International Journal of Healthcare Sciences ISSN 2348-5728 (Online) Vol. 9, Issue 1, pp: (133-138), Month: April 2021 - September 2021, Available at: www.researchpublish.com
A SHORT REVIEW FOR THE TREATMENT ASPECTS OF MUCORMYCOSIS Megha Mishra1, Karuna Raghuwanshi2 1 2
Swami Vivekanand college of Pharmacy Bhopal, India
Department of Pharmacy, Barkatullah University Bhopal, India Corresponding Author- megham.pharma@gmail.com
Abstract: Mucormycosis or black fungus is a serious type of fungal infection caused by mucormycetes which are made up of group of molds. In this paper, we studied about what is fungus, mucormycosis, types of fungal infection and preventions, and amphotericin B is a choice of drug and other drugs like posconazole, isavuconazole are used as a salvage therapy. Surgical debridement is also one of the treatment for mucormycosis by removal of necrotic tissues. Deferasirox also used in mucormycosis treatment but further studies also required for better results. Hyperbaric oxygen also has been used in some patients of mucormycosis but research to be continue for more benefits. Keywords: Black Fungus, Mucormycosis, Infections, Amphotericin B, Salvage therapy.
1. INTRODUCTION Fungus- A plant which are not green and does not have leaves or flowers or like a wet powder and grows on old wood or food, walls etc. A fungus is a group of eukaryotic organisms like yeasts, molds[1]. Fungus is a microbe that causes infections to human beings. ‗Mycology‘ is the study of fungi. Fungus, in plural called as fungi. Though fungi are the infectious agents, that producing infection in the human body, there are few fungi such as edible fungi. Examples for edible fungi is mushrooms. And some fungi are used in fermentation. Antifungal drugs are used for the treatment of fungal infections. Candidiasis is caused by fungus yeast[2]. Types of Fungus: Three types of fungus such as white fungus, black fungus and yellow fungus. 1. White fungus like Aspergeilosis infection caused by Aspergillis, it is a type of fungus that lives in outdoor as well as indoor. This type of infection includes allergic infection, lung infection and also seen in other body organs. Candidians caused by candida which lives in skin and inside the body like throat,mouth,gut,vagina without causes any serious health problems, 2. Whereas black fungus is white in color but it causes tissue damage which appears black in color. It mainly affects the sinus, brain and lungs 3. Apart from white and black fungus yellow fungus is very rare and less found in human beings[3]. In present pandemic or in Covid-19 crises, patients have high risk of black fungus. Blackfungus infection mainly occurs in post Covid-19 patients due to intake of high dose of steroids. This infection also seen in patients having diabetes (Diabetes mellitus) [4]. Mucormycosis- It is a type of fungal infections. Mucormycetes is a group of molds which causes fungal infection. These molds live throughout the atmosphere. Mucormycosis is being increasingly diagnosed worldwide after Covid-19 pandemic, particularly in India [5]. The recent trend is due to the increased awareness, advances in diagnostic techniques, and the increase in the pervasiveness of predisposing factors [6, 7]. Mucormycosis affects mainly the Human being, who have health problems or take medicines which lower the body's ability to fight germs and sickness. Commonly it affects on the lungs after inhaling fungal spores from the air. It is also present on the skin after a cut, wound and burn, or other
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