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P HARM ACY A N D P H A RMACEUTI CAL 20 26 ANNUAL REP ORT SCI ENCE S

2026 Annual Report | Department of Pharmacy and Pharmaceutical Sciences

Table of Contents 4

Department Staff Listing

By the Numbers

Department Overview

About the Chair

Division of Pharmaceutical Sciences

Division of Pharmaceutical Sciences Faculty

Division of Pharmaceutical Sciences Programs

Division of Pharmaceutical Services

Division of Pharmaceutical Services Faculty

Division of Pharmaceutical Services Programs

Departmental Administrative Team

Honors and Awards

Departmental Extramural Funding

Publications

2026 Annual Report | Department of Pharmacy and Pharmaceutical Sciences

DEPARTMENT STAFF LISTING

FACULT Y

Robert Mobley, PhD

Melissa Bourque, PharmD

FULL MEMBERS

PH A RM ACEUT I CA L S CI EN CES STA F F

Sreenath Nair, PhD

Toya Bowman

Jürgen Bulitta, PhD

Mohammad Aslam Khan, PhD

Carl Panetta, PhD

Becky Boyd

William E. Evans, PharmD (Emeritus)

Gaby Baniulyte

Tracy Peters, MS

Tennille Boyd

Kathy Barker, PhD

Aditi Prasad

Allison Bragg, PharmD

James M. Hoffman, PharmD, MS Kelly Barnett, PhD

Alice Radin-Olivier

Cindy Brasher, PharmD, MS

Mark Leggas, PhD

LaChelle Buckley

Natalia Riva, PharmD

Sharon Brittmon

Mary V. Relling, PharmD (Emerita)

Keshia Cadet

Alaa Sayed, PhD

Felicia Brooks

William Caufield, PhD

P. David Rogers, PharmD, PhD (Chair)

Nick Selvo

Mike Brown

Kami Chauncy

Mansi Shah

Kinley Buss

Alessia Ciaffoni

Xindi Shan, PhD

Derrick Calhoun

Landon Choi

Hanfu Shi, MS

Liz Carlton

Erin DeWitt

Ana Oliveira Souza, PhD

Susan Carr, PharmD

Guoqing Du, PhD

Abi Stolarski

Stephen Chemel

Abeer Adel Shaban Elsayed

Megan Walker, PhD

Andy Christensen, PharmD

Dawn Fisher

Chao Wang

Elizabeth Cleaves, PharmD

Burgess Freeman, PharmD

Lindsey Wang, PhD

Madison Cole, PharmD

Wenbo Ge

Yao Wang, MD

Jennifer Cooper

Sadakatali Gori, PhD

Allexie Williams

Meilssa Cordeiro

Tomoka Gose, PhD

Liu Yang, PhD

Nicole Cox

Sarah Heller

Kelly Caudle, PharmD, PhD

Wenjian Yang, PhD

Brad Crihfield, PharmD

Jane Holton

Cyrine Haidar, PharmD

Kazuto Yasuda, PhD

Shane Cross, PharmD

Jamie Horn, PhD

Daniel Savic, PhD

Qing Zhang

Maria Darby

Yu-Chih Hsiao, MS

Yongzhen Zhang, PhD

Paula Davies

David Jackson

Alan Zhou

LaChaka Davis

John D. Schuetz, PhD Clinton F. Stewart, PharmD (Emeritus) Jun J. Yang, PhD (Division Director, Pharmaceutical Sciences)

ASSOCIATE MEMBERS Brooke Bernhardt, PharmD, MS (Division Director, Pharmaceutical Services)

ASSISTANT MEMBERS

Rossie Jimenez Nieves

Samuel Brady, PhD

Peng Jin, MD

Peijun M. Ma, PhD

Harini Jogiraju

Christian Meyer, PhD

Karon Johnson

Jeffrey Rybak, PharmD, PhD

Sarah Jones Taehyung Kim

DEPARTMENT L E ADER SHIP TE A M David Aguero, PharmD, MSTL Carla Cook, MS Kristine R. Crews, MS, PharmD William Humphrey, MS, MBA, BS Pharm

Julia Kincaide, MS Elaine King Brandon Klee, PharmD Yinzi Lang, PhD Ebony Lee Zhenhua Li, PhD Lili Liu

John McCormick, PharmD

Xiaoli Liu, PhD

Alejandro Molinelli, PhD

John Lynch, PhD

Andrew Pappas

Andrey Matlin

Steve Pate, DPh

Logan McGrath

Jennifer Robertson, PharmD

Ben McKinley

Nousheen DeRenzo, PharmD P HA R M AC E U TIC A L S E RV IC E S STA FF

Roseann Donnelly, PharmD Katie Duncan

Tekoa Akins

Ryan Duncan, PharmD

Delia Allen, PharmD

Liz Edmundson

Kyla Anderson

Nicole EdwardsDurden, PharmD

Eric Andrews, MS Chris Askins, PharmD Dina Bachor PJ Barker, PharmD Amy Bass, PharmD Alysa Baumann, PharmD, MBA Kaitlin Beyler, PharmD Debra Black Hui Black, PhD Ellie Boldreghini, RN Lorraine Bonifacio Kymira Boone

2026 Annual Report | Department of Pharmacy and Pharmaceutical Sciences

Debra Ethridge, PharmD Joseph Evans, PharmD Tamra Filkins Tabetha Filiatreau, PharmD Caroline Flint, PharmD Camden Francavilla Liz Gallimore, PharmD Emma Gant, PharmD Randy Garrett Bruce Girdler Kelly Gossett, RN

DEPARTMENT STAFF LISTING

Elbony Gray

Ted Morton, PharmD

Chernica Turner

Catina Greer

Heather Mullins, PharmD

Renita Turner

P HA R M AC Y R E S ID E NTS

Elaine Hale, RN

Dhara Naik, PharmD

Brent Turpen

Duha Baamir, PharmD

Danaka Hancock, PharmD

Jon Nash, PharmD

Dagny Ulrich, PharmD, PhD

Sonali Chikersal, PharmD

Tory Hardin

Tiffany Nason, PharmD

Liz Velazquez

Ojashwi Giri, PharmD

Nekia Harris

Rachel Ness, PharmD

Anderson Wall

Anne Thomas Hooper, PharmD

Rachel Harris, PhD

Tam Nguyen

Lynlie Wallach, RN

Matt Middleton, PharmD

Jennifer Hasfjord, PharmD

Doraine Isingizwe Nyamurinda

Deborah Ward, PharmD

Parichehr Shoureshi, PharmD

Jaclyn Hopp, PharmD

Christina Owens

Angela Watson

Paula Houston

Amber Pagan

Yvette White

Timothy Howze, PharmD

Justin Palmer

Courtney Wilburn Lee

G R A D UATE STU D E NTS

Kristen Hughes, PharmD

Monica Patel, PharmD

Cheri Wilkerson, PharmD

Ashley Gray

Kipp Hunter

Riley Payne, PharmD

Barry Williams, BS Pharm

Prakash Khanal

Million Irvin

Matthew Pearson, PharmD

Corrina Windrick

Ann Kate Meagher, PharmD

Shervin Izadian, PharmD

Trina Peery, PharmD

Megan Wright, Pharm

Joey Miller

Nevonda Jackson, PharmD

Kristen Prieto

Diana Wu, PharmD

Kumar Niloy

Tim Jacobs, PharmD

Rachel Pyun

Jing Xie

Trevor Penix

Jana Janakiraman

John Ramser, PharmD

Keith Young, BS Pharm

Faten Usrof

Stephanie Jeffries

Julie Richardson, PharmD

Lauren Young

Garrett Weeks

Sherree Johns

Sheri Ring, RN

Cat Zambrano

Allexie Williams

Clara Johnson, MS

Jennifer Robertson, PharmD

David Johnson

Katherine Robinson, PharmD

Jenny Knych, PharmD

Tonya Robinson

P O STD O C TO R A L FE LLO W S

Trevor Lannom, PharmD

Charles Rose

Srijan Acharya, PhD

P HA R M AC Y INTE R NS

Brandon Lea

Robert Rutschman, PharmD

Jinna Bai, PhD

Jylexus Burks

David Lewis

Courtney Sartain

Akash Bhaskar, PhD

May Lin

Nichole Lewis, RN

Linda Schiff, PharmD

Quanita J. Choudhury, PhD

Diana Makram

Lie Li, PhD

Chris Scobey, PharmD

Laura Doorley, PhD

Mary Marcos

Maira Lopez

Giri Shankar

Meghan Garg, PhD

Madeline Matheson

Natiya Lundy

Melody Shettles

Luisa Gomez Londono, PhD

Jon Nash

William Mabry

Taneka Shumpert

Ruida Hou, MD, PhD

Riley Payne

Shane Marshall, PharmD

Nicole Sims

Shutaro Inoue

Rachel Pyun

Ashley Martin

Kelsey Finnell Smith, PharmD

Prakash Khanal, PhD

Will Rhinehardt

Conor Martin, PharmD

Kevin Smith, PharmD, HMBA

Sihan Li, PhD

Anderson Wall

Kim McClelland, MBA

Hope Swanson, PharmD

Luisa Gomez Londono, PhD

Kylar Willliams

Kaitlyn McGinnis

Kelly Tartera, PharmD

Amin Mannan, PhD

Abby McKinney

Paula Taylor

Milre Matherne, PharmD

Kristy McRae

Willie Taylor III

Damilola Oluwalana, PhD

Shevette Milan

Nick Thomas, MS

Darian Santana, PhD

Camille Miller

Adam Thompson, PharmD

Sophie Tilley, PharmD

Thomas Mills, PharmD

Bailey Tibben, PhD

Zehui Yu, DVM

Chris Moon

Laura Todd

Huanbin Zhao, PhD

Ben Moore, PharmD

Deni Trone, PharmD

Jingwen Zhu, PhD

2026 Annual Report | Department of Pharmacy and Pharmaceutical Sciences

BY THE NUMBER S

Pharmacists

45 PhD scientists

BPS certified pharmacists

Post-doctoral fellows

PGY2 pharmacy residents

Graduate students

Faculty members

$7,384,988

$7,214,984

Grant funding/ active extramural funding

Total active NIH funding

2026 Annual Report | Department of Pharmacy and Pharmaceutical Sciences

BY THE NUMBER S

National Academy of Medicine members

Fellow of the American Academy of Microbiology

Fellows of the American College of Clinical Pharmacy

Fellows of the American Society of Health-System Pharmacists

Fellow of the American Society for Pharmacology & Experimental Therapeutics

8.8 Median journal impact factor

Fellows of the American Association of Pharmaceutical Scientists

Fellows of the American Association for the Advancement of Science

110 Total publications

Fellows of the American Medical Informatics Association

>280 Employees

Publications in journals with an impact factor of >10

>$145M Annual Budget

2026 Annual Report | Department of Pharmacy and Pharmaceutical Sciences

DEPARTMENT OVERVIEW

The mission of the Department of Pharmacy & Pharmaceutical Sciences is to generate new knowledge to advance pharmacotherapy and provide the best patient care for children with catastrophic diseases. With a focus on patient care, discovery and implementation, and training and advocacy, the department comprises the Division of Pharmaceutical Sciences and the Division of Pharmaceutical Services. Both research and treatment are highly integrated at St. Jude Children’s Research Hospital, and many of our departmental faculty and staff members are extensively involved in both domains. Indeed, the synergies and efficiencies of having the research and patient care components in a single academic department have been hallmarks of St. Jude since its

Many aspects comprise the Department of Pharmacy and Pharmaceutical Sciences vision. Patient Care ■

Translate research findings into better treatments

■

Optimize treatments for individual patients

■

Improve overall care

Discovery and Implementation ■

differences ■

Identify genetic determinants of drug effects

■

Develop preclinical models and integrate them into translational clinical studies

establishment in 1962, and they facilitate the success of our institution. Our vision is to transform pharmacotherapy for patients with catastrophic childhood diseases. Survival rates for children with cancer, rare neurological diseases, hematologic disorders and infectious diseases continue

Clarify biological basis of drug response

Training and Advocacy ■

Faculty-led interdisciplinary St. Jude programs

■

Lead and participate in national and international research collaborations and consortia

■

Regular workshops, journal clubs and seminars

to increase, largely through the improved use of drug therapy. Failure of current therapies and unacceptable adverse effects are partly due to suboptimal use of medications. We aim to elucidate the biological basis of

We develop preclinical models to systematically

inter-individual differences in pharmacologic response,

characterize the determinants of human variation in

translate our findings into more rational therapeutics

drug response and integrate our work into translational

and improve patient care.

clinical studies. Laboratory work informs clinical studies, and clinical challenges drive much of our laboratory

Heterogeneity in many drugs’ metabolism, transport,

work.

elimination, targets and receptors and consequent variability in therapeutic or adverse effects may

Faculty members lead and participate in

result from germline genetic differences or genetic

interdisciplinary St. Jude programs and national

alterations in malignant cells. Nongenetic factors,

cooperative research collaborations. Our research

such as drug interactions, host organ function and

integrates genome-wide analyses, molecular analyses,

maturity, disease severity, and adherence to therapy

functional genomics, and pharmacokinetics and

also influence drug response. Genetic variability in the

pharmacodynamics to identify genetic determinants

infecting pathogen can further impact anti-infective

of drug effects, with the long-term goal of optimizing

therapy, resulting in anti-infective tolerance or

therapy for individual patients. The Department

resistance.

comprises faculty members, post-doctoral fellows,

2026 Annual Report | Department of Pharmacy and Pharmaceutical Sciences

DEPARTMENT OVERVIEW

residents, undergraduate and graduate students, over 25 board-certified pharmacists, and full-time staff members working as computing experts, research Research and clinical implementation often inform each other in a continuous cycle.

nurses, technical, laboratory, administrative and clinical staff. The department is led by David Rogers, PharmD, PhD,

Basic Research

who serves as chair, and Jun J. Yang, PhD, and Brooke Bernhardt, PharmD, MS, vice-chairs of the Divisions of Pharmaceutical Sciences and Pharmaceutical Services, respectively.

Integrated Models in Translational Studies

The department is supported in part by grants from industry, foundations, and the National Institutes of Health. The research in the department includes clinical

Clinical Questions or Problems

and fundamental pharmacology, pharmacokinetics, pharmacodynamics and pharmacogenomics. The

Clinical Research

Division of Pharmaceutical Sciences occupies over 15,000 square feet of contiguous, state-of-the-art laboratory and office space, and the Division of Pharmaceutical Services occupies over 18,000 square feet of space in the clinical areas of St. Jude. The department hosts weekly research workshops and journal clubs, as well as monthly seminars that are open to the entire institution. Additionally, we host multiple laboratory- and services–specific meetings, webinars with national and international colleagues, and regular

Learn more about our department and the work we do:

pharmacogenomics meetings.

Chair:

Division Director of

David Rogers, PharmD, PhD

Pharmaceutical Sciences:

Pharmaceutical Services:

Jun J. Yang, PhD

Brooke Bernhardt, PharmD, MS

2026 Annual Report | Department of Pharmacy and Pharmaceutical Sciences

ABOUT THE CHAIR

About the Chair

2026 Annual Report | Department of Pharmacy and Pharmaceutical Sciences

ABOUT THE CHAIR

David Rogers, PharmD, PhD Member and Chair St. Jude Endowed Chair in Pharmaceutical Sciences

Scan the QR code to view Dr. Rogers’ website

David Rogers, PharmD, PhD, serves as Chair of the Department of Pharmacy and Pharmaceutical Sciences at St. Jude and holds the St. Jude Endowed Chair in Pharmaceutical Sciences. He received his Doctor of Pharmacy degree from the University of Tennessee and his Master of Science and Doctor of Philosophy in Microbiology and Immunology from the University of Mississippi. Dr. Rogers completed his residency in

Mechanisms of Antimicrobial Resistance (DDR) Study

pharmacy practice (PGY1) at the Regional Medical

Section and currently serves as an Ex Officio Member

Center, Memphis, and residency (PGY2) and clinical

of the National Academies Forum on Antimicrobial

fellowship in infectious diseases pharmacy practice at

Threats. Dr. Rogers’ research program is focused on

the University of Mississippi Medical Center.

improving antifungal pharmacotherapy by studying how pathogenic fungi develop resistance to antifungal

Before joining the faculty at St. Jude, he was a Professor

agents. He has authored over 300 publications and

of Clinical Pharmacy and Translational Science at the

scientific abstracts, and his laboratory has been

University of Tennessee College of Pharmacy. There,

continuously funded by the NIH for over two decades.

he also held the First Tennessee Endowed Chair of Excellence in Clinical Pharmacy, served at various times as Vice Chair of the Department of Clinical Pharmacy and Translational Science, Associate Dean for Clinical and Translational Research, and Director of the UTHSC Center of Excellence for Pediatric Experimental Therapeutics. He is an elected Fellow of the American College of Clinical Pharmacy (ACCP) and the American Academy of Microbiology. He has served on the Board of Trustees for the ACCP Foundation and on the Board of Directors for the Society of Infectious Diseases Pharmacists. In 2021, he received both the ACCP Russell R. Miller Award and the ACCP Therapeutic Frontiers Lecture Award. In 2025 he was elected to the National Academy of Medicine. He has recently served as a member of the NIH Drug Discovery and

2026 Annual Report | Department of Pharmacy and Pharmaceutical Sciences

DIVISION OF PHARMACEUTICAL SCIENCES FACULT Y

Division of Pharmaceutical Sciences The core mission of the Division of Pharmaceutical Sciences is to generate new and fundamental knowledge about how to individualize drug therapy for children with catastrophic diseases. Basic science has always been represented in our research portfolio, with faculty exploring fundamental biology of drug transport, metabolism, toxicity and resistance. We continue to build on our groundbreaking efforts in pharmacogenomics and lead the world in the discovery and clinical implementation of pharmacogenomics-guided precision medicine. Our faculty study genomic and epigenomic architecture of drug phenotypes, develop more accurate models of pediatric cancers for preclinical evaluation, and elucidate the molecular basis of resistance to anticancer and antiinfective agents. The Division integrates expertise in pharmacokinetics, pharmacodynamics, and pharmacogenomics with state-of-the-art technologies to drive discovery research in therapeutic science across disease specialties. Importantly, our unique strength also lies in the ability to translate our laboratory discoveries into patient care, in some cases shifting the paradigm of how pharmacotherapy is practiced. Housed on the 5th floor of the Chili’s Care Center, the laboratories of the division faculty provide superb infrastructure for translational research and an outstanding training environment for graduate students, postdoctoral fellows, and clinician-scientist trainees.

