Immunobiology Question Bank
Course Introduction
Immunobiology explores the complex mechanisms by which organisms defend themselves against pathogens and maintain health. This course delves into the cellular and molecular foundations of immune responses, covering innate and adaptive immunity, antigen recognition, immune cell communication, and the development of immune memory. Students will examine the roles of various immune cells and molecules, the process of immunological tolerance, and the consequences of immune dysfunction, such as allergies, autoimmunity, and immunodeficiency diseases. The course also introduces contemporary topics such as immunotherapies, vaccine development, and the interaction between the immune system and emerging infectious diseases.
Recommended Textbook
Cellular and Molecular Immunology 8th Edition by Abul K. Abbas
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20 Chapters
214 Verified Questions
214 Flashcards
Source URL: https://quizplus.com/study-set/1168
Page 2
Chapter 1: Activation of T Lymphocytes
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10 Verified Questions
10 Flashcards
Source URL: https://quizplus.com/quiz/23120
Sample Questions
Q1) This molecule becomes an active transcription factor on dephosphorylation.
A)CD3
B)Lck
C)Zap-70
D)LAT
E)Ras
F)PLC
G)PIP2
H)PIP3
I)IP3
J)DAG
K)Calcineurin
L)NFAT
M)Jun
N)Fos
O)NF- B
Answer: L
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Chapter 2: Antibodies and Antigens
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10 Verified Questions
10 Flashcards
Source URL: https://quizplus.com/quiz/23121
Sample Questions
Q1) The isotype only found in membrane-bound form on naive B cells
A)IgA
B)IgD
C)IgE
D)IgG
E)IgM
Answer: B
Q2) A proteolytic fragment of an antibody molecule that contains an intact antigen-binding site
A)Conformational determinant
B)Linear determinant
C)Neoantigenic determinant
D)Hinge region
E)Immunocomplex
F)Fab
G)Fc
H)Tail piece
I)Hapten
Answer: F
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Chapter 3: Antigen Processing and Presentation to T Lymphocytes
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10 Verified Questions
10 Flashcards
Source URL: https://quizplus.com/quiz/23122
Sample Questions
Q1) Required for proteolytic generation of class I MHC-binding peptides
A)T cell receptor on CD4 T cells
B)Endosomes
C)Endoplasmic reticulum
D)MHC class II compartment/class II vesicle (MIIC/CIIV)
E)Class II-associated invariant chain peptide (CLIP)
F)LMP-2 and LMP-7
G)Acidic proteases
H)T cell receptor on CD8 T cells
I)HLA-DM
Answer: F
Q2) A helper T cell response to a protein antigen requires the participation of antigen-presenting cells that express which of the following types of molecules?
A) Class II MHC and costimulators
B) Class I MHC and CD4
C) Class II MHC and CD8
D) CD4 and costimulators
E) Class II MHC and CD4
Answer: A
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Chapter 4: Antigen Receptors and Accessory Molecules of T Lymphocytes
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14 Verified Questions
14 Flashcards
Source URL: https://quizplus.com/quiz/23123
Sample Questions
Q1) VLA-4
A)B<sub>7</sub>-1, B<sub>7</sub>-2
B)Class II MHC
C)LFA-3
D)VCAM-1
E)Sialylated Lewis X
Q2) Variable Ig domain
Q3) P-selectin
A)B<sub>7</sub>-1, B<sub>7</sub>-2
B)Class II MHC
C)LFA-3
D)VCAM-1
E)Sialylated Lewis X
Q4) E-selectin
A)B<sub>7</sub>-1, B<sub>7</sub>-2
B)Class II MHC
C)LFA-3
D)VCAM-1
E)Sialylated Lewis X
Q5) Constant Ig domain
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Chapter 5: B Cell Activation and Antibody Production
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11 Verified Questions
11 Flashcards
Source URL: https://quizplus.com/quiz/23124
Sample Questions
Q1) Phagocytosis
A)IgM
B)IgD
C)IgG
D)IgE
E)IgA
Q2) Unclear functional role
A)IgM
B)IgD
C)IgG
D)IgE
E)IgA
Q3) An allergy attack
A)IgM
B)IgD
C)IgG
D)IgE
E)IgA
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Chapter 6: Effector Mechanisms of Cell-Mediated Immunity
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10 Verified Questions
10 Flashcards
Source URL: https://quizplus.com/quiz/23125
Sample Questions
Q1) This product of TH2 cells promotes immunity to helminthic infections.
