Pharmacy Immunology Exam Review
Course Introduction
Pharmacy Immunology explores the fundamental principles of the immune system with an emphasis on concepts relevant to pharmaceutical sciences and clinical practice. The course covers the cellular and molecular mechanisms underlying innate and adaptive immunity, antigen-antibody interactions, immunopathology, hypersensitivity reactions, autoimmunity, immunodeficiency diseases, and the impact of immunological principles on the development and use of vaccines, immunotherapies, and biologic drugs. Students will learn how immunological responses affect drug action and safety, as well as the role of pharmacists in immunization programs and managing immunological disorders.
Recommended Textbook
Basic Immunology Functions and Disorders of the Immune System 4th Edition by Abul K. Abbas
Available Study Resources on Quizplus
12 Chapters
181 Verified Questions
181 Flashcards
Source URL: https://quizplus.com/study-set/1165 Page 2
Chapter 1: Introduction to the Immune System
Available Study Resources on Quizplus for this Chatper
16 Verified Questions
16 Flashcards
Source URL: https://quizplus.com/quiz/23007
Sample Questions
Q1) A previously healthy 8-year-old boy is infected with an upper respiratory tract virus for the first time. During the first few hours of infection, which one of the following events occurs?
A)The adaptive immune system responds rapidly to the virus and keeps the viral infection under control.
B)The innate immune system responds rapidly to the viral infection and keeps the viral infection under control.
C)Passive immunity mediated by maternal antibodies limits the spread of infection. D)B and T lymphocytes recognize the virus and stimulate the innate immune response.
E)The virus causes malignant transformation of respiratory mucosal epithelial cells, and the malignant cells are recognized by the adaptive immune system. Answer: B
To view all questions and flashcards with answers, click on the resource link above. Page 3
Chapter 2: Innate Immunity
Available Study Resources on Quizplus for this Chatper
17 Verified Questions
17 Flashcards
Source URL: https://quizplus.com/quiz/23008
Sample Questions
Q1) Toll-like receptors and other receptors are potent activators of various components of the innate immune system. All of the following proteins are expressed in response to signaling by these receptors EXCEPT:
A)Interleukin-12
B)E-selectin
C)Tumor necrosis factor
D)Inducible nitric oxide synthase (iNOS)
E)CD28
Answer: E
Q2) Toll-like receptors (TLRs) are a family of homologous receptors expressed on many cell types and are involved in innate immune responses. Ten different mammalian TLRs have been identified, and several ligands for many of these receptors are known. Which of the following is a TLR ligand?
A)Single-stranded RNA
B)Transfer RNA
C)Double-stranded DNA
D)Unmethylated CpG DNA
E)Heterochromatin
Answer: D
To view all questions and flashcards with answers, click on the resource link above.
4
Chapter 3: Antigen Capture and Presentation to Lymphocytes
Available Study Resources on Quizplus for this Chatper
17 Verified Questions
17 Flashcards
Source URL: https://quizplus.com/quiz/23009
Sample Questions
Q1) A child who suffers from a persistent viral infection is found to have a deficiency in lymphocyte production and very few T and B cells. Other bone marrow-derived cells are produced in normal numbers, and MHC molecule expression on cells appears normal. Transfusion of mature T cells from an unrelated donor who had recovered from a previous infection by the same virus would not be expected to help the child clear his infection. Which one of the following is a reasonable explanation for why this therapeutic approach would fail?
A)Viral infections are cleared by antibodies, not T cells.
B)The patient's own immune system would destroy the transfused T cells before they could respond to the viral infection.
C)T cells recognize peptides, not viral particles.
D)Donor T cell viral antigen recognition is restricted by MHC molecules not expressed in the patient.
E)In responding to the previous infection, the donor would have used up all his T cells specific for that virus.
Answer: D
To view all questions and flashcards with answers, click on the resource link above.
Page 5
Chapter 4: Antigen Recognition in the Adaptive Immune System
Available Study Resources on Quizplus for this Chatper
17 Verified Questions
17 Flashcards
Source URL: https://quizplus.com/quiz/23010
Sample Questions
Q1) A 2-year-old boy suffers from recurrent bacterial infection of his ears, sinuses, lungs, and skin; laboratory studies indicate absence of sialylated Lewis X on his leukocytes. He is diagnosed with leukocyte adhesion deficiency type 2 (LAD-2). Which type of adhesive interaction required for leukocyte migration is defective in this boy?
A)E-selectin ligand binding to E-selectin
B)CD4 binding to class II MHC
C)VLA-4 binding to VCAM-1
D)Ig Fc receptor binding to Ig-coated cells
E)LFA-1 binding to ICAM-1
Q2) Which of the following is NOT a property shared by both CD4 and CD8?