2026 Annual Report | Department of Pharmacy and Pharmaceutical Sciences

DIVISION OF PHARMACEUTICAL SCIENCES FACULT Y

Jun J. Yang, PhD Member, Division Director Division of Pharmaceutical Sciences St. Jude Endowed Chair in Pharmacogenomics

Scan the QR code to view Dr. Yang’s website

Dr. Jun J. Yang is a Member and holds the St. Jude Endowed Chair in Pharmacogenomics and serves as the Director for the Division of Pharmaceutical Sciences. His research focuses on pharmacogenomics of anticancer drugs in children with a particular interest in childhood acute lymphoblastic leukemia (ALL). The goal is to ultimately develop pharmacogenomics-guided treatment strategies to personalize therapy for children with catastrophic diseases.

In an additional effort, the team published an investigation into how age influences drug sensitivity

Toward this effort, in 2024, Dr. Yang and his team published work that analyzed the single-cell transcriptomes of human B-cells, leading to the discovery that the developmental state of leukemia cells correlates with asparaginase sensitivity and the identification of a potential target to enhance aspariginase efficacy pharmaceutically. The work emphasized the potential of single-cell systems pharmacology to predict effective combination therapies based on the developmental heterogeneity within leukemia.

and treatment responses in B-cell ALL (B-ALL). Specifically, they showed that children exhibited greater sensitivity to mercaptopurine, independent of leukemia subtype, stressing the need for age-specific treatment considerations. Dr. Yang continues research on drug-induced liver toxicity through an innovative collaborative project that has challenged our scientists’ ingenuity and maximized our shared resources. The team developed an ultrahigh parameter flow cytometry assay using 48 distinct fluorophores to precisely track cellular changes in the

The Yang lab continued exploring how genetic variants affect thiopurine toxicity and tolerability in children with ALL. With findings regarding lower dose tolerations in patients of Hispanic heritage with TPMT mutations and NUDT15 genetic variants, the work highlights the importance of genetic testing,

liver following drug treatment. By integrating these findings with single-cell sequencing, spatial-omics and data from a rich clinical cohort, they are uncovering the fundamental mechanisms of drug-induced liver toxicity while generating promising avenues for potential interventions.

particularly in Hispanic populations, for TPMT and NUDT15 variants to guide thiopurine dosing in pediatric ALL patients to reduce toxicity and improve therapeutic outcomes.

2026 Annual Report | Department of Pharmacy and Pharmaceutical Sciences

DIVISION OF PHARMACEUTICAL SCIENCES FACULT Y

Samuel Brady, PhD Assistant Member

Scan the QR code to view Dr. Brady’s website

Samuel Brady, PhD, joined the Department of Pharmacy and Pharmaceutical Sciences in 2023. Since joining, he has established his lab and hired staff to support their research endeavors. The overarching objective within the Brady lab is to improve cancer treatment and reduce toxicity using genomics as a starting point. Genomic alterations in a tumor can predict response or resistance to various therapeutics; the Brady lab aims to understand why and how this occurs so that therapies can be tailored appropriately. The team also uses mutational signatures to understand how existing therapies may induce secondary cancers in survivors later in life. Many pediatric cancer survivors will undergo treatment and be cured of their initial cancer but then develop a second cancer due to their prior therapy. The Brady lab uses mutational signatures and other genomic techniques to understand how therapy can induce specific mutations that initiate second cancers, as shown in the lab’s recent study of 200 second neoplasms from childhood cancer survivors (Cancer Discov 16: 1590–1610, 2026). The results of this work could help inform which therapies should be reduced to a lower dosage and which should be avoided

Finally, the Brady lab aims to tackle new therapeutic targets using existing or new therapies. Many current cancer therapies are toxic, which is a significant problem for pediatric patients because their bodies are still developing. In order to develop treatments that will have the maximum impact on cancer cells with minimal impact on healthy tissue, the team is working to identify the genes that are unnecessary for human survival but vital to a cancer cell’s survival. For example, the team recently identified IRS4 as a promising target in pediatric cancer, which is dispensable for humans (Sci Adv 12:eaeb3503, 2026), and the lab is seeking to exploit this vulnerability therapeutically. This research will allow the identification of existing drugs that can target the function of these genes or the development of new therapies to target specific proteins and minimize treatment toxicity.

entirely in certain patient populations. Therapyinduced mutational signatures can also fuel tumor heterogeneity and drug resistance. Thus, they may help identify approaches to sequence therapies so that highly mutagenic therapies are avoided during certain phases of therapy when drug resistance is more likely to develop.

2026 Annual Report | Department of Pharmacy and Pharmaceutical Sciences

DIVISION OF PHARMACEUTICAL SCIENCES FACULT Y

Jürgen B. Bulitta, PhD Member

Scan the QR code to view Dr. Bulitta’s website

Multidrug-resistant Gram-negative bacteria have been highlighted by the CDC and many other organizations as the cause of a critical human health crisis in the U.S. and worldwide. Such resistant isolates are particularly problematic in patients with an impaired immune system as well as patients in low- and middle-income countries. Gram-negative pathogens are causing significant numbers of life-threatening infections, leading to substantial morbidity and mortality. This causes substantial challenges to clinicians.

studies and hollow fiber infection models at St. Jude. Moreover, we are identifying which sets of PBPs should

The discovery of penicillin, a β-lactam antibiotics, has fundamentally transformed modern medicine and enabled physicians to reliably prevent infections and cure patients with serious infections, prior to the global rise of multidrug-resistant bacteria. The β-lactam antibiotics are safe in patients of all ages, and all β-lactams target one or more penicillin-binding proteins (PBPs), which are arguably the best clinically validated antibiotic targets. All bacteria have, however, multiple different PBPs with various biochemical functions, and it is not well known which of these PBPs should be targeted by antibiotics. Moreover, substantial gaps remain in our understanding of how to maximize the bacterial target site concentrations of antibiotics. Our lab has is developing a platform of cutting-edge assays for the bacterial target site penetration and PBPbinding in intact cells of Gram-negative bacteria. We are employing a series of mechanistic and phenotypic assays leveraging latest technologies such as UPLC-MS/ MS, flow cytometry, confocal microscopy, single-cell

be targeted by rationally optimized combinations of available β-lactam antibiotics to ultimately optimize treatment outcomes in patients. These data are being integrated by Quantitative and Systems Pharmacology modeling to understand drug penetration and drug action at a mechanistic level and to support drug discovery and development. Our team is significantly contributing to developing several classes of novel, non-β-lactam PBP-binding antibiotics through collaborations with medicinal chemists at St. Jude, as well as collaborations with academia and pharmaceutical industry. Non-β-lactam PBP-binding antibiotics are highly promising, since they are not affected by the most important resistance mechanisms for β-lactam antibiotics. Ultimately, our translational pharmacology research aims to provide safe and effective treatment strategies that can successfully target resistant bacteria using available and future antibiotics for patients with catastrophic diseases.

2026 Annual Report | Department of Pharmacy and Pharmaceutical Sciences

DIVISION OF PHARMACEUTICAL SCIENCES FACULT Y

William E. Evans, PharmD Emeritus Faculty

Scan the QR code to view Dr. Evans’ website

The Evans lab examined the pharmacogenomics of anticancer agents, specializing in childhood acute lymphoblastic leukemia (ALL). Evans and his team aimed to elucidate genomic determinants of toxicity and efficacy of anticancer agents and translate this knowledge into new diagnostics and treatment strategies to optimize ALL therapy. They achieved their aims by evaluating patient cohorts’ leukemia cells for drug sensitivity and clinical response in prospective clinical trials. They used comprehensive DNA and RNA sequencing to identify genes and genome variations that are important determinants of antileukemic agents’ disposition and effects. The Evans lab closed in 2021 and no longer accepts students or post-doctoral trainees. As an emeritus faculty member, he and his collaborators continue to analyze and report data generated over the last several years to improve the safety and efficacy of medications used to treat children with cancer.

2026 Annual Report | Department of Pharmacy and Pharmaceutical Sciences

DIVISION OF PHARMACEUTICAL SCIENCES FACULT Y

Mark Leggas, PhD Member Director, Center for Translational Pharmacology

Scan the QR code to view Dr. Leggas’ website

Dr. Mark Leggas is a Member of the Department of Pharmacy and Pharmaceutical Sciences and the Director of the Center for Translational Pharmacology. The Leggas Lab has a vested interest in translational pharmacology to optimize the clinical use of existing drugs or new drug candidates. The lab has a longstanding project to develop a new targeted therapy for Ewing sarcoma and is concluding a project assessing the utility of a non-opioid medication to treat neonates physically dependent on opioids. A major new effort aims to optimize lymphodepletion and use patient metabolic phenotyping to improve outcomes in patients treated with adoptive cell therapies such as CAR T–cell products.

dependent on opioids due to prenatal exposure. In 2024, the Leggas Lab further advanced the study of neonatal opioid exposure by publishing clinical trial results and a pharmacometric model to optimize clonidine dosing regimens. These efforts have positively contributed to the treatment of neonatal opioid withdrawal syndrome (NOWS).

The Ewing sarcoma project focuses on semisynthetically modified mithramycin analogs, which have shown the ability to interfere with the oncogenic transcription factor responsible for Ewing sarcoma growth. This is significant because this oncogenic transcription factor (i.e., EWS-FLI1) is recognized as the Achilles’ heel of Ewing sarcoma yet attempts to develop treatments that disrupt its function have failed. Currently, several analogs are advancing through preclinical evaluation and, if successful, will move to the NCI Experimental Therapeutics program to complete all the preclinical assessments needed for entry into the clinic.

The CAR T–cell project aims to optimize lymphodepletion conditioning therapy for all CAR T–cell products under development at St. Jude. This is essential because the effects of lymphodepleting agents on CAR T–cell kinetics and pharmacodynamics have not been systematically studied. Additionally, the lab is developing advanced analytical methods and informatics platforms that will enable comprehensive metabolic phenotyping of patients receiving CAR T– cell treatment. This is important because host-related small molecules derived from physiological processes, nutritional status, or environmental sources may significantly influence CAR T–cell signaling. Ultimately,

The neonate project is centered around a randomized controlled clinical trial that evaluated the use of clonidine, an alpha-2 adrenoceptor agonist, compared to morphine for treating neonates born physically

biomarkers of CAR T–cell disposition (similar to drug metabolism) and phenotype in relation to efficacy and toxicity (pharmacodynamics) will be developed, along with semi-mechanistic models that establish exposure (by phenotype) – response relationships.

2026 Annual Report | Department of Pharmacy and Pharmaceutical Sciences

DIVISION OF PHARMACEUTICAL SCIENCES FACULT Y

Peijun Ma, PhD Assistant Member

Scan the QR code to view Dr. Ma’s website

Dr. Peijun Ma joined the Department of Pharmacy and Pharmaceutical Sciences as an Assistant Member in 2023. Her previous research focused on developing bacterial single-cell RNA sequencing technology and understanding the evolution of antibiotic resistance in gram-negative bacterial pathogens. At St. Jude, Dr. Ma’s research group aims to investigate bacterial heterogeneity and its impact on the evolution of antibiotic resistance and persistence using bacterial single-cell transcriptomics. The emergence of antibiotic resistance and persistence can directly lead to treatment failure, posing a significant threat to human health. A major issue in our current efforts to combat antibiotic resistance and persistence is the predominant characterization of bacteria as whole populations. However, resistant and persistent clones typically arise from single-cell events. The heterogeneity in bacterial populations has not been well-characterized, and the mechanisms leading to this heterogeneity remain unclear. To address this problem, the Ma Lab will apply innovative bacterial single-cell transcriptomics to characterize bacterial drug-induced heterogeneity at the single-cell level. Additionally, Ma’s team will characterize the microbiome using bacterial single-cell transcriptomics to understand the evolution of antibiotic resistance and persistence in the context of the host microenvironment, particularly in pediatric patients with recurrent bacterial infections. This work will provide novel and exciting insight into bacterial heterogeneity and lead to the identification of drug targets for treating bacterial infections associated with antibiotic resistance and persistence.

2026 Annual Report | Department of Pharmacy and Pharmaceutical Sciences

DIVISION OF PHARMACEUTICAL SCIENCES FACULT Y

Christian Meyer, PhD Assistant Member

Scan the QR code to view Dr. Meyer’s website

Drug combinations form the backbone of modern medicine. Whether by design or inadvertently, drug– drug interactions, colloquially referred to as “drug synergy,” can dramatically alter the therapeutic activity and risk for toxicity compared to single-drug regimens. A paucity of analytical and experimental platforms to measure and predict the efficacy and safety of these interactions is a critical barrier to improving outcomes in our patients. Our lab uses a combination of wet-lab experiments, computational modeling, and mathematical theory to discover better ways of combining drugs.

Finally, our lab aims to investigate the fundamental mechanisms of cell death in response to antibiotics and how these mechanisms relate to the activity of antibiotics being used in patient care. In summary,

For patients at St. Jude, cancer is not their only risk. The immunosuppressive nature of chemotherapy and the early development stage of their immune system make these patients at risk for life-threatening infections. Such infections commonly stem from biofilms that

using a combination of high-throughput screening, machine learning, mathematical models, and live cell microscopy, we are creating a cutting-edge systems pharmacology research program to study and optimize drug combinations used to treat St. Jude patients.

can form on medically implanted devices. Biofilms are communities of bacteria that form superstructures and are highly resistant to antibiotics. Complicating matters, these bacteria are already reacting to the chemotherapy before the infection is detected. Our lab is interested in understanding the mechanistic basis of how host-directed therapies modify the activity of antibiotics, as well as describing the physiological changes that are induced by chemotherapy in clinical biofilms. In particular, through the lens of electrophysiology, we are examining how changes in membrane potential within a single bacterium propagate across the biofilm to modify the sensitivity of the population.

2026 Annual Report | Department of Pharmacy and Pharmaceutical Sciences

DIVISION OF PHARMACEUTICAL SCIENCES FACULT Y

Mary V. Relling, PharmD Emerita Faculty

Scan the QR code to view Dr. Relling’s website

Mary Relling, PharmD, became a faculty member in the Department of Pharmaceutical Sciences at St. Jude in 1988 and served as department chair from 2003 to 2020. Her primary research efforts focused on translational research in childhood acute lymphoblastic leukemia (ALL), aiming to identify the host- and treatment-related risk factors for adverse treatment outcomes. The Relling lab’s use of precision medicine approaches to tailor therapeutic dosages enabled them to incorporate pharmacogenetically-based dosage adjustments in ALL trials and for all other St. Jude patients via the clinical protocol PG4KDS. Relling co-founded the Clinical Pharmacogenetics Implementation Consortium (CPIC), an NIH-supported genomics resource focused on facilitating the clinical implementation of germline pharmacogenetic testing. After stepping down as department chair and moving to part-time status in 2021, Relling retired in June of 2023, but her collaborators continue to build on her tireless work.

2026 Annual Report | Department of Pharmacy and Pharmaceutical Sciences

DIVISION OF PHARMACEUTICAL SCIENCES FACULT Y

Jeffrey M. Rybak, PharmD, PhD Assistant Member

Scan the QR code to view Dr. Rybaks’s website

Jeffrey M. Rybak, PharmD, PhD, joined the Department of Pharmacy and Pharmaceutical Sciences faculty at St. Jude Children’s Research Hospital in September 2020. Previously, his research focused on discovering the molecular mechanisms underpinning antifungal resistance among challenging fungal pathogens such as Aspergillus fumigatus and Candidozyma (Candida) auris. Employing whole genome and transcriptome sequencing, in vitro evolution studies and targeted allelic replacement, Rybak and his colleagues revealed mutations in the A. fumigatus HMG-CoA reductase gene, hmg1, and the C. auris zinc-cluster transcription factor (ZCF) gene, TAC1B, as widespread genetic determinants of clinical triazole antifungal resistance. Rybak’s current research focuses on advancing the treatment of invasive fungal infections by developing new therapeutic strategies to overcome difficult-totreat fungal pathogens. In pursuit of this objective, the Rybak lab has developed the C. auris-optimized Episomal Plasmid Induced Cas9 (EPIC) system, capable of single nucleotide-editing, and used this system to interrogate the role of the fungal-specific zinc-cluster transcription factors (ZCF) in regulating the response to antifungal-induced stress in C. auris. They have demonstrated that targeted disruption of one of these ZCF genes, UPC2, results in ablation of the normal C. auris transcriptional response to triazole treatment, reduced production of the key fungal sterol ergosterol, and diminished resistance to triazole antifungals. Furthermore, the Rybak lab has observed that while triazoles are conventionally limited to fungistatic activity against species of Candida, disruption of C. auris UPC2 conferred rapid fungicidal activity to the triazole

agents at pharmacologically achievable concentrations both in vitro and in vivo. Their ongoing studies seek to characterize the C. auris UPC2 regulatory network and to reveal molecular weak points that can be targeted to restore and enhance the activity of the triazoles and amphotericin B. The Rybak lab also seeks to advance the treatment of invasive mold infections. Recently, they demonstrated that a specific group of commonly observed mutations in the cyp51A gene, which alter the glycine-54 residue (G54), confer increased resistance to long-lipophilic triazoles such as posaconazole while creating a previously unknown collateral sensitivity to compact triazoles. They then demonstrated that this vulnerability could be therapeutically exploited to treat even pantriazole-resistant A. fumigatus clinical isolates with G54 altering mutations by utilizing targeted combinations of clinically available triazoles in a murine model of pulmonary aspergillosis. In addition to his benchtop research, Rybak is a member of the Antimicrobial Utilization and Improvement Committee (AUIC) and co-authored the updated St. Jude Antifungal Utilization Guidelines.

2026 Annual Report | Department of Pharmacy and Pharmaceutical Sciences

DIVISION OF PHARMACEUTICAL SCIENCES FACULT Y

Daniel Savic, PhD Associate Member

Scan the QR code to view Dr. Savic’s website

Dr. Daniel Savic leads a research program focused on understanding the bidirectional relationship between therapeutic agents and cellular regulatory states — how drugs reshape gene regulatory networks and how preexisting regulatory landscapes influence therapeutic response, drug resistance, and treatment outcome in childhood leukemia. The Savic laboratory integrates functional genomics, genome engineering, chromatin biology, and computational modeling to define how enhancer networks and the noncoding genome control

mechanisms that govern therapy-sensitive and therapyresistant cellular states. Third, the laboratory investigates how inherited and

cancer cell behavior and therapeutic response.

somatic noncoding genetic variants alter enhancer

The laboratory’s research program spans three major

and treatment outcome in childhood leukemia. Using

areas. First, the laboratory investigates the regulatory architecture of acute leukemia by mapping chromatin accessibility, enhancer activity, and three-dimensional genome organization in primary patient samples and cellular model systems. These studies generated one of the largest chromatin accessibility resources in acute lymphoblastic leukemia to date, profiling over 150 primary patient samples across multiple molecular subtypes to define regulatory landscapes associated with leukemia biology and therapeutic response. Second, the Savic laboratory studies how therapeutic agents remodel enhancer networks and cellular regulatory states to influence drug sensitivity and resistance. Using integrated genomic and functional approaches, the laboratory examines how therapeutic agents reshape transcription factor occupancy, enhancer activity, and chromatin states across leukemia model systems and patient-derived samples. Complementary studies examine how pre-existing chromatin states and enhancer networks influence therapeutic response and resistance in childhood leukemia. These studies aim to define the regulatory

function and influence drug response, relapse risk, massively parallel reporter assays, the laboratory systematically measures the functional effects of regulatory variation on enhancer activity and gene expression. Complementary CRISPR-based functional screening approaches identify enhancer perturbations that influence therapeutic response and drug resistance phenotypes. By integrating these approaches with patient-derived genomic datasets, the laboratory defines how noncoding variation and enhancer dysfunction contribute to therapeutic response in childhood leukemia. Ultimately, the Savic laboratory aims to define the regulatory principles that govern therapeutic response and resistance, with the long-term goal of advancing precision medicine approaches for childhood cancers. Beyond his primary research role in the Department of Pharmacy and Pharmaceutical Sciences, Dr. Savic maintains important affiliations with the Hematological Malignancies Program at St. Jude, the Pharmacogenomics Global Research Network, and the Children’s Oncology Group, enabling broader collaboration and impact in the field.

