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Pharmacology in Physical Therapy Practice Study Guide Questions - 430 Verified Questions

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Pharmacology in Physical Therapy Practice Study Guide Questions

Course Introduction

This course explores the fundamental principles of pharmacology with a focus on medications commonly encountered in physical therapy practice. Students will examine drug classifications, mechanisms of action, therapeutic effects, side effects, interactions, and the impact of pharmaceuticals on patient rehabilitation and outcomes. Emphasis is placed on understanding how medications influence the musculoskeletal and neuromuscular systems, pain management, and healing processes, as well as on the safe integration of pharmacology knowledge into patient care planning, interprofessional communication, and patient education.

Recommended Textbook

Pharmacology for Rehabilitation Professionals 2nd Edition by Barbara Gladson

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27 Chapters

430 Verified Questions

430 Flashcards

Source URL: https://quizplus.com/study-set/852

Page 2

Chapter 1: Introduction

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Sample Questions

Q1) The year it was required that marketed drugs be shown by the pharmaceutical company to be both efficacious and relatively safe is __________.

A)1855

B)1909

C)1934

D)1962

Answer: D

Q2) Before a drug is approved,the company must submit data verifying that the drug

A)is efficacious

B)has acceptable toxicity

C)should be marketed at a particular dose and indication

D)All of the above

Answer: D

Q3) The effectiveness of a drug in large populations is the subject of __________.

A)pharmacogenomics

B)pharmacodynamics

C)pharmacoepidemiology

D)pharmacokinetics

Answer: C

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Chapter 2: Pharmacodynamics: Mechanism of Action

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9 Verified Questions

9 Flashcards

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Sample Questions

Q1) Antagonists _________.

A)block the receptor by changing its conformation into an unresponsive state

B)can always be displaced by an agonist

C)block endogenous compounds from stimulating the receptor

D)after chronic use can decrease the number of receptors

Answer: C

Q2) If the dose-response curve (increasing doses vs.physiological effects)of an agonist is plotted and then another curve is obtained when an antagonist has been added to the agonist,then the second curve is moved _________.

A)parallel to the left in case of a competitive antagonist

B)parallel to the right in case of a competitive antagonist

C)parallel to the left in case of a non-competitive antagonist

D)parallel to the right in case of a non-competitive antagonist

Answer: B

Q3) With a dose-response curve,the Kd ______________.

A)is the dose necessary to achieve Emax

B)is the dose at half the Emax

C)determines efficacy

D)is equivalent to the toxic index

Answer: B

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Chapter 3: Pharmacokinetics and Drug Dosing

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21 Verified Questions

21 Flashcards

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Sample Questions

Q1) Small lipid soluble or lipophilic drugs penetrate cell membranes by ___________.

A)passive diffusion

B)endocytosis

C)water filled channels

D)special transport systems

Answer: A

Q2) A person in shock would not respond to IM injections of medication because of which of the following reasons?

A)Diminished biliary functioning

B)Glomerular filtration impairments

C)Impaired liver metabolism

D)Impaired peripheral circulation

Answer: D

Q3) All of the following may affect the duration of a drug's effects except _______________.

A)the rate of metabolism from active drugs to inactive metabolites

B)the rate of absorption into the bloodstream

C)the rate of excretion of inactive metabolites

D)the amount of protein binding

Answer: C

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Chapter 4: Adverse Drug Reactions

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8 Flashcards

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Sample Questions

Q1) A food-drug interaction can be caused by __________.

A)acidic foods and weak basic drugs

B)milk

C)grapefruit juice

D)All of the above

Q2) Which of the following groups are least likely to experience the adverse effects of drugs?

A)Persons with renal disease

B)Elderly people

C)Persons with liver disease

D)Persons

Q3) A drug should only be prescribed if the __________.

A)benefit outweighs the risk

B)drug has no serious adverse reactions

C)drug is affordable by the patient

D)patient is not pregnant

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Chapter 5: Drugs Acting on the Autonomic Nervous System

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Sample Questions

Q1) Alpha receptors are located at all of the following except the______________.

A)blood vessels

B)GI tract

C)bronchi

D)iris of the eye

Q2) A patient faints while quickly getting up from a hot pool.Which of the following drugs could have caused this event?

A)Salmeterol

B)Prazosin

C)Phenylephrine

D)Metaprolol

Q3) Noradrenergic neurotransmission involves ______________.