A)Binds to nonpolymorphic regions of MHC molecules
B)Cytoplasmic tail associates with the Src family kinase Lck
C)Is a member of the Ig superfamily
D)Functions as a coreceptor for TCRs
E)Is expressed on the majority of mature blood T cells
To view all questions and flashcards with answers, click on the resource link above. Page 6
Chapter 5: T Cell Mediated Immunity
Available Study Resources on Quizplus for this Chatper
15 Verified Questions
15 Flashcards
Source URL: https://quizplus.com/quiz/23011
Sample Questions
Q1) All of the following protein-protein interactions are involved in activation of naive helper T cells by antigen-presenting cells (APCs) EXCEPT:
A)Binding of peptide-MHC complexes on the APC to the TCR on the T cell
B)Binding of CD4 on the T cell to nonpolymorphic regions of class II MHC molecules on the APC
C)Binding of integrins on the T cell with adhesion ligands on the APC
D)Binding of B7-2 on the APC with CD28 on the T cell
E)Binding of CD40L on the T cell with CD40 on the APC
Q2) Which one of the following accurately depicts the correct order of events in a TCR signal transduction pathway?
A)TCR Lck Zap-70 LAT Grb-2 SOS Ras Erk Fos
B)TCR Lck Zap-70 LAT SOS Grb-2 Ras Erk Fos
C)TCR Lck ITK LAT Grb-2 SOS Ras Erk Fos
D)TCR Lck Zap-70 LAT SOS Grb-2 Ras Erk Jun
E)TCR Lck Zap-70 LAT PLC DAG calcium release
To view all questions and flashcards with answers, click on the resource link above. Page 7
Chapter 6: Effector Mechanisms of T Cell Mediated Immunity
Available Study Resources on Quizplus for this Chatper
10 Verified Questions
10 Flashcards
Source URL: https://quizplus.com/quiz/23012
Sample Questions
Q1) A 23-year-old man who was recently infected by the HIV virus volunteered for investigative studies of his immune response to the virus. Investigators identified cytolytic T lymphocytes (CTLs) in the patient's blood that recognized a particular peptide derived from a protein encoded by the HIV gag gene. Six months later, viral isolates from the patient showed point mutations in the gag gene sequence encoding that peptide. Which of the following statements about the HIV gag mutations is most likely to be correct?
A)The patient's CTL response to the virus provided selective pressure for the emergence of virus carrying the mutation.
B)The CTL that recognized the original gag-encoded peptide will still be able to recognize the mutated Gag peptide.
C)The CTLs specific for the original Gag peptide were incapable of killing HIV-infected cells.
D)The gag mutation will enhance the ability of natural killer cells to recognize and kill HIV infected cells.
E)The gag mutations have more relevance to the viral evasion of the antibody response rather than the CTL response.
To view all questions and flashcards with answers, click on the resource link above. Page 8
Chapter 7: Humoral Immune Responses
Available Study Resources on Quizplus for this Chatper
17 Verified Questions
17 Flashcards
Source URL: https://quizplus.com/quiz/23013
Sample Questions
Q1) Which of the following events does NOT occur within germinal centers?
A)Somatic mutation of Ig V genes
B)Generation of memory B cells
C)B cell proliferation
D)Affinity maturation
E)Ig gene V(D)J recombination
Q2) Antibody feedback is mediated by which of the following molecules?
A)Ig Fc RIIB
B)Ig Fc
C)Ig Fc RI
D)CR1
E)IgM
Q3) Which one of the following B cell responses is NOT stimulated by CD40 ligand?
A)Association of TRAFs with the cytoplasmic tails of CD40 molecules
B)Activation of NF- B
C)Enhanced expression of B7-1 and B7-2
D)Enhanced Ig isotype switch recombinase activity
E)Enhanced production of membrane Ig
To view all questions and flashcards with answers, click on the resource link above.
Chapter 8: Effector Mechanisms of Humoral Immunity
Available Study Resources on Quizplus for this Chatper
13 Verified Questions
13 Flashcards
Source URL: https://quizplus.com/quiz/23014
Sample Questions
Q1) Up to half of the IgG found in the serum of a normal individual is produced by which of the following cells?
A)Naive B cells in lymph nodes
B)Activated B cells in the spleen
C)B cells in germinal centers of lymph nodes
D)B lymphocytes in the gastrointestinal tract
E)Long-lived plasma cells in the bone marrow
Q2) Which of the following events initiates activation of the alternative complement pathway?
A)C1q binding to a microbial surface
B)Mannose-binding lectin (MBL) binding to a microbial surface
C)Complement receptor 1 (CR1) binding of C3b
D)Factor I cleavage of C3
E)Spontaneous cleavage of C3 to C3b
Q3) Which of the following is NOT a property of the classical pathway C3 convertase?
