Pharmacy Immunology
Final Exam Questions
Course Introduction
Pharmacy Immunology is a foundational course that explores the principles and mechanisms of the immune system with a focus on their relevance to pharmaceutical sciences and patient care. The course covers topics such as the innate and adaptive immune responses, antigen-antibody interactions, immunological disorders, vaccines, immunotherapy, and the role of immunology in drug development and pharmacotherapy. Students will gain an understanding of how immunity influences disease mechanisms, the action of pharmaceuticals, and the development of new therapeutic agents, preparing them for informed clinical decision-making and research in pharmacy practice.
Recommended Textbook
Basic Immunology Functions and Disorders of the Immune System 4th Edition by Abul K. Abbas
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12 Chapters
181 Verified Questions
181 Flashcards
Source URL: https://quizplus.com/study-set/1165 Page 2
Chapter 1: Introduction to the Immune System
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16 Verified Questions
16 Flashcards
Source URL: https://quizplus.com/quiz/23007
Sample Questions
Q1) A vaccine administered in the autumn of one year may protect against the prevalent strain of influenza virus that originated in Hong Kong that same year, but it will not protect against another strain of influenza virus that originated in Russia. This phenomenon illustrates which property of the adaptive immune system?
A)Specificity
B)Amnesia
C)Specialization
D)Cultural diversity
E)Self-tolerance
Answer: A
Q2) In addition to T cells, which cell type is required for initiation of all T cell-mediated immune responses?
A)Effector cells
B)Memory cells
C)Natural killer cells
D)Antigen-presenting cells
E)B lymphocytes
Answer: D
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Chapter 2: Innate Immunity
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17 Verified Questions
17 Flashcards
Source URL: https://quizplus.com/quiz/23008
Sample Questions
Q1) A 4-year-old girl stepped on a rusty nail in her backyard. Two days later, she is taken to the pediatrician because her heel is painful, red, and swollen and is warm to the touch. All of the following are mechanisms of innate immunity that may be protecting the patient against pathogenic microbes in the heel wound EXCEPT:
A)Epithelial barrier function of the skin of her foot
B)Intraepithelial lymphocytes present in the skin
C)Circulating neutrophils migrating to the site of the wound
D)Soluble cytokines that induce a local inflammatory response
E)Circulating anti-tetanus toxin antibodies
Answer: E
Q2) Macrophages and neutrophils express several enzymes that are involved in biochemical mechanisms that kill ingested microbes. Which of the following is NOT an enzyme expressed by these cells?
A)Inducible nitric oxide synthase (iNOS)
B)Granzyme B
C)Phagocyte oxidase
D)Myeloperoxidase
E)Lysozyme
Answer: B
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Page 4
Chapter 3: Antigen Capture and Presentation to Lymphocytes
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17 Verified Questions
17 Flashcards
Source URL: https://quizplus.com/quiz/23009
Sample Questions
Q1) Which type of antigen-presenting cell is most important for activating naive T cells?
A)Macrophage
B)Dendritic cell
C)Endothelial cell
D)B lymphocyte
E)Epithelial cell
Answer: B
Q2) The required number of complexes of a microbial peptide and a particular class II MHC allele on the surface of an antigen-presenting cell to initiate a T cell response specific for the viral peptide is:
A)At least equal to the number of complexes of self peptides with class II MHC on the cell surface
B)Greater than 10³
C)Less than or equal to 0.1% of the total number of class II MHC molecules on the cell surface
D)Greater than 10
E)Zero
Answer: C
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Chapter 4: Antigen Recognition in the Adaptive Immune System
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17 Verified Questions
17 Flashcards
Source URL: https://quizplus.com/quiz/23010
Sample Questions
Q1) After 2 years of hard work, a graduate student finally succeeds in creating a gene knockout mouse lacking CD4. The student is particularly careful to keep this mouse line in a microbe-free animal facility because these mice are expected to show:
A)No ability to produce IgM antibodies
B)Impaired ability to produce antibodies and activate macrophages
C)No ability to activate naive class I-restricted T cells
D)Complete absence of cytotoxic T lymphocyte (CTL) responses to viral infections
E)Failure to produce neutrophils
Q2) CD44 expressed on the surface of T cells is critical for the binding of activated T cells to endothelium at sites of inflammation, and for the retention of T cells in extravascular tissues at sites of infection. CD44 does this by binding to which one of the following molecules?
