Histopathology Test Questions
Course Introduction
Histopathology is the study of the microscopic structure of diseased tissues, providing crucial insights into disease processes, diagnosis, and progression at the cellular level. This course explores the fundamental principles and techniques of tissue preparation, staining, and microscopic examination, emphasizing the identification of pathological changes associated with major diseases. Students will learn to recognize and interpret the morphological alterations resulting from injury, infection, inflammation, neoplasia, and other disease states, integrating this knowledge with clinical findings to understand the pathogenesis and implications for patient care. Through practical sessions and case-based learning, the course equips students with essential skills for diagnostic pathology and research in biomedical sciences.
Recommended Textbook
Histology and Cell Biology An Introduction to Pathology 3rd Edition by Abraham L Kierszenbaum
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23 Chapters
246 Verified Questions
246 Flashcards
Source URL: https://quizplus.com/study-set/1028 Page 2
Chapter 1: Epithelium
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18 Verified Questions
18 Flashcards
Source URL: https://quizplus.com/quiz/20394
Sample Questions
Q1) The type of epithelium found lining small capillaries where it modulates diffusion is
A) Simple columnar
B) Simple cuboidal
C) Simple squamous
D) Stratified cuboidal
E) Stratified squamous
Answer: C
Q2) Through which part of a junctional complex can ions freely flow between adjacent cells?
A) Gap junction
B) Hemidesmosomes
C) Macula adherens
D) Zonula adherens
E) Tight junctions
Answer: A
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Chapter 2: Epithelial Glands
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6 Verified Questions
6 Flashcards
Source URL: https://quizplus.com/quiz/20395
Sample Questions
Q1) Which phrase does NOT describe one of the functions of proteins of the plasma membrane?
A) Acting as a receptor for substances external to the cell
B) Binding to a substance to carry it through the membrane
C) Forming a channel through the membrane
D) Increasing the rate of a chemical reaction
E) Initiating the replication of the genetic material
Answer: E
Q2) Exocrine glands are derived from
A) Connective tissue
B) Endocrine glands
C) Epithelial tissue
D) Muscle tissue
E) Nervous tissue
Answer: C
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4
Chapter 3: Cell Signaling
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6 Verified Questions
6 Flashcards
Source URL: https://quizplus.com/quiz/20396
Sample Questions
Q1) A ligand binding to a(n) _____ receptor directly results in phosphorylation
A) Cytokine
B) G protein-coupled
C) Intracellular
D) Threonine kinase
E) Tyrosine kinase
Answer: E
Q2) Which of the following functions by diffusing across the cell membrane to bind to intracellular protein receptors, resulting in gene activation or repression?
A) Acetylcholine
B) Insulin
C) Nitric oxide
D) Prostaglandin
E) Testosterone
Answer: E
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5
Chapter 4: Connective Tissue
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23 Verified Questions
23 Flashcards
Source URL: https://quizplus.com/quiz/20397
Sample Questions
Q1) Which type of cartilage is found in the respiratory tract and the nose?
A) Elastic cartilage
B) Fibrocartilage
C) Hyaline cartilage
D) Osteocartilage
E) Pericartilage
Q2) Connective tissue called _____ lines the _____ cavity of long bones
A) Endosteum epiphyseal
B) Endosteum medullary
C) Perichondrium medullary
D) Periosteum diaphyseal
E) Periosteum medullary
Q3) Which of the following is true of interstitial, rather than appositional, chondrogenesis?
A) Chondroblasts differentiate within the chondrogenic layer of the perichondrium
B) Isogenous groups are formed by chondroblast mitosis
C) Interstitial chondrogenesis begins from undifferentiated cells
D) It results in an increase in the diameter or thickness of the cartilage
E) Spindle-shaped cells cluster together in the outer layer of the perichondrium
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Page 6
Chapter 5: Osteogenesis
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10 Verified Questions
10 Flashcards
Source URL: https://quizplus.com/quiz/20398
Sample Questions
Q1) Which of the following is true of intramembranous, rather than endochondral, ossification?
