ISSN 2348-1218 (print) International Journal of Interdisciplinary Research and Innovations ISSN 2348-1226 (online) Vol. 11, Issue 1, pp: (17-26), Month: January 2023 - March 2023, Available at: www.researchpublish.com
HBVR: A Global Repository for Genomics, Phylogenetics, and Therapeutics Research on Hepatitis B Virus Vanshika Sharma1 1
MTech (Bioinformatics), Department of Biological Sciences & Engineering 1
Netaji Subhas University of Technology, New Delhi, India DOI: https://doi.org/10.5281/zenodo.7541317
Published Date: 16-January-2023
Abstract: Hepatitis B is a pernicious disease that causes liver contagion and is spread by the hepatitis B virus. It is well known to cause acute as well as chronic infection in the body and expose people to major diseases such as hepatic cirrhosis and hepatocellular carcinoma (liver cancer). To facilitate research on this virus, a multi-omics platform called HBVR (Hepatitis B Virus Repository) has been developed containing information related to the Hepatitis B virus, which specifically focuses on the genomic, phylogenetic and therapeutic study of the virus. This database comprises genome sequences as well as related functional information of the viral proteins. It renders complex analysis results such as codon usage and context, CpG islands, and phylogenetic analysis. In addition, glycosylation patterns and primers interpretation were analysed for the viral protein and genome sequences respectively. New promising candidates were predicted for therapeutically important constituents such as vaccine epitopes, smallinterfering RNAs, micro RNAs, and information about the useful drug and drug targets on viral genome sequences. The therapeutic results predicted in the research further can be used to design effective hepatitis B vaccines and drugs. The repository is freely available at www.hbvr-nsut.in and is built in C#, ASP.Net Framework 4.7, and MS SQL Server 2016, with majority of the browsers supported. Keywords: Hepatitis B Virus, Genomics, Multi-Omics Database, Phylogenetic, Therapeutic, Web Repository.
I. INTRODUCTION 1.1 Hepatitis B Overview Hepatitis B is amongst the major worldwide spread viral contagion that invades the liver and may cause acute and chronic diseases. W.H.O estimates that in 2019, 296 million people were facing chronic hepatitis B disease, and each year approximately 1.5 million new infections have been recorded. In 2019, hepatitis B resulted in approximately 8.2 lakh deaths due to liver carcinoma. The hepatitis B virus (HBV) is transferred via biological liquid such as blood, urine, etc., or from an infected mother during child delivery, as well as, from unreliable injections [1]. Chronic hepatitis B virus is associated with developing liver cirrhosis, followed by hepatocellular carcinoma (HCC), i.e., amongst the major types of human liver cancer [2]. Nowadays, available anti-HBV drugs are being used to prevent the disease but are not able to cure it completely. Chronic HBV infection has been detected amongst 15-40% population of the world, out of which 25% people die prematurely because of such diseases. Hepatitis B positive population is also susceptible to hepatitis D virus infection [3].
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