Neuropharmacology Exam Preparation Guide
Course Introduction
Neuropharmacology explores the effects of drugs on the nervous system, focusing on how various substances interact with neural pathways to influence behavior, cognition, and physiological functions. This course covers the fundamental principles of neurotransmission, the pharmacodynamics and pharmacokinetics of neuroactive drugs, and the molecular mechanisms underlying drug action in the brain. Key topics include the pharmacology of major neurotransmitter systems, the therapeutic use of psychoactive and neuroactive compounds, the treatment of neurological and psychiatric disorders, and issues related to drug abuse and addiction. Through lectures, readings, and case studies, students gain a comprehensive understanding of the role of pharmacology in nervous system function and its clinical applications.
Recommended Textbook
Drugs and the Neuroscience of Behavior An Introduction to Psychopharmacology 2nd Edition by
Available Study Resources on Quizplus
15 Chapters
1711 Verified Questions
1711 Flashcards
Source URL: https://quizplus.com/study-set/2326 Page 2
Chapter 1: Introduction to Psychopharmacology
Available Study Resources on Quizplus for this Chatper
113 Verified Questions
113 Flashcards
Source URL: https://quizplus.com/quiz/46230
Sample Questions
Q1) A drug's generic name is a nonproprietary name indicating the classification of a drug.
A)True
B)False
Answer: True
Q2) Which of the following describe a pharmacodynamic action?
A) A drug is injected in the arm and later enters the bloodstream.
B) A drug binds to a neuron and alters the neuron's activity.
C) A drug binds to another drug in the body.
D) A drug enters the liver and is quickly metabolized.
Answer: B
Q3) The field of __________________ may help explain why one person is naturally a fast metabolizer for a drug,whereas another person is naturally a slow metabolizer for the drug.
A) pharmacodynamics
B) physiodynamics
C) pharmacogenetics
D) pharmacokinetics
Answer: C
To view all questions and flashcards with answers, click on the resource link above.
Page 3
Chapter 2: The Nervous System
Available Study Resources on Quizplus for this Chatper
114 Verified Questions
114 Flashcards
Source URL: https://quizplus.com/quiz/46231
Sample Questions
Q1) Relative to the central nervous system,motor neurons are referred to as afferent neurons.
A)True
B)False
Answer: False
Q2) The parts of neurons that receive information from other neurons are called: A) axons. B) dendrites. C) synapses.
D) somas.
Answer: B
Q3) The ________________ nervous system controls involuntary movements. Answer: autonomic
Q4) Sympathetic nervous system neurons contact muscle tissue at neuromuscular junctions.
A)True
B)False
Answer: False
Q5) The ________________ of a neuron receive information from other neurons. Answer: dendrites
Page 4
To view all questions and flashcards with answers, click on the resource link above.
Chapter 3: Neurotransmission
Available Study Resources on Quizplus for this Chatper
114 Verified Questions
114 Flashcards
Source URL: https://quizplus.com/quiz/46232
Sample Questions
Q1) Where is a presynaptic receptor located?
A) Inside a neuron
B) On the postsynaptic terminal
C) On the axon terminal
D) On preganglionic neurons
Answer: C
Q2) Why might the speed of electrical transmission be faster for a mylenated neuron compared to an unmyelated neuron?
A) Actions potentials need only occur at gaps between myelin sheaths.
B) Actions potentials have a greater magnitude.
C) They are thicker, allowing for more actions potentials to occur.
D) Myelin increases the concentration of ions within the neuron.
Answer: A
Q3) Ions flow through pores in a neuron's membrane called:
A) local potentials.
B) ion channels.
C) axon channels.
D) EPSPs.
Answer: B
To view all questions and flashcards with answers, click on the resource link above.
Page 5
Chapter 4: Properties of Drugs
Available Study Resources on Quizplus for this Chatper
112 Verified Questions
112 Flashcards
Source URL: https://quizplus.com/quiz/46233
Sample Questions
Q1) Analyzing the amount of psychoactive drug in brain tissue would allow a researcher to determine:
A) the drug's pKa.
B) the drug's active transport through the blood-brain barrier.