A) A hyaline cartilage model is used
B) Long bones are formed
C) Mesenchymal cells differentiate into osteoblasts within connective tissue
D) Periosteal buds invade the lacunae left behind by dead chondrocytes
E) Secondary ossification centers form in the epiphyses
Q2) During the lengthening of long bones, the zone in which cartilage cells undergo cell division and become organized into rows of isogenous cells is the
A) Calcification zone
B) Hypertrophic zone
C) Proliferative zone
D) Reserve zone
E) Vascular invasion zone
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Chapter 6: Blood and Hematopoiesis
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14 Verified Questions
14 Flashcards
Source URL: https://quizplus.com/quiz/20399
Sample Questions
Q1) Where is the primary site of hemopoiesis?
A) Adipose tissue
B) Blood vessels
C) Bone marrow
D) Liver
E) Lymph nodes
Q2) Which cell type differentiates into macrophages?
A) Basophil
B) Eosinophil
C) Lymphocyte
D) Monocyte
E) Neutrophil
Q3) During homing and inflammation, _____ occurs following rolling and attachment
A) Adhesion
B) Macrophage activation
C) Migration of T-cells
D) Selectin expression
E) Tumor necrosis factor - secretion
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8
Chapter 7: Muscle Tissue
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9 Verified Questions
9 Flashcards
Source URL: https://quizplus.com/quiz/20400
Sample Questions
Q1) The H-zone of a sarcomere contains which of the following proteins?
A) Myosin only
B) Actin only
C) Troponin and tropomyosin
D) B and C only
E) All of the above
Q2) When comparing skeletal, cardiac, and smooth muscle structure
A) Cardiac muscle contains triads while skeletal muscle contains diads
B) Sarcomere structure in smooth muscle and cardiac muscle are the same
C) Skeletal muscle thin filaments have actin, troponin, and tropomyosin; smooth muscle lacks troponin
D) Skeletal muscles consume more energy than cardiac muscle as a result of the abundance of mitochondria
E) T-tubule diameter in smooth muscle is smaller than in cardiac muscle
Q3) Connective tissue that surrounds individual muscle cells is called the _____.
A) Endomysium
B) Epimysium
C) Perimysium
D) Sarcolemma
E) Sarcoplasmic reticulum
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Chapter 8: Nervous Tissue
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9 Verified Questions
9 Flashcards
Source URL: https://quizplus.com/quiz/20401
Sample Questions
Q1) Interneurons are found
A) Only in the brain
B) Only in the central nervous system
C) Only in the peripheral nervous system
D) Only in the spinal cord
E) Throughout the nervous system
Q2) Sensory information is conducted toward the spinal cord via
A) Bipolar neurons
B) Multipolar neurons
C) Pseudounipolar neurons
D) Purkinje cells
E) Pyramidal cells
Q3) The neuroglial cells responsible for myelinating axons in the central nervous system are
A) Astrocytes
B) Ependymal cells
C) Microglial cells
D) Oligodendrocytes
E) Schwann cells
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Page 10
Chapter 9: Sensory Organs: Vision and Hearing
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10 Verified Questions
10 Flashcards
Source URL: https://quizplus.com/quiz/20402
Sample Questions
Q1) The membrane that separates the fluid-filled cochlear chamber from the air-filled middle ear, helping to regulate pressure in the inner ear, is called the _____
A) Cochlear duct
B) Cochlear membrane
C) Oval window
D) Round window
E) Tympanic membrane
Q2) When auditory vibrations enter the cochlear duct, the _____ membrane remains stationary, resulting in a shearing action of the vibrating hair cells, leading to the stimulation of the cochlear nerve
A) Basilar
B) Reissner's
C) Sacular
D) Tectorial
E) Tympanic
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Chapter 10: Immune Lymphatic System
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8 Verified Questions
8 Flashcards
Source URL: https://quizplus.com/quiz/20403
Sample Questions
Q1) The major histocompatibility complex
A) Activates B cells to produce specific antibodies
B) Differentiates into cytotoxic T cells upon re-exposure to a known pathogen
C) Helps T cells recognize antigens as nonself
D) Recognizes and kills viral cells by secreting perforin
E) Secretes interferon on contact with a virus
Q2) Activated B cells proliferate in the _____ of a lymph node.
