Pharmacy Immunology Question Bank
Course Introduction
Pharmacy Immunology provides students with a comprehensive understanding of the immune system's components, functions, and regulatory mechanisms as they relate to health, disease, and therapeutic intervention. This course explores the molecular and cellular basis of immune responses, including innate and adaptive immunity, immunopathology, hypersensitivity reactions, transplantation, immunodeficiency, and autoimmunity. Special emphasis is placed on the role of immunology in the development and use of vaccines, immunotherapies, and biologic drugs, as well as the implications for pharmaceutical care. The course integrates case studies and current research to illustrate the relevance of immunology in clinical pharmacy practice.
Recommended Textbook
Basic Immunology Functions and Disorders of the Immune System 4th Edition by Abul K. Abbas
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12 Chapters
181 Verified Questions
181 Flashcards
Source URL: https://quizplus.com/study-set/1165 Page 2
Chapter 1: Introduction to the Immune System
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16 Verified Questions
16 Flashcards
Source URL: https://quizplus.com/quiz/23007
Sample Questions
Q1) Which of the following infectious diseases was prevented by the first successful vaccination?
A)Polio
B)Tuberculosis
C)Smallpox
D)Tetanus
E)Rubella
Answer: C
Q2) Which of the following is a unique property of the adaptive immune system?
A)Highly diverse repertoire of specificities for antigens
B)Self-nonself discrimination
C)Recognition of microbial structures by both cell-associated and soluble receptors
D)Protection against viral infections
E)Responses that have the same kinetics and magnitude on repeated exposure to the same microbe
Answer: A
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3
Chapter 2: Innate Immunity
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17 Verified Questions
17 Flashcards
Source URL: https://quizplus.com/quiz/23008
Sample Questions
Q1) All of the following molecules are opsonins that facilitate efficient phagocytosis of microbes by neutrophils and macrophages EXCEPT:
A)C3b
B)C5a
C)C-reactive protein
D)IgG
E)Mannose-binding lectin
Answer: B
Q2) Which one of the following statements about inhibitory receptors on natural killer (NK) cells is true?
A)Inhibitory receptors on NK cells express ITAM motifs in their cytoplasmic tails.
B)Some inhibitory receptors on NK cells recognize HLA-A or HLA-C.
C)Some inhibitory receptors on NK cells are members of the integrin family.
D)Some inhibitory receptors on NK cells are members of the Toll-like receptor family.
E)Inhibitory receptors on NK cells are not expressed on the same NK cells that express activating receptors.
Answer: B
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Chapter 3: Antigen Capture and Presentation to Lymphocytes
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17 Verified Questions
17 Flashcards
Source URL: https://quizplus.com/quiz/23009
Sample Questions
Q1) In the class I MHC pathway of antigen presentation, cytoplasmic proteins are tagged for proteolytic degradation by covalent linkage with which of the following molecules?
A)Calreticulin
B)Nuclear factor (NF)- B
C)Tapasin
D)Ubiquitin
E)Calnexin
Answer: D
Q2) In the class I MHC pathway of antigen presentation, peptides generated in the cytosol are translocated into the endoplasmic reticulum in which of the following ways?
A)By ATP-dependent transport via the transporter associated with antigen-processing (TAP) 1/2 pump
B)By passive diffusion
C)By receptor-mediated endocytosis
D)Through membrane pores
E)Via the proteasome
Answer: A
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5
Chapter 4: Antigen Recognition in the Adaptive Immune System
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17 Verified Questions
17 Flashcards
Source URL: https://quizplus.com/quiz/23010
Sample Questions
Q1) CD8 is a protein that functions as a coreceptor for a subset of T cells and plays a significant role in all of the following EXCEPT:
A)Recognition of peptide antigen bound to class I MHC molecules
B)Maturation of MHC class I-restricted T cells
C)Infection of T cells by human immunodeficiency virus (HIV)
D)Signaling via Lck tyrosine kinase to initiate T cell activation
E)Strengthening the binding of T cells to antigen-presenting cells, albeit with low affinity
Q2) Most T lymphocytes have a dual specificity for which one of the following pairs of molecules?