A)synthesis of norepinephrine (NE) by monoamine oxidase or MAO

B)synthesis of NE from epinephrine

C)interaction with adrenergic gamma and delta receptors

D)termination of action which is usually via re-uptake into the neuron

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Chapter 6: Antihypertensive

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23 Flashcards

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Sample Questions

Q1) Hydrochlorothiazide ___________.

A)enhances the secretion of Ca

B)may cause hypokalemia

C)is contraindicated in patients prone to form renal calculi

D)has been shown to lower blood pressure, morbidity and mortality

Q2) Which of the following statements is false?

A)Normal blood pressure is considered to be 130 over 90

B)Prehypertension is usually treated with diet and exercise

C)Stage I hypertension may be treated first with thiazide diuretics followed by other antihypertensive drugs if needed

D)Severe hypertension is usually treated with two or even three drug combinations

Q3) Calcium channel blockers ___________.

A)increase calcium fluxes in arterial smooth muscles

B)dilate blood vessels and depress cardiac activity

C)are also used to treat headaches and migraines

D)are frequently combined with beta-blockers

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8

Chapter 7: Drug Therapy of Coronary Atherosclerosis and Its Repercussions

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29 Verified Questions

29 Flashcards

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Sample Questions

Q1) Aspirin _________.

A)inhibits platelet aggregation

B)inhibits the enzyme cyclooxygenase reversibly

C)is given as 80 mg per day for its anti-platelet effect

D)allows normal platelet function about 32 hours after cessation of therapy

Q2) Which of the following statements about statin drugs is false?

A)They inhibit endogenous formation of cholesterol.

B)They vary greatly in efficacy.

C)They carry the risk of liver and muscle damage.

D)Cost can be a factor in choosing the right drug.

Q3) Which one of the following adverse effects is associated with nitroglycerin?

A)Hypertension

B)Throbbing headache

C)Bradycardia

D)Abdominal bloating

Q4) Which one of the following statements concerning warfarin is false?

A)It interferes with the synthesis of vitamin K dependent clotting factors.

B)Ingestion of large amounts of broccoli and cauliflower enhance its activity.

C)It should not be used during pregnancy.

D)It takes as many as 5 days to reach therapeutic levels.

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Chapter 8: Drug Therapy for Congestive Heart Failure and Cardiac Arrhythmias

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20 Flashcards

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Sample Questions

Q1) Beta-blockers __________.

A)increase contractility and cardiac output

B)reduce sympathetic tone to the heart

C)show a relatively fast improvement of clinical signs

D)can cause tachyarrhythmias

Q2) Which one of the following statements for congestive heart failure is false?

A)It refers to the inability of the heart to cause a normal cardiac output.

B)It is caused by hypertension, valvular diseases and/or coronary artery disease.

C)It is treated with drugs which improve contractility and decrease preload and afterload.

D)It is defined by an ejection fraction of 50% or less.

Q3) Which of the following may be an adverse effect associated with antiarrhythmic agents?

A)Bronchodilation

B)Increased cardiac output

C)Other arrhythmias

D)Sinus tachycardia

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Page 10

Chapter 9: Drug Therapy for Pulmonary Disorders

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17 Flashcards

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Sample Questions

Q1) Theophylline ______________.

A)is the generic name for caffeine

B)blocks muscarinic receptors causing bronchodilation

C)is often the oral drug of first choice

D)can cause a number of adverse drug interactions

Q2) Exercise induced asthma ______________.

A)is a relative rare occurrence

B)will get worse the more a person exercises

C)can be prevented by using a short-acting beta 2 agonist 15-60 minutes before exercise

D)has been shown not to be influenced by warm-up procedures before exercise

Q3) Cromolyn and nedocromil ______________.

A)inhibit the release of histamine and leukotrienes from mast cells

B)cause bronchodilation by stimulating H1 receptors

C)can quickly terminate an asthmatic attack

D)are seldom used because of their adverse reactions

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11

Chapter 10: Anesthetic Agents

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9 Verified Questions

9 Flashcards

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Sample Questions

Q1) A patient seen post-op for therapy ____________.

A)may still be confused

B)should suppress coughing

C)should be encouraged to breathe slowly

D)may engage in strengthening activities

Q2) A patient with COPD should receive which of the following drugs prior to surgery?

A)Bronchodilators

B)Aspirin

C)Anti-viral agents

D)Opioids

Q3) Which one of the following drugs is used in a balanced anesthesia?

A)NSAIDs

B)Opioids

C)Respiratory stimulants

D)Oral antidiabetic drugs

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12

Chapter 11: Drugs for the Treatment of Pain and Inflammation

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22 Verified Questions

22 Flashcards

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Sample Questions

Q1) Death due to an overdose of morphine is due to _______________.

