The South African Journal of Science is a multidisciplinary science journal published bimonthly by the Academy of Science of South Africa. Our mandate is to publish original research with an interdisciplinary or regional focus and to provide a forum for discussion of news and developments in research and higher education. This special issue on Radical Reason brings together a selection of critical contributions from thinkers from around the world, who all offer provocations for thinking anew what it means to be human now and here. These contributions either capture or extend presentations and conversations that were part of the HSRC Radical Reason ‘Conversations with Global Thinkers’ series that took place at the 2020 Science Forum South Africa.