2026 Annual Report | Department of Pharmacy and Pharmaceutical Sciences

DIVISION OF PHARMACEUTICAL SCIENCES FACULT Y

John D. Schuetz, PhD Member

Scan the QR code to view Dr. Schuetz’s website

Investigations in the John Schuetz laboratory examine how membrane transporters and cellular metabolism influence physiology, inherited disease, cancer, and therapeutic response. Using genetics, structural and computational biology, biochemistry, proteomics, metabolomics, and disease models, the laboratory studies how transport proteins and metabolic pathways

losing the conformational communication required for

regulate cellular function, vulnerability, and drug

effective ATP-dependent transport.

resistance. Metabolic regulation is another central area of One major focus is ABCB6, an ATP-binding cassette

investigation. Studies of protoporphyrin IX (PPIX),

transporter involved in porphyrin and heme biology

a potentially toxic heme intermediate, identified

and genetically linked to dyschromatosis universalis

connections among PPIX accumulation, iron

hereditaria (DUH). Although DUH is primarily recognized

metabolism, oxidative phosphorylation, mitochondrial

as a pigmentation disorder, some affected individuals

antioxidant defenses, and ferroptosis. The laboratory

also experience hearing impairment. Recent studies

showed that mitochondrial PRDX3 protects cells from

combined cryogenic electron microscopy with

PPIX-induced oxidative damage and that increasing

biochemical, computational, cellular, zebrafish, and

PPIX can promote ferroptotic cell death in susceptible

mouse models to show how disease-associated ABCB6

cancer cells, including leukemia cells.

variants disrupt transporter function. Loss of Abcb6 altered sensory hair-cell and otolith development

Recent work on ABCC4 has also expanded the view

in zebrafish and reduced hearing sensitivity in mice,

of transporters beyond isolated drug-efflux pumps.

supporting a direct role for ABCB6 in inner-ear

The laboratory identified an ABCC4-centered protein

development and hearing.

network involving SCRIB, cytoskeletal proteins, and cell-junction components that regulates transporter

The laboratory also studies ABCG2, a transporter

abundance, stability, mobility, and cyclic-AMP export.

important in drug disposition and multidrug resistance. Research has shown how the electrostatic and

Collectively, the Schuetz laboratory reveals how

hydration properties of its binding cavity influence

transporter structure, metabolism, redox homeostasis,

recognition and transport of diverse compounds.

developmental signaling, and protein-interaction

Analysis of the medulloblastoma-associated Q393K

networks shape disease and therapeutic response,

mutation further demonstrated that a transporter can

with the goal of identifying new strategies for treating

retain expression and substrate interactions while

inherited disorders, cancer, and drug resistance.

2026 Annual Report | Department of Pharmacy and Pharmaceutical Sciences

DIVISION OF PHARMACEUTICAL SCIENCES FACULT Y

Clinton F. Stewart, PharmD Emeritus Faculty

Scan the QR code to view Dr. Stewart’s website

Dr. Clinton Stewart joined St. Jude in 1991, and during his tenure his work has focused on translational research of anti-cancer drugs in children with solid tumors and brain tumors. The Stewart Lab has addressed clinically relevant problems encountered in the therapy of children with brain tumors, primarily the central nervous system (CNS) penetration of novel compounds used to treat pediatric brain tumors. The process used includes tumor subgroup-specific models of pediatric CNS tumors grown in mice, cerebral microdialysis sampling of tumor extracellular fluid and ventricular cerebrospinal fluid, drug measurement using mass spectrometry, and pharmacokinetic modeling and simulation of the derived data to directly assess the unbound partition coefficient for the drug under study. As little is known about the disposition of most anticancer agents in children with cancer, the Stewart Lab has collaborated with clinical investigators to conduct comprehensive pharmacology studies in clinical trials. These studies include pharmacokinetic, pharmacogenetic, and pharmacodynamic studies of novel drugs to gain a better understanding of the variability in drug disposition in children with cancer. The lab has contributed to studies that advance the understanding of pharmacologic therapies across diseases states such as medulloblastoma, glioma, AT/RT, neuroblastoma, retinoblastoma and sarcoma. Beyond these contributions, the Stewart Lab has translated findings from the lab to clinic for several

topotecan had better antitumor responses. This led to a series of studies where Bayesian analysis of pharmacokinetic data determined a patient’s system clearance and allowed for individualized topotecan dosage. According to our most recent research, this can be done with a simple single-sample approach. Further delving into clinical dosing, sorafenib improves outcomes in adult hepatocellular carcinoma, but not without toxicities. Both efficacy and toxicity are related to sorafenib systemic exposure, which is highly variable in children based upon studies conducted at St. Jude. Thus, as part of an ongoing clinical trial our lab conducted a study of pharmacokinetically-guided sorafenib dosing. A primary objective of the trial was to determine if sorafenib systemic exposure can be targeted to a systemic exposure by day 21 of course 1 in 60% of patients when given in combination. The safety run-in phase met the objective of successfully targeting at least 60% of the individuals. The median targeted sorafenib dosage was 41% lower than the conventional dose of 90 mg/m2 and we have not observed any grade 3 or higher sorfenib-related toxicities.

drugs. For example, we found that mice treated with

2026 Annual Report | Department of Pharmacy and Pharmaceutical Sciences

DIVISION OF PHARMACEUTICAL SCIENCES PROGR AMS

Center for Translational Pharmacology The Center for Translational Pharmacology advances the implementation of pharmacokinetic and pharmacodynamic translational research at St. Jude. The mission of the Center is to centralize high-quality, competitively funded, peer-reviewed

Director Mark Leggas, PhD

clinical pharmacology research in the context of clinical trials. Equipped with state-of-the-art equipment and experienced personnel, the Center is positioned to increase the impact and value of clinical trials at St. Jude by providing expertise

Associate Director Research Operations Kristine Crews, MS, PharmD

in pharmacokinetic and pharmacodynamic study design, developing and applying novel mathematical models, and providing high-quality data. The staff assists with building electronic sample orders, laboratory test procedures, and educating clinical staff on protocol-specific procedures. Dedicated research nurses facilitate proper sample collection

Associate Director Bioanalytical Operations Burgess Freeman, PharmD

and logistical support to ensure efficient sample handling, processing, storage, and distribution. The Center offers bioanalytical assay development and validation under FDA guidelines and sample analysis for accurate measurement of drug and metabolite concentrations in plasma, blood, and other relevant biological matrices. The Center also offers state-of-the-art mathematical modeling and simulation, providing quantitative input toward rational study design and interpretation. Services are available to all faculty who initiate St. Jude trials as well as to those participating in externally collaborative projects, industry-sponsored studies, and consortium-led clinical initiatives.

2026 Annual Report | Department of Pharmacy and Pharmaceutical Sciences

DIVISION OF PHARMACEUTICAL SCIENCES PROGR AMS

The Pharmacotyping Resource Over the past 40 years, pharmacogenomics has been a central research endeavor for the Department of Pharmacy

Director Jun J. Yang, PhD

and Pharmaceutical Sciences at St. Jude. Our discoveries of the genetic determinants of drug toxicity and response have fundamentally improved pediatric cancer therapy and made St. Jude a leader in pharmacogenomics-driven precision medicine. Pharmacotyping — defining interpatient variability in drug sensitivity — is the starting point for correlating drug phenotype to patient genomic profiles.

Associate Director Kristine Crews, MS, PharmD

The Pharmacotyping Resource, located within the Division of Pharmaceutical Sciences, supports the opportunity to “embrace the challenge to create a new tomorrow.” The mission of the Pharmacotyping Resource is to leverage drug screening technology to enable collaborative pharmacogenomics research that improves cancer treatment outcomes. The Resource has supported research leading to discoveries that have uncovered novel mechanisms of drug resistance and have pointed to strategies for overcoming them. The Resource offers a state-of-the-art imaging platform to test drug sensitivity profiles (pharmacotyping) of primary patient tumor cells as a functional precision medicine method. A team of research technologists, led by Jun J. Yang, PhD and Kristine Crews, PharmD, operates the Resource with expertise in high-content imaging, deep machine learning, drug assay development, preclinical drug evaluation and research informatics. Building upon our strength in this field, we use a modern pharmacotyping platform to discover new therapeutic opportunities for leukemia. To this end, the Pharmacotyping Resource is equipped with a PerkinElmer Operetta CLS high-content analysis system for imaging-based drug sensitivity testing. The Operetta CLS is an automated confocal spinning disk fluorescence microscope. It is capable of imaging in 96 or 384 well plate formats. This imager is combined with the PerkinElmer Harmony data analysis software that allows for quantitative image analysis with image analysis capabilities powered by machine learning. The team offers a pharmacotyping assay validated in tumor cells collected from patients treated for leukemia in clinical trials run by the Hematological Malignancies Program. Leukemia cells obtained from patients are tested for ex vivo sensitivity to 40 anti-leukemia drugs, and genomic profiling is done in parallel by whole genome sequencing and other assays. Our published data shows wide variability among patients in drug sensitivity and an association between sensitivity profiles and event free survival. These findings point to therapeutic implications of genomic alterations in acute lymphoblastic leukemia (ALL). The integration of tumor cell sensitivity measures with genomic data advances pharmacogenomics discovery research at St. Jude and guides the next generation of pediatric cancer therapy.

2026 Annual Report | Department of Pharmacy and Pharmaceutical Sciences

DIVISION OF PHARMACEUTICAL SERVICES FACULT Y

Division of Pharmaceutical Services Pharmaceutical Services is led by Brooke Bernhardt, PharmD and is staffed by pharmacists, pharmacy technicians, research and administrative staff and faculty, all dedicated to providing patients the best pharmaceutical care possible at St. Jude while supporting a collective research endeavor. Working with other clinicians in a cutting-edge and highly collaborative environment, our personnel ensure the best possible drug therapy outcomes. Nearly 180 pharmacy staff are involved in these care efforts. Their work emphasizes integrating optimal conduct of St. Jude’s medication-related clinical research, helping to fulfill our organizational mission to “advance cures and means of prevention for pediatric catastrophic diseases through research and treatment.” Over 30 pharmacists are certified as specialists by the Board of Pharmacy Specialties, and four other pharmacists carry at least one credential from other certifying organizations, testifying to the staff’s commitment to a deep understanding and high level of clinical practice of pharmacotherapy and research. Pharmaceutical Services had several significant achievements in 2025. Members of Pharmaceutical Services won the Tennessee Pharmacist Association awards for 1) Shining Star Compounding Pharmacy Technician, 2) Health-System Distinguished Service Pharmacist, 3) Health-System Pharmacy Technician of the Year and 4) Health-System Residency Program of the Year for 2025.

2026 Annual Report | Department of Pharmacy and Pharmaceutical Sciences

DIVISION OF PHARMACEUTICAL SERVICES FACULT Y

Brooke Bernhardt, PharmD, MS Associate Member, Division Director Division of Pharmaceutical Services Chief Pharmacy Officer

Scan the QR code to view Dr. Bernhardt’s website

Brooke Bernhardt, PharmD, MS, joined St. Jude in 2023 as Associate Member, Division Director, and Chief Pharmacy Officer for the Division of Pharmaceutical Services. As a board-certified pediatric and oncology pharmacist, Dr. Bernhardt brings a wealth of experience to her leadership roles within the department. Her interests encompass pharmacogenomic factors that influence drug disposition, metabolomics, toxicity, and survival in children with cancer. She serves as the site PI for the NCI U54 REducing Disparities in Acute Leukemia (REDIAL) SPORE, working in close collaboration with other department faculty and external collaborators to study the role of pharmacogenomics on disparate outcomes across

As the senior leader of the Division of Pharmaceutical Services, Bernhardt strives to ensure that the Division provides the highest level of pharmaceutical care to the patients of St. Jude. To achieve this, the Division

different populations of children with cancer.

collaborates closely with the Division of Pharmaceutical

Dr. Bernhardt has also served as a pharmacist leader

care. The Division also collaborates with other clinical

in cooperative group clinical trials as an NCI-funded pharmacist for the Children’s Oncology Group (COG) and as the Vice-Chair of the Pharmacy Discipline within COG. In this capacity, she has also contributed to over 50 cooperative group clinical trials through COG and the NCI’s Pediatric Early Phase Clinical Trials Network (PEP-CTN). She continues to lead in this space and is actively designing new studies leveraging COG data, including data obtained through the NCI’s Molecular Characterization Initiative, through a collaboration between the COG Pharmacy Discipline and COG Epidemiology Domain Committee.

Sciences to optimize opportunities for translational departments, including Oncology, Hematology, and Epidemiology and Cancer Control. The Division of Pharmaceutical Services is also committed to training the next generation of pharmacists, with a significant focus on training pharmacy students and pharmacy residents. Bernhardt has created a Clinical Pharmacy Fellowship to allow for additional sub-specialty research training. Finally, Bernhardt is leading the launch of two new initiatives for the Division, specifically clinical and research programs in Clinical Pharmaceutics, Pharmacoeconomics, Formulation Sciences and 3D printing.

2026 Annual Report | Department of Pharmacy and Pharmaceutical Sciences

DIVISION OF PHARMACEUTICAL SERVICES FACULT Y

Kelly Caudle, PharmD, PhD Associate Member

Scan the QR code to view Dr. Caudle’s website

Dr. Kelly Caudle is an Associate Member within the Department of Pharmacy and Pharmaceutical Sciences. Through global collaboration, Dr. Caudle’s lab mission is to curate and synthesize knowledge using rigorous scientific standards to support informed prescribing decisions and enhance medication-related health outcomes. With a vision for widespread integration of pharmacogenomics and other medication safety measures into standard health care practice worldwide, Dr. Caudle is dedicated to ensuring that every patient receives personalized, effective and safe medication — ultimately improving outcomes and reducing health care costs. As Principal Investigator and Director of the Clinical Pharmacogenetics Implementation Consortium (CPIC), an NIH-funded international consortium of more than 800 members, Dr. Caudle’s team leads a globally influential effort to advance precision medicine by translating pharmacogenetic discoveries into clinical practice. CPIC develops, curates, and disseminates freely available, peer-reviewed, and regularly updated gene–drug clinical practice guidelines that are used worldwide to support safer and more effective medication prescribing. CPIC’s global reach and multidisciplinary composition are central to its impact. Its membership spans academia, health systems, industry, and government, and includes pharmacists, physicians, scientists, and a wide range of healthcare professionals, reflecting the broad clinical relevance of pharmacogenetics. Importantly, nearly one-quarter of current guideline authors are based outside the United States, underscoring CPIC’s international leadership and the global applicability of its recommendations.

To date, CPIC has produced 29 active guidelines (47 total publications including updates), providing actionable guidance across 35 genes and 165 medications. These guidelines are highly influential, having been cited more than 14,000 times since 2011, with several individual guidelines cited over 600 times. The authorship includes highly accomplished investigators across disciplines, further reinforcing the scientific rigor and credibility of CPIC outputs. Through these efforts, Dr. Caudle has positioned CPIC as a cornerstone resource in genomic medicine, directly shaping clinical decision-making and implementation of pharmacogenetics worldwide. In addition to pharmacogenomic guideline development, her research focuses on implementation science, addressing the challenges clinicians face in adopting pharmacogenomic testing and other medication safety initiatives. As a clinical pharmacist and scientist, she is uniquely positioned to identify these barriers and drive solutions. Her work also extends to the standardization of pharmacogenomics, ensuring its seamless integration into clinical practice. She actively collaborates with the Pharmacogenomics Program to implement these guidelines and incorporate pharmacogenomic testing into patient care at St. Jude.

2026 Annual Report | Department of Pharmacy and Pharmaceutical Sciences

DIVISION OF PHARMACEUTICAL SERVICES FACULT Y

Cyrine-Eliana Haidar, PharmD Associate Member

Scan the QR code to view Dr. Haidar’s website

Cyrine-Eliana Haidar, PharmD, joined St. Jude Children’s Research Hospital in 2004 and was promoted to an associate faculty member in January 2024. Her work within the Department of Pharmacy and Pharmaceutical Sciences implements preemptive pharmacogenomic testing into clinical practice, which helps clinicians tailor the pharmacotherapy of patients based on their pharmacogenomic profile. This involves developing ways to best integrate pharmacogenomics testing into the electronic health record. For clinicians, this creates easy access and utilization of the pharmacogenomic test results during their day-to-day patient treatment. In addition, patients are taught about the lifelong implications of their pharmacogenomic test results, which hopefully empowers them to share these results with their non-St. Jude health care providers when they return home.

or dosage levels on treatment outcomes. Notably, her collaboration with Jun J. Yang, “Clinical actionability of the NUDT15*4 (p.R139H) allele and its association with Hispanic ethnicity,” was published in August 2024 in the Clinical Pharmacology and Therapeutics and investigates the relationship between the rare NUDT15*4 variant and tolerance to thiopurine medicines.

In 2023, Haidar focused on starting the Pharmacogenomics Clinic at St. Jude. This clinic saw its first patient in November of 2023 and focuses on the return of pharmacogenomic test results to patients and their families. Additionally, she has worked closely with Epic in establishing and coleading the Pharmacogenomics Brain Trust, Epic’s first genomic-based brain trust. Drawing from the St. Jude pharmacogenomic implementation expertise and Epic’s experience, the Brain Trust’s goal is to create robust and standardized support for pharmacogenomics within Epic and across organizations. This would enable a more seamless integration of pharmacogenomics within the electronic health record frameworks. Haidar’s clinical research explores the impact of patients’ genetics combined with certain medications

2026 Annual Report | Department of Pharmacy and Pharmaceutical Sciences

DIVISION OF PHARMACEUTICAL SERVICES FACULT Y

James M. Hoffman, PharmD, MS Member Senior Vice President, Quality and Safety Scan the QR code to view Dr. Hoffman’s website

James Hoffman, PharmD, MS, joined St. Jude and the Department of Pharmaceutical Sciences in 2004. In 2015, he assumed the hospital leadership role of Chief Patient Safety Officer, and in 2022, he was promoted to Senior Vice President – Quality and Safety. Hoffman has focused on identifying and evaluating risks for patient harm and advancing patient safety. His work spans patient safety event detection, safety culture, clinical informatics, decision support, and

a paper in BMJ Quality & Safety that identified priorities

improvement science in complex healthcare systems.

for measuring safe outpatient pediatric medication use. Hoffman is deeply engaged with the Institute for

In his institutional role, Hoffman continues to lead

Healthcare Improvement (IHI), including service on the

the development of the St. Jude Quality System and

IHI Scientific Advisory Group.

advance new approaches to quality and safety. His team led St. Jude’s transition to DNV as the institution’s

Hoffman works to implement pharmacogenomics as a

accreditation partner, which began in 2022. Over the

patient safety strategy. These efforts include PG4KDS:

last year, St. Jude has continued its progression toward

Clinical Implementation of Pharmacogenetics at St.