A)respiratory depression

B)ventricular fibrillation

C)bronchoconstriction

D)All of the above

Q2) Which one of the following is not a vasodilating,inflammatory mediator?

A)Certain prostaglandins

B)Bradykinin

C)Histamine

D)Thromboxane

Q3) Which one of the following statements regarding NSAIDs is true?

A)They reduce pain and allow more rigorous training to be performed to obtain better muscle strength.

B)They may produce low BP in some individuals.

C)They are useful in reducing pain and inflammation but caution should be applied when used in patients with HTN.

D)They have replaced acetaminophen as the drug of choice in the treatment of osteoarthritic knees.

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Chapter 12: Drug Treatment for Arthritis-Related Conditions

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13 Verified Questions

13 Flashcards

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Sample Questions

Q1) Which one of the following statements is correct?

A)Probenicid and sulfinpyrazone increase renal uric acid excretion.

B)Increased fluid intake is ineffective since it does not increase uric acid secretion.

C)Allopurinol increases the metabolism of uric acid by the body.

D)All of the above

Q2) Occurrence of a black stool during NSAIDs therapy is a sign of bleeding from ________________.

A)the rectum

B)the stomach or intestines

C)the liver

D)A and B are correct

Q3) Which of the following drug classes is used in the treatment of RA?

A)Gold compounds to reduce the immune response

B)NSAIDs drugs to reduce inflammation

C)Antibiotics to slow the infectious process

D)All of the above

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14

Chapter 13: Selective Topics in Endocrine Pharmacology

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20 Verified Questions

20 Flashcards

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Sample Questions

Q1) Which of the following is a side effect of oral contraceptive agents?

A)Ovulation

B)Gynecomastia

C)DVT

D)Improved fertility

Q2) The post-coital drug mifepristone ________________.

A)antagonizes the effects of androgens causing uterine contractions

B)is effective only for 14 days after unprotected intercourse

C)causes the release of estrogens which prevents egg implantation

D)acts like misoprostol

Q3) Levothyroxine ________________.

A)is converted to T4 as the active form

B)has a wide margin of safety

C)therapy can lead to osteoporosis and fractures

D)All of the above

Q4) Plan B drug ________________.

A)uses levonorgestrel which expels the implanted egg

B)is now available on the pharmacy shelf without a prescription

C)must be taken within 72 hours

D)can terminate an existing pregnancy

Page 15

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Chapter 14: Drug Treatment for Osteoporosis and Diabetes

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21 Verified Questions

21 Flashcards

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Sample Questions

Q1) Glucose absorption from the intestines is inhibited by ______________.

A)alpha glucosidase inhibitors

B)dipeptidyl peptidase inhibitors

C)pramlintide

D)All of the above

Q2) Type II diabetes mellitus ______________.

A)can be due to decreased responsiveness of insulin receptors on tissues

B)is associated with obesity

C)can be caused by decreased pancreatic release of insulin

D)All of the above

Q3) Calcium supplementation ______________.

A)can even be taken by individuals prone to have kidney stones

B)should be taken with meals

C)can cause some constipation and gas

D)All of the above

Q4) Which of the following drugs has no significant effect on bone loss?

A)Corticosteroids

B)Chemotherapeutic/transplant drugs

C)Cardiovascular drugs

D)Aromatose inhibitors

Page 16

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Chapter 15: Drugs for Epilepsy and Attention

Deficit/Hyperactivity Disorder

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13 Verified Questions

13 Flashcards

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Sample Questions

Q1) Which of the following may be given with an opioid for the treatment of neuropathic pain syndromes?

A)Antihistamines

B)Anticholinergics

C)Anticonvulsants

D)NSAIDs

Q2) Which drug would be contraindicated in children with ADHD?

A)d-Amphetamine

B)Clonidine

C)Tricyclic antidepressants

D)Atypical antipsychotics

Q3) A patient receiving anti-epileptic medications might mostly experience

A)sedation and ataxia

B)tachycardia and hypertension

C)weight loss and kidney stone formation

D)All of the above

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Page 17

Chapter 16: Antispasticity Medications and Skeletal Muscle

Relaxants

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14 Verified Questions

14 Flashcards

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Sample Questions

Q1) Cyclobenzaprine _____________.

A)acts in the spinal cord

B)can be used for months

C)can cause an uncomfortable dry mouth

D)relaxes muscles but has no effect on pain

Q2) The antispastic action of diazepam _____________.