A)VCAM-1
B)Hyaluronate
C)ICAM-1
D)Fibronectin
E)E-selectin
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Page 6
Chapter 5: T Cell Mediated Immunity
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15 Verified Questions
15 Flashcards
Source URL: https://quizplus.com/quiz/23011
Sample Questions
Q1) Which one of the following signaling molecules, if mutated, would affect B cell maturation and function primarily without affecting T cell function?
A)Btk
B)Itk
C)Tec
D)PI-3 kinase
E)Zap-70
Q2) All of the following protein-protein interactions are involved in activation of naive helper T cells by antigen-presenting cells (APCs) EXCEPT:
A)Binding of peptide-MHC complexes on the APC to the TCR on the T cell
B)Binding of CD4 on the T cell to nonpolymorphic regions of class II MHC molecules on the APC
C)Binding of integrins on the T cell with adhesion ligands on the APC
D)Binding of B7-2 on the APC with CD28 on the T cell
E)Binding of CD40L on the T cell with CD40 on the APC
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Chapter 6: Effector Mechanisms of T Cell Mediated Immunity
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10 Verified Questions
10 Flashcards
Source URL: https://quizplus.com/quiz/23012
Sample Questions
Q1) The induction phase of a cell-mediated immune response includes which of the following events?
A)CD4 T cell secretion of interferon- leading to macrophage activation
B)CD8 T cell lysis of a virally infected cell
C)Clonal expansion of CD8 T cells within a lymph node
D)Migration of CD4 effector T cells from blood vessels into a tissue site of infection
E)Migration of a naive CD4 T cell from the thymic medulla into the circulation
Q2) Which pair of molecules is a component of cytolytic T lymphocyte (CTL) granules and is important in the mechanism of CTL killing of target cells?
A)Perforin and Fas ligand
B)P-selectin and tumor necrosis factor
C)Major basic protein and granzyme B
D)C9 and interferon-
E)Perforin and granzyme B
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8
Chapter 7: Humoral Immune Responses
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17 Verified Questions
17 Flashcards
Source URL: https://quizplus.com/quiz/23013
Sample Questions
Q1) Which one of the following statements about primary and secondary antibody responses is NOT true?
A)Antibodies in primary responses generally have lower affinity for antigen than those produced in secondary responses.
B)Secondary responses reach peak levels more quickly than primary responses.
C)Primary responses require higher concentrations of antigen for initiation than secondary responses.
D)Primary responses occur to all types of antigens, but secondary responses mostly occur only to protein antigens.
E)Primary responses are characterized by IgG antibodies, whereas secondary responses are dominated by IgM antibodies.
Q2) Which one of the following molecules is important for the production of IgE antibodies?
A)CD28
B)CD40
C)IFN-
D)IL-2
E)TGF-
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Page 9
Chapter 8: Effector Mechanisms of Humoral Immunity
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13 Verified Questions
13 Flashcards
Source URL: https://quizplus.com/quiz/23014
Sample Questions
Q1) An 8-month-old boy infant with a 3-month history of recurrent upper and lower respiratory tract infections is admitted to the hospital. The physicians consider the possibility of a hereditary immune disorder and run several tests, eventually determining that the patient has undetectable levels of serum IgA. The infant is treated with strong antibiotics and recovers. Which of the following is NOT a medical problem likely to occur in this patient as he gets older?