C) the drug's bioavailability.
D) the amount of biotransformation that took place.
Q2) The selective destruction of axons by a neurotoxin is called:
A) transmission toxicity.
B) neuronpathy.
C) myelinopathy.
D) axonopathy.
Q3) Psychoactive drugs rely on active transport mechanisms to cross the blood-brain barrier.
A)True
B)False
Q4) ____________ tolerance can prevent a drug from reaching its site of action.
A) Conditioned
B) Behavioral
C) Pharmacodynamic
D) Pharmacokinetic
Page 6
To view all questions and flashcards with answers, click on the resource link above.
Chapter 5: Drugs of Abuse
Available Study Resources on Quizplus for this Chatper
114 Verified Questions
114 Flashcards
Source URL: https://quizplus.com/quiz/46234
Sample Questions
Q1) According to the incentive-salience model,describe the following: wanting,liking,and craving.
Q2) An animal that presses a lever in order to intracranial self-stimulation is likely:
A) engaging in goal-directed behavior.
B) demonstrating latent inhibition.
C) exhibiting tolerance.
D) using the stimulant as a discriminative stimulus.
Q3) All of the following are likely associated with increased levels of dopamine except: A) when going to a familiar place.
B) when presented with stimuli that predict positive outcomes.
C) while experiencing reinforcing effects.
D) when encountering something new.
Q4) According to opponent-process theory,withdrawal effects occur from unchecked processes in the body that normally counteract the effects of a drug.
A)True
B)False
Q5) Name and describe the different stage of the drug addiction cycle.
To view all questions and flashcards with answers, click on the resource link above.
7
Chapter 6: Psychostimulants
Available Study Resources on Quizplus for this Chatper
114 Verified Questions
114 Flashcards
Source URL: https://quizplus.com/quiz/46235
Sample Questions
Q1) The quickest drug onset for cocaine occurs through the ______________ route of administration.
Q2) All of the following are steps in the production of cocaine except:
A) the salt form of cocaine is typically packaged and shipped because it can be easily smoked.
B) coca leaves are broken down into a coca paste.
C) the base from of cocaine is processed into the salt form in crystal labs.
D) crack cocaine is made by converting the salt form of cocaine in a base form.
Q3) All of the following are physiological effects from psychostimulant administration except:
A) decreased body temperature.
B) increased heart rate.
C) tooth decay.
D) inhibited digestion.
Q4) All of the following are related except:
A) purposeless behavior.
B) stereotypy.
C) rate-dependent effects.
D) punding.
Q5) A psychostimulant found in Ephedra Sinica is ______________.
Page 8
To view all questions and flashcards with answers, click on the resource link above.
Chapter 7: Nicotine and Caffeine
Available Study Resources on Quizplus for this Chatper
114 Verified Questions
114 Flashcards
Source URL: https://quizplus.com/quiz/46236
Sample Questions
Q1) Direct administration of nicotine in the nucleus accumbens will produce an increase in dopamine concentrations in the __________.
Q2) Cigars typically contain less nicotine than cigarettes.
A)True
B)False
Q3) Why do long-term smokers exhibit decreased activity of monoamine oxidase enzymes?
Q4) In addition to caffeine,all of the following is used in energy drinks except:
A) kola nut.
B) yerba mate.
C) atropine.
D) theobromine.
Q5) Smokeless tobacco products consist of any tobacco form intended for absorption in the mouth.
A)True
B)False
Q6) The flue curing process makes tobacco smoke less harsh to inhale.
A)True
B)False
Q7) Describe the process of nicotinic receptor activation and desensitization.
To view all questions and flashcards with answers, click on the resource link above. Page 9
Chapter 8: Alcohol
Available Study Resources on Quizplus for this Chatper
114 Verified Questions
114 Flashcards
Source URL: https://quizplus.com/quiz/46237
Sample Questions
Q1) Distillation provides a means of:
A) making alcohol up to a 15 percent concentration.
B) making alcohol without using yeast at any stage of the process.
C) bypassing a fermentation process completely.
D) going beyond the limits of alcohol production from fermenting.
Q2) Describe how GABAA receptors mediate alcohol's reinforcing effects.