A)is due to its binding to the GABAA gated Cl channel

B)occurs within the motor cortex and basal ganglia

C)occurs also by an additional direct effect on skeletal muscles

D)All of the above

Q3) Which of the following statements is correct?

A)Botulinus toxin selectively destroys skeletal muscle cholinergic receptors.

B)A nerve block is caused by an injected chemical which impairs nerve function.

C)Ethanol causes a nerve block lasting up to 6 months.

D)Ethanol selectively destroys the spinal nerve terminals.

Q4) Fluori-Methane _____________.

A)should be sprayed from muscle insertion to origin of muscle

B)spray should be applied to an untouched muscle

C)should be sprayed until the muscle is super-cooled

D)can be reapplied after the muscle has warmed

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Chapter 17: Pharmacologic Management of Degenerative Neurologic Disorders

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20 Verified Questions

20 Flashcards

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Sample Questions

Q1) Which one the following combinations is mismatched?

A)Bromocriptine - stimulation of dopamine receptors

B)Selegiline - inhibition of MAO-B

C)Entacapone - inhibition of COMT

D)Amantadine - stimulation of dopamine synthesis

Q2) Which of the following adverse reactions might be experienced by a patient treated with an acetylcholinesterase inhibitor?

A)Diarrhea

B)Tremors

C)Tachycardia

D)Fever

Q3) Mitoxantrone _____________.

A)interferes with RNA action

B)can cause renal and pulmonary problems

C)has been shown to have antimicrobial actions

D)is approved for use in MS and also as an anti-cancer drug

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Chapter 18: Drug Treatment for Depression and Anxiety

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18 Flashcards

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Sample Questions

Q1) Antidepressants usually _______________.

A)have a quick onset of therapeutic action

B)have a delayed onset of therapeutic action

C)have a delayed onset of adverse reactions

D)reduce early on the risk of suicide

Q2) The neurotransmitter system which seems to play no or only a minor role in the pathogenesis of depression is _______________.

A)a deficiency of the serotonin system

B)a deficiency of the norepinephrine system

C)excess of corticotrophin-releasing hormone

D)excessive acetylcholine

Q3) Which of the following statements is correct?

A)Barbiturates but not benzodiazepines can cause physical dependence.

B)Barbiturates and benzodiazepines have the same mode of action.

C)Barbiturates and benzodiazepines can cause tolerance.

D)Benzodiazepines are more efficacious in inducing p450 enzymes.

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Chapter 19: Drug Treatment for Schizophrenia and Bipolar Illness

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10 Flashcards

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Sample Questions

Q1) Which of the following behaviors is the most likely to be eliminated by the typical antipsychotic drugs?

A)Hallucinations

B)Apathy

C)Social withdrawal

D)Flat affect

Q2) Which one of the following is true regarding antipsychotics?

A)They have a high affinity for dopamine receptors.

B)They produce mania.

C)They stimulate the chemoreceptor trigger zone to produce vomiting.

D)They have cholinergic side effects.

Q3) Which of the following signs of Schizophrenia respond poorly to anti-psychotic agents?

A)Hallucinations

B)Flattened emotions

C)Posturing

D)Echopraxia

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Page 21

Chapter 20: Antimicrobial Agents

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9 Flashcards

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Sample Questions

Q1) Which of the following physical activities should be avoided most by a patient taking ciprofloxacin?

A)Running on an incline

B)Exercise on a rowing machine

C)Back extension exercise on a roman chair

D)Exercise on a stairmaster

Q2) Treatment of Clostridium difficile infection may include which of the following?

A)Metronidazole

B)Erythromycin

C)Tetracyclines

D)Doxycycline

Q3) Duration of drug treatment for active Tuberculosis not resistant to isoniazid is which of the following?

A)2 months

B)6 months

C)12 months

D)15 months

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Chapter 21: Antiviral Agents and Selected Drugs for Fungal

Infections

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10 Flashcards

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Sample Questions

Q1) Which of the following represents innate immunity to viruses?

A)Phagocytes

B)B cells

C)Antibodies

D)Nucleocapsids

Q2) Primary HIV infection is characterized by which of the following?

A)Kaposi's sarcoma

B)Flu-like symptoms

C)CD8 counts under 200

D)Lypodystrophy

Q3) Nucleotide Reverse Transcriptase inhibitors work by which of the following actions?

A)Bind to the reverse transcriptase enzyme to inactivate it

B)Act as a DNA chain terminator

C)Bind to the surface of the glycoprotein on the viral envelope

D)Fuse to the new viral envelope

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23

Chapter 22: Cytotoxic Agents and Immune Modulation

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Sample Questions

Q1) A patient with a transplant is treated with an immunosuppressant drug.to help reduce the risk of _______________.

