ISSN 2348-313X (Print) International Journal of Life Sciences Research ISSN 2348-3148 (online) Vol. 8, Issue 1, pp: (64-70), Month: January - March 2020, Available at: www.researchpublish.com
EVALUATION OF VARIOUS BRANDS OF TELMISARTAN IP FOR ITS QUALITY CONTROL TEST Vinoth R1, Sowmya M2, Dr K Balamurugan3, Dr M Swamivelmanickam4 Department of Pharmacy, Annamalai University, Chidambaram, Tamil Nadu, India vinothbpharm16@gmail.com
Abstract: Telmisartan is a Cardiovascular drug used to treat high blood pressure, heart failure, and diabetic kidney disease and belongs to the Angiotensin II receptor blocker. The drug absorption varies in different patients from the gut. Selected brands of Telmisartan IP 40 mg were procured from the market with the same label claim amount of drug for quality control test. Various quality control tests such as weight variation, friability, disintegration, dissolution and uniformity content were performed as per Indian Pharmacopeia. The quality control tests were done for five different brands of Telmisartan IP marketed Products. The result proved that the Telmisartan IP 40 mg, varies with disintegration, dissolution, uniformity content tests but within the limit. Further studies are needed to support the variation in the quality control test with human volunteers. Keywords: Telmisartan, Angiotensin II receptor, Drug absorption, Quality control tests.
1. INTRODUCTION Telmisartan is a Cardiovascular drug. It is widely used to treat high blood pressure, heart failure, and diabetic kidney disease and belongs to the Angiotensin II receptor blocker. It works by blocking the renin-angiotensin system (ACE Inhibitors). It usually binds with the angiotensin II type 1 (AT1) receptors which have a high affinity, causing the inhibition of the action of the angiotensin II on vascular smooth muscle, which leads to the decrease in the arterial blood pressure[1]. Usually, the drug absorption varies with different patients from the gut. In the higher dose, it may lead to a fast heartbeat, severe dizziness, and fainting. The objective of the present experiment was to evaluate the quality control tests of various brands of commercially available Telmisartan IP 40mg tablets. Various quality control tests such as weight variation, friability, disintegration, uniformity content, and dissolution were performed as per Indian Pharmacopeia.
2. QUALITY CONTROL TEST I. Weight Variation: The weight of the tablet is usually determined by the quantity of powder fill in the die of a tablet press. The volume of fill is adjusted with the first few tablets to yield the desired weight and content[2]. If there is any improper flow of powder to the die, it forms the uneven tablets which contain the low dose or high dose of the drug. The percentage of deviation allowed as per IP is 10% for 80mg or less, 7.5 % for 80mg to 250mg, 5% for more than 250mg. For Telmisartan tablets it is 10%. II. Friability: Friability is a tablet's durability or the ability of the tablets to withstand the mechanical shocks during manufacturing, packing, handling, and shipping. It is intended to determine the physical strength of the tablet. It is one of the in-process quality control tests for tablets. The maximum loss of percentage allowed as per IP is 1%. For Telmisartan tablets of various brands, the average is found to be 0.8%.
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