A)Composed of proteolytic fragments of C4 and C2
B)Has protease activity specific for C3 to form C3b
C)Inhibited by decay acceleration factor (DAF)
D)Stabilized by C4 binding protein (C4bp)
E)Same substrate specificity as the alternative pathway C3 convertase
To view all questions and flashcards with answers, click on the resource link above. Page 10
Chapter 9: Immunological Tolerance and Autoimmunity
Available Study Resources on Quizplus for this Chatper
17 Verified Questions
17 Flashcards
Source URL: https://quizplus.com/quiz/23015
Sample Questions
Q1) Which of the following factors generally favors stimulation of an adaptive immune response to an antigen, and not tolerance?
A)Intravenous portal of entry of antigen
B)Presence of antigen in generative lymphoid organs
C)Absence of costimulatory molecules on antigen-presenting cells
D)Innate immune response to the antigen
E)Presence of antigen during the neonatal period
Q2) Which one of the following is NOT a mechanism of T cell tolerance?
A)Inhibition of T cell activation by interleukin-12 from regulatory T cells.
B)Apoptosis induced by Fas ligand binding to Fas.
C)Anergy induced by B7-1 or B7-2 binding to CTLA-4.
D)Anergy induced by peptide-major histocompatibility complex (MHC) binding to T cell receptors (TCRs) without B7-1 or B7-2 binding to CD28.
E)TCR-mediated up-regulation of Bim or similar pro-apoptotic proteins.
To view all questions and flashcards with answers, click on the resource link above. Page 11
Chapter 10: Immune Responses against Tumors and Transplants
Available Study Resources on Quizplus for this Chatper
10 Verified Questions
10 Flashcards
Source URL: https://quizplus.com/quiz/23016
Sample Questions
Q1) All of the following statements about immune responses to tumors are true EXCEPT:
A)T cells specific for tumor antigens can be found in many human tumor patients.
B)Antibodies specific for tumor antigens can be found in many human tumor patients.
C)The presence of lymphocytic infiltrates in certain tumors is associated with a better prognosis than lymphocyte-poor tumors of the same histologic type.
D)Immunodeficient individuals are more likely to develop the most common forms of cancer than are immunocompetent individuals.
E)The host immune response is usually incapable of eradicating tumors once they are established.
Q2) Which of the following molecules is involved in the principal mechanism by which the immune system kills tumor cells?
A)Perforin
B)Complement C3
C)IgG
D)TGF-
E)Interleukin-2
To view all questions and flashcards with answers, click on the resource link above. Page 12
Chapter 11: Hypersensitivity
Available Study Resources on Quizplus for this Chatper
14 Verified Questions
14 Flashcards
Source URL: https://quizplus.com/quiz/23017
Sample Questions
Q1) Which of the following would NOT be a likely therapy for treating autoimmune diseases?
A)Corticosteroids
B)Small molecule inhibitor of VLA-4
C)Cyclosporine
D)CTLA-4 antagonist
E)Plasmapheresis
Q2) In which of the following disorders is the underlying pathogenic mechanism NOT due to antibody-mediated damage to cells or tissues?
A)Pernicious anemia
B)Autoimmune hemolytic anemia
C)Pemphigus vulgaris
D)Acute rheumatic fever
E)Hyperacute allograft rejection
Q3) Which of the following is a common cause of hypersensitivity diseases?
A)Failure of lymphocyte maturation
B)Treatment with corticosteroids
C)Disseminated cancer
D)Failure of self-tolerance
E)Malnutrition
To view all questions and flashcards with answers, click on the resource link above. Page 13
Chapter 12: Congenital and Acquired Immunodeficiencies
Available Study Resources on Quizplus for this Chatper
18 Verified Questions
18 Flashcards
Source URL: https://quizplus.com/quiz/23018
Sample Questions
Q1) Human immunodeficiency virus (HIV) is NOT a:
A)Herpesvirus
B)RNA virus
C)Enveloped virus
D)Retrovirus
E)Lentivirus
Q2) Which of the following strategies would be expected to be LEAST effective in the prevention and/or treatment of AIDS?
A)Abstinence from intravenous drug use and unprotected sexual intercourse
B)Vaccination with recombinant gp120 protein to elicit antibodies against HIV
C)Chronic administration of a single non-nucleoside reverse transcriptase inhibitor
D)Chronic administration of highly active antiretroviral therapy (HAART)
E)Short-term administration of a nucleoside reverse transcriptase inhibitor to HIV-positive pregnant women during labor and the months preceding delivery
To view all questions and flashcards with answers, click on the resource link above.
14