A)A particular allelic form of a major histocompatibility complex (MHC) molecule and a peptide bound to the MHC molecule
B)Both MHC class I and class II molecules
C)Both peptide and glycolipid antigens
D)Both soluble peptides and peptide-MHC complexes
E)MHC molecules and CD4 or CD8
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Page 6
Chapter 5: T Cell Mediated Immunity
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15 Verified Questions
15 Flashcards
Source URL: https://quizplus.com/quiz/23011
Sample Questions
Q1) Which one of the following statements about T cells involved in an immune response is NOT true?
A)Activated T cells receive survival signals from antigen during an infection.
B)Activated T cells contribute to the activation of antigen-presenting cells via CD40 ligand.
C)Memory T cells generated during a primary immune response express high levels of interleukin-2 receptors and actively proliferate long after the primary response is completed.
D)The major effector function of helper T cells is to activate macrophages and other cells by releasing cytokines.
E)When an infection is eliminated, activated T cells die by apoptosis.
Q2) Which one of the following descriptions of cytokine interleukin-2 is NOT true?
A)Expression of its gene requires multiple transcription factors, such as Fos, Jun, and NFAT.
B)It acts as an autocrine growth factor for T cells.
C)It binds to CD25 on the cell membrane of T cells.
D)It is only involved in the proliferation of helper T cells and not CTLs.
E)It promotes susceptibility of T cells to apoptosis.
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Page 7
Chapter 6: Effector Mechanisms of T Cell Mediated Immunity
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10 Verified Questions
10 Flashcards
Source URL: https://quizplus.com/quiz/23012
Sample Questions
Q1) Which of the following statements about cell-mediated immunity (CMI) is NOT true?
A)Deficiencies in CMI result in susceptibility to infections by viruses and intracellular bacteria.
B)CMI can be adoptively transferred by injecting serum from one individual to another.
C)Delayed-type hypersensitivity (DTH) is not a protective response against intracellular bacteria such as Mycobacterium tuberculosis.
D)The principal form of CMI that protects against viral infections is mediated by CD8 cytolytic T lymphocytes.
E)Phagocytes are essential in the effector phase of CMI responses to bacteria such as Listeria monocytogenes.
Q2) Differentiation of TH2 cells from naive precursor cells is dependent on which of the following?
A)Toll-like receptor (TLR) ligands
B)T-bet
C)Interleukin-12
D)GATA-3
E)Interferon-
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Page 8
Chapter 7: Humoral Immune Responses
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17 Verified Questions
17 Flashcards
Source URL: https://quizplus.com/quiz/23013
Sample Questions
Q1) Which of the following events does NOT occur within germinal centers?
A)Somatic mutation of Ig V genes
B)Generation of memory B cells
C)B cell proliferation
D)Affinity maturation
E)Ig gene V(D)J recombination
Q2) Which one of the following B cell responses is NOT stimulated by CD40 ligand?
A)Association of TRAFs with the cytoplasmic tails of CD40 molecules
B)Activation of NF- B
C)Enhanced expression of B7-1 and B7-2
D)Enhanced Ig isotype switch recombinase activity
E)Enhanced production of membrane Ig
Q3) Which one of the following molecules is important for the production of IgE antibodies?
A)CD28
B)CD40
C)IFN-
D)IL-2
E)TGF-
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Chapter 8: Effector Mechanisms of Humoral Immunity
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13 Verified Questions
13 Flashcards
Source URL: https://quizplus.com/quiz/23014
Sample Questions
Q1) All of the following are accurate statements about neonatal immunity EXCEPT:
A)Transfer of maternal IgG across the placenta is mediated by an Fc receptor structurally similar to class I MHC.
B)IgA is absorbed in the gut from breast milk and re-secreted by the infant into the bronchial mucosa.
C)IgA secretion into breast milk involves transport through breast epithelial cells, and is dependent on the poly-Ig receptor.
D)Transport of IgG across the neonatal intestinal epithelium is mediated by an Fc receptor structurally similar to class I MHC.
E)Loss of maternal antibodies is partly responsible for increased frequency of infections in infants at about 6 months of age.