Q3) How much alcohol is eliminated from the body per hour?
A) 100 to 140 ml
B) 0 to 4 mL
C) 10 to 14 mL
D) 1.4 to 2.8 mL
Q4) Why might someone experience weaker effects from alcohol with a full stomach?
A) People consume less alcohol on a full stomach than on an empty stomach.
B) Alcohol soaks into food in the stomach, preventing alcohol absorption.
C) There is longer exposure to alcohol dehydregenase enzymes.
D) Thiamine in food prevents the transportation of alcohol through intestinal walls.
Q5) ________ blackout consists of incomplete memories from a period of alcohol intoxication.
Q6) Describe the metabolic steps for alcohol.
Page 10
To view all questions and flashcards with answers, click on the resource link above.
Chapter 9: GHP and Inhalants
Available Study Resources on Quizplus for this Chatper
119 Verified Questions
119 Flashcards
Source URL: https://quizplus.com/quiz/46238
Sample Questions
Q1) In a drug discrimination procedure using GHB as a training drug,why might the GABAB receptor agonist baclofen produce full substitution?
A) GABAB receptors produce inhibitory effects similar to positive modulation of GABAA receptors.
B) GABAB receptors interact with GHB receptors.
C) GHB is an agonist for GABAB receptors.
D) baclofen is also an agonist for GHB receptors.
Q2) GHB is an agonist for:
A) GABAB receptors.
B) GABAA receptors.
C) GABAC receptors.
D) metabotropic GABA receptors.
Q3) An inhalant referred to as poppers is called:
A) ethylene.
B) toulene.
C) nitrous oxide.
D) amyl nitrite.
Q4) 1,4-butanediol and gamma-hydroxybutyraldehyde (GBL)use the metabolic pathway for ____________ to produce GHB.
To view all questions and flashcards with answers, click on the resource link above. Page 11
Chapter 10: Opioids
Available Study Resources on Quizplus for this Chatper
114 Verified Questions
114 Flashcards
Source URL: https://quizplus.com/quiz/46239
Sample Questions
Q1) Methadone is used for ultra-rapid detoxification from opioid use.
A)True
B)False
Q2) How do opioid agonists produce analgesic effects?
Q3) Define the following opioids: naturally occurring,semisynthetic,and fully synthetic.
Q4) Increased neurotransmission by orphanin FQ would imply increased synthesis of: A) prodynorphin.
B) proopiomelanocortin.
C) pronociceptin.
D) proenkaphalin.
Q5) The initial phase of an opioid agonist's positive subjective effects is called a: A) nod.
B) rush.
C) euphoria.
D) high.
Q6) Neoendorphins bind to delta opioid receptors.
A)True
B)False
To view all questions and flashcards with answers, click on the resource link above. Page 12
Chapter 11: Cannabinoids
Available Study Resources on Quizplus for this Chatper
114 Verified Questions
114 Flashcards
Source URL: https://quizplus.com/quiz/46240
Sample Questions
Q1) Many of the health risks with cannabis use suggests that A) the vehicle for delta-9-THC can be harmful.
B) delta-9-THC may cause cancer.
C) cannabinoid compounds other than delta-9-THC may increase cancer risk.
D) endocannabinoids may be an endogenous risk factor for cancer.
Q2) U.S.law now allows for using cannabis for medical purposes.
A)True
B)False
Q3) Delta-9-THC may produce an accelerated sense of time by acting in the cerebellum.
A)True
B)False
Q4) Anandamide re-enters a neuron that released it via the A) amino acid transporter.
B) endocannabinoid transporter.
C) anandamide transporter.
D) diacylglycerol transporter.
Q5) An amotivational syndrome reduces the interest in using cannabis.
A)True
B)False
Page 13
To view all questions and flashcards with answers, click on the resource link above.
Chapter 12: Psychedelic Drugs
Available Study Resources on Quizplus for this Chatper
113 Verified Questions
113 Flashcards
Source URL: https://quizplus.com/quiz/46241
Sample Questions
Q1) If a user co-administered the drug d-amphetamine,a dopamine releaser,with MDMA,the user will likely mostly experience
A) greater hallucinogenic effects.
