International Journal of Healthcare Sciences ISSN 2348-5728 (Online) Vol. 8, Issue 2, pp: (261-276), Month: October 2020 - March 2021, Available at: www.researchpublish.com
Pharmacological approach for the treatment of diabetic neuropathic pain: A Control of discomfort using gene therapy Yousif Safaa Aldeen Subhi Al Daghestani1, Faruk Yusuf1, Manish Kumar1, Indu Melkani1, Bimlesh Kumar1*, Linu Dash1, Anupriya1, Varimadugu Bhanukirankumar Reddy1, Amrik Singh2, Amarish Kumar Sarma3 1
School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, India 2
School of Hotel Management, Lovely Professional University, Phagwara, Punjab, India
3
Scool of Bioengineering & Bioscience, Lovely Professional University, Phagwara, Punjab, India.
Abstract: Diabetes Mellitus is one of the most common diseases in the world, affecting millions of peoples every year, one of its most serious complications is diabetic neuropathy and the associated neuropathic pain resulting from various causes within the body of a diabetic patient, most commonly it is the nerve damage that causes this pain due to over accumulation of glucose in the body, but this is not the sole reason for pain generation. In this review article, different factors causing the pain in diabetic patients is discussed alongside with pathogenesis of diabetic neuropathy to understand the mechanism of pain generation and it treatment options based on gene therapy techniques dealing with pain generation and sensation on cellular and molecular basis. Gene therapy is a modern revolutionary technique aiming at treating the cause of the pain rather than masking the pain sensation like conventional therapy techniques do, however, gene therapy is a novel technique which is still not fully developed and still have a number of challenges and limitations regarding its safety, effectiveness and cost. Keywords: Neuropathic Pain, Gene Therapy, Diabetes Mellitus, Diabetic Neuropathy.
1. INTRODUCTION 1.1 Diabetes Mellitus Diabetes mellitus, commonly known as “diabetes”, is a chronic noncommunicable prevalence disease globally, occurring when there is inadequate production of insulin from the pancreas (Type 1) or the inability of the body to utilize the produced insulin effectively (Type 2), uncontrolled diabetes can lead to accumulation of glucose in the blood, elevating it levels, creating a status of “hyperglycaemia” causing multiple hazards to the health and well-being of the patient, including damage to the blood vessels, nerves and other vital organs.1 Diabetes mellitus has been increasing at an alarming rate, as showing in the below charts, according to the International Diabetes Federation (IDF) database, there has been more than 205% increase in diagnosed cases from 2000 to 2019, with further increase expected in the upcoming years.2
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