ISO 9001 certification as part of its ongoing quality

Jude and international efforts through the NIH-funded

system development. Hoffman also recruited St. Jude’s

Clinical Pharmacogenetics Implementation Consortium

first embedded human factors engineer, giving the

(CPIC).

institution new capability to design safer systems. He serves on the Clinical Steering Committee for Solutions

Hoffman remains a leader in topics relevant to

for Patient Safety, a network of more than 150 pediatric

pharmaceutical policy and pharmacy practice. He

hospitals working together to eliminate serious patient

serves as Deputy Editor for the ASHP Pharmacy

harm.

Forecast, an annual report to which he has contributed for more than a decade that provides strategic

Hoffman helps build the reputation of St. Jude as

guidance for health-system pharmacy leaders. He is also

an academic leader in quality, patient safety, and

an author of the annual drug expenditures forecast and

improvement science for children with catastrophic

serves as Contributing Editor for Content Strategy for

diseases. He often works at the intersection of safety

the American Journal of Health-System Pharmacy.

and technology, including a recent publication focused on optimizing the use of dose error reduction software for intravenous infusion pumps. More recently, his work has focused on outpatient medication safety, including

2026 Annual Report | Department of Pharmacy and Pharmaceutical Sciences

DIVISION OF PHARMACEUTICAL SERVICES PROGR AMS

2026 Annual Report | Department of Pharmacy and Pharmaceutical Sciences

DIVISION OF PHARMACEUTICAL SERVICES PROGR AMS

The Clinical Pharmacokinetics (CPK) Laboratory The Clinical Pharmacokinetics (CPK) Laboratory, located in the Division of Pharmaceutical Sciences, supports the St. Jude mission by providing state-of-the-art therapeutic drug monitoring and pharmacogenetic testing that clinical pharmacists interpret to

Director Alejandro Molinelli, PhD

ensure optimal drug dosing. It is directed by Alejandro Molinelli, PhD, with translational support from Kristine Crews, PharmD. The CPK lab is certified as a high-complexity laboratory by CLIA (Clinical Laboratory Improvement Amendments) and is accredited by the College of American Pathologists. Our staff consists of licensed medical laboratory scientists. Every year, the laboratory processes and analyzes approximately 8000 clinical specimens and sends out another 550 to reference laboratories. The laboratory’s in-house test menu includes multiple high-complexity assays ranging from therapeutic drug determinations (e.g., immunosuppressant, antifungal drugs) to glomerular filtration rate estimation using 99mTc-DTPA. Some of our resources include random access immunochemistry analyzers (e.g., Roche Cobas c303) and analytical instrumentation (e.g., LC-MS/MS, HPLC). Most of our instruments have bidirectional interfaces with the Epic electronic health record. The laboratory also handles pharmacogenetic testing for the hospital, offering genotyping results that accompany consults prepared by clinical pharmacists or pharmacy specialty residents. The laboratory staff and pharmacists at St. Jude work closely to provide prompt results. Once a test result is obtained, the laboratory scientists alert the pharmacist, who then prepares a clinical consult. This close integration of care ensures that our patients receive the best treatment while minimizing adverse drug effects. The laboratory staff is also involved in clinical translational science projects, for which tests developed in the research laboratories are validated and incorporated into the CPK lab test menu to bring cutting-edge care to our patients. In addition to the samples for clinical testing, the CPK laboratory staff members also process thousands of patient research specimens yearly in support of St. Jude clinical trials for the Center for Translational Pharmacology.

2026 Annual Report | Department of Pharmacy and Pharmaceutical Sciences

DIVISION OF PHARMACEUTICAL SERVICES PROGR AMS

Clinical Pharmacogenomics Program

Kelly Caudle, PharmD, PhD

Kristine Crews, MS, PharmD

Cyrine Haidar, PharmD

James Hoffman, PharmD, MS

Jun J. Yang, PhD

The Clinical Pharmacogenomics Program aims to integrate preemptive pharmacogenomic testing into patient care to improve the safety and efficacy of medication use. A pharmacist-led Pharmacogenomics Clinic, one of the first nationwide, provides in-person counseling to patients and families about their individualized pharmacogenomic test results and emphasizes the importance of sharing these results with healthcare providers. Integration with clinical informatics remains critical to preemptive pharmacogenomic testing. We recently published an analysis of 4,783 clinical decision support alerts guided by pharmacogenomics presented to St. Jude clinicians for 12 genes and 60 drugs. We found clinicians adhered to the therapeutic recommendations provided in 4392 alerts (92%). The Clinical Pharmacogenomics Program advances the ability for other organizations to build similar pharmacogenomics capabilities in their electronic health record. Notably, Dr. Haidar serves as one of the founding Chairs of the Epic Pharmacogenomics Brain Trust. She was also elected to the Epic Genetics Specialty Steering Board to represent the pharmacogenomics perspective of genomic implementation. To facilitate evidence-based clinical pharmacogenomic testing worldwide, the NIH-funded Clinical Pharmacogenetics Implementation Consortium (CPIC®) was created in 2011 by Mary Relling, PharmD. Kelly Caudle, PharmD, PhD, now leads CPIC as co-PI and Director with James Hoffman, PharmD, as co- leader of CPIC informatics. The Department is well represented in CPIC with additional involvement as co-authors and other roles from Cyrine Haidar, PharmD; Kristine Crews, PharmD; Alejandro Molinelli, PhD; Jun Yang, PhD; and others. CPIC membership has grown to over 800 members of international clinicians and scientists and continues to provide education and valuable resources to guide the implementation of pharmacogenomics into clinical practice. CPIC guidelines are indexed in PubMed as clinical guidelines, endorsed by ASHP and ASCPT, cited more than 14,000 times and integrated into leading pharmacogenomics resources, including the Clinical Genome Resource (ClinGen) and ClinPGx. Their widespread adoption and use underscore the significant global impact of CPIC on both clinical implementation and pharmacogenomics research, a topic recently highlighted in Clinical Pharmacology & Therapeutics. The goal at St. Jude is to implement all genes and drugs encompassed by CPIC guidelines. As of 2025, the Clinical Pharmacogenomics Program has implemented 16 genes and 75 drugs at St. Jude. Over 7,700 patients have consented for pre-emptive pharmacogenomic testing through the multidisciplinary PG4KDS protocol. To continually advance clinical implementation, the Clinical Pharmacogenomics Program personnel train the next generation of pharmacogenomics professionals through the PGY2 residency in Clinical Pharmacogenomics and educate health care professionals and patients. Through the Department’s Clinical Pharmacogenomics Program, pharmacogenomic testing benefits St. Jude patients and resources to advance pharmacogenomics implementation.

2026 Annual Report | Department of Pharmacy and Pharmaceutical Sciences

DIVISION OF PHARMACEUTICAL SERVICES PROGR AMS

Clinical Pharmacy Services By providing clinical pharmacy services to the institution, Clinical Pharmacy Specialists extend the reach of Pharmaceutical Services to direct patient care. Our clinicians provide support to the Leukemia/Lymphoma, Solid Tumor, Neuro-Oncology, Bone

Director John McCormick, PharmD

Marrow Transplant & Cellular Therapy, Intensive Care, Surgery, (non-malignant) Hematology, Infectious Diseases consult service and HIV. As we continue to grow, we have developed a clinical/academic clinical pharmacy role that is embedded in the HIV and St. Jude Life/After Completion of Therapy teams. We are also expanding our services to provide assistance to our colleagues in the Quality-of-Life program. Our board-certified Clinical Pharmacy Specialists are credentialed members of the medical staff with collaborative authority to perform direct patient assessment and prescribe medication therapy and associated laboratory tests. These pharmacists provide pharmacokinetic assessments, which include individualized targeted therapy for antineoplastics and other medications. Further individualization incorporates the use of clinical pharmacogenomics in medication selection and dosing approaches. Our pharmacists work closely with clinicians to provide oversight and development of care plans (non-protocol treatment plan) for patients who are not managed on an approved research protocol. We also provide departmental and institutional support for research protocol development and implementation. Our pharmacists offer expertise for services including intra- and inter-departmental education as well as post graduate training in pediatric hematology/oncology medication management and disease states. Team members continue involvement in multiple collaborative efforts. We provide leadership and direction for the antimicrobial stewardship program which helps maintain the institution’s status as an Antimicrobial Stewardship Center of Excellence as designated by the Infectious Diseases Society of America. This is an ongoing collaboration between our department and the Department of Infectious Diseases. Expanding our reach beyond St. Jude and Memphis, our clinical pharmacists support patient care needs in collaboration with our colleagues at St. Jude affiliate sites and provide educational assistance in support of our Global Pediatric Medicine program.

2026 Annual Report | Department of Pharmacy and Pharmaceutical Sciences

DIVISION OF PHARMACEUTICAL SERVICES PROGR AMS

Pharmaceutical Services Medication Safety and Policy Team The Pharmaceutical Services Medication Safety and Policy team, led by Jennifer Robertson, PharmD, ensures safe, standardized medication systems across St. Jude. The team focuses on five core areas: guideline and policy development, formulary management

Director Jennifer Robertson, PharmD

(including high-cost medication stewardship), medication safety, infusion pump library management, and quality improvement. In collaboration with the Pharmacy and Therapeutics (P&T) Committee, the team develops and revises medication use policies, maintains drug information resources and drug therapy guidelines, manages the drug formulary, and supports cost savings initiatives. Delia Allen, PharmD, Medication Use Policy Manager, serves as Vice-Chair of the P&T Committee, and leads these efforts with support from Madison Cole, PharmD, P&T Secretary. Ongoing formulary and utilization initiatives in partnership with stakeholders across the institution have resulted in more than $5 million in cost savings and avoidance in FY2026. P&T subcommittees advance safety and stewardship efforts, including the newly established High-Cost Medication Committee, which drives appropriate, safe, and cost-effective use of ultra– high-cost medications and advanced therapeutics. The Medication Use Safety Team (MUST), chaired by Dr. Robertson, drives both reactive and proactive medication safety initiatives. The team investigates medication events, conducts cause analyses, and implements system improvements – particularly within the electronic health record (EHR) - to prevent recurrence. Proactive strategies include failure modes and effects analyses (FMEA) and emerging approaches such as learning teams, debriefs, and safety huddles. The team has also contributed to the broader field through publication of a manuscript describing a framework for how other institutions may develop a medication safety strategic plan and has applied for designation as an ASHP Center of Excellence in Medication-Use Safety and Policy, reflecting its leadership in advancing best practices nationally. Infusion pump management is a joint effort across Pharmaceutical Services, Informatics, Nursing and Biomedical Engineering. The Medication Infusion Technology Task Force, co-led by Kristen Hughes, PharmD, oversees efforts related to the improvement of infusion pumps at St. Jude, including implementation of innovative technology, drug library maintenance, and compliance monitoring. Under her leadership, smart pump library compliance has increased from 50% to 95%. Dr. Robertson also leads a division quality improvement committee that oversees ongoing improvement projects and provides direction as needed. This past year, the group developed the Pharmacy Quality Plan, a dashboard that is updated monthly and represents safety and regulatory metrics from all areas of Pharmaceutical Services. Ongoing improvement projects include efforts to increase utilization of home infusion services for pegfilgrastim administration, decrease nephrotoxic medication-associated acute kidney injury, and increase medication adherence documentation. Finally, the group supports academic training and workforce development through didactic lectures for the University of Tennessee College of Pharmacy and precepting students on Medication Safety rotations. In FY26, the program graduated its eleventh Medication-Use Safety and Policy resident, reflecting its ongoing role in preparing clinicians in medication safety. 2026 Annual Report | Department of Pharmacy and Pharmaceutical Sciences

DIVISION OF PHARMACEUTICAL SERVICES PROGR AMS

Pharmacy Informatics The Pharmacy Informatics Community is composed of the Pharmacy Automation Team, the Epic - Willow Team, Pharmacy Analytics Services, and Clinical Informatics Pharmacists, with embedded support from Medication Safety, Revenue

Director David Aguero, PharmD, MSTL

Integrity, and Compliance. This Community is responsible for the implementation, maintenance, and optimization of bestin-class medication-use technology solutions and analytics that support exceptional pharmaceutical care. Through partnerships with clinical staff, Finance, Compliance, Quality and Patient Safety, and Information Services, the Community delivers practical solutions that reinforce patient outcomes, workflow efficiency, comprehensive analytics, and resource stewardship within the medication-use process at St. Jude Children’s Research Hospital. The informatics ecosystem at St. Jude is highly complex, and this group plays a critical role in ensuring its functionality in support of excellent patient care. The Pharmacy Automation Team manages a broad portfolio of solutions including inventory control tools, automated dispensing cabinets, infusion pumps, sterile compounding devices, autonomous medication delivery robots, and other essential pharmacy automation technologies. The Epic - Willow Team builds and configures medication-management workflows across Willow Inpatient, Ambulatory, Specialty, Home Infusion, and Willow Inventory within the Epic electronic health record (EHR), while Clinical Informatics Pharmacists bridge the gap between operational practice and technical functionality. The Community also supports innovation, scholarship, and education - including the PGY-2 Pharmacy Informatics Residency Program, APPE student rotations, and a growing portfolio of AI pilots evaluating practical, governed use cases for the medication-use system. Medication-management data is essential for guiding departmental operations and serves as a benchmark for pharmaceutical data stewardship both within St. Jude and externally. As an Analytics Program Franchise Partner, Pharmacy Analytics Services leverages this data to develop and maintain a comprehensive business intelligence portfolio - anchored in Epic’s Cogito suite and an Azure-based pharmacy data lake - as part of the department’s data strategy, empowering data-driven decision-making across the organization. The team contributes to institutional data governance through the Data Analytics Governance Council, supports self-service analytics through the institutional data catalog (Microsoft Purview), and serves as data stewards for the medication-use domain. Pharmacy Supply Chain Services Pharmacy Supply Chain Services (PSCS) is an operational coalition overseeing a service line focused on two key areas: •

Pharmacy Supply Chain Operations - Oversees inventory movement, ensures consistent customer service, supervises purchasing decisions, optimizes inventory, aligns inventory systems with regulatory and 340B compliance requirements, and facilitates communication and coordination during drug shortages.

•

Strategic Sourcing - Manages pharmaceutical vendor relationships, accounts payable, contracts, drug shortage monitoring, and risk-based sourcing decisions. The team collaborates with our Group Purchasing Organization (Vizient) and leverages our strategic partnership with our primary wholesaler (McKesson) to maintain a reliable supply while ensuring responsible stewardship of St. Jude resources.

This team plays a vital role in maintaining a stable, resilient, and efficient pharmacy supply chain to support patient care at St. Jude. Though leveraging acuity scoring and risk-based sourcing tools - including geographical supply data to anticipate and mitigate disruptions before they reach the bedside.

2026 Annual Report | Department of Pharmacy and Pharmaceutical Sciences

DIVISION OF PHARMACEUTICAL SERVICES PROGR AMS

Acute Care Pharmacy Operations The Acute Care Pharmacy team is led by William Humphrey, DPh, MS, MBA. Two pharmacy managers support Humphrey: Alysa Baumann, PharmD, MBA, BCPS, DPLA and Cindy Brasher, PharmD, MS, BCSCP. Acute Care operations comprehensively

Director William Humphrey, DPh, MS, MBA

address the needs of St. Jude patients across the inpatient and ambulatory infusion spaces. A team of investigational drug services pharmacists and certified pharmacy technicians helps execute many drugrelated clinical trials conducted through St. Jude, supported by manager Chris Scobey, PharmD, HMBA, CCRP. This team assists with proper protocol development, handling investigational drugs and developing information for all pharmacy staff related to each protocol. Each pharmacist is dedicated to the research mission, assessing and ensuring proper drug therapy compliance with the definitions of each unique protocol to which individual patients consent. The Inpatient Pharmacy team is responsible for verifying medication orders and coordinating the preparation and dispensing of all inpatient doses of medications. The inpatient team is also responsible for all sterile compounding for hazardous and nonhazardous intravenous medications, including chemotherapy, intravenous fluids and anti-infectives. An extension of this service includes the Infusion Center Pharmacy, which provides sterile products for patients treated in the clinics, procedure areas, diagnostic areas and the infusion center. A second extension of this service is staffing the Bone Marrow & Cellular Therapies pharmacy satellite, likewise with order verification and sterile compounding for nonhazardous and hazardous medications. The inpatient pharmacists also respond to Harvey Team (code) events and provide the needed drug support to the responding team. Decentralized clinical staff pharmacists also support the Inpatient Chemo Service and the Intensive Care Unit. The acute care pharmacy team comprises clinical staff pharmacists and certified pharmacy technicians.

2026 Annual Report | Department of Pharmacy and Pharmaceutical Sciences

DIVISION OF PHARMACEUTICAL SERVICES PROGR AMS

Ambulatory Pharmacy Operations The Ambulatory Pharmacy team is led by Steve Pate, DPh, supported by pharmacy managers Cheri Wilkerson, PharmD; Tiffany Nason, PharmD; and Ryan Duncan, PharmD. Ambulatory Pharmacy Operations comprehensively addresses the needs of

Director Steve Pate, DPh

St. Jude patients across the outpatient continuum of care. The Ambulatory Pharmacy team includes the Outpatient Pharmacy, Specialty Pharmacy, prescription mail service and the Home Infusion Pharmacy. These pharmacies are accredited by outside accreditation organizations to ensure highquality patient care, regardless of location. The ambulatory pharmacy team continually seeks opportunities to bring care closer to patients. The Outpatient Pharmacy installed the first medication dispensing kiosk at St. Jude within local domicile , allowing patients to pick up their medications when most convenient. When patients from outside Memphis return home, pharmacists ensure continuity of care through mail order or local contracted or affiliate pharmacies. Because medications are shipped nationwide, the team carefully complies with unique regulatory requirements of each state. Similarly, the broad geographic dispersion of patients necessitates interaction with many state and commercial insurance programs, requiring attention to reimbursement and payer network requirements. Specialty pharmacy services are dually accredited by URAC and ACHC. This helps ensure optimal use of these high-cost, high-risk medications, facilitates reimbursement, and allows patients to receive more of their medications at home. Acute Care and Ambulatory Pharmacy Operations Services extend beyond the typical services, as St. Jude provides home infusion therapy to patients requiring medications at home or in a local domicile. This service supplies medications to support therapy in the local delivery area and collaborates with outside agencies to deliver care to patients outside that region. The Home Infusion Pharmacy is accredited by ACHC to ensure patients receive the highest levels of care. Clinical staff pharmacists and certified pharmacy technicians deliver optimal inpatient and outpatient care consistent with the defined research protocol or non-protocol care plan and assist with transition of care coordination for prescription access. Technical staff prepare and provide medications, while pharmacists manage medication therapy to align with treatment plans and prevent adverse effects. These pharmacists serve as patient and family educators and resources when drug-related questions arise. Clinical staff pharmacists collaborate with clinical pharmacy specialists to ensure proper conduct of medications reconciliation as patients move from inpatient to outpatient care and back. Finally, the department collaborates directly with the eight St. Jude Affiliates to help ensure that patients managed at these locations throughout the United States have all their medication-related needs addressed.

