking education, research and industry collaboration.
“SEMI brings together leaders from across the semiconductor ecosystem,” says Jonathan Bird.

UB is dedicated to advancing the frontiers of quantum science, engineering and technology through interdisciplinary research, education and innovation.
Learn more about UB’s leadership in Quantum Science and Technology
Exploring how matter and energy behave
The UB Quantum Institute is a new initiative that draws upon the university’s research expertise to develop breakthrough innovations that address pressing societal challenges.
The institute unites UB scholars across physics, engineering, materials science, computer science, chemistry and other fields to create a leadingedge hub of innovation and education. These cross-disciplinary teams engage with industry and government partners.
“The new Quantum Institute serves as a catalyst for the second quantum revolution — uniting cutting-edge experimentation, deeper theoretical insights and application-driven innovation to spark transformative discoveries and prepare the next generation of quantum leaders,” says Sambandamurthy Ganapathy.

By Cory Nealon
Published November 5, 2025
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A physics shortcut makes quantum math more manageable
Physicists at UB have extended a computationally affordable method known as the truncated Wigner approximation (TWA), a sort of physics shortcut that makes quantum math more manageable, to problems once thought to require massive computing power.
“Our approach offers a significantly lower computational cost and a much simpler formulation of the dynamical equations,” says the study’s corresponding author, Jamir Marino. “We think this method could, in the near future, become the primary tool for exploring these kinds of quantum dynamics on consumer-grade computers.”

Physicists can use supercomputing resources on the systems that need a full-fledged quantum approach and solve the rest quickly with our approach.
Jamir Marino, PhD Assistant Professor, Department of Physics, College of Arts and Sciences
By Tom Dinki
Published October 13, 2025
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Here at UB, our dedication to research is matched only by a commitment to create lasting positive change.
Our researchers are tackling some of humanity’s most pressing problems, by allowing their curiosity to drive society forward.
Sign up for UB’s Impact in Action Newsletter

Modeling of ice sheets and glaciers is one of the best ways that we can understand how much sea level rise we need to prepare for in the coming decades to centuries. This is a matter of national security in the United States, but also a global challenge for planning and adaptation to rising sea level.
Sophie Nowicki, PhD
Empire Innovation Professor, Department of Earth Sciences, College of Arts and Sciences
Photo: Douglas Levere
Ice sheet mapping is critical to understanding climate change
Melt from the Earth’s ice sheets is already contributing to flooding throughout the U.S., and globally, and is expected to increase in the coming decades. Adaptation to reduce the destructiveness of future ocean floods is underway and depends critically, inch by inch, on the work of an international group of polar scientists.
UB researchers are contributing to this effort through the development of the latest computer simulations to map out the most plausible outcomes, thanks to a new $2.1 million grant from the Heising-Simons Foundation.
Highlights from an article by
Tom Dinki
Published July 15, 2025
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An unusual tool for engineers
Yubie, UB’s robot dog, is adept at exploring and doesn’t shy away from small spaces that can be dark, dirty and full of cobwebs. This is good news for engineers responsible for maintaining the roughly 350 culverts that run underneath the Erie Canal to prevent flooding and maintain the canal’s structural integrity. A new pilot program between UB and the New York State Canal Corporation aims to make this process safer and more efficient by tapping into the capabilities of the robot dog.
“Up until now, it’s been up to human inspectors to crawl inside the culverts and find the defects. With a robot such as Yubie, that may not be the case in the near future.”
Karthik Dantu, PhD Associate Professor, Department of Computer Science and Engineering, School of Engineering and Applied Sciences; Founding Director, Center for Embodied Autonomy and Robotics; Director, DRONES Lab
Digitizing the printed notebooks of Marianne Moore
The Marianne Moore Digital Archive is expanding thanks to a $300,000 grant from the National Endowment for the Humanities. The funding supports technical and editorial staff who digitize the printed notebooks of Marianne Moore, one of the foremost modernist poets of the early 20th century, making them publicly accessible for the first time.
“Most poets keep notebooks, but not to the extent of Moore. No other modernist poet kept anything as rich and varied as Moore. Her notebooks are spectacular, a holding space for things she returned to, which often landed in her poetry.”
Cristanne Miller, PhD Professor Emerita, Department of English, College of Arts and Sciences
Highlights from an article by Laurie Kaiser
Published October 16, 2025
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Highlights from an article by Bert Gambini
Published September 11, 2025
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Explore the Marianne Moore Digital Archive:


Wheat straw insulates well, withstands pressure, study finds
Traditional thermal insulation for homes and commercial buildings is often energy-intensive to manufacture, producing significant greenhouse gas emissions. UB researchers are pioneering a sustainable organic alternative: wheat straw. This agricultural waste product, typically burned after harvest, insulates well, withstands pressure and is more flame-retardant than other organic materials.
“Unlike fossil fuels, which take millions of years to form, biomass materials, such as wheat straw, can be harvested and replanted regularly. This makes for an eco-friendlier insulation material.”
Chi Zhou, PhD
Associate Professor and Director of Graduate Studies, Department of Industrial and Systems Engineering, School of Engineering and Applied Sciences
This bacteria may even eat some of their toxic byproducts
In the quest to take the “forever” out of “forever chemicals,” bacteria might be our ally. A UB-led team identified a strain of bacteria that can break down and transform at least three types of per- and polyfluoroalkyl substances (PFAS) and, perhaps even more crucially, some of the toxic byproducts of the bond-breaking process.
“If bacteria survive in a harsh, polluted environment, it’s probably because they have adapted to use surrounding chemical pollutants as a food source, so they don’t starve. Through evolution, some bacteria can develop effective mechanisms to use chemical contaminants to help them grow.”
Diana Aga, PhD SUNY Distinguished Professor and Henry M. Woodburn Chair, Department of Chemistry, College of Arts and Sciences; Director, UB RENEW Institute
Highlights from an article by Laurie Kaiser
Published June 24, 2025
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Highlights from an article by Tom Dinki
Published January 27, 2025
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