ISSN 2348-1218 (print) International Journal of Interdisciplinary Research and Innovations ISSN 2348-1226 (online) Vol. 10, Issue 2, pp: (22-29), Month: April - June 2022, Available at: www.researchpublish.com
STUDIES ON PHYTOCHEMISTRY, ANTI-CANCER PROPERTIES OF BETULA UTILIS Sandeep Singh Bhau1, Dr. Arti Chaurasia2 1
Research Scholar, Department of Chemistry NIMS University, Jaipur
2
Asst. Professor, Dr. Arti Chaurasia Department of Chemistry NIMS University, Jaipur DOI: https://doi.org/10.5281/zenodo.6524653 Published Date: 06-May-2022
Abstract: Betula is a versatile plant with several applications. D. Don (family Betulaceae) is a long-lived tree that has been known in Sanskrit for about 400 years as Himalayan birch, bhojpatra, or Bhurja. Its usefulness as a therapeutic plant is well acknowledged. Birch bark has recently been the topic of scientific study and industry given the presence contains triterpenoids including such betulinic acid as well as oleanolic acid, that are well for their anticancer actions. A new anticancer medication, betulinic acid promotes apoptosis in the cancer cells. Therefore, It was unique from other cancer treatments. A number of B. utilis species have been reported to contain phenolics as well as flavonoids. Suitable investigations were carried out to assess phytochemicals qualitatively using various solvents, as well as anticancer activities utilising the SRB test. Keywords: phytochemicals, anticancer medication, cancer cells.
1. INTRODUCTION There are several uses for Betula, a plant. Betulaceae tree D. Don (also called as Himalayan birch, bhojpatra, as well as Bhurja in Sanskrit) is a long-lived tree which has been recognised for about 400 years. It's well accepted that this plant has medical properties. Because of its high altitude and sensitivity to soil instability and/or severe snowfall, the Betula utilis tree can only be found in the Himalayas. Various ailments and diseases, such skin disinfection, wound healing, bronchitis, leprosy, convulsions, as well as ear and blood issues may be treated using the stem bark of B. utilis. It has been shown to possess antibacterial, antihyperglycemic, antitumor, antioxidant, as well as anti-HIV activities pharmacologically. The anticancer qualities of triterpenoids like betulinic acid as well as oleanolic acid, found in birch bark, have spurred recent industrial and scientific interest in the bark. Betulinic acid, a new anticancer medication, causes cancer cells to die by triggering apoptosis. As a result, it varies from traditional anticancer drugs. Phenolics and flavonoids are two more types of chemicals found in B. utilis species. The measurement of components in B. utilis was previously reported using high-performance thin-layer chromatography16, which had limited sensitivity and resolution. As a result, for progressive output in this work, ultrahigh-performance liquid chromatography (UHPLC) is utilised. Because of its unique and better grade sensitivity, the UHPLC- triple quadrupole/linear ion trap (QqQLIT) mass spectrometer makes it simple to identify analytes in ultra-low concentrations. Because of its precision, sensitivity, as well as ability to measure several analytes in complex matrices at the same time, the multiple reaction monitoring (MRM) approach is chosen in this investigation.
2. LITERATURE REVIEW (Selzer et al., 2000) The effects of betulinic acid on malignant melanoma cells were investigated both on its own and in conjunction with irradiation. Betulinic acid was strong and continuously suppressed the proliferation and colony formation of all the human tumor cell lines. When betulinic acid and ionising radiation were used in colony-forming tests, the effect on development suppression was greater. Human melanoma cells were also caused to die by betulinic acid, according to this study.
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