International Journal of Healthcare Sciences ISSN 2348-5728 (Online) Vol. 8, Issue 2, pp: (342-346), Month: October 2020 - March 2021, Available at: www.researchpublish.com
CLINICOPATHOLOGY PROFILE OF GIANT CELL TUMOR OF BONE IN RSUP SANGLAH 2015-2019 Jude Arvind Raj K Gerald Anthony1, I Wayan Juli Sumadi2, I Made Gotra2, Ni Putu Ekawati2 1
Programme of Medicine and Health, Faculty of Medicine, Udayana University, Denpasar, Bali
2
Departmen of Pathology Anatomy RSUP Sanglah/ Faculty of Medicine, Udayana University, Denpasar, Bali Email: judearvindraj@gmail.com
Abstract: Giant cell tumors of bone (GCTB) are kind of benign tumors with potential of aggressive and capability to metastase. GCTB is more common in Asia and occur around the knee. In Asia, most cases shown in men. Curettage alone has been the standard treatment for GCTB, but it has been associated with a relatively high risk of local recurrence ranging up to 35–40%. The study was cross sectional conducted with retrospective descriptive design. Samples of 38 patients diagnosed with Giant Cell Tumor of Bone (GCTB) at the Sanglah Hospital Denpasar Medical Record Installation, Bali for the period 2015-2019 were selected based on inclusion and exclusion criteria. Data were analyzed using SPSS software to obtain distribution, frequency based on age, sex, tumor location, mitotic activity, recurrency. The case of giant cell tumor of bone (GCTB) of bone at Sanglah General Hospital Denpasar Bali in 2015-2019 was 38 people, the patient characteristics were mostly women (65,8%) with an age range dominated by the 2nd to 4th decade or life (47.4%). Characteristics of GCT of bone indicate the location of the distal femur is the most common case (26,3%) with mitotic activity of 1 and 3 per 10 hpfs and only 5.3% of cases of recurrent GCTB. It was concluded that the case of gian cell tumor of bone (GCTB) of bone at Sanglah General Hospital Denpasar Bali in 2015-2019 mostly women (21-40) and the location of the distal femur is the most common case with mitotic activity of 1 and 3 per 10 hpfs and only 5.3% of cases of recurrent GCTB. Keywords: clinicopathology, recurrenct, giant cell tumor of bone (GCTB).
1. INTRODUCTION Giant cell tumors (GCT) are some kind of benign tumors with potential of aggressive behaviour and capability to metastase. GCT represents about 5% of all main bone tumors with the metastase rate is around 1%-9%. Approximately half of these lesions occur at the age of 30 to 40. 1 GCT of bone (GCTB) is one of the GTCs that is locally aggressive composed of mononuclear cell’s sheets, affecting the metaphysis of long bones primarily. Recently, the incidence was estimated at between 1.03-1.33 per million per year in the registry of Australia, Japan and Sweden. Median age of onset ranges between 20-40 years old with an equal distribution between gender, although female are slightly predominance.2 The prevalence of GCT peaks during the 3rd decade, with 80% of cases occurring between 20 and 50 years of age. Less than 3% of cases occur before the age of 14 years, and only 13% of cases occur in patients over the age of 50 years. Most lesions develop in long bones (75%–90%), with the majority of cases (50%–65%) occurring about the knee. The three most common locations are the distal femur, proximal tibia, and distal radius, respectively. GCT may occur in association with Paget disease, most commonly in the skull, facial bones, pelvis, and spine. GCTB is more common in Asia, accounting for 20% of primary bone tumor and occur around the knee. In Asia, most cases shown in men with gender
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