International Journal of Healthcare Sciences ISSN 2348-5728 (Online) Vol. 8, Issue 2, pp: (126-140), Month: October 2020 - March 2021, Available at: www.researchpublish.com
ASPIRIN RESISTANCE & LOW OMEGA-3 INDEX – GREATER CHANCES OF CVD MORTALITY ESPECIALLY IN COVID-19 1
Dr. Manoj Kumar, 2Dr. Nishant Tyagi, 3Mahima Singla, 4Himanshu Bhatia, 5 Aaeesha Vyas, 6Ved Sharma 1
M.D., D.M. (Cardiology), FACC Director Cardiology & HOD Cath Lab, Max Super Speciality Hospital, Patparganj, Delhi, India 2
MBBS, MD Medicine, DNB Cardiology Senior Consultant, Max Super Speciality Hospital, Patparganj, Delhi, India 3
MSc., M. Phil.( Interdisciplinary Sciences) Product Manager, Butson Biosciences, Delhi, India 4
M. Pharm (Pharmaceutical Sciences) Group Product Manager, Butson Biosciences, Delhi, India 5
MBA Assistant Product Development Manager, Butson Biosciences, Delhi, India 6
Premedical Graduate Product Development Manager, Butson Biosciences, Delhi, India
Abstract: Low mortality rate of about 1.5% and optimism bias have changed the attitude of general public towards COVID-19. Though COVID-19 cases are increasing in India but mostly they remain in mild stage with 92.6% recovery and 1.48% mortality rate till 10th Nov. 2020 as per WHO reports. According to another study more than 75% of patients experience mild to moderate symptoms and recover without hospitalization. Just 5% patients progress to critical stage with 2-2.5% mortality rate. COVID-19 associated coagulopathy (CAC), the main cause of mortality have been reported mainly in subgroup of patients with comorbidities like CVD, hypertension, diabetes and cancer etc. OBJECTIVE:- Our objective is to identify the factors responsible for COVID-19 symptoms progressing to life threatening CAC and their management. DISCUSSION:- Excessive coagulation with fibrinolytic shutdown is the hallmark of CAC. Cytokine storm induced over expression of Tissue Factor is the potential trigger for CAC. Pharmacological properties of aspirin, like antiinflammatory and antithrombotic can be used as an evidence to hypothesize its use as a primary preventive treatment for CAC. Most of the patients are already taking aspirin for this purpose. But rising trend in aspirin resistance has made aspirin totally undependable. Omega-3 index (Omega-6/ omega-3 ratio) determines cardiovascular health. More than 8% is cardioprotective and less than 4% leads to major adverse cardiac events. Omega-3 reduces platelet aggregation, coagulation and thrombosis. High omega-6 levels cause coagulation. Omega-6 fatty acid (AA) is the substrate for the synthesis of a variety of proinflammatory/ proaggregatory molecule such as prostaglandin E2, thromboxane A2 (TXA2), & leukotriene B4.
Page | 126 Research Publish Journals