ISSN 2348-313X (Print) International Journal of Life Sciences Research ISSN 2348-3148 (online) Vol. 10, Issue 4, pp: (92-96), Month: October - December 2022, Available at: www.researchpublish.com
Functional indices of vitamin D status and consequences of vitamin D deficiency FAHAD ABDULAZIZ ALKHARAAN1*, NAWAF TURKY ALENIZI2, MOHAMMED HADI ALHABABI3, NORA MUNAHI ALMUTAIRI4, Abdullah Abdulrzaq Aljuwayi5 1*
2
Corresponding Author: HEALTH ADMINISTRATION SPECIALIST, GENERAL DIRICTORATE OF HEALTH AFFAIRS IN RIYADH REGION, Riyadh, SA
HEALTH INFORMATIC SPECIALIST, GENERAL DIRICTORATE OF HEALTH AFFAIRS IN RIYADH REGION, Riyadh, SA
3
RADIOLOGY TECHNICIAN, GENERAL DIRICTORATE OF HEALTH AFFAIRS IN RIYADH REGION, Riyadh, SA 4
NURSE TECHNICIAN, GENERAL DIRICTORATE OF HEALTH AFFAIRS IN RIYADH REGION, Riyadh, SA 5
Medical technologist II, KFMC, Riyadh, SA DOI: https://doi.org/10.5281/zenodo.7488592
Published Date: 28-December-2022
Abstract: Serum 25-hydroxyvitamin D3 [25(OH)D3] concentrations are currently recognized as the functional status indicator for vitamin D. Evidence is reviewed that shows that serum 25(OH)D 3 concentrations of < 80 nmol/L are associated with reduced calcium absorption, osteoporosis, and increased fracture risk. For typical older individuals, supplemental oral intakes of ~1300 IU/d are required to reach the lower end of the optimal range. Evidence of substantial problems in routine clinical measurement of serum 25(OH)D3 concentrations among patients is cited. There is great need for standardization and improved reproducibility and sensitivity of measurements of serum 25(OH)D3 concentrations. Keywords: Rickets, Osteomalacia, Osteoporosis, Calcium absorption, Fractures, Serum 25-hydroxyvitamin D3.
1. INTRODUCTION In its recent review of recommended intakes of bone-related nutrients, the Food and Nutrition Board (FNB) identified serum concentrations of 25-hydroxyvitamin D3 [25(OH)D3] as a suitable functional indicator of vitamin D status (1) . However, based on the evidence available at the time, the FNB Panel on Calcium and Related Nutrients was unable to associate specific serum 25(OH)D3 concentrations with various health and disease states. The panel report also recognized that solar vitamin D synthesis in the skin is an important source of vitamin D, but the data available at the time did not allow estimation of the usual or optimal ratios of intakes from dermal and ingested sources. p> However, the increase in intake recommendations from 200 IU/day (5 µg/day) before age 50 to 600 IU/day (15 µg/day) at age ≥70 years reflects the realization that the contribution from cutaneous sources decreases with age. In addition, in the absence of the required information, the FNB again used the absence of rickets and osteomalacia as de facto indicators of vitamin D adequate intake. Other health or disease-related consequences were not considered in the vitamin D intake recommendations. Although much additional work remains to be done, enough information has been developed over the past 8 years to fill some of the information gaps faced by the Panel on Calcium and Related Nutrients in its deliberations in the mid 1990's This brief overview highlights certain aspects of this new information.
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