2026 Annual Report | Department of Pharmacy and Pharmaceutical Sciences

DIVISION OF PHARMACEUTICAL SERVICES PROGR AMS

Pharmacy Residents and Research Fellows The department is expanding postdoctoral training opportunities through the development of a PGY1 Community-Based Pharmacy residency with experiences focused in Specialty Pharmacy.

Duha Baamir, PharmD

Sonali Chikersal, Pharm

Pharmacy Oncology

Pharmacy Informatics

Ojashwi Giri, PharmD

Anne Thomas Hooper, PharmD

Pharmacogenomics

Medication-Use Safety and Policy

Matt Middleton, PharmD

Parichehr Shoureshi, PharmD

Oncology

Infectious Diseases

2026 Annual Report | Department of Pharmacy and Pharmaceutical Sciences

DEPARTMENTAL ADMINISTR ATIVE TE AM

Administrative Team The Department of Pharmacy & Pharmaceutical Sciences Administrative Team plays a vital role in advancing the

Director Carla Cook, MS

department’s mission and supporting the lifesaving work of St. Jude Children’s Research Hospital. Under the leadership of Carla Cook, MS, Administrative Director, the team provides comprehensive operational and strategic support that ensures excellence across departmental activities.

The administrative team supports a wide range of functions, including executive calendar management, large-scale event coordination, recruitment and onboarding, guest and visitor relations and pre- and post-award grant administration with associated budget oversight. Through their expertise and attention to detail, the team ensures the smooth and efficient operation of departmental programs while contributing to the hospital’s broader institutional goals. As of 2026, the team consists of nine administrative professionals with a combined 49+ years of service to St. Jude. Four team members—Carla Cook, Dawn Fisher (Sr. Administrative Coordinator), April Blankenship (Executive Coordinator), and LaChelle Buckley (Senior Administrative Specialist)—are graduates of the St. Jude Leadership Academy, reflecting a strong commitment to professional growth and leadership excellence. Recognized for their high-quality service and collaborative approach, team members frequently partner with departments across the institution, serving as trainers and mentors for administrative professionals. Beyond their core responsibilities, the team remains actively engaged in community outreach, community groups, patient-centered initiatives and on-campus events, exemplifying the values of service and compassion central to St. Jude’s mission. Recent years have included strategic growth within the team, with the addition of Sarah Heller and Melody Shettles as Senior Administrative Specialists across the Divisions of Pharmaceutical Sciences and Pharmaceutical Services. These investments in talent further strengthen the department’s administrative foundation and capacity to support its expanding scope of work.

2026 Annual Report | Department of Pharmacy and Pharmaceutical Sciences

HONOR S & AWARDS

Honors & Awards Dr. Nousheen DeRenzo, Lead-Clinical Informatics Pharmacist, was honored in the 2025 St. Jude Values Book for Value 4: “Embrace the challenge to create a new tomorrow.” Nousheen has been essential since the start of our Epic journey as one of our Clinical Informatics Pharmacists. She led key outpatient advances, including adopting Compass Rose (now Willow Specialty), early Willow Inventory work, and many creative workflows that improve patient care. She’s now recognized for her major role in implementing Willow Home Infusion with Ryan Duncan - and they continue to refine the system.

Natiya Lundy, Senior Certified Pharmacy Technician, was honored in the 2025 St. Jude Values Book for Value 7: “Make the most of St. Jude resources and be mindful of those who provided them.”Natiya has played an essential role over the past couple of years in ensuring that our waste documentation of medications is correct so that the pharmacy can receive reimbursement to help drive the St. Jude mission forward. She has taken a lead in the establishment of expanded services from the BMT Satellite Pharmacy for the ICU, and she has helped to ensure that the correct medications are stocked and available for this population.

2026 Annual Report | Department of Pharmacy and Pharmaceutical Sciences

HONOR S & AWARDS

In October 2025, Dr. David Rogers, PharmD, PhD, Chair, Department of Pharmacy and Pharmaceutical Sciences was elected to the National Academy of Medicine (NAM). This is one of the highest honors in the field of health and medicine. His selection was based on his discoveries in medical mycology and antifungal pharmacology that have contributed to the understanding of the molecular and genetic basis of clinical antifungal drug resistance in pathogenic fungi and the improvement of antifungal pharmacotherapy. Brooke Bernhardt, PharmD, Chief Pharmacy Officer, named on Becker’s Hospital Review’s 101 Hospital and Health System Chief Pharmacy Officers to Know list. James M. Hoffman, PharmD, MS, Senior Vice President, Quality and Safety, named on Becker’s Hospital Review’s 145 Patient Experts Leaders to Know list. Kelsey Finnell Smith, Pharm, was presented with the Annual Good Catch Award during the Kaden Bachor Patient Safety Lecture. Ojashwi Giri, PharmD, PGY2 Resident, was awarded the top abstract award at the annual Midsouth Pharmacy Resident Conference. Duha Baamir, PharmD, PGY2 Resident, was awarded second place in the St. Jude Annual Clinical Fellow Research Symposium poster session. Sonali Chikersal, PharmD, PGY2 Resident, was awarded third place in the St. Jude Annual Clinical Fellow Research Symposium poster session. Kelly Tartera, PharmD, Clinical Staff Pharmacist II, was awarded the Christiansen Young Investigator award at the annual Pediatric Pharmacy Association meeting in Arlington, VA. Theodore Morton, PharmD, BCIDP,received ASHP Foundation 2025 Pharmacy Residency Excellence Preceptor Award.

2026 Annual Report | Department of Pharmacy and Pharmaceutical Sciences

DEPARTMENTAL EXTR AMUR AL FUNDING

Departmental Extramural Funding NE W AWARDS FO R F Y 2 6 Brooke Bernhardt

Mark Leggas

NCI U54 - $572,230

St. Baldrick’s Foundation - $5,000

September 2025 – August 2030

January 2026 – December 2027

Reducing ethnic disparities in acute leukemia (REDIAL)

St. Baldrick’s Summer Fellowship

Brooke Bernhardt

Christian Meyer

NCI P30 - $163,725

NIAID R00 - $497,998

March 2026 – February 2027

September 2025 – August 2027

CCSG Developmental Funds

The electrophysiology of biofilm development and drug resistance

Jürgen Bulitta NIAID P01 - $3,209,973

Jeffrey Rybak

January 2026 – May 2029

NIAID U19 - $124,400

Translational development of new agents alone and

May 2026 – April 2027

in combination to combat Gram-negative pathogens

Advancing Genomic Technologies to Combat Infectious

important in Ventilator- Associated Bacterial Pneumonia:

Disease: Mapping Dynamics within Single Cells, Individual

Leveraging the Gram-negative toolbox that is ready for

Hosts, and Global Populations

prime time John Schuetz Jürgen Bulitta

NHGRI R01 - $914,695

NIAID R01 -$212,722

July 2025 – April 2030

January 2026 – November 2027

The roles of MRP9 in cholangiocyte metabolism

Precise Combination Strategies Targeting CarbapenemResistant Klebsiella pneumoniae

Jun J. Yang NCI R01 - $962,132

Ruida Hou

August 2025 – July 2029

PhRMA Postdoctoral Fellowship - $120,000

Identifying Relapse Predictors and Therapeutic

January 2026 – December 2027

Vulnerabilities in Ph+ and Ph-like Acute Lymphoblastic

Exploiting DHODH for Pediatric Acute Lymphoblastic

Leukemia

Leukemia Therapy

2026 Annual Report | Department of Pharmacy and Pharmaceutical Sciences

DEPARTMENTAL EXTR AMUR AL FUNDING

OTH ER ACT IVE FU N D I NG F Y 2 6 Kelly Caudle

Daniel Savic

NHGRI U24 – $423,593

NHGRI R01 - $816,511

July 2025 to June 2026

April 2026 – March 2027

Clinical Implementation Resources for

Deciphering the underlying structure of the

Pharmacogenomics (CIRP)

glucocorticoid gene regulatory network

Mark Leggas

John Schuetz

Pfizer ONITT – $18,316

NIDDK R01 - $39,569

February 2026 – February 2027

June 2026 – May 2027

(Federico) A Randomized Phase I/II Study of Onivyde

Inhibition of Apical cAMP/cGMP transporter (MRP4) in

in Combination with Talazopraib or Temozolomide

Gut Induces Diarrhea

in Children and Young Adults with Recurrent Solid Malignancies and Ewing Sarcoma (ONITT)

Jun J. Yang NCI R01 - $599,172

Mark Leggas

July 2025 – June 2026

Ipsen ONITT – $26,688

Biomarkers of dasatinib response and resistance in T-cell

May 2026 – May 2027

acute lymphoblastic leukemia

(Federico) A Randomized Phase I/II Study of Onivyde in Combination with Talazopraib or Temozolomide

Jun J. Yang

in Children and Young Adults with Recurrent Solid

NCI U01 - $202,835

Malignancies and Ewing Sarcoma (ONITT)

September 2025 – August 2026 Clonal Therapy for Pediatric T-cell Acute Lymphoblastic

Mark Leggas

Leukemia

NCI P30 - $334,217 March 2026 – February 2027

Jun J. Yang

CCSG PKSR

NCI R01 - $29,249 May 2026 – April 2027

Peijun Ma

Understanding the Increased Risk of Childhood Acute

NIGMS R35 - $462,500

Lymphoblastic Leukemia in Latinos

December 2025 – November 2026 Deciphering the genetic regulation of stress-response

Jun J. Yang

mediated antibiotic persistence using bacterial single-cell

NCI R01 - $35,102

transcriptomics

March 2026 – February 2027 Predictors of Systemic Exposure to Oral 6MP During

P. David Rogers

Maintenance in Adolescents and Young Adults with Acute

NIAID R01 - $1,233,501

Lymphoblastic Leukemia

March 2026 – February 2027 Mapping the genomic and molecular mechanisms of antifungal resistance in the emerging fungal pathogen Candida auris

2026 Annual Report | Department of Pharmacy and Pharmaceutical Sciences

PUBLICATIONS

Highlighted Publications Science Advances IRS4 is a PI3K-activating cancer dependency up-regulated through DNA rearrangements or epigenetic mechanisms in multiple solid tumors

Banu K, Khan MA, Li S, Reynolds-Gagliano M, Wang X, Mobley RJ, Barnett KR, Wielgosz MM, Bauler M, Wincek C, Kodali K, Wang W, Pagala V, High AA, Putnam D, Kotecha RS, Cheung LC, Ma X, Throm RE, Pruett-Miller SM, Savic D, Brady SW. Sci Adv 12:eaeb3503-, 2026. PMCID: PMC13127590 PUBMEDID: 42054459 (Journal Impact Factor 2026=12.5)

Clinical Microbiology and Infection Relative contributions of the ERG11(VF125AL) and MRR1A(N647T) mutations to fluconazole resistance in Clade III Candidozyma (Candida) auris clinical isolates

Barker KS, Zhang Q, Peters TL, Rybak JM, Morschhäuser J, Cuomo CA, Rogers PD. Clin Microbiol Infect 32:285-291, 2026. PMCID: PMC12713649 PUBMEDID: 41115594 (Journal Impact Factor 2026=8.5)

Pharmaceutics Automated 3D printing-based non-sterile compounding technology for pediatric corticosteroid dosage forms in a health system pharmacy setting

Bernhardt MB, Shokraneh F, Hrizanovska L, Lahtinen J, Brasher CA, Sandler N. Pharmaceutics 17:762-, 2025. PMCID: PMC12197057 PUBMEDID: 40574074 (Journal Impact Factor 2025=5.5)

Journal of Clinical Oncology Pediatric-friendly formulations: Critical to maximizing benefit of novel therapeutics such as selumetinib for children with neurofibromatosis and other neoplasms

Bernhardt MB, Weigel BJ. J Clin Oncol 44:832-834, 2026. PUBMEDID: 41592260 (Journal Impact Factor 2026=41.9)

Cancer Discovery Therapy-related mutational signatures in subsequent neoplasms among survivors of childhood cancer

Brady SW, Arnold MA, Wang M, Alsallaq R, Dong L, Khan MA, Yang W, Stratton KL, Liu W, Chen Y, Plyler E, Steele JA, Powers BB, Rosenfeld D. , Edmonson MN, Feng Y, Terekhanova NV, Hagiwara K, Arunachalam S, Mulder HL, Srivastava DK, Rusch M, Nolan VG, McDonald A, Sapkota Y, Gramatges MM, Turcotte LM, Im C, Howell RM, Easton J, Ma X, Wang Z, Leisenring WM, Conces M, Neglia JP, Yasui Y, Bhatia S, Ellison DW, Zhang J, Armstrong GT. Cancer Discovery (2026). DOI: 10.1158/2159-8290.CD-25-0231. PMID: 42001506. #Corresponding author.

Blood Differentiation-dependent EBF1 activity determines CD22 transcription and leukemia sensitivity to inotuzumab ozogamicin

2026 Annual Report | Department of Pharmacy and Pharmaceutical Sciences

PUBLICATIONS

Cancer Cell The landscape of structural variation in pediatric cancer

Greenhalgh R*, Brady SW*, Yang W*, Flasch DA, Edmonson MN, Terekhanova NV, Liu Y, Wang J, Szlachta KA, Tian L, Putnam DK, Rahbarinia D, Kolekar P, Zhou X, Gerhard DS, Ma X, Zhang J. Cancer Cell 44:1-16 (2026). PMID: 41825442 PMCID: PMC12991425. (*Co-first authors.)

American Journal of Health-System Pharmacy A proactive approach to medication safety: Developing and successfully using a medication safety strategic plan

Hughes K, Hoffman J, Robertson JJ. Am J Health Syst Pharm: -, 2026. PUBMEDID: 41686697 (Journal Impact Factor 2026=2.3)

Nature Communications Inferring chromosome segregation error stage and crossover in trisomic disorders with application to Down syndrome

Li Z, Yang W, Wu G, Chang TC, Cheng Z, Devidas M, Shago M, Carroll AJ, Heerema NA, Gastier-Foster JM, Wood BL, Sanclemente L, Raetz EA, Hunger SP, Loh ML, Feingold E, Rosser TC, Allen EG, Sherman SL, Rabin KR, Lupo PJ, Yang JJ. Nat Commun 16:6316-, 2025. PMCID: PMC12238278 PUBMEDID: 40628699 (Journal Impact Factor 2025=15.7)

Nature Communications Molecular and pharmacological heterogeneity of ETV6::RUNX1 acute lymphoblastic leukemia

Li Z, Zhao H, Yang W, Maillard M, Yoshimura S, Hsiao YC, Huang X, Gocho Y, Rowland L, Brown A, Choi L, Crews KR, Mullighan CG, Brady SW, Cheng C, Chang TC, Wu G, Loh ML, Yeoh AEJ, Antillon-Klussmann F, Jeha S, Inaba H, Yu J, Pui CH, Karol SE, Evans WE, Yang JJ. Nat Commun 16:1153-, 2025. PMCID: PMC11779914 PUBMEDID: 39880832 (Journal Impact Factor 2025=15.7)

Nature Communications Pre-treatment bacterial cell states shape antibiotic-induced transcriptional reprogramming and survival

Liu Q, Yu Z, Liu X, Iverson A, Simmons T, Rosch JW, Ma P. Nat Commun: -, 2026. PUBMEDID: 42230649 (Journal Impact Factor 2026=15.7)

Journal of Clinical Investigation The NUDIX hydrolase NUDT5 regulates thiopurine metabolism and cytotoxicity

Maillard M, Nishii R, Vu HS, Bhattarai KR, Yang W, Li J, Hofmann U, Savic D, Bhatia S, Schwab M, Ni M, Yang JJ. J Clin Invest 135:e190443-, 2025. PMCID: PMC12259257 PUBMEDID: 40662362 (Journal Impact Factor 2025=13.6)

Blood Advances Desensitization to calaspargase pegol appears to be less successful than pegaspargase

Matherne MM, Panetta JC, Hopp J, Inaba H, Pui CH, Karol SE, Swanson HD. Blood Adv 9:1492-1496, 2025. PMCID: PMC11985031 PUBMEDID: 39903102 (Journal Impact Factor 2025=7.1)

2026 Annual Report | Department of Pharmacy and Pharmaceutical Sciences

PUBLICATIONS

Med (NY) Rethinking the role of synergy calculations in the next century of drug combination discovery

Meyer CT, Dai Y, Pomeroy AE, Twarog NR, Bender A, Rosenfeld SS, Antonarakis ES, Mettetal JT, Huang RS, Quaranta V, Tang J, Shelat AA, Smith MA, Palmer AC. Med (N Y) 7:101103-, 2026. PUBMEDID: 42054999 (Journal Impact Factor 2026=11.8)

Pharmaceutics Preclinical pharmacokinetic evaluation of mithramycin and mithramycin SA tryptophanconjugated analog

Niloy KK, Horn J, Bhuiyan NH, Shaaban KA, Bhosale SS, Prisinzano TE, Thorson JS, Rohr J, Leggas M. Pharmaceutics 17:765-, 2025. PMCID: PMC12197275 PUBMEDID: 40574077 (Journal Impact Factor 2025=5.5)

Haematologica Changes in asparaginase exposure and toxicity profiles in obese pediatric acute lymphoblastic leukemia patients

Panetta JC, Ashcraft E, Jeha S, Pui CH, Inaba H, Karol SE, Cheng C, Swanson HD. Haematologica 110:1849-1853, 2025. PMCID: PMC12358778 PUBMEDID: 39945009 (Journal Impact Factor 2025=7.9)

Blood Advances Age-adjusted dosing of fludarabine for lymphodepletion in CAR T-cell therapy: A clinical trial simulation study

Panetta JC, Talleur AC, Naik S, Gottschalk S, Leggas M. Blood Adv 9:4676-4682, 2025. PMCID: PMC12496251 PUBMEDID: 40609087 (Journal Impact Factor 2025=7.1)