A) Capsule
B) Germinal center
C) Mantle zone
D) Subcapsular sinus
E) Trabeculae
Q3) Helper T cells
A) Activate B cells to produce specific antibodies
B) Differentiate into cytotoxic T cells upon re-exposure to a known pathogen
C) Help T cells recognize antigens as nonself
D) Recognize and kill viral cells by secreting perforin
E) Secrete interferon upon contact with a virus
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12
Chapter 11: Integumentary System
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11 Verified Questions
11 Flashcards
Source URL: https://quizplus.com/quiz/20404
Sample Questions
Q1) Langerhans cells
A) Are located in the stratum basale of the epidermis
B) Are mechanoreceptor cells
C) Can be found within a cornified cell envelope
D) Have granules in their cytoplasm
E) Present antigens to T cells as part of the immune response
Q2) Which of the following is NOT true of the stratum spinosum?
A) It contains immunity-conferring cells called Langerhans cells
B) It is also called the "spiny" layer
C) It is comprised mostly of keratinocytes
D) It is superficial to the stratum granulosum and the stratum germinativum
E) Keratins 5 and 14 are replaced by keratins 1 and 10 following basal keratinocyte migration
Q3) Nail production occurs at the nail _____.
A) Bed
B) Body
C) Eponychium
D) Hyponychium
E) Matrix
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Page 13
Chapter 12: Cardiovascular System
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12 Verified Questions
12 Flashcards
Source URL: https://quizplus.com/quiz/20405
Sample Questions
Q1) Which of the following is true of angiogenesis rather than vasculogenesis?
A) Capillary sprout is formed following basal laminal degradation of the parent vessel
B) Endothelial capillary tubes are formed following angioblast proliferation
C) Angiogenesis is dependent upon vascular endothelial growth factor and vascular endothelial growth factor receptor-2
D) Angiogenesis occurs solely in the embryo
E) Angiogenesis produces new vessels from scratch rather than forming new vessels from pre-existing ones
Q2) In the heart's conduction system, the electrical signal travels from the atrioventricular node to the
A) Atrioventricular bundle (bundle of His)
B) Bundle branches
C) Junctional fibers
D) Purkinje fibers
E) Sinoatrial node
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14
Chapter 13: Respiratory System
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11 Verified Questions
11 Flashcards
Source URL: https://quizplus.com/quiz/20406
Sample Questions
Q1) In the respiratory system, air moves from the larynx into the
A) Bronchi
B) Bronchioles
C) Laryngopharynx
D) Oropharynx
E) Trachea
Q2) Which of the following cells in the olfactory epithelium are structurally bipolar neurons?
A) Basal cells
B) Bowman's cells
C) Columnar cells
D) Olfactory cells
E) Sustentacular cells
Q3) Which of the following statements about the larynx is not true?
A) It is lined with respiratory epithelium
B) The false vocal folds contain the space of Reinke
C) The subglottis is inferior to the anterior and posterior commissures
D) The true vocal folds are found in the glottis
E) Vocal cords are abducted during inspiration
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Page 15
Chapter 14: Urinary System
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14 Verified Questions
14 Flashcards
Source URL: https://quizplus.com/quiz/20407
Sample Questions
Q1) Urine flows from the major calyx directly to which kidney structure?
