Pathology Exam Questions - 246 Verified Questions

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Pathology Exam Questions

Course Introduction

Pathology is the branch of medicine that studies the causes, mechanisms, and effects of disease on the body. This course provides a comprehensive introduction to the fundamental concepts of pathology, including cellular adaptations, inflammation, tissue repair, hemodynamic disorders, genetic diseases, and neoplasia. Students will explore both general pathology, which deals with basic disease processes, and systemic pathology, which examines diseases affecting specific organ systems. The course emphasizes the morphological and functional changes that underlie disease processes, integrating microscopic and gross pathology with clinical correlations to foster a deeper understanding of human disease for healthcare professionals.

Recommended Textbook

Histology and Cell Biology An Introduction to Pathology 3rd Edition by Abraham L Kierszenbaum

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23 Chapters

246 Verified Questions

246 Flashcards

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Chapter 1: Epithelium

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Sample Questions

Q1) The apical surface modifications of the cells lining the small intestine contain which of the following proteins?

A) Actin

B) Claudin

C) Elastin

D) Myosin

E) Occludin

Answer: A

Q2) The epithelial specializations most likely to be found in absorptive epithelia are

A) Cilia

B) Flagella

C) Microtubules

D) Microvilli

E) Stereocilia

Answer: D

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Page 3

Chapter 2: Epithelial Glands

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6 Flashcards

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Sample Questions

Q1) Which organelle is responsible for degrading proteins?

A) Golgi apparatus

B) Lysosome

C) Mitochondrion

D) Rough endoplasmic reticulum

E) Smooth endoplasmic reticulum

Answer: B

Q2) Which of the following is the site of steroid hormone synthesis?

A) Golgi apparatus

B) Mitochondria

C) Ribosomes

D) Rough endoplasmic reticulum

E) Smooth endoplasmic reticulum

Answer: E

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Chapter 3: Cell Signaling

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Sample Questions

Q1) A secreted chemical messenger meant to act on an adjacent cell is called a(n)

A) Autocrine

B) Hormone

C) Neurohormone

D) Neurotransmitter

E) Paracrine

Answer: E

Q2) The binding of a ligand to a G protein--coupled receptor will result in activation of adenylyl cyclase, which in turn will initiate which of the following pathways?

A) Ca² -calmodulin

B) cAMP

C) cGMP

D) MAP kinase

E) Phospholipase C-Ca²

Answer: B

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Chapter 4: Connective Tissue

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23 Verified Questions

23 Flashcards

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Sample Questions

Q1) Osteons are defined by a central canal surrounded by _____ lamellae.

A) Calcified

B) Concentric

C) Inner circumferential

D) Interstitial

E) Outer circumferential

Q2) Connective tissue cells responsible for synthesizing connective tissue proper matrix are

A) Chondroblasts

B) Fibroblasts

C) Mast cells

D) Mesenchymal cells

E) Osteoblasts

Q3) Dense regular connective tissue

A) Attaches bone to muscle and bone to bone

B) Is composed of a random arrangement of collagen fibers

C) Is composed primarily of fibroblasts in dense bundles

D) Owes its characteristics to the predominance of collagen II

E) Surrounds the walls of hollow organs

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Page 6

Chapter 5: Osteogenesis

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Sample Questions

Q1) Secondary ossification centers are found

A) At the outer surface of the diaphysis

B) At the surface of the epiphyses

C) In the center of the epiphyses

D) In the dermis of the skin

E) In the medullary cavity of the diaphysis

Q2) Which of the following is true of intramembranous, rather than endochondral, ossification?

A) A hyaline cartilage model is used

B) Long bones are formed

C) Mesenchymal cells differentiate into osteoblasts within connective tissue

D) Periosteal buds invade the lacunae left behind by dead chondrocytes

E) Secondary ossification centers form in the epiphyses

Q3) Each of the following statements about epiphyseal plates is correct EXCEPT

A) Appositional growth occurs on the epiphyseal side

B) Bone replaces cartilage on the diaphyseal side

C) Mitotically active chondrocytes are distributed throughout the zone of reserve cartilage

D) These chondrocytes are required for lengthening of long bones

E) They contain a portion of healthy hyaline cartilage

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Chapter 6: Blood and Hematopoiesis

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Sample Questions

Q1) Erythropoietin

A) Blocks the production of red blood cells

B) Inhibits blood clotting

C) Is a hormone released by the pituitary gland

D) Stimulates red blood cell destruction in the spleen

E) Stimulates red blood cell production in the bone marrow

Q2) Which of the following cell types are functionally related to mast cells in that they release histamine and other vasoactive substances?