Q2) Which of the following is NOT a property of the classical pathway C3 convertase?
A)Composed of proteolytic fragments of C4 and C2
B)Has protease activity specific for C3 to form C3b
C)Inhibited by decay acceleration factor (DAF)
D)Stabilized by C4 binding protein (C4bp)
E)Same substrate specificity as the alternative pathway C3 convertase
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Chapter 9: Immunological Tolerance and Autoimmunity
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17 Verified Questions
17 Flashcards
Source URL: https://quizplus.com/quiz/23015
Sample Questions
Q1) Which of the following statements about induction or maintenance of T cell tolerance is NOT true?
A)Central tolerance is induced when immature developing T cells in bone marrow or thymus encounter self antigens.
B)Peripheral T cell tolerance results when mature naive T cells recognize antigens without adequate B7-1- or B7-2-mediated costimulation.
C)Peripheral T cell tolerance results when T cells recognize antigen in the setting of an innate immune response to the antigen.
D)Peripheral T cell tolerance to some antigens is induced when mature T cells recognize antigen and bind B7-1 or B7-2 via the inhibitory CTLA-4 receptor.
E)Peripheral T cell tolerance to an antigen may be induced by persistent and repeated stimulation of lymphocytes by that antigen in tissues.
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11
Chapter 10: Immune Responses against Tumors and Transplants
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10 Verified Questions
10 Flashcards
Source URL: https://quizplus.com/quiz/23016
Sample Questions
Q1) All of the following statements about immune responses to tumors are true EXCEPT:
A)T cells specific for tumor antigens can be found in many human tumor patients.
B)Antibodies specific for tumor antigens can be found in many human tumor patients.
C)The presence of lymphocytic infiltrates in certain tumors is associated with a better prognosis than lymphocyte-poor tumors of the same histologic type.
D)Immunodeficient individuals are more likely to develop the most common forms of cancer than are immunocompetent individuals.
E)The host immune response is usually incapable of eradicating tumors once they are established.
Q2) Which of the following molecules is involved in the principal mechanism by which the immune system kills tumor cells?
A)Perforin
B)Complement C3
C)IgG
D)TGF-
E)Interleukin-2
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Chapter 11: Hypersensitivity
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14 Verified Questions
14 Flashcards
Source URL: https://quizplus.com/quiz/23017
Sample Questions
Q1) Which of the following conditions is NOT associated with immune complex deposition?
A)Arthus reaction
B)Autoimmune hemolytic anemia
C)Serum sickness
D)Systemic lupus erythematosus
E)Poststreptococcal glomerulonephritis
Q2) An 8-year-old boy from the intermountain region of the United States is brought to the pediatrician with fever, rash, and pain in his knees and ankles. Pericarditis is evident on auscultation, and echocardiography confirms mitral valve regurgitation. Three weeks before this episode, the patient had experienced a sore throat but had not received medical attention. High titers of antistreptococcal antibodies are present in the serum. This child's disease is a result of which one of the following phenomena?
A)Clonal anergy
B)Peripheral tolerance
C)Epitope spreading
D)Central tolerance
E)Molecular mimicry
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Chapter 12: Congenital and Acquired Immunodeficiencies
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18 Verified Questions
18 Flashcards
Source URL: https://quizplus.com/quiz/23018
Sample Questions
Q1) A 3-year-old boy is taken to the pediatrician because of a nosebleed (epistaxis). He has a history of severe, recurrent sinopulmonary infection. Physical examination is remarkable for dry, red patches of skin (eczema) and multiple petechiae (tiny hemorrhagic spots). Laboratory findings include thrombocytopenia and reduced IgM levels. The boy's maternal uncle died of bleeding complications after an emergency appendectomy. Which of the following is the most likely diagnosis?
A)Reticular dysgenesis
B)Wiskott-Aldrich syndrome (WAS)
C)Chédiak-Higashi syndrome
D)Ataxia-telangiectasia
E)DiGeorge syndrome
Q2) Which one of the following is typically NOT associated with T cell immunodeficiencies?
A)Cancer
B)Viral infection
C)Autoimmunity
D)Infection with intracellular microbes
E)Infection with pyogenic bacteria
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