A)infections

B)hepatotoxicity

C)nephrotoxicity

D)neurotoxicity

Q2) Cytotoxic drugs _______________.

A)act on all phases of the cell cycle

B)will kill a certain fraction of the growing tumor cells

C)can kill all tumor cells if given in combination

D)are more effective in slow growing than in fast growing tumors

Q3) Choice of a cytotoxic drug depends mostly on_______________.

A)the tissue of cancer origin

B)the age of the patient

C)the size of the tumor

D)the growth of the tumor

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Chapter 23: Drugs for Gastrointestinal Disorders

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Sample Questions

Q1) Patients taking histamine 2 blockers need to be monitored for adverse drug reactions due to which of the following reasons?

A)They inhibit the liver microsomal metabolizing enzymes.

B)They inhibit intestinal absorption of important minerals and nutrients.

C)They reduce basal food-stimulated gastric acid release.

D)They increase bicarbonate secretion.

Q2) NSAIDs contribute to GI ulcer formation by which of the following mechanisms?

A)Vasoconstriction of the venous portal system

B)Enhanced release of mucus

C)Increased acid secretion

D)Inhibits COX-1 mediated prostaglandin production

Q3) A patient who is currently receiving warfarin following a Deep Venous Thrombosis (DVT)takes bismuth subsalicylate for recurrent diarrhea.What of the following red flags should the therapist watch for indicating an adverse drug reaction?

A)Orthostatic hypotension

B)Bruising

C)Tachycardia

D)Peripheral neuropathy

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25

Chapter 24: Vitamins and Minerals

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Sample Questions

Q1) If MVMPs are used,it is best to use preparations that ____________.

A)are approved by the Department of Health

B)have been tested by the National Institute of Health

C)are recommended by the American Medical Association

D)are manufactured by a reputable manufacturing company

Q2) A patient is using an anticoagulant and asks if it is OK to use a MVMP.The MVMP could cause problems because it contains ____________.

A)vitamin A

B)vitamin K

C)calcium

D)selenium

Q3) The intake of large doses of vitamins or minerals might not help but is safe since ____________.

A)these are natural products necessary for bodily functions

B)excesses are quickly metabolized before toxicity occurs

C)excesses are quickly excreted before toxicity occurs

D)None of the above

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Chapter 25: Topical Drugs and Treatments Used in Wound Management

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Sample Questions

Q1) The most distinguishing sign between an inflammation and an infection is

A)color of redness

B)presence of pus

C)degree of swelling

D)All of the above

Q2) Antibiotics are used to help a wound heal faster.Which of the following statements is true?

A)They should be used for all wounds to prevent infections.

B)They should only be used if an infection exists.

C)They only affect bacteria but not healthy host cells.

D)They will not cause bacterial resistance since they are used topically.

Q3) Wound dressings ______________.

A)should keep wounds dry

B)should keep wounds moist

C)should prevent drainage from the wound

D)can slightly damage surrounding healthy tissue

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Page 27

Chapter 26: Complementary and Alternative Medicine in Pharmacology

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8 Flashcards

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Sample Questions

Q1) Which of the following would be a legal claim for marketing a dietary supplement?

A)Lowers blood pressure

B)Is heart healthy

C)Lowers cholesterol

D)Prevents cardiovascular disease

Q2) Which of the following may be beneficial effects of CoQ10?

A)Lowers blood pressure

B)Reduces the myopathy that may occur with statin drugs

C)Improves exercise tolerance in patients with heart failure

D)All of the above

Q3) Which one of the following is contraindicated for the treatment of a 52-year-old woman who suffers from vasomotor instability related to menopause and who also has high risk factors for cardiac disease?

A)Hormone replacement therapy (estrogen and medroxyprogesterone)

B)SSRIs

C)Antiepilepsy drugs

D)Phytoestrogens such as soy

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28

Chapter 27: Drugs of Abuse: Anabolic Steroids and Other Doping Agents

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18 Flashcards

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Sample Questions

Q1) Cocaine deaths are often the result of ___________.

A)suicide

B)nasal metastatic cancers

C)cardiac arrest

D)respiratory depression

Q2) Alcohol is metabolized by all of the following except ___________.

A)alcohol dehydrogenase

B)aldehyde dehydrogenase

C)alcohol esterase

D)p450 system

Q3) The abuser of anabolic steroids increases the risk of all of the following health risks except ___________.

A)reduced sperm production

B)heart attacks

C)muscle strain

D)liver cancer

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