A) Basophils

B) Eosinophils

C) Erythrocytes

D) Monocytes

E) Neutrophils

Q3) Where is the primary site of hemopoiesis?

A) Adipose tissue

B) Blood vessels

C) Bone marrow

D) Liver

E) Lymph nodes

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Page 8

Chapter 7: Muscle Tissue

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9 Flashcards

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Sample Questions

Q1) All of the following occur during the contraction of a sarcomere except

A) Shortening of A-band

B) Shortening of H-zone

C) Shortening of I-band.

D) Thin filaments slide toward M-line

E) Z-lines move closer together

Q2) Following the release of acetylcholine at the neuromuscular junction, an action potential travels along the _____ to the interior of the muscle cell.

A) Sarcomere

B) Sarcoplasmic reticulum

C) Thick filament

D) Thin filament

E) Transverse tubule

Q3) Which of the following is NOT a structural component of a triad?

A) Myofibril

B) Sarcolemma

C) Sarcoplasmic reticulum

D) Terminal cisterna

E) Transverse tubule

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Chapter 8: Nervous Tissue

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Sample Questions

Q1) Which of the following neuroglial cells is phagocytic?

A) Astrocytes

B) Ependymal cells

C) Oligodendrocytes

D) Microglial cells

E) Satellite cells

Q2) The neuroglial cells responsible for myelinating axons in the central nervous system are

A) Astrocytes

B) Ependymal cells

C) Microglial cells

D) Oligodendrocytes

E) Schwann cells

Q3) Interneurons are found

A) Only in the brain

B) Only in the central nervous system

C) Only in the peripheral nervous system

D) Only in the spinal cord

E) Throughout the nervous system

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Page 10

Chapter 9: Sensory Organs: Vision and Hearing

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10 Flashcards

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Sample Questions

Q1) Which of the following components prevents the aqueous humor from infiltrating the cornea?

A) Bowman's layer

B) Corneal endothelium

C) Corneal epithelium

D) Descemet's membrane

E) Stroma

Q2) In the dark, Na+ channels are ____ and neurotransmitter release is ____. In bright light, on the other hand, the Na+ channels are ____ and neurotransmitter release ____

A) Closed, continuous, open, ceases

B) Closed, continuous, open, increases

C) Open, absent, closed, increases

D) Open, continuous, closed, ceases

E) Open, continuous, closed, increases

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Chapter 10: Immune Lymphatic System

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Sample Questions

Q1) Activated B cells proliferate in the _____ of a lymph node.

A) Capsule

B) Germinal center

C) Mantle zone

D) Subcapsular sinus

E) Trabeculae

Q2) The humoral immune response is carried out by

A) B lymphocytes

B) Erythrocytes

C) Neutrophils

D) T lymphocytes

E) Thrombocytes

Q3) Helper T cells

A) Activate B cells to produce specific antibodies

B) Differentiate into cytotoxic T cells upon re-exposure to a known pathogen

C) Help T cells recognize antigens as nonself

D) Recognize and kill viral cells by secreting perforin

E) Secrete interferon upon contact with a virus

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Chapter 11: Integumentary System

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Sample Questions

Q1) These cells are responsible for producing a pigment that protects underlying tissue from ultraviolet radiation

A) Basal (satellite) cells

B) Keratinocytes

C) Langerhans cells

D) Melanocytes

E) Merkel cells

Q2) Langerhans cells

A) Are located in the stratum basale of the epidermis

B) Are mechanoreceptor cells

C) Can be found within a cornified cell envelope

D) Have granules in their cytoplasm

E) Present antigens to T cells as part of the immune response

Q3) Nail production occurs at the nail _____.

A) Bed

B) Body

C) Eponychium

D) Hyponychium

E) Matrix

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Page 13

Chapter 12: Cardiovascular System

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12 Flashcards

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Sample Questions

Q1) ____ capillaries, found in the pancreas, are highly porous and allow high volumes of fluids to pass through them, whereas ____ capillaries, found in the muscles, consist of more tightly joined cells that allow a high degree of selective materials to pass through them.