B) greater stimulant effects.
C) weaker hallucinogenic effects.
D) weaker stimulant effects.
Q2) LSD is structurally similar to the neurotransmitter ________.
Q3) An antagonist of serotonin receptors would weaken the hallucinogenic effects of LSD.
A)True
B)False
Q4) The posterior cingulate cortex is involved in the default mode network.
A)True
B)False
Q5) The most known drug among the mixed stimulant-psychedelic drugs is A) 3,4-methylenedioxymethamphetamine.
B) dextroampehtamine.
C) 2,4-methamphetaminelyseric acid.
D) methylempathogen.
Q6) How is a good trip different from a bad trip?
Page 14
To view all questions and flashcards with answers, click on the resource link above.
Chapter 13: Treatments for Depression and Bipolar Disorder
Available Study Resources on Quizplus for this Chatper
114 Verified Questions
114 Flashcards
Source URL: https://quizplus.com/quiz/46242
Sample Questions
Q1) In clinical trials for an antidepressant drug,depressed participants in the placebo control group often
A) quit a clinical study soon after the study begins
B) can tell that they were given a placebo.
C) continued to worsen until medication must be given.
D) develop clear improvements in their depressive symptoms.
Q2) Depressive symptoms caused by poor blood flow is called ________ depression.
Q3) An antidepressant drug that is causing erectile dysfunction or a loss of sexual drive is producing
A) a serotonin syndrome.
B) sexual side effects.
C) affective blunting.
D) comorbid anxiety.
Q4) In the U.S.,the approximate lifetime prevalence of major depressive disorder is
A) 1%
B) 15%
C) 30%
D) 60%
Q5) Antagonists for ________ receptors cause dry mouth.
Q6) The dissociative anesthetic drug ________ produces antidepressant effects.
Page 15
To view all questions and flashcards with answers, click on the resource link above.
Chapter 14: Treatments for Anxiety Disorders
Available Study Resources on Quizplus for this Chatper
114 Verified Questions
114 Flashcards
Source URL: https://quizplus.com/quiz/46243
Sample Questions
Q1) After a doctor performs a routine blood analysis and finds unusually high levels of cortisol,what might she ask her patient?
A) Have you been facing a lot of stress lately?
B) Have you been eating foods high in cholesterol?
C) Have you been abusing any drugs?
D) Have you been feeling depressed?
Q2) The first anxiolytic drug was a(n)
A) antidepressant drug.
B) barbiturate.
C) idoleamine.
D) benzodiazepine.
Q3) A persistent state of physiological arousal or exaggerated response to certain stimuli,particularly those associated with a traumatic event,occurs with A) posttraumatic stress disorder.
B) agoraphonia.
C) generalized anxiety disorder.
D) social anxiety disorder.
Q4) A barbiturate with effects that last only 30 minutes is referred to as a(n)____________ acting barbiturate.
To view all questions and flashcards with answers, click on the resource link above. Page 16
Chapter 15: Antipsychotic Drugs
Available Study Resources on Quizplus for this Chatper
114 Verified Questions
114 Flashcards
Source URL: https://quizplus.com/quiz/46244
Sample Questions
Q1) The DISC1 protein
A) plays a role in neuron development.
B) is a precusor for the synthesis of dopamine.
C) specifically grows neurons in the ventral tegmental area.
D) is found concentrated in the hippocampus.
Q2) A hypothesis of schizophrenia that states that abnormal nervous system development leads to changes in the brain that cause schizophrenia is called the A) neurodegenerative hypothesis.
B) dopamine hypothesis.
C) prodromal hypothesis.
D) neurodevelopmental hypothesis.
Q3) Antagonism of 5-HT C receptors is associated with A) depressive symptoms in schizophrenia.
B) atypical antipsychotic effects.
C) weight gain.
D) QT interval prolongation.
Q4) Patients who do not respond after multiple rounds of antipsychotic treatment are identified as having ________ schizophrenia.
Q5) Name and describe the two major hypotheses for atypical antipsychotic drugs.
To view all questions and flashcards with answers, click on the resource link above. Page 17