A) Minor calyx
B) Nephron
C) Renal papillae
D) Renal pelvis
E) Ureter
Q2) Podocytes comstitute the ____ of the renal corpuscle
A) Basal lamina
B) Glomerulus
C) Inner visceral layer of Bowman's capsule
D) Mesangium
E) Outer parietal layer of Bowman's capsule
Q3) Simple cuboidal epithelium containing long microvilli lines the
A) Bowman's capsule
B) Collecting duct
C) Distal convoluted tubule
D) Loop of Henle
E) Proximal convoluted tubule
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16
Chapter 15: Upper Digestive Segment
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15 Verified Questions
15 Flashcards
Source URL: https://quizplus.com/quiz/20408
Sample Questions
Q1) The secretion of which cell type is needed to begin the process of digesting proteins?
A) Chief cells
B) Gastroenteroendocrine cells
C) Mucous neck cells
D) Parietal cells
E) Stem cells
Q2) Which of the following are not mucosal specializations that increase absorptive surface area?
A) Enterocytes
B) Microvilli
C) Plicae circularis
D) Rugae
E) Villi
Q3) The outer surface of the tooth's root is covered by _____.
A) Cementum
B) Dentin
C) Enamel
D) Gingivae
E) Pulp
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Page 17
Chapter 16: Lower Digestive Segment
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9 Verified Questions
9 Flashcards
Source URL: https://quizplus.com/quiz/20409
Sample Questions
Q1) Cholecystokinin
A) Inhibits gastric juice secretion
B) Inhibits pancreatic juice secretion
C) Stimulates antigen endocytosis
D) Stimulates lysozyme secretion
E) Stimulates the gallbladder to secrete bile
Q2) All of the following cell types participate in the immunity of the intestine EXCEPT
A) Eosinophils
B) Macrophages
C) Mast cells
D) Neutrophils
E) Plasma cells
Q3) Where are electrolytes actively absorbed, and where is water passively absorbed?
A) Duodenum
B) Ileum
C) Jejunum
D) Large intestine
E) Stomach
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18
Chapter 17: Digestive Glands
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13 Verified Questions
13 Flashcards
Source URL: https://quizplus.com/quiz/20410
Sample Questions
Q1) Sublingual glands
A) Are the largest salivary glands
B) Contain protein-rich granules
C) Contain serous but not mucous cells
D) Have a well-defined capsule
E) Have poorly developed intercalated ducts
Q2) All of the following are found in the islets of Langerhans EXCEPT
A) Cells that secrete a bicarbonate-rich alkaline fluid
B) Cells that secrete a hormone responsible for lowering blood glucose levels
C) Cells that secrete a hormone that results in the liver's breaking down glycogen
D) Cells that stimulate glycogen synthesis
E) Insulin-secreting cells
Q3) Which of the following does not differentiate the gallbladder from the liver?
A) Microvilli are present on gallbladder epithelial cells
B) The gallbladder epithelium is folded
C) The muscularis mucosae of the gallbladder is thicker than that of the liver
D) There are no mucus-producing cells in the gallbladder
E) Water is reabsorbed from the bile in the gallbladder
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Chapter 18: Neuroendocrine System
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7 Verified Questions
7 Flashcards
Source URL: https://quizplus.com/quiz/20411
Sample Questions
Q1) The hormone that stimulates insulin-like growth factor-1 production in the hepatocytes is secreted by
A) Acidophils
B) Basophils
C) Chromophobe cells
D) Herring bodies
E) Pituicytes
Q2) Which endocrine structure is composed of several cell types, including chromophobe cells, acidophils, and basophils?
A) Adrenal gland
B) Anterior pituitary
C) Parathyroid gland
D) Pineal gland
E) Posterior pituitary
Q3) Prolactin secretion is _____ by _____.
A) Inhibited dopamine
B) Inhibited somatostatin
C) Stimulated dopamine
D) Stimulated growth hormone-releasing hormone
E) Stimulated nerve impulse from the hypothalamus
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Chapter 19: Endocrine System
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9 Verified Questions
9 Flashcards
Source URL: https://quizplus.com/quiz/20412
Sample Questions
Q1) What happens immediately after insulin binds to the -subunit of the insulin receptor?