A) Continuous, fenestrated

B) Fenestrated, continuous

C) Fenestrated, sinusoidal

D) Sinusoidal, continuous

E) Sinusoidal, fenestrated

Q2) In the heart's conduction system, the electrical signal travels from the atrioventricular node to the

A) Atrioventricular bundle (bundle of His)

B) Bundle branches

C) Junctional fibers

D) Purkinje fibers

E) Sinoatrial node

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Chapter 13: Respiratory System

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Sample Questions

Q1) Alveolar cells that manufacture and secrete pulmonary surfactant are

A) Alveolar macrophages

B) Clara cells

C) Endothelial cells

D) Type I alveolar cells

E) Type II alveolar cells

Q2) Keratinized epithelium becomes nonkeratinized at which of the following structures?

A) Nasal vestibule

B) Nasopharynx

C) Olfactory region of nasal cavity

D) Oropharynx

E) Posterior nasal cavity

Q3) Among other cells, goblet cells and cells of Kulchitsky are located in which structure?

A) Alveoli

B) Bronchioles

C) Larynx

D) Nasopharynx

E) Trachea

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Chapter 14: Urinary System

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14 Flashcards

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Sample Questions

Q1) Following filtration, most water and solutes are reabsorbed in the

A) Bowman's capsule

B) Distal convoluted tubule

C) Glomerulus

D) Loop of Henle

E) Proximal convoluted tubule

Q2) All of the following statements about the distal thick segment of the renal tubule are true EXCEPT

A) It does not have a brush border

B) It empties into the collecting duct

C) It excretes sodium ions and absorbs potassium ions

D) It has a larger diameter than the loop of Henle

E) It is impermeable to water outside the presence of ADH (antidiuretic hormone)

Q3) The loop of Henle

A) Comprises the macula densa

B) Descends into the renal medulla

C) Is lined by cuboidal or columnar epithelium

D) Is the longest section of the renal tubule

E) Is where glomerular filtrate is produced

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Page 16

Chapter 15: Upper Digestive Segment

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15 Flashcards

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Sample Questions

Q1) Which of the following is true of the fungiform lingual papillae?

A) There are 8 to12 of them along the sulcus terminalis

B) They are single, evenly spaced, and are located on the tongue's margin

C) They are the largest lingual papillae and contain the most taste buds

D) They are the smallest and most numerous papillae and give the tongue its characteristic rough appearance

E) They help to clean oral surfaces as well as manipulate and process food

Q2) Which of the following are simple coiled tubular glands lined almost entirely with mucus-secreting cells?

A) Cardiac glands

B) Esophageal glands

C) Fundic glands

D) Gastric glands

E) Pyloric glands

Q3) The muscularis externa of the ____ is partially striated and partially smooth.

A) Esophagus

B) Large intestine

C) Small intestine

D) Stomach

E) None of the above -- the entire alimentary canal is lined with smooth muscle

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Chapter 16: Lower Digestive Segment

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9 Flashcards

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Sample Questions

Q1) Which of the following is characteristic of the ileum but not of the duodenum or jejunum?

A) Brunner's glands

B) Leaf-shaped villi

C) Glandless submucosa

D) Paneth cells

E) Peyer's patches

Q2) Fat-filled pouches in the large intestinal adventitia are called

A) Appendices epiploicae

B) Peyer's patches

C) Plicae circulares

D) Rugae

E) Taeniae coli

Q3) Cholecystokinin

A) Inhibits gastric juice secretion

B) Inhibits pancreatic juice secretion

C) Stimulates antigen endocytosis

D) Stimulates lysozyme secretion

E) Stimulates the gallbladder to secrete bile

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Page 18

Chapter 17: Digestive Glands

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Sample Questions

Q1) Portal triads of the liver

A) Are found at the corners of the classic lobules

B) Drain bile from the lobules

C) Drain deoxygenated blood from the liver parenchyma

D) Supply deoxygenated blood from the hepatic portal system

E) Supply oxygenated blood to the parenchyma of the liver

Q2) Portal triads are made up of vessels carrying all of the following EXCEPT

A) Bile away from the liver cells

B) Deoxygenated blood away from the liver cells

C) Deoxygenated blood to the liver cells

D) Nutrient-rich blood to the liver cells

E) Oxygenated blood to the liver cells

Q3) Which of the following is not an accurate statement about salivary gland secretory acini?

A) Acini are surrounded by myoepithelial cells

B) Fused secretory cells form compound acini called serous demilunes

C) Mucous acini lumina have a spongy appearance

D) Serous acini secrete salivary amylase

E) Submandibular glands contain primarily mucous acini with serous demilunes

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Page 19

Chapter 18: Neuroendocrine System

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Sample Questions

Q1) Prolactin secretion is _____ by _____.