A)Interferon-
B)Interleukin (IL)-10
C)IL-12
D)CD40L
E)CD40
F)STAT6
G)STAT4
H)IL-5
Q2) This intracellular signaling molecule and transcription factor is required for differentiation of TH2 cells and for responses of other cells to TH2 cells.
A)Interferon-
B)Interleukin (IL)-10
C)IL-12
D)CD40L
E)CD40
F)STAT6
G)STAT4
H)IL-5
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Chapter 7: Cells and Tissues of the Immune System
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10 Verified Questions
10 Flashcards
Source URL: https://quizplus.com/quiz/23126
Sample Questions
Q1) Broad-spectrum antibiotic present in the skin and in neutrophil granules; its synthesis is increased in response to inflammatory cytokines
A)Defensin
B)Opsonin
C)Natural antibody
D)Adjuvant
E)Complement
F)Inflammation
G)C-reactive protein
H)Mannose-binding lectin
I)Reactive oxygen intermediate
J)Inducible nitric oxide synthase
Q2) The signaling pathways triggered by Toll-like receptors typically result in activation of which of the following pairs of transcription factors?
A) NFAT and T-bet
B) AP-1 and GATA-3
C) Fos and STAT-6
D) NFkB and AP-1
E) Lck and Jun
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Chapter 8: Congenital and Acquired Immunodeficiencies
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13 Verified Questions
13 Flashcards
Source URL: https://quizplus.com/quiz/23127
Sample Questions
Q1) A generalized deficiency in the ability to mount delayed-type hypersensitivity (DTH) responses, as described in question 3, is called:
A) Clinical atopy
B) Clonal ignorance
C) Clinical anergy
D) Clonal deletion
E) Seroconversion
Q2) In which of the following conditions would you be LEAST likely to see a robust delayed-type hypersensitivity (DTH) response to a Candida antigen skin challenge?
A) X-linked agammaglobulinemia
B) DiGeorge syndrome
C) Selective IgA deficiency
D) Common variable immunodeficiency
E) Chronic granulomatous disease
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Chapter 9: Cytokines
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14 Verified Questions
14 Flashcards
Source URL: https://quizplus.com/quiz/23128
Sample Questions
Q1) Expressed as a membrane molecule on the surface of activated T cells, it binds to a receptor found on many cell types, including T cells, and induces apoptosis.
A)TNF-RI
B)CD40
C)Fas ligand
D)RANK
E)Lymphotoxin
Q2) Important in dendritic cell and T cell localization in lymph nodes
A)CXCL8 (IL-8)
B)CXCL10 (IP-10)
C)CCL19 (ELC)
D)CCL11 (Eotaxin)
E)CCR5
F)CXCR1
G)CX3CL1 (Fractalkine)
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11
Chapter 10: Diseases Caused by Immune Responses:
Hypersensitivity and Autoimmunity
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10 Verified Questions
10 Flashcards
Source URL: https://quizplus.com/quiz/23129
Sample Questions
Q1) All of the following are effector mechanisms of antibody-mediated disease EXCEPT:
A) Opsonization and phagocytosis of cells
B) Fas-dependent apoptosis of cells
C) Complement- and Fc receptor-mediated inflammation and tissue injury
D) Antibody stimulation of cell surface receptors in the absence of the physiologic ligands
E) Fc R crosslinking
Q2) In which of the following disorders is the underlying pathogenic mechanism NOT due to antibody-mediated damage to cells or tissues?
A) Pernicious anemia
B) Autoimmune hemolytic anemia
C) Pemphigus vulgaris
D) Acute rheumatic fever
E) Hyperacute allograft rejection
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Chapter 11: General Properties of Immune Response
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6 Verified Questions
6 Flashcards
Source URL: https://quizplus.com/quiz/23130
Sample Questions
Q1) The principal function of the immune system is:
A) Defense against cancer
B) Repair of injured tissues
C) Defense against microbial infections
D) Prevention of inflammatory diseases
E) Protection against environmental toxins
Q2) Which of the following cell types is required for all humoral immune responses?