American Journal of Human Genetics The Clinical Pharmacogenetics Implementation Consortium’s consensus-based framework for assigning allele function

Tibben BM, Gaedigk A, Gong L, Sangkuhl K, Whirl-Carrillo M, Relling MV, Donnelly RS, Klein TE, Caudle KE. Am J Hum Genet 112:2842-2859, 2025. PMCID: PMC12766749 PUBMEDID: 41175864 (Journal Impact Factor 2025=8.1)

American Journal of Human Genetics National trends in prescription drug expenditures and projections for 2026

Tichy EM, Rim MH, Tadrous M, Schumock GT, Cuellar S, Johnson TJ, Newell MK, Hoffman JM. Am J Health Syst Pharm:-, 2026. PUBMEDID: 42059345 (Journal Impact Factor 2026=2.3)

Nature Communications Protein Kinase A and assembly of an ABCC4 protein network

Zhu J, Ranjit S, Gose T, Nourse A, Pagala VR, Yuan ZF, Lynch J, Wang Y, Pitre A, Crawford R, Peng J, Wijaya J, Naren AP, Schuetz JD. Nat Commun 17:166-, 2025. PMCID: PMC12780066 PUBMEDID: 41339628. (Journal Impact Factor 2025=15.7)

2026 Annual Report | Department of Pharmacy and Pharmaceutical Sciences

PUBLICATIONS

Publications Acharya S, Patel GK, Khan MA, Clark AM, Saranyutanon S, Anand S. Editorial: Unraveling the role of receptor signaling in tumorigenesis and cancer therapy. Front Cell Dev Biol 14:1770251-, 2026. PMCID: PMC12980076 PUBMEDID: 41836301 (Journal Impact Factor 2026=4.3) Adeleye KL, Oluwalana D, Krutilina R, Xie Y, Pochampally S, Waltz L, Miranda-Carboni GA, Miller DD, Seagroves TN, Li W. A novel colchicine-binding site inhibitor suppresses triple-negative breast cancer growth and metastasis and synergizes with anti-PD-L1 immunotherapy in an immunogenic cancer model. Biomed Pharmacother 198:119353-, 2026. PMCID: PMC13225900 PUBMEDID: 41966805 (Journal Impact Factor 2026=7.5) Aguero D, Gross K, Shaw BG, Amerine LB, Tryon J. The chief pharmacy officer’s role in integrating artificial intelligence across the enterprise. Am J Health Syst Pharm: -, 2026. PUBMEDID: 42087301 (Journal Impact Factor 2026=2.3) Ahlgren L, Pilheden M, Sturesson H, Song G, Walsh MP, Yang M, Maillard M, Zhao H, Cheng Z, Singh V, Castor A, Pronk CJ, Marquart HV, Lausen B, Schneider P, Barbany G, Pokrovskaja Tamm K, Abrahamsson J, Lohi O, Fogelstrand L, Menendez P, Pieters R, Zhang J, Lindkvist-Petersson K, Yang JJ, Gruber TA, Stam RW, Ma J, Hagström-Andersson AK. The genomic landscape of relapsed infant and childhood KMT2A-rearranged acute leukemia. Nat Commun 16:8964-, 2025. PMCID: PMC12508131 PUBMEDID: 41062506 (Journal Impact Factor 2025=15.7) Anjie SI, D’Haens GR, Baert F, Bossuyt P, Hoentjen F, Clasquin E, Molnár T, Löwenberg M, Vermeire S, Panetta JC, Dervieux T. Higher vedolizumab clearance associates with poor therapeutic outcomes during intravenous vedolizumab maintenance therapy in crohn’s disease. Inflamm Bowel Dis 32:390-393, 2026. PMCID: PMC12857423 PUBMEDID: 41211680 (Journal Impact Factor 2026=4.3) Bahman M, Bernhardt MB, Brasher CA, Lahtinen J, Airaksinen S, Topelius NS. Advancing non-sterile pediatric pharmacotherapy through automated compounding and 3D printing of ondansetron hcl dihydrate dosage forms. J Oncol Pharm Pract 32:71-86, 2026. PMCID: PMC12647376 PUBMEDID: 41138268 (Journal Impact Factor 2026=0.9) Banu K, Khan MA, Li S, Reynolds-Gagliano M, Wang X, Mobley RJ, Barnett KR, Wielgosz MM, Bauler M, Wincek C, Kodali K, Wang W, Pagala V, High AA, Putnam D, Kotecha RS, Cheung LC, Ma X, Throm RE, Pruett-Miller SM, Savic D, Brady SW. IRS4 is a PI3K-activating cancer dependency up-regulated through DNA rearrangements or epigenetic mechanisms in multiple solid tumors. Sci Adv 12:eaeb3503-, 2026. PMCID: PMC13127590 PUBMEDID: 42054459 (Journal Impact Factor 2026=12.5) Barker KS, Patterson HP, Morschhäuser J, Cuomo CA, Wiederhold NP, Rogers PD. Mutations in transcription factors that confer fluconazole resistance also confer reduced susceptibility to manogepix in Candida auris (Candidozyma auris), Candida albicans, Candida parapsilosis, and Candida glabrata (Nakaseomyces glabratus). Antimicrob Agents Chemother 69:e0068025-, 2025. PMCID: PMC12406679 PUBMEDID: 40698819 (Journal Impact Factor 2025=4.5) Barker KS, Santana DJ, Zhang Q, Peters TL, Rybak JM, Morschhäuser J, Cuomo CA, Rogers PD. Mutations in TAC1B drive increased CDR1 and MDR1 expression and azole resistance in Candida auris. Antimicrob Agents Chemother 69:e0030025-, 2025. PMCID: PMC12486835 PUBMEDID: 40824653 (Journal Impact Factor 2025=4.5)

2026 Annual Report | Department of Pharmacy and Pharmaceutical Sciences

PUBLICATIONS

Barker KS, Zhang Q, Peters TL, Rybak JM, Morschhäuser J, Cuomo CA, Rogers PD. Relative contributions of the ERG11(VF125AL) and MRR1A(N647T) mutations to fluconazole resistance in Clade III Candidozyma (Candida) auris clinical isolates. Clin Microbiol Infect 32:285-291, 2026. PMCID: PMC12713649 PUBMEDID: 41115594 (Journal Impact Factor 2026=8.5) Baumann A, Fitzpatrick N, Fitzgerald D, Brasher C. Implementation of dispense waste functionality with new electronic health record system. Am J Health Syst Pharm 83:e358-e362, 2026. PUBMEDID: 41359489 (Journal Impact Factor 2026=2.3) Belsky JA, Chavana A, Banerjee A, Zobeck M, Schafer ES, Rabin KR, Gramatges M, Sim A, Leisinger A, Reddy T, Parod MJ, Lupo P, Scheurer M, Brown AL, Bernhardt MB. Delayed excretion of high-dose methotrexate in pediatric acute leukemia correlates with laxative and constipation management. Pediatr Blood Cancer 72:e31377-, 2025. PMCID: PMC11803646 PUBMEDID: 39387373 (Journal Impact Factor 2025=2.3) Bernhardt MB, Shokraneh F, Hrizanovska L, Lahtinen J, Brasher CA, Sandler N. Automated 3D printing-based non-sterile compounding technology for pediatric corticosteroid dosage forms in a health system pharmacy setting. Pharmaceutics 17:762-, 2025. PMCID: PMC12197057 PUBMEDID: 40574074. (Journal Impact Factor 2025=5.5) Bernhardt MB, Weigel BJ. Pediatric-friendly formulations: Critical to maximizing benefit of novel therapeutics such as selumetinib for children with neurofibromatosis and other neoplasms. J Clin Oncol 44:832-834, 2026. PUBMEDID: 41592260 (Journal Impact Factor 2026=41.9) Bidoli C, Yang W, Karol SE, Lucafò M, Stocco G, Yang JJ. Unraveling novel genetic determinants of thiopurine response via TWAS. Clin Pharmacol Ther 119:84-88, 2026. PMCID: PMC12746518 PUBMEDID: 40908865 (Journal Impact Factor 2026=5.5) Bittle E, Arnold S, Hijano DR, Landman BM, Morton T, Hines M. Safety data for baricitinib use in children with severe SARSCoV-2 infection. Hosp Pediatr 15:e203-e208, 2025. PUBMEDID: 40204287 (Journal Impact Factor 2025=2.1) Brady SW#, Arnold MA, Wang M, Alsallaq R, Dong L, Khan MA, Yang W, Stratton KL, Liu W, Chen Y, Plyler E, Steele JA, Powers BB, Rosenfeld D, Edmonson MN, Feng Y, Terekhanova NV, Hagiwara K, Arunachalam S, Mulder HL, Srivastava DK, Rusch M, Nolan VG, McDonald A, Sapkota Y, Gramatges MM, Turcotte LM, Im C, Howell RM, Easton J, Ma X, Wang Z, Leisenring WM, Conces M, Neglia JP, Yasui Y, Bhatia S, Ellison DW, Zhang J, Armstrong GT. Therapy-related mutational signatures in subsequent neoplasms among survivors of childhood cancer. Cancer Discovery (2026). DOI: 10.1158/21598290.CD-25-0231. PMID: 42001506. #Corresponding author. (Journal Impact Factor 2026=29.5) Canedo JE, Andrews E, Mabry WA, Allen DC, Robertson J, Hoffman JM, Aguero D. Development of an acuity scoring system to proactively address drug shortages and increase supply chain resiliency. Am J Health Syst Pharm: -, 2026. PUBMEDID: 41570085 (Journal Impact Factor 2026=2.3) Caudle KE, Whirl-Carrillo M, Relling MV, Hoffman JM, Donnelly RS, Haidar CE, Bourque MS, Frear S, Gong L, Sangkuhl K, Whaley R, Klein TE. Advancing clinicalpharmacogenomics worldwide through the Clinical Pharmacogenetics Implementation Consortium (CPIC). Clin Pharmacol Ther 118:1512-1522, 2025. PMCID: PMC13037831 PUBMEDID: 40678821 (Journal Impact Factor 2025=5.5)

2026 Annual Report | Department of Pharmacy and Pharmaceutical Sciences

PUBLICATIONS

Cavallari LH, Hicks JK, Patel JN, Elchynski AL, Smith DM, Bargal SA, Fleck A, Aquilante CL, Killam SR, Lemke L, Ochi T, Ramsey LB, Haidar CE, Ho T, El Rouby N, Monte AA, Allen JD, Beitelshees AL, Bishop JR, Bousman C, Campbell R, Cicali EJ, Cook KJ, Duong B, Tsermpini EE, Girdwood ST, Gregornik DB, Grimsrud KN, Lamb N, Lee JC, Lopez RO, Mazhindu TA, Morris SA, Nagy M, Nguyen J, Pasternak AL, Petry N, van Schaik RHN, Schultz A, Skaar TC, Al Alshaykh H, Stevenson JM, Stone RM, Tran NK, Tuteja S, Woodahl EL, Yuan LC, Lee CR. The Pharmacogenomics Global Research Network Implementation Working Group: Global collaboration to advance pharmacogenetic implementation. Pharmacogenet Genomics 35:1-11, 2025. PMCID: PMC11664750 PUBMEDID: 39485373 (Journal Impact Factor 2025=1.7) Chauhan A, Carolus H, Sofras D, Kumar M, Kumar P, Nair R, Narayanan A, Yadav K, Ali B, Biriukov V, Saini A, Leaves I, Vergauwen R, Romero CL, Malavia-Jones D, Singh A, Banerjee A, Rudramurthy SM, Chakrabarti A, Mondal AK, Gaur NA, Sanyal K, Rybak JM, Gabaldón T, Van Dijck P, Gow NAR, Prasad R. Multi-omics analysis of experimentally evolved Candida auris isolates reveals modulation of sterols, sphingolipids, and oxidative stress in acquired amphotericin B resistance. Mol Microbiol 124:154-172, 2025. PMCID: PMC7617760 PUBMEDID: 40468551 (Journal Impact Factor 2025=2.6) Chavana AN, Mason EJ, Woodhouse JP, Taylor OA, Gramatges MM, Yi JS, Pruitt S, Bernhardt BM, Ludwig K, Klesse L, Heym K, Griffin T, Roberts M, Erana R, Bernini JC, Zhu H, Lupo PJ, Rabin KR, Scheurer ME, Mittelman SD, Huynh V, Orgel E, Brown AL. Incidence and outcomes of treatment-associated hepatotoxicity during pediatric acute lymphoblastic leukemia induction therapy: A Reducing Ethnic Disparities in Acute Leukemia (REDIAL) Consortium report. Haematologica:-, 2026. PUBMEDID: 41568528 (Journal Impact Factor 2026=7.9) Chen C, Xu J, Sussman JH, Vincent T, Tumulty JS, Yoshimura S, Alikarami F, Yu W, Ding YY, Chen CH, Li EY, Yang A, Qin X, Bandyopadhyay S, Peng J, Pölönen P, Newman H, Wood BL, Hu J, Shraim R, Hughes AD, Diorio C, Uppuluri L, Shi G, Ryan T, Fuller T, Loh ML, Raetz EA, Hunger SP, Pounds SB, Mullighan CG, Frank D, Yang JJ, Bernt KM, Teachey DT, Tan K. Singlecell panleukemia signatures of HSPC-like blasts predict drug response and clinical outcome. Blood 145:2685-2700, 2025. PMCID: PMC12163743 PUBMEDID: 40089994 (Journal Impact Factor 2025=23.1) Chen C, Cai J, Wu X, Hu Q, Wu X, Guo X, Hu S, Zhai X, Qi B, Zhang W, Wang N, Xu F, Fang Y, Li CK, Liang C, Wang L, Zhu J, Deng W, Tian X, Ju X, Zhang G, Tang J, Cheng C, Yang J, Shen S, Pui CH. Risk factors and outcomes of asparaginaseassociated pancreatitis in pediatric patients with ALL. Blood 146:2417-2427, 2025. PUBMEDID: 40789043 (Journal Impact Factor 2025=23.1) Compagner C, Aguero D, Campbell PK. Evaluating medication record creation before and after an electronic health record transition. Am J Health Syst Pharm 83:e349-e357, 2026. PUBMEDID: 41313721 (Journal Impact Factor 2026=2.3) Doorley LA, Meza-Perez V, Jones SJ, Rybak JM. A Candidozyma (Candida) auris-optimized episomal plasmid-induced Cas9editing system reveals the direct impact of the S639F-encoding FKS1 mutation. J Infect Dis 232:e529-e536, 2025. PMCID: PMC12455316 PUBMEDID: 40569759 (Journal Impact Factor 2025=4.5) Eadon MT, Hein DW, Andersen MA, Chapman AB, Cooper-DeHoff RM, Desta Z, Duarte JD, Elchynski AL, Gaedigk A, Karol SE, Limdi NA, Lteif C, Sosinski L, Zubiaur P, Whirl-Carrillo M, Klein TE, Caudle KE, Donnelly RS, Agúndez JAG. Clinical pharmacogenetics implementation consortium guideline for NAT2 genotype and hydralazine therapy. Clin Pharmacol Ther 118:1430-1436, 2025. PMCID: PMC12641075 PUBMEDID: 40974042 (Journal Impact Factor 2025=5.5)

2026 Annual Report | Department of Pharmacy and Pharmaceutical Sciences

PUBLICATIONS

Escherich CS, Li Z, Barnett KR, Li Y, Walker M, Yoshimura S, Yang W, Huang X, Yu J, Stock W, Paietta E, Konopleva MY, Kornblau SM, Jabbour E, Litzow MR, Inaba H, Pui CH, Loh ML, Evans WE, Savic D, Yang JJ. Differentiation-dependent EBF1 activity determines CD22 transcription and leukemia sensitivity to inotuzumab ozogamicin. Blood 146:471-481, 2025. PUBMEDID: 40435412 (Journal Impact Factor 2025=23.1) Esquivel BD, Santos A, Rybak JM, Santana DJ, Rogers PD, White TC. Mutations in ERG11, TAC1B, and CDR1 reduce fluconazole accumulation in drug-resistant Candidozyma auris isolates. MBio :e0395725-, 2026. PMCID: PMC12977551 PUBMEDID: 41649269 (Journal Impact Factor 2026=4.7) Fangusaro J, Onar-Thomas A, Young Poussaint T, Lensing S, Ligon AH, Lindeman N, Banerjee A, Kilburn LB, Lenzen A, Pillay-Smiley N, Pollack IF, Robison NJ, Partap S, Qaddoumi I, Landi D, Jones DTW, Stewart CF, Fouladi M, Dunkel IJ. A phase 2 PBTC study of selumetinib for recurrent/progressive pediatric low-grade glioma: Strata 2, 5, and 6 with long-term outcomes on strata 1, 3, and 4. Neuro Oncol 27:2415-2428, 2025. PMCID: PMC12526141 PUBMEDID: 40241281 (Journal Impact Factor 2025=13.4) Garcia-Solorio J, Molina-Garay C, Sánchez-Martínez VJ, Villegas-Torres BE, Campos-Perez I, Jiménez-Olivares M, FloresEspino F, Casique-Aguirre D, Núñez-Enriquez JC, Flores-Lujano J, Mata-Rocha M, Peñaloza-Gonzalez JG, OlivaresVillalpando VH, Baños-Lara MDR, García-Soto Á, Galván-Díaz CA, Olaya-Vargas A, Solano-Cardozo M, Garrido-Hernández MÁ, Luna-Silva NC, Cano-Cuapio LS, Carrillo-Sanchez K, Flores-Lagunes LL, Mendoza-Caamal EC, González-Osnaya V, Pelayo-Camacho R, Mejía-Arangure JM, Yang JJ, Alaez-Verson C. Prevalence of TPMT and NUDT15 diplotypes in Mexican children with B-cell acute lymphoblastic leukemia. Pharmacogenet Genomics 36:143-150, 2026. PMCID: PMC13200876 PUBMEDID: 41630471 (Journal Impact Factor 2026=1.7) Gartrell J, Mulrooney DA, Hsu CW, Pan H, Federico SM, Pappo AS, Helmig S, Meredith CJ, Pease P, Christensen AM, Beasley G, Bishop MW. Acute cardiotoxicity in pediatric and adolescent patients with solid tumors treated with tyrosine kinase inhibitors. Cancer 131:e35940-, 2025. PUBMEDID: 40543049 . (Journal Impact Factor 2025=5.1) Gómez Londoño LF, Souza ACO, Burt B, Das S, Ge W, Meza-Perez V, Wiederhold NP, Shelat AA, Cuomo CA, Fortwendel JR, Rogers PD. Prevalence of cyp51A variants in a US collection of Aspergillus fumigatus clinical isolates and comparative analysis of their contribution to triazole antifungal resistance. J Antimicrob Chemother 81:dkag124-, 2026. PMCID: PMC13096733 PUBMEDID: 42011663 (Journal Impact Factor 2026=3.6) Gong L, Klein CJ, Caudle KE, Moyer AM, Scott SA, Whirl-Carrillo M, Klein TE. Integrating pharmacogenomics into the broader construct of genomic medicine: Efforts by the ClinGen Pharmacogenomics Working Group (PGxWG). Clin Chem 71:36-44, 2025. PMCID: PMC12037359 PUBMEDID: 39749515 (Journal Impact Factor 2025=6.3) Greear J, Steele L, Swanson HD, Bhakta N, Inaba H, Pui CH, Smith K, Karol SE. Nutrition management of children with acute necrotizing pancreatitis following asparaginase: A case series. JPGN Rep 6:549-555, 2025. PMCID: PMC12611604 PUBMEDID: 41245044 (Journal Impact Factor 2025=N/A) Greene BL, Allen DC, Unguru Y, Marron JM. Boots on the ground in childhood cancer drug shortages: A multilevel approach. Perspect Biol Med 68:337-350, 2025. PUBMEDID: 40485460 (Journal Impact Factor 2025=0.7)