A) Inhibited dopamine

B) Inhibited somatostatin

C) Stimulated dopamine

D) Stimulated growth hormone-releasing hormone

E) Stimulated nerve impulse from the hypothalamus

Q2) Which of the following statements about the neurohypophysis is not true?

A) Contains glial-like cells called pituicytes

B) It synthesizes, stores, and secretes antidiuretic hormone (ADH) and oxytocin

C) Its axons derive from the paraventricular and supraoptic nuclei

D) Secretion of its hormones is controlled by nerve impulses from the hypothalamus

E) The hypothalamohypophyseal tract runs through the infundibulum

Q3) Melatonin

A) Is secreted by the neurohypophysis

B) Is secreted immediately following synthesis by acidophils

C) Is transported along pinealocyte axons

D) Production is stimulated by sunlight

E) Stimulates growth hormone secretion

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Chapter 19: Endocrine System

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Sample Questions

Q1) Which endocrine structure secretes epinephrine and norepinephrine?

A) Adenohypophysis

B) Adrenal cortex

C) Adrenal medulla

D) Neurohypophysis

E) Thyroid gland

Q2) What happens immediately after insulin binds to the -subunit of the insulin receptor?

A) It activates the adjacent tyrosine kinase ( -subunit)

B) It increases glucose uptake by the cell

C) It stimulates glucagon secretion by the cells

D) It stimulates the synthesis of GLUT-4 (glucose transporter-4)

E) It transports the GLUT-4 protein to the cell membrane

Q3) Parathyroid hormone

A) Decreases blood calcium levels

B) Inhibits calcium resorption in the uriniferous tubules

C) Is released by parafollicular cells

D) Is secreted and synthesized by chief cells

E) Release is stimulated by an increase in serum calcium levels

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Page 21

Chapter 20: Spermatogenesis

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Sample Questions

Q1) Meiosis II occurs in the

A) Primary spermatocyte

B) Secondary spermatocyte

C) Spermatid

D) Spermatogonia

E) Spermatozoa

Q2) Diploid spermatogenic cells in direct contact with the basal lamina are

A) Sertoli cells

B) Spermatocytes

C) Spermatogenic cells

D) Spermatogonia

E) Spermatozoa

Q3) During which phase of spermiogenesis does the manchette develop?

A) Acrosomal phase

B) Cap phase

C) Golgi phase

D) Maturation phase

E) Spermatid rotation phase

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22

Chapter 21: Sperm Transport and Maturation

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Sample Questions

Q1) Sperm are matured and stored in what structure?

A) Epididymidis

B) Prostate

C) Seminal vesicle

D) Testis

E) Vas deferens

Q2) Sperm move from the tubuli recti into the

A) Ductuli efferentes

B) Epididymidis

C) Rete testis

D) Seminiferous tubules

E) Vas deferens

Q3) Which of the following structures secretes the largest component of seminal fluid?

A) Bulbourethral gland

B) Ductuli efferentes

C) Ductus epididymidis

D) Prostate gland

E) Seminal vesicle

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23

Chapter 22: Follicle Development and the Menstrual Cycle

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Sample Questions

Q1) Which of the following does not occur as a result of the luteinizing hormone surge?

A) Formation of the corpus luteum

B) Increased estrogen secretion

C) Ovulation

D) Secondary oocyte completes meiosis I

E) Secretion of proteolytic enzymes from the mature follicle

Q2) The inner layer of the uterus is called the

A) Cervix

B) Endometrium

C) Germinal epithelium

D) Mesovarium

E) Myometrium

Q3) Oocytes surrounded by granulosa cells are found in the A) Corona radiata

B) Corpus luteum

C) Cumulus oophorus

D) Theca folliculus

E) Zona pellucida

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Chapter 23: Fertilization, Placentation, and Lactation

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Sample Questions

Q1) What cells are found between the basement membrane and the epithelium of the lactiferous ducts?

A) Columnar cells

B) Cuboidal cells

C) Fat cells

D) Myoepithelial cells

E) Secretory cells

Q2) Following fertilization and after about 3 days of cell division, the developing organism is considered a ____ as it moves along the uterine tube toward the uterus.

A) Blastula

B) Fetus

C) Gastrula

D) Morula

E) Zygote

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