A) Natural killer cells
B) Dendritic cells
C) Cytolytic T lymphocytes
D) B lymphocytes
E) Helper T lymphocytes
Q3) Antibodies and T lymphocytes are the respective mediators of which two types of immunity?
A) Innate and adaptive
B) Passive and active
C) Specific and nonspecific
D) Humoral and cell-mediated
E) Adult and neonatal
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Page 13
Chapter 12: The Major Histocompatibility Complex
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9 Verified Questions
9 Flashcards
Source URL: https://quizplus.com/quiz/23131
Sample Questions
Q1) Peptide-binding groove
Q2) 2-Microglobulin
Q3) Human class I MHC allele
A)HLA- 1
, -B7, -Cw4, -DPw5, -DQw10, -DR8
B)H-2
C)HLA-DQ7
D)I-Ad
E)HLA-B5
F)H-2KdI-AdI-EdDdLd
Q4) Polymorphic region
Q5) Mouse class II MHC allele
A)HLA- 1
, -B7, -Cw4, -DPw5, -DQw10, -DR8
B)H-2
C)HLA-DQ7
D)I-Ad
E)HLA-B5
F)H-2KdI-AdI-EdDdLd
Q6) CD8-binding site
Page 14
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Chapter 13: Effector Mechanisms of Humoral Immunity
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10 Verified Questions
10 Flashcards
Source URL: https://quizplus.com/quiz/23132
Sample Questions
Q1) Which of the following anatomic regions is normally protected from pathogens only by humoral immune responses and not by cell-mediated immune responses?
A) Skin
B) Intestinal lumen
C) Intestinal epithelium
D) Central nervous system
E) Spleen
Q2) This complement fragment is a component of the membrane attack complex.
A)C3b
B)iC3b
C)C3d
D)C5b
E)C5a
Q3) Produced by C3 convertases, this opsonin promotes phagocytosis of microbes.
A)C3b
B)iC3b
C)C3d
D)C5b
E)C5a
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Page 15
Chapter 14: Immediate Hypersensitivity
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10 Verified Questions
10 Flashcards
Source URL: https://quizplus.com/quiz/23133
Sample Questions
Q1) Soluble factor that promotes inflammation and late-phase reaction and activates endothelial expression of adhesion molecules critical for sequential neutrophilic infiltrate
A)Histamine
B)Tryptase
C)Prostaglandin D<sub>2</sub>
D)Leukotriene C<sub>4</sub>
E)Platelet-activating factor
F)Interleukin-5
G)Tumor necrosis factor-a
Q2) Cyclooxygenase-pathway product of arachidonic acid metabolism that causes vascular dilatation, smooth muscle contraction, and neutrophil chemotaxis
A)Histamine
B)Tryptase
C)Prostaglandin D<sub>2</sub>
D)Leukotriene C<sub>4</sub>
E)Platelet-activating factor
F)Interleukin-5
G)Tumor necrosis factor-a
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16
Chapter 15: Innate Immunity
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12 Verified Questions
12 Flashcards
Source URL: https://quizplus.com/quiz/23134
Sample Questions
Q1) This molecule is expressed on activated endothelium, is a member of the immunoglobulin superfamily, and binds to b1 integrins on activated T cells.
A)Peripheral lymph node addressin
B)Intercellular adhesion molecule-1 (ICAM-1)
C)Very late activation antigen-4 (VLA-4)
D)E-selectin
E)P-selectin ligand
F)CCR7
G)CXCR5
H)MadCAM-1
I)Vascular cell adhesion molecule-1 (VCAM-1)
Q2) Which of the following is the generative lymphoid organ for T lymphocytes?
