International Journal of Healthcare Sciences ISSN 2348-5728 (Online) Vol. 10, Issue 1, pp: (1-7), Month: April 2022 - September 2022, Available at: www.researchpublish.com
A Literature Review of Hereditary Sensory and Autonomic Neuropathy (HSAN/HSN) Thanakrit Vasuprasat Triam Udom Suksa Phatthanakan School, Bangkok, Thailand
Published Date: 08-April-2022
Abstract: Hereditary Sensory and Autonomic Neuropathy (HSAN/HSN) are genetically heterogeneous disorders of the peripheral nervous system that affect the sensory and autonomic neurons. Hereditary Sensory and Autonomic Neuropathy (HSAN/HSN) there are total of 13 different genes are mutated and the disease is transmitted through Autosomal recessive and Autosomal dominant inheritance. Which all 13 genes will cause different types of Hereditary Sensory and Autonomic Neuropathy (HSAN/HSN) each type of Hereditary Sensory and Autonomic Neuropathy (HSAN/HSN) has different symptoms according to each type. Objective: In order to collect information about the Hereditary Sensory and Autonomic Neuropathy (HSAN/HSN) Methods: A literature review on Hereditary Sensory and Autonomic Neuropathy (HSAN/HSN) related articles and researches Keywords: Hereditary sensory and Autonomic neuropathy, Hereditary Sensory and Neuropathy, Hereditary sensory and Autonomic neuropathy Type I, Hereditary sensory and Autonomic neuropathy Type IA, Hereditary sensory and Autonomic neuropathy Type IB, Hereditary sensory and Autonomic neuropathy Type IC, Hereditary sensory and Autonomic neuropathy Type ID, Hereditary sensory and Autonomic neuropathy Type IE, Hereditary sensory and Autonomic neuropathy Type II, Hereditary sensory and Autonomic neuropathy Type IIA, Hereditary sensory and Autonomic neuropathy Type IIB, Hereditary sensory and Autonomic neuropathy type III, Hereditary sensory and Autonomic neuropathy Type IV, Hereditary sensory and Autonomic neuropathy Type V, Hereditary sensory and Autonomic neuropathy Type VI, Hereditary sensory and Autonomic neuropathy Type VII, Hereditary sensory and Autonomic neuropathy Type VIII, HSAN, HSAN I, HSAN IA, HSAN IB, HSAN IC, HSAN ID, HSAN IE, HSAN IIA, HSAN IIB, HSAN III, HSAN IV, HSAN V, HSAN VI, HSAN VII, HSAN VIII, HSN, Congenital sensory neuropathy, Familial dysatonomia, Congenital insensitivity to pain with anhidrosis, CIPA, Congenital insensitivity to pain, CIP.
I. INTRODUCTION Hereditary Sensory and Autonomic Neuropathy (HSAN/HSN) is a genetic disorders a type caused by a single gene disorder which describes the neurodegenerative disease that progressive loss of function that predominantly affects the peripheral sensory nerves. There are a total of 8 types different clinical entities have been described under hereditary sensory and autonomic neuropathies. Each Hereditary Sensory and Autonomic Neuropathy (HSAN/HSN) are all characterized such as Cause, Gene, Symptom. Hereditary Sensory and Autonomic Neuropathy Type I (HSAN I / HSN I) Hereditary Sensory and Autonomic Neuropathy Type I (HSAN I / HSN I) is a condition characterized by nerve abnormalities in the legs and feet. People with Hereditary Sensory and Autonomic Neuropathy Type I (HSAN I / HSN I) have tingling, weakness, and a reduced ability to feel pain and sense hot and cold in their leg and feet. somebody affected individuals do not lose sensation, but instead feel shooting pains. When the disorder progresses without treatment the sensory abnormalities can affect the hands, arms, shoulders, and abdomen. People with Hereditary Sensory and Autonomic Neuropathy Type I (HSAN I / HSN I) often have open sores on their feet, hands or infections of the soft tissue of the fingertips. The patient has a slow self-healing because affected individuals cannot feel the pain of these sores before the infection sores is knows, the sores may have dead tissue all ready. It rarely, people with Hereditary Sensory and
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