International Journal of Healthcare Sciences ISSN 2348-5728 (Online) Vol. 9, Issue 1, pp: (78-84), Month: April 2021 - September 2021, Available at: www.researchpublish.com
COVID-19 IN OLDER ADULTS ANTIBODY RESPONSES OF INACTIVATED SARS-CoV-2 (VERO CELL-SINOVAC) VACCINE FOR ELDERLY COMPARING WITH YOUNGER Bülent Abut ÖZSEZİKLİ 1,2,3, Simay AKDEMİR1, Hatice YILDIZ1, Hande SAVAŞAN AKTAY1 , Zafer ÖZOK1 1 2
NŞMS Foundation Barınyurt Nursing Home
Girne American University Physiotherapy & Rehabilitation 3
Ozsezikli Physiotherapy & Rehabilitation Group
Abstract: Background: Nowadays, researches are being done along with the ongoing vaccination process worldwild. Although the Covid-19 mostly affected the elderly, evidence based studies about the effectiveness and reliability of the vaccine in geriatric population older than 65, is insufficient. So this unique scientific review, aimed to evaluate the Sinovac vaccine outcomes. Methods: The two doses of the inactivated SARS-CoV-2 (Vero Cell-SINOVAC) vaccine was applied to lodgers and staff. 3 weeks after each dosage, the blood samples were taken from participants to evaluate antibody formation ratios. The outcomes between the lodger and staff groups were compared for vaccine effectiveness at different age groups. Results: Datas from 34 lodgers with the average age of 78.85±12.56 and from 39 staff with the average age of 48.37±11.37 were taken. In lodgers, 61.8% efficiency of SARS-CoV-2 vaccine with first dose, is increased to 85.3% after the second dose. The increased antibody ratios in the lodgers group is found statistically significant (p<0.05).In staff, 69.2% efficiency of SARS-CoV-2 vaccine with first dose is increased to 97.4% after the second dose. This improved antibody formation between doses was statistically significant within staff group. Also statistically significant difference at the antibody scores between two doses of vaccination in both groups is seen. Conclusion: According to the age related results with the young staff presented with higher scores compared to elderly lodgers, in our Barınyurt Nursing Home conducted research study, the SARS-CoV-2 (SINOVAC) vaccine is found 91.8% beneficial with the positive antibody score in 67 individuals. Keywords: Covid-19, Pandemic, Sinovac vaccine, Geriatric population, Nursing home, Antibody score.
I. INTRODUCTION Corona virus which emerged on December, 2019, became a public health problem across worldwide by spreading and infecting more than 94 million people and causing more than 2 million deaths [3]. According to the genetic evaluations, Covid-19 was found as a member of the family of coronaviridae as a beta type Coronavirus like SARS-CoV and Middle East Respiratory Syndrome which all, infects the human and animal kinds [5]. Because of the genomic appearance of the virus is similar to the severe acute respiratory syndrome Coronavirus (SARS-CoV), the current name of the emerged virus was determined as SARS-CoV-2 and because of the rapid widespread of the cases, it is declared as pandemic on March 11, by World Health Organization (WHO) [2] [5]. Although the virus affects the people from all ages, most severely elderly people who are older than 60 years old of age or have chronic diseases, were faced with serious symptoms and
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