2026 Annual Report | Department of Pharmacy and Pharmaceutical Sciences

PUBLICATIONS

Greenhalgh R*, Brady SW*, Yang W*, Flasch DA, Edmonson MN, Terekhanova NV, Liu Y, Wang J, Szlachta KA, Tian L, Putnam DK, Rahbarinia D, Kolekar P, Zhou X, Gerhard DS, Ma X, Zhang J. The landscape of structural variation in pediatric cancer. Cancer Cell 44:1-16 (2026). PMID: 41825442 PMCID: PMC12991425. (*Co-first authors.) (Journal Impact Factor 2026=56.1) Hijano DR, Allen DC, Burlison J, Ross HS, Ferrolino JA, Dallas RH, Hayden RT, Morton TH, Greene WL, Wolf J, Ramilo O, Flynn PM, Cross SJ. Improvement in palivizumab administration in severely immunocompromised children: A single-institution quality improvement initiative. Pediatr Qual Saf 10:e822-, 2025. PMCID: PMC12178292 PUBMEDID: 40538556 (Journal Impact Factor 2025=1.1) Hou C, Bhosale S, Yasuda K, Yetirajam R, Leggas M, Rohr J, Tsodikov OV. The position of indole methylation controls the structure, DNA binding, and cellular functions of mithramycin SA-Trp analogues. Chembiochem 26:e202401084-, 2025. PMCID: PMC12119220 PUBMEDID: 40246689 (Journal Impact Factor 2025=2.8) Howze TJ, Carr SD, Wilkins ML, Nason TM, Patel ND. Telehealth-enabled pill swallowing training for a pediatric patient living with HIV: A multi-disciplinary approach. J Am Pharm Assoc (2003) 66:103006-, 2026. PUBMEDID: 41380940 (Journal Impact Factor 2026=2.5) Howze TJ, Graves SM, Carr SD, Sabbatini GM, Nason TM, Patel ND. Effects of doxycycline post-exposure prophylaxis on bacterial sexually transmitted infections and antiretroviral therapy adherence among adolescents and young adults living with HIV. J Infect Public Health 19:103206-, 2026. PUBMEDID: 41831429 (Journal Impact Factor 2026=4.0) Howze TJ, Nason TM, Carr SD, Pate SM, Roe AL, Patel ND. Improving medication adherence and viral load suppression in pediatric, adolescent, and young adult patients living with HIV using a specialty pharmacy. HIV Res Clin Pract 26:2513847-, 2025. PUBMEDID: 40476639 (Journal Impact Factor 2025=1.8) Hu H, Zhao H, Lu P, Ma T, Yoshimura S, Karol SE, Pui CH, Teachey DT, Yang JJ, Ng AHC, Lu Y. μPharma: A microfluidic, AIdriven pharmacotyping platform for single-cell drug sensitivity prediction in leukemia. Med (N Y) 7:100966-, 2026. PUBMEDID: 41619724 (Journal Impact Factor 2026=11.8) Hu M, Ochoada J, Actis M, McGowan K, Jarusiewicz JA, Yoshimura S, McGrath L, Neelakantan U, Aggarwal A, Mayasundari A, Young SM, Zhang M, Yang L, Li Y, Mercer S, Babu MM, Fischer M, Young BM, Yang JJ, Nishiguchi G, Shelat AA, Blair DJ. Direct-to-biology enabled molecular glue discovery. J Am Chem Soc 148:20-27, 2026. PMCID: PMC12814336 PUBMEDID: 41443594 (Journal Impact Factor 2026=15.6) Huang X, Hou X, Li Y, Yang JJ, Yu J. Protocol for predicting the single-cell network-based gene activity landscape during human B cell development. STAR Protoc 6:103614-, 2025. PMCID: PMC11850216 PUBMEDID: 39921864 (Journal Impact Factor 2025=1.3) Hughes K, Hoffman J, Robertson JJ. A proactive approach to medication safety: Developing and successfully using a medication safety strategic plan. Am J Health Syst Pharm:-, 2026. PUBMEDID: 41686697 (Journal Impact Factor 2026=2.3)

2026 Annual Report | Department of Pharmacy and Pharmaceutical Sciences

PUBLICATIONS

Im C, Raduski AR, Mills LJ, Bhattarai KR, Mobley RJ, Barnett KR, Lu Z, Liao K, Anderson N, Johnson RA, Langer E, Hooten AJ, Seif AE, Bernt KM, Tsang M, Mamou BA, Gil-de-Gómez L, Wolfson JA, Friedman DN, Shukla N, Klesse LJ, Marcotte EL, Ji L, Dang A, Luo M, Zhong Y, Langie J, Chiang CWK, de Smith A, Wiemels JL, DeWan A, Ma X, Metayer C, Wang Z, Nelson HH, Pankratz N, Yang T, Basu S, Turcotte LM, Yang JJ, Savic D, Scheurer ME, Spector LG. Genome-wide association study of childhood B-cell acute lymphoblastic leukemia reveals novel African ancestry-specific susceptibility loci. Nat Commun 16:8974-, 2025. PMCID: PMC12546916 PUBMEDID: 41125582 (Journal Impact Factor 2025=15.7) Klein CJ, Gong L, Caudle KE, Naik H, Empey PE, Hoffman JM, Scherer S, Iwuchukwu OF, Gregornik D, Monte AA, Swen JJ, Scott SA, Whirl-Carrillo M, Klein TE. Toward an integrated resource for pharmacogenomics (PGx): Survey findings from the genomic medicine communities. Genet Med 27:101529-, 2025. PMCID: PMC12375431 PUBMEDID: 40662343 (Journal Impact Factor 2025=6.2) Kundu D, Acharya S, Wang S, Cao Y, Kim HJ, Cheong JH, Kim KM. Roles of metabotropic signaling of nicotine receptors in the development and maintenance of nicotine reward through regulation of dopamine D(3) receptor expression. J Neurochem 169:e16271-, 2025. PUBMEDID: 39696743 (Journal Impact Factor 2025=4.0) Langie J, Chan TF, Yang W, Kang AY, Morimoto L, Stram DO, Mancuso N, Ma X, Metayer C, Lupo PJ, Rabin KR, Scheurer ME, Wiemels JL, Yang JJ, de Smith AJ, Chiang CWK. The impact of Indigenous American-like ancestry on the risk of acute lymphoblastic leukemia in Hispanic/Latino children. HGG Adv 7:100534-, 2026. PMCID: PMC12664375 PUBMEDID: 41261530 (Journal Impact Factor 2026=3.6) Li Z, Yang W, Wu G, Chang TC, Cheng Z, Devidas M, Shago M, Carroll AJ, Heerema NA, Gastier-Foster JM, Wood BL, Sanclemente L, Raetz EA, Hunger SP, Loh ML, Feingold E, Rosser TC, Allen EG, Sherman SL, Rabin KR, Lupo PJ, Yang JJ. Inferring chromosome segregation error stage and crossover in trisomic disorders with application to Down syndrome. Nat Commun 16:6316-, 2025. PMCID: PMC12238278 PUBMEDID: 40628699 (Journal Impact Factor 2025=15.7) Li Z, Zhao H, Yang W, Maillard M, Yoshimura S, Hsiao YC, Huang X, Gocho Y, Rowland L, Brown A, Choi L, Crews KR, Mullighan CG, Brady SW, Cheng C, Chang TC, Wu G, Loh ML, Yeoh AEJ, Antillon-Klussmann F, Jeha S, Inaba H, Yu J, Pui CH, Karol SE, Evans WE, Yang JJ. Molecular and pharmacological heterogeneity of ETV6:RUNX1 acute lymphoblastic leukemia. Nat Commun 16:1153-, 2025. PMCID: PMC11779914 PUBMEDID: 39880832 (Journal Impact Factor 2025=15.7) Li-Harms X, Lu J, Fukuda Y, Lynch J, Sheth A, Pareek G, Kaminski MM, Ross HS, Wright CW, Smith AL, Wu H, Wang YD, Valentine M, Neale G, Vogel P, Pounds S, Schuetz JD, Ni M, Kundu M. Somatic mtDNA mutation burden shapes metabolic plasticity in leukemogenesis. Sci Adv 11: eads8489-, 2025. PMCID: PMC11691655 PUBMEDID: 39742470 (Journal Impact Factor 2025=12.5) Liu Q, Yu Z, Liu X, Iverson A, Simmons T, Rosch JW, Ma P. Pre-treatment bacterial cell states shape antibiotic-induced transcriptional reprogramming and survival. Nat Commun:-, 2026. PUBMEDID: 42230649 (Journal Impact Factor 2026=15.7) Liu Y, Jiang H, Liu J, Stuani L, Merchant M, Jager A, Koladiya A, Chang TC, Domizi P, Sarno J, Wang A, Keyes T, Jedoui D, Meng J, Hartmann FJ, Hou R, Fries C, Pirillo C, Gao Q, Iacobucci I, Bendall SC, Huang M, Lacayo NJ, Sakamoto KM, Mullighan CG, Loh M, Yu J, Yang JJ, Ye J, Davis KL. DHODH as a targetable metabolic Achilles’ heel for chemotherapyresistant B-ALL. Blood 147:2328-2343, 2026. PUBMEDID: 41576347 (Journal Impact Factor 2026=23.1)

2026 Annual Report | Department of Pharmacy and Pharmaceutical Sciences

PUBLICATIONS

Liu Y, Ju B, Dong L, Loyd M, Brady SW, Ries R, Feng Y, Mulder H, Plyler E, Deardorff C, McBride A, Jones T, Eckert A, Kolekar P, Fan L, Li H, Briviba M, Zhao H, Bennett D, Neale G, Chang TC, Chen W, Pounds S, Wu G, Mullighan C, Geeleher P, Ji L, Yang JJ, Meshinchi S, Brown PA, Carroll WL, Zhang J, Loh ML, Easton J, Ma X. Uncovering the genomic complexity of PAX5 intragenic tandem multiplication via long-read and short-read sequencing. Blood 147:1498-1502, 2026. PMCID: PMC13077480 PUBMEDID: 41587071 (Journal Impact Factor 2026=23.1) Lovell AL, Makamo N, Veal GJ, Bernhardt MB, Barr R, Gala RM, Gordon E, Ladas EJ, Prasad M, Rogers PC, Schoeman J, Slone JS, Viani K, Tissing WJE, Huibers MHW. Nutritional status, body composition and chemotherapy dosing in children and young people with cancer: A systematic review by the SIOP nutrition network. Br J Cancer 133:275-285, 2025. PMCID: PMC12322071 PUBMEDID: 40571762 (Journal Impact Factor 2025=6.8) Lu C, Matt GY, Paul R, Wang J, Sioson E, Acić A, Willems A, Zaldívar Peraza A, Reilly C, Pölönen P, Gao Q, Li Q, Pounds SB, Zeng AGX, Li S, Nadarajah N, Brady SW, Iacobucci I, Haferlach T, Rose MC, Mullighan CG, Zhou X. The ASH HematOmics Program supports integrative analysis of genomic and clinical data in hematologic diseases. Blood: -, 2026. PUBMEDID: 41940951 (Journal Impact Factor 2026=23.1) Ma P, Chen PD, Jadhav S, He LL, Laibinis HH, Hung DT, Moffitt KL. Longitudinal antibody responses to SARS-CoV-2 infection in children: Impact of age, vaccines and symptoms. Pediatr Infect Dis J 44:1181-1184, 2025. PUBMEDID: 40856606 (Journal Impact Factor 2025=2.2) Maillard M, Nishii R, Vu HS, Bhattarai KR, Yang W, Li J, Hofmann U, Savic D, Bhatia S, Schwab M, Ni M, Yang JJ. The NUDIX hydrolase NUDT5 regulates thiopurine metabolism and cytotoxicity. J Clin Invest 135: e190443-, 2025. PMCID: PMC12259257 PUBMEDID: 40662362 (Journal Impact Factor 2025=13.6) Maillard M, Schwab M, Whirl-Carrillo M, Moyer AM, Suarez-Kurtz G, Pui CH, Stein CM, Klein TE, Spahn C, Kwon S, Hartono JL, de Boer NK, Ahmad T, Antillon-Klussmann FG, Caudle KE, Kato M, Yeoh AEJ, Schmiegelow K, Yang JJ. Clinical Pharmacogenetics Implementation Consortium (CPIC) guideline for thiopurine dosing based on TPMT and NUDT15 genotypes: 2025 update. Clin Pharmacol Ther 119:916-927, 2026. PMCID: PMC12997511 PUBMEDID: 41618934 (Journal Impact Factor 2026=5.5) Mandrell BN, Johnson LM, Gattuso JS, Hines-Dowell S, Ring S, Crews KR, Haidar CE, Howard-Sharp KM, Nichols KE. Precision-based care: A multidisciplinary approach. J Pediatr Hematol Oncol Nurs 43:75-82, 2026. PUBMEDID: 41914954 (Journal Impact Factor 2026=1.5) Manolio TA, Rider R, Bult CJ, Chisholm RL, Deverka PA, Ginsburg GS, Green ED, Jarvik GP, Mensah GA, Narula J, Ramos EM, Relling MV, Roden DM, Rowley R, Abul-Husn NS, Buchanan AH, Chute CG, Del Fiol G, Elhanan G, Haga SB, Hamid R, Horowitz CR, Hulick PJ, James CA, Jeff JM, Korf B, Landry L, McGraw D, McLeod HL, Mendelsohn NJ, Osterman T, Taylor CO, Pritchard D, Rehm HL, Tsosie KS, Vassy JL, Watson K, Wiley K Jr, Williams MS. Advancing the science of genomic learning healthcare systems. Learn Health Syst 9: e70027-, 2025. PMCID: PMC12569450 PUBMEDID: 41169653 (Journal Impact Factor 2025=2.6)

2026 Annual Report | Department of Pharmacy and Pharmaceutical Sciences

PUBLICATIONS

Mason EJ, Crain AM, Scheurer ME, Lupo PJ, Rabin KR, Taylor OA, Roberts M, Woodhouse JP, Chavana A, Ludwig K, Klesse L, Heym K, Griffin T, Erana R, Bernini JC, Gramatges MM, Yi JS, Pruitt SL, Bernhardt MB, Zhu H, Mittelman SD, Huynh V, Orgel E, Schraw JM, Brown AL. An analysis of diagnostic metabolomic profiles associated with hepatotoxicity during childhood ALL induction therapy. Blood Adv 9:5802-5810, 2025. PMCID: PMC12663015 PUBMEDID: 40829116 (Journal Impact Factor 2025=7.1) Massic L, Doorley LA, Jones SJ, Richardson I, Siao DD, Siao L, Dykema P, Hua C, Schneider E, Cuomo CA, Rogers PD, Van Hooser S, Parker JE, Kelly SL, Hess D, Rybak JM, Pandori M. Acquired amphotericin B resistance attributed to a mutated ERG3 in Candidozyma auris. Antimicrob Agents Chemother 69: e0060125-, 2025. PMCID: PMC12587534 PUBMEDID: 40980913 (Journal Impact Factor 2025=4.5) Matherne MM, Panetta JC, Hopp J, Inaba H, Pui CH, Karol SE, Bernhardt MB, Swanson HD. Impact of dosing interval adherence on pharmacokinetic outcomes of recombinant Erwinia asparaginase in pediatric leukemia or lymphoma. Pharmacotherapy 46: e70146-, 2026. PUBMEDID: 42011546 (Journal Impact Factor 2026=3.4) Matherne MM, Panetta JC, Hopp J, Inaba H, Pui CH, Karol SE, Swanson HD. Desensitization to calaspargase pegol appears to be less successful than pegaspargase. Blood Adv 9:1492-1496, 2025. PMCID: PMC11985031 PUBMEDID: 39903102 (Journal Impact Factor 2025=7.1) McCarville MB, Ashcraft E, Ribeiro RC, Rees M, Swanson HD, Inaba H, Jeha S, Cheng C, Pui CH, Karol SE. Asparaginaseassociated pancreatitis during therapy for pediatric acute lymphoblastic leukemia. Haematologica 111:335-339, 2026. PMCID: PMC12775779 PUBMEDID: 40820809 (Journal Impact Factor 2026=7.9) McCastlain K, Welsh C, Ni Y, Ding L, Chang TC, Autry RJ, Sejdiu BI, Pan Q, Franco M, Chen W, Wu H, Gonzalez-Pena V, Schreiner P, Arunachalam S, Joo JH, Brady S, Zhang J, Gawad C, Evans WE, Babu MM, Khrapko K, Yu J, Wu G, Pounds S, Kundu M. Somatic mtDNA mutations at intermediate levels of heteroplasmy are a source of functional heterogeneity among primary leukemic cells. Sci Adv 11: eadt3873-, 2025. PMCID: PMC12422205 PUBMEDID: 40929251 (Journal Impact Factor 2025=12.5) Menig S, Militano O, Ostrenga A, Bernhardt MB, Lee B, Unguru Y. Methotrexate scarcity among children’s oncology group institutions: Results of a multinational survey. Oncologist 30: -, 2025. PMCID: PMC12396948 PUBMEDID: 38069904 (Journal Impact Factor 2025=4.2) Meyer CT, Dai Y, Pomeroy AE, Twarog NR, Bender A, Rosenfeld SS, Antonarakis ES, Mettetal JT, Huang RS, Quaranta V, Tang J, Shelat AA, Smith MA, Palmer AC. Rethinking the role of synergy calculations in the next century of drug combination discovery. Med (N Y) 7:101103-, 2026. PUBMEDID: 42054999. (Journal Impact Factor 2026=11.8) Molinelli AR, Cross SJ, Leggas M. Recent advances in therapeutic drug monitoring of antineoplastic and antimicrobial agents in children. Clin Lab Med 45:315-327, 2025. PUBMEDID: 40348442. (Journal Impact Factor 2025=1.3) Montefiori LE, Iacobucci I, Gao Q, Moore J, Wright WC, Wei H, Baviskar P, Sona S, Jin H, Budhraja A, Lott J, Tatarata QZ, Cheng Z, Khan T, Backhaus Wagner EA, Johnson M, Mehr CM, Freeman B, Janke L, Haferlach T, Geeleher P, Mead PE, Konopleva M, Opferman JT, Mullighan CG,. Venetoclax plus gilteritinib is effective in preclinical models of FLT3-mutant BCL11B-a lineage-ambiguous leukemia. Blood 146:2350-2356, 2025. PMCID: PMC12377505 PUBMEDID: 40811853 (Journal Impact Factor 2025=23.1)