A)Anaphylactic reactions to blood transfusions
B)Chronic gastrointestinal infections
C)Lactose and wheat gluten intolerance
D)Inflammatory skin disease
E)Recurrent nasal sinus congestion
Q2) Which of the following anatomic regions is normally protected from pathogens only by humoral immune responses and not by cell-mediated immune responses?
A)Skin
B)Intestinal lumen
C)Intestinal epithelium
D)Central nervous system
E)Spleen
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Chapter 9: Immunological Tolerance and Autoimmunity
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17 Verified Questions
17 Flashcards
Source URL: https://quizplus.com/quiz/23015
Sample Questions
Q1) Which one of the following is NOT a mechanism of T cell tolerance?
A)Inhibition of T cell activation by interleukin-12 from regulatory T cells.
B)Apoptosis induced by Fas ligand binding to Fas.
C)Anergy induced by B7-1 or B7-2 binding to CTLA-4.
D)Anergy induced by peptide-major histocompatibility complex (MHC) binding to T cell receptors (TCRs) without B7-1 or B7-2 binding to CD28.
E)TCR-mediated up-regulation of Bim or similar pro-apoptotic proteins.
Q2) Which of the following is NOT a property of regulatory T cells?
A)Interleukin-2 receptor (CD25) expression
B)Secretion of transforming growth factor-
C)Maturation in the thymus
D)Secretion of interferon-
E)Inhibition of function of other T cells
Q3) Failure of self-tolerance is the cause of which one of the following types of diseases?
A)Allograft rejection
B)Autoimmunity
C)Atopy
D)Anergy
E)Acne
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Page 11
Chapter 10: Immune Responses against Tumors and Transplants
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10 Verified Questions
10 Flashcards
Source URL: https://quizplus.com/quiz/23016
Sample Questions
Q1) Patients with which of the following disorders would be LEAST likely to develop Epstein-Barr virus-associated Burkitt's lymphoma?
A)AIDS
B)Bruton's disease
C)DiGeorge syndrome (congenital absence of the thymus)
D)Malarial infection
E)Immunosuppressive therapy for renal allograft
Q2) Which of the following molecules is involved in the principal mechanism by which the immune system kills tumor cells?
A)Perforin
B)Complement C3
C)IgG
D)TGF-
E)Interleukin-2
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Page 12
Chapter 11: Hypersensitivity
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14 Verified Questions
14 Flashcards
Source URL: https://quizplus.com/quiz/23017
Sample Questions
Q1) A 14-year-old boy is brought to the pediatrician's office in mid summer because of an itchy, blistering rash on his calves and forearms. The rash developed 24 hours after he returned from a weekend Boy Scout camping trip. The pediatrician suspects the lesion is caused by poison ivy. If the doctor is correct, which one of the following is NOT a prominent component in the immunologic mechanisms causing the skin lesions?
A)T cells
B)IgE-coated mast cells
C)Interferon-
D)Endothelial adhesion molecules
E)Chemokines
Q2) Which type of hypersensitivity disease is caused by deposition of antigen-antibody complexes in blood vessel walls?
A)Type I
B)Type II
C)Type III
D)Type IV
E)Type V
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Chapter 12: Congenital and Acquired Immunodeficiencies
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18 Verified Questions
18 Flashcards
Source URL: https://quizplus.com/quiz/23018
Sample Questions
Q1) All of the following have a direct role in mediating human immunodeficiency virus (HIV) entry into susceptible cells EXCEPT:
A)CD4
B)MHC class I
C)CCR5
D)CXCR4
E)Env
Q2) An 18-month-old girl is brought to the pediatrician because of recurrent upper respiratory tract infections. She has a fever, labored breathing, and a dry cough. Diagnostic tests confirm infection with Pneumocystis jiroveci. Serum studies are remarkable for negligible levels of IgG and IgA in the presence of high concentrations of IgM. The family history is unremarkable; in particular, the patient's three older brothers are in excellent health. This patient most likely carries a mutation in which of the following molecules?
A)CD18
B)CD40L
C)ZAP-70
D)B7
E)CD40
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Page 14