A) It activates the adjacent tyrosine kinase ( -subunit)
B) It increases glucose uptake by the cell
C) It stimulates glucagon secretion by the cells
D) It stimulates the synthesis of GLUT-4 (glucose transporter-4)
E) It transports the GLUT-4 protein to the cell membrane
Q2) Parafollicular cells
A) Are found in the parathyroid glands
B) Are found in the zona glomerulosa
C) Constitute the pars tuberalis
D) Secrete a hormone that lowers blood calcium levels
E) Secrete hormones responsible for establishing the basal metabolic rate
Q3) Which endocrine structure secretes epinephrine and norepinephrine?
A) Adenohypophysis
B) Adrenal cortex
C) Adrenal medulla
D) Neurohypophysis
E) Thyroid gland
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Chapter 20: Spermatogenesis
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8 Verified Questions
8 Flashcards
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Sample Questions
Q1) Spermatogenic cells and Sertoli cells are found in the
A) Epididymides
B) Prostate
C) Rete testes
D) Seminiferous tubules
E) Vas deferens
Q2) Meiosis II occurs in the
A) Primary spermatocyte
B) Secondary spermatocyte
C) Spermatid
D) Spermatogonia
E) Spermatozoa
Q3) Which of the following is not true of Sertoli cells?
A) Their function is regulated by follicle-stimulating hormone
B) They are found in testicular interstitial tissue
C) They prevent cytotoxic agents from moving to the seminiferous tubules from the blood by forming tight junctions with adjacent Sertoli cells
D) They provide mechanical support for spermatogenic cells
E) They provide nutrition for spermatogenic cells
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Page 22
Chapter 21: Sperm Transport and Maturation
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6 Verified Questions
6 Flashcards
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Sample Questions
Q1) Which of the following structures secretes the largest component of seminal fluid?
A) Bulbourethral gland
B) Ductuli efferentes
C) Ductus epididymidis
D) Prostate gland
E) Seminal vesicle
Q2) Sperm are matured and stored in what structure?
A) Epididymidis
B) Prostate
C) Seminal vesicle
D) Testis
E) Vas deferens
Q3) Sperm move from the tubuli recti into the
A) Ductuli efferentes
B) Epididymidis
C) Rete testis
D) Seminiferous tubules
E) Vas deferens
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23
Chapter 22: Follicle Development and the Menstrual Cycle
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10 Verified Questions
10 Flashcards
Source URL: https://quizplus.com/quiz/20415
Sample Questions
Q1) Developing follicles are found in the
A) Ovarian cortex
B) Ovarian medulla
C) Oviduct
D) Tunica albuginea
E) Uterus
Q2) Which of the following does not occur as a result of the luteinizing hormone surge?
A) Formation of the corpus luteum
B) Increased estrogen secretion
C) Ovulation
D) Secondary oocyte completes meiosis I
E) Secretion of proteolytic enzymes from the mature follicle
Q3) Which of the following statements about the corpus luteum is incorrect?
A) It degenerates into the corpus albicans approximately 14 days following fertilization
B) It forms following ovulation
C) It has increased vascularization
D) Its folded structure is formed by the collapsing of the follicular wall
E) The theca interna and granulosa cells accumulate lutein
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Chapter 23: Fertilization, Placentation, and Lactation
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8 Verified Questions
8 Flashcards
Source URL: https://quizplus.com/quiz/20416
Sample Questions
Q1) What structure secretes estrogen and progesterone for approximately 3 months following fertilization?
A) Corpus albicans
B) Corpus luteum
C) Mature follicle
D) Placenta
E) Tunica albuginea
Q2) Following fertilization and after about 3 days of cell division, the developing organism is considered a ____ as it moves along the uterine tube toward the uterus.
A) Blastula
B) Fetus
C) Gastrula
D) Morula
E) Zygote
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