2026 Annual Report | Department of Pharmacy and Pharmaceutical Sciences

PUBLICATIONS

Moore C, Bourque MS, Halman A, Agúndez JAG, Prows CA, Hikino K, Schwab M, Oxencis CJ, Chauhan D, Diekstra MHM, Long SE, Bell GC, Gaedigk A, Whirl-Carrillo M, Klein TE, Caudle KE, Conyers R. Clinical Pharmacogenetics Implementation Consortium (CPIC) guideline for CYP2D6 genotype and use of 5-HT(3) receptor antagonists: 2026 update. Clin Pharmacol Ther: -, 2026. PUBMEDID: 41979467 (Journal Impact Factor 2026=5.5) Moore C, Williams E, Dyas R, Halman A, Stenta T, Khatri D, Elliott DA, Lange PW, Caudle KE, Conyers R. CYP2D6 genotype and associated 5-HT (3) receptor antagonist outcomes: A systematic review and meta-analysis. Clin Transl Sci 18: e70108-, 2025. PMCID: PMC11789932 PUBMEDID: 39899439 (Journal Impact Factor 2025=2.8) Mullin C, Lin K, Choe E, Sha C, Shukla Z, Campbell K, McCarter AC, Wang A, Nieves-Salva J, Khan S, Keeley TM, Liang S, Wang Q, Melnick AF, Evans P, Monovich AC, Iyer A, Kodgule R, Deng Y, da Veiga Leprevost F, Barnett KR, Pölönen P, Khoriaty R, Savic D, Teachey DT, Mullighan CG, Cieslik M, Nesvizhskii AI, Samuelson LC, Jones M, Li Q, Ryan RJ, Chiang MY. The hematopoietic stem cell MYB enhancer is essential for and recurrently amplified during T cell leukemogenesis. J Clin Invest 136: e187998-, 2026. PMCID: PMC12721900 PUBMEDID: 41129262 (Journal Impact Factor 2026=13.6) Nair S, Owens T, Stolarski A, Gartrell J, Tinkle C, Stewart CF. Quantitative determination of Selinexor concentrations in plasma samples from children with non-rhabdomyosarcoma soft-tissue sarcomas: Troubleshooting plasma instability issues. J Chromatogr B Analyt Technol Biomed Life Sci 1263:124700-, 2025. PUBMEDID: 40532580 (Journal Impact Factor 2025=2.8) Nason T, Patel ND, Allen H, Jurbergs N. Leveraging interdisciplinary collaboration and team-based care to develop a standardized model for the assessment of medication adherence and barriers. J Am Coll Clin Pharm 8:688-693, 2025. (Journal Impact Factor 2025=1.5) Neupane A, Liu Q, Taneja S, French J, Ehrhardt MJ, Brinkman TM, Webster R, Yang JJ, Im C, Turcotte LM, Neglia JP, Gramatges MM, Howell RM, Bhatia S, Ness KK, Hudson MM, Armstrong GT, Robison LL, Yasui Y, Sapkota Y. Contributions of cancer treatment and genetic predisposition to risk of subsequent neoplasms in long-term survivors of childhood cancer: a report from the St Jude Lifetime Cohort and the Childhood Cancer Survivor Study. Lancet Oncol 26:806-816, 2025. PMCID: PMC12204326 PUBMEDID: 40449499 (Journal Impact Factor 2025=35.9) Newman H, Lee SHR, Pölönen P, Shraim R, Li Y, Liu H, Aplenc R, Bandyopadhyay S, Chen C, Devidas M, Diorio C, Dunsmore K, Elghawy O, Elhachimi A, Fuller T, Gupta S, Hall J, Hughes AD, Hunger SP, Loh ML, Martinez Z, McCoy MF, Mullen CG, Pounds SB, Raetz E, Seffernick AE, Shi G, Sussman J, Tan K, Uppuluri L, Vincent TL, Wang’ondu R, Winestone LE, Winter SS, Wood BL, Wu G, Xu J, Yang W, Mullighan CG, Yang JJ, Bona K, Teachey DT. Impact of genetic ancestry on genomics and survival outcomes in T-cell acute lymphoblastic leukemia. Blood Cancer Discov 6:412-424, 2025. PMCID: PMC12405861 PUBMEDID: 40434808 (Journal Impact Factor 2025=11.5) Niloy KK, Horn J, Bhuiyan NH, Shaaban KA, Bhosale SS, Prisinzano TE, Thorson JS, Rohr J, Leggas M. Preclinical pharmacokinetic evaluation of mithramycin and mithramycin SA tryptophan-conjugated analog. Pharmaceutics 17:765-, 2025. PMCID: PMC12197275 PUBMEDID: 40574077 (Journal Impact Factor 2025=5.5) Oni-Orisan A, Yee SW, Haldar T, Whirl-Carrillo M, Caudle K, Voora D, Kim RB. An update to the Clinical Pharmacogenetics Implementation Consortium (CPIC) SLCO1B1 allele functionality table leveraging evidence from participants of predominantly sub-Saharan African ancestry. Clin Pharmacol Ther 119:1133-1135, 2026. PMCID: PMC13055011 PUBMEDID: 41321195 (Journal Impact Factor 2026=5.5)

2026 Annual Report | Department of Pharmacy and Pharmaceutical Sciences

PUBLICATIONS

Pai AA, Devasia AJ, Panetta JC, Mani S, Stallon Illangeswaran RS, Mohanan E, Balakrishnan B, Lakshmi KM, Kulkarni U, Aboobacker FN, Korula A, Abraham A, Srivastava A, Mathews V, George B, Balasubramanian P. Corrigendum to “Pharmacokinetics and efficacy of generic melphalan is comparable to innovator formulation in patients with multiple myeloma undergoing autologous stem cell transplantation” [Clin Lymphoma Myeloma Leuk. 20/2 (2020) 130-135.e1]. Clin Lymphoma Myeloma Leuk 25:379-, 2025. PUBMEDID: 39955257 (Journal Impact Factor 2025=2.7) Panetta JC, Ashcraft E, Jeha S, Pui CH, Inaba H, Karol SE, Cheng C, Swanson HD. Changes in asparaginase exposure and toxicity profiles in obese pediatric acute lymphoblastic leukemia patients. Haematologica 110:1849-1853, 2025. PMCID: PMC12358778 PUBMEDID: 39945009 (Journal Impact Factor 2025=7.9) Panetta JC, Talleur AC, Naik S, Gottschalk S, Leggas M. Age-adjusted dosing of fludarabine for lymphodepletion in CAR T-cell therapy: A clinical trial simulation study. Blood Adv 9:4676-4682, 2025. PMCID: PMC12496251 PUBMEDID: 40609087 (Journal Impact Factor 2025=7.1) Patel N, Surman SL, Jones BG, Penkert RR, Ringwald-Smith K, DeLuca K, Richardson J, Zheng Y, Tang L, Hurwitz JL. Randomized controlled clinical trial of pediatric pneumococcus and hepatitis A vaccinations with or without a high-dose oral vitamin A supplement. Biomolecules 15:540-, 2025. PMCID: PMC12024622 PUBMEDID: 40305237 (Journal Impact Factor 2025=4.8) Phillips KJ, Sun Y, Tang L, Pappas A, Cross SJ, Pauley JL, McCormick J, Molinelli AR, Bissler JJ, Christensen AM, Stewart CF. Comparison of GFR estimation equations using creatinine, cystatin C, and their combination in pediatric hematology-oncology: No single equation is superior across subgroups. Pediatr Nephrol 40:2907-2917, 2025. PUBMEDID: 40266335 (Journal Impact Factor 2025=2.6) Prideaux J, Britto MT, Vaughn LM, Auger KA, Fetters CD, Hoffman JM, Kim JM, Walsh KE. Key partner priorities for measures of safe outpatient paediatric medication use. BMJ Qual Saf: -, 2025. PUBMEDID: 40866296 (Journal Impact Factor 2025=6.5) Purvis K, Zhou Y, Karol SE, Rubnitz JE, Ribeiro RC, Lee S, Yang JJ, Bowman WP, Wang L, Dixon SB, Roberts KG, Gao Q, Cheng C, Mullighan CG, Jeha S, Pui CH, Inaba H. Outcomes in patients with ETV6::RUNX1 or high-hyperdiploid B-ALL treated in the St. Jude Total Therapy XV/XVI studies. Blood 145:190-201, 2025. PMCID: PMC11738036 PUBMEDID: 39316653 (Journal Impact Factor 2025=23.1) Reitler P, DeJarnette CA, Kumar R, Tucker KM, Peters TL, Twarog NR, Shelat AA, Palmer GE. A screen to identify antifungal antagonists reveals a variety of pharmacotherapies that induce echinocandin tolerance in Candida albicans. Antimicrob Agents Chemother 69: e0048425-, 2025. PMCID: PMC12486808 PUBMEDID: 40824714 (Journal Impact Factor 2025=4.5) Robinson KM, McNulty MD, Crews KR, Bragg AW, Ribeiro RC, Bertrand KC, Inaba H, Takemoto CM, Geck RC, Haidar CE. G6PD activity in pediatric patients with the G6PD Ilesha variant: A case series G6PD Ilesha variant in pediatric patients. Clin Biochem :111143-, 2026. PUBMEDID: 42128218 (Journal Impact Factor 2026=2.1) Ross HS, Dallas RH, Ferrolino JA, Johnson MB, Allison KJ, Cross SJ, Hayden RT, Mejias A, Hijano DR. Clinical outcomes of respiratory syncytial virus infection among pediatric immunocompromised hosts. Pediatr Blood Cancer 72: e31484-, 2025. PUBMEDID: 39690820 (Journal Impact Factor 2025=2.3)

2026 Annual Report | Department of Pharmacy and Pharmaceutical Sciences

PUBLICATIONS

Sabet S, Hollman N, Hendrix-Dicken A, Raschka M, La N, Oldham MM, Richardson J, Schmidt D, Carr S, Atkins A, Williams MB. HIV-specific vs universal immunization coverage in US children with HIV: A multi-site study. J Pediatric Infect Dis Soc 15: piag026-, 2026. PMCID: PMC13221952 PUBMEDID: 41925218 (Journal Impact Factor 2026=2.6) Santana DJ, Cauldron NC, Rogers PD, Cuomo CA. Deciphering the multidrug resistance paradigm in Candida auris. Antimicrob Agents Chemother 70: e0106224-, 2026. PMCID: PMC13041361 PUBMEDID: 41837697 (Journal Impact Factor 2026=4.5) Sofras D, Carolus H, Subotić A, Lobo Romero C, Ennis CL, Cuypers L, Lagrou K, Hernday AD, Nobile CJ, Rybak JM, Van Dijck P. A systematic comparison of CRISPR-Cas9 allele editing in Candida auris demonstrates unreliable cassette integration and effective episomal plasmid-based editing. Sci Rep 15:35105-, 2025. PMCID: PMC12508224 PUBMEDID: 41062549 (Journal Impact Factor 2025=3.9) Tark JY, Renwick A, Tettamanti G, Harris RD, Desrosiers TA, Olshan AF, Janitz AE, Scheurer ME, Shumate CJ, Scheuerle AE, Plon SE, Huff CD, Nordgren A, Luke B, Lupo PJ, Schraw JM. A population-based assessment of cancer risk in children with VACTERL. Am J Med Genet A 200:1004-1011, 2026. PUBMEDID: 41432111 (Journal Impact Factor 2026=1.7) Taylor ZL, Miller TP, Board SG, Poweleit EA, Chavana A, Weisnicht A, Brown AL, Bernhardt MB, Schafer ES, O’Brien MM, Castellino SM, Ramsey LB. What is the expected clearance of methotrexate? A therapeutic drug monitoring reference guide for high-dose methotrexate use in pediatric malignancies. Pediatr Blood Cancer 72: e31744-, 2025. PUBMEDID: 40254820 (Journal Impact Factor 2025=2.3) Tibben BM, Gaedigk A, Gong L, Sangkuhl K, Whirl-Carrillo M, Relling MV, Donnelly RS, Klein TE, Caudle KE. The Clinical Pharmacogenetics Implementation Consortium’s consensus-based framework for assigning allele function. Am J Hum Genet 112:2842-2859, 2025. PMCID: PMC12766749 PUBMEDID: 41175864 (Journal Impact Factor 2025=8.1) Tichy EM, Rim MH, Tadrous M, Schumock GT, Cuellar S, Johnson TJ, Newell MK, Hoffman JM. National trends in prescription drug expenditures and projections for 2026. Am J Health Syst Pharm: -, 2026. PUBMEDID: 42059345 (Journal Impact Factor 2026=2.3) Tilley S, Li Y, Brasher CA, Rimmer MA, Ranathunge TA, Mercer S, Yang L, Bernhardt MB. Stability of extemporaneously compounded cobimetinib oral suspensions. J Oncol Pharm Pract :10781552261449183-, 2026. PUBMEDID: 42089812 (Journal Impact Factor 2026=0.9) Wang’ondu RW, Ashcraft E, Chang TC, Roberts KG, Brady SW, Fan Y, Evans W, Relling MV, Crews KR, Yang J, Yang W, Pounds S, Wu G, Devidas M, Maloney K, Mattano L, Schore RJ, Angiolillo A, Larsen E, Salzer W, Burke MJ, Loh ML, Jeha S, Pui CH, Inaba H, Cheng C, Mullighan CG. Heterogeneity of IKZF1 genomic alterations and risk of relapse in childhood B-cell precursor acute lymphoblastic leukemia. Leukemia 39:1595-1606, 2025. PMCID: PMC12759290 PUBMEDID: 40360879 (Journal Impact Factor 2025=13.4) Wieduwilt MJ, Yin J, Kour O, Teske R, Stock W, Escherich C, Yang J, Li Z, Byrd K, Doucette K, Mangan J, Hall S, Mims AS, Jamieson K, Dinner SN, Bseiso AW, Giordano G, Saygin C, Uy GL, Litzow MR, Stone RM. Inotuzumab ozogamicin then blinatumomab for older adults with newly diagnosed B-cell ALL: Alliance study A041703 cohort 1 results. J Clin Oncol 43:35263535, 2025. PMCID: PMC13093227 PUBMEDID: 41026957 (Journal Impact Factor 2025=41.9)

2026 Annual Report | Department of Pharmacy and Pharmaceutical Sciences

PUBLICATIONS

Wu D, Williams MR, Patwardhan AA, Bi Y, Selukar S, Pauley JL, McCormick J, Sharma A. Concomitant azole initiation decreases time to stable goal sirolimus concentrations in pediatric allogeneic transplant recipients. J Pediatr Hematol Oncol: -, 2025. PUBMEDID: 40793923 (Journal Impact Factor 2025=0.8) Xu J, McCoy M, Martinez Z, Sussman JH, Gao D, Vincent T, Wang H, Ma C, Elghawy O, Chen GM, Yang AG, Pölönen P, Natan K, Shraim R, Newman H, Hofmann TJ, Scoma S, DiNofia AM, Hunger SP, Yang JJ, Mullighan CG, Bernt KM, Hexner EO, Grupp SA, Watanabe K, June CH, Tan K, Teachey DT, Diorio C. CCR4 expression defines a targetable subset of T-cell acute lymphoblastic leukemia. Blood Adv 10:2676-2686, 2026. PMCID: PMC13101778 PUBMEDID: 41671457 (Journal Impact Factor 2026=7.1) Xu J, Sussman JH, Yang A, Yoshimura S, Hu J, Chen C, Vincent T, Bandyopadhyay S, Li EY, Lim T, Elghawy O, Barsouk A, Karanfilovski D, Wald SL, Chen GM, Wu D, Newman H, Li A, Sun Y, Chen CH, Bernt K, Wood BL, Winter SS, Dunsmore KP, Raetz E, Devidas M, Pounds S, Loh M, Hunger SP, Chiang MY, Diorio C, Di Giacomo D, Pölönen P, Mullighan CG, Yang JJ, Tan K, Teachey DT. STAT1-mediated interferon signatures are associated with preclinical JAK inhibitor sensitivity in T-ALL. Blood 145:2793-2798, 2025. PMCID: PMC12163734 PUBMEDID: 40101143 (Journal Impact Factor 2025=23.1) Yang W, Wu G, Klco JM, Nichols KE, Jeha S, Inaba H, Pui CH, Bhakta N, Broeckel U, Yang JJ, Haidar CE. Inferring germline pharmacogenomics from tumor transcriptome. Pharmacogenet Genomics 36:1-8, 2026. PUBMEDID: 40995674 (Journal Impact Factor 2026=1.7) Yarur AJ, Dervieux T, Ungaro R, Spencer EA, Bruss A, Nunez L, Berens B, Vermeire S, Wang Z, Panetta JC, Dreesen E, Dubinsky MC. Ustekinumab drug clearance is better associated with disease control than serum trough concentrations in a prospective cohort of inflammatory bowel disease. Pharmaceutics 17:187-, 2025. PMCID: PMC11859385 PUBMEDID: 40006554 (Journal Impact Factor 2025=5.5) Zhu J, Ranjit S, Gose T, Nourse A, Pagala VR, Yuan ZF, Lynch J, Wang Y, Pitre A, Crawford R, Peng J, Wijaya J, Naren AP, Schuetz JD. Protein Kinase A and assembly of an ABCC4 protein network. Nat Commun 17:166-, 2025. PMCID: PMC12780066 PUBMEDID: 41339628 (Journal Impact Factor 2025=15.7) Zhu Q, Van de Velde S, Wijnants S, Carolus H, Jacobs S, Sofras D, Vandecruys P, Van Goethem O, Feil R, Vergauwen R, Van Genechten W, Van den Ende W, Rybak JM, Himmelreich U, Lunn JE, Van Dijck P. Accumulation of trehalose 6-phosphate in Candidozyma auris results in decreased echinocandin resistance and tolerance. Nat Commun 17:311-, 2025. PMCID: PMC12789422 PUBMEDID: 41390499 (Journal Impact Factor 2025=15.7) Zudeh G, Franzin M, Lucafò M, Bramuzzo M, Curci D, Yang JJ, Maillard M, Decorti G, Stocco G. Azathioprine metabolites in erythrocytes and DNA for therapy monitoring in very early onset inflammatory bowel disease pediatric patients. ACS Pharmacol Transl Sci 8:2009-2017, 2025. PMCID: PMC12260932 PUBMEDID: 40672687 (Journal Impact Factor 2025=3.7)

2026 Annual Report | Department of Pharmacy and Pharmaceutical Sciences