A) Bone marrow
B) Spleen
C) Lymph node
D) Thymus
E) Tonsil
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Chapter 16: Immunologic Tolerance
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10 Verified Questions
10 Flashcards
Source URL: https://quizplus.com/quiz/23135
Sample Questions
Q1) Mechanism of central tolerance of B cells
A)Immature (IgM<sup>+</sup>IgD<sup>-</sup>)
B)Thymic cortex
C)Bone marrow
D)Antigen recognition without T cell help
E)Receptor editing
F)Activation-induced cell death
G)Regulatory T cell-mediated suppression
H)Antigen recognition with costimulation
I)Double positive (CD4<sup>+</sup>CD8<sup>+</sup>)
J)Anergy
K)Thymic medulla
Q2) Failure of self-tolerance is the cause of which one of the following types of diseases?
A) Allograft rejection
B) Autoimmunity
C) Atopy
D) Anergy
E) Acne
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Chapter 17: Lymphocyte Maturation and Expression of Antigen Receptor Genes
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11 Verified Questions
11 Flashcards
Source URL: https://quizplus.com/quiz/23136
Sample Questions
Q1) Which of the following is NOT an example of a checkpoint in lymphocyte maturation that contributes to the selective maturation of cells with useful antigen receptors?
A) B cell precursors that cannot express Ig g heavy chains die by apoptosis.
B) T cell precursors that cannot express TCR b chains die by apoptosis.
C) Immature B cells that bind to self antigen with high affinity die by apoptosis.
D) Developing T cells that fail to express TCR a chains die by apoptosis.
E) Developing T cells that recognize self major histocompatibility complex (MHC) molecules with high affinity die by apoptosis.
Q2) Which of the following is NOT a property of the V(D)J recombinase?
A) Recognizes specific DNA sequences flanking gene segments in the antigen receptor gene loci
B) Introduces double-stranded nicks in the DNA between recombination signal sequences and the adjacent V, D, or J coding sequences
C) Promotes joining V-to-J, D-to-J, and V-to-D
D) Repairs double-stranded DNA breaks
E) Splices out intronic sequences from primary RNA transcripts
Q3) Encodes the isotype of antibodies made by naive B cells
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Page 19
Chapter 18: Immunity to Microbes
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10 Verified Questions
10 Flashcards
Source URL: https://quizplus.com/quiz/23137
Sample Questions
Q1) Induction of a T cell-dependent antibody response to polysaccharides, such as Haemophilus influenzae B and pneumococcal capsular polysaccharides
A)Live attenuated or killed bacteria
B)Live attenuated oral virus
C)Synthetic viral subunit vaccines
D)Conjugate vaccines
E)Recombinant viral vectors
F)DNA vaccines
G)Purified subunit vaccines
Q2) Composed of viral proteins synthesized from recombinant viral genes
A)Live attenuated or killed bacteria
B)Live attenuated oral virus
C)Synthetic viral subunit vaccines
D)Conjugate vaccines
E)Recombinant viral vectors
F)DNA vaccines
G)Purified subunit vaccines
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20
Chapter 19: Transplantation Immunology
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10 Verified Questions
10 Flashcards
Source URL: https://quizplus.com/quiz/23138
Sample Questions
Q1) Can induce anergy in T cells through inhibition of costimulatory signaling
A)Azathioprine
B)Cyclosporine
C)Mycophenolate mofetil
D)Rapamycin
E)Anti-CD40L antibody
F)Anti-IL-2R antibody
G)CTLA4-Ig
H)OKT3
I)Corticosteroids
Q2) Common glycan that is fucosylated to form the H antigen
A)A
B)B
C)O
D)RhD
E)Lewis
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21
Chapter 20: Immunity to Tumors
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14 Verified Questions
14 Flashcards
Source URL: https://quizplus.com/quiz/23139
Sample Questions
Q1) A protein that is expressed only in immunologically privileged tissue
A)AFP
B)Bcr/Abl
C)CA-125
D)CD20
E)CEA
F)EBNA
G)MAGE
H)p53
I)PSA
J)Ras
Q2) Carcinoembryonic antigen (CEA)
A)Product of a cellular oncogene
B)Overexpressed unmutated cellular proteins
C)Product of unmutated genes normally silent in most tissues
D)Overexpressed surface glycolipid
E)Oncofetal antigen
F)Tissue differentiation antigen
G)Product of an oncogenic virus
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