Hematopathology Test Preparation
Course Introduction
Hematopathology is a specialized branch of pathology focused on the study, diagnosis, and understanding of diseases affecting blood, bone marrow, and lymphoid tissues. This course provides an in-depth exploration of the cellular and molecular abnormalities underlying various hematologic disorders, including anemias, leukemias, lymphomas, and coagulopathies. Students will learn diagnostic techniques such as morphological examination, immunophenotyping, cytogenetics, and molecular pathology, and will discuss current classification systems and treatment implications. Emphasis is placed on clinical-pathological correlation, fostering a comprehensive understanding of how laboratory findings integrate with patient management in hematologic disease.
Recommended Textbook
Hematology in Practice 2nd Edition by Betty Ciesla
Available Study Resources on Quizplus
19 Chapters
414 Verified Questions
414 Flashcards
Source URL: https://quizplus.com/study-set/3886 Page 2
Chapter 1: Introduction to Hematology and Basic Laboratory Practice
Available Study Resources on Quizplus for this Chatper
20 Verified Questions
20 Flashcards
Source URL: https://quizplus.com/quiz/77408
Sample Questions
Q1) Which of the following is the definition of a reference interval?
A) A solution of a known amount of analyte
B) Materials analyzed concurrently with unknown samples
C) Values established for a particular analyte, given a method, instrument, or patient population
D) Validation techniques on flagged samples
Answer: C
Q2) Standard deviation is a measurement of precision.
A)True
B)False
Answer: True
Q3) The average of a group of data points is defined as the:
A) Mean
B) Mode
C) Median
D) Modicum
Answer: A
To view all questions and flashcards with answers, click on the resource link above.
Page 3
Chapter 2: From Hematopoiesis to the Complete Blood Count
Available Study Resources on Quizplus for this Chatper
20 Verified Questions
20 Flashcards
Source URL: https://quizplus.com/quiz/77407
Sample Questions
Q1) Bone marrow aspiration is usually required in conditions of:
A) Anemia
B) Hypoxia
C) Leukemia
D) Hepatosplenomegaly
Answer: C
Q2) Patients with moderate anemias (7 to 10 g/dL) may be asymptomatic.
A)True
B)False
Answer: True
Q3) T cells are responsible for humoral immunity.
A)True
B)False
Answer: False
Q4) What is the average M:E ratio for normal adult bone marrow?
A) 1:3
B) 4:1
C) 1:4
D) 6:1
Answer: B
To view all questions and flashcards with answers, click on the resource link above. Page 4
Chapter 3: Red Blood Cell Production, Function, and
Relevant Red Blood Cell Morphology
Available Study Resources on Quizplus for this Chatper
24 Verified Questions
24 Flashcards
Source URL: https://quizplus.com/quiz/77406
Sample Questions
Q1) The last nucleated stage of erythrocytic maturation is the:
A) Pronormoblast
B) Orthochromic normoblast
C) Polychromatophilic normoblast
D) Basophilic normoblast
Answer: B
Q2) Increased plasma cholesterol may lead to the development of which of these abnormal red cell morphologies?
A) Spherocytes
B) Target cells
C) Microcytes
D) Helmet cells
Answer: B
Q3) The higher the N:C ratio, the more mature the cell.
A)True
B)False
Answer: False
To view all questions and flashcards with answers, click on the resource link above.
Page 5
Chapter 4: Hemoglobin Function and Principles of Hemolysis
Available Study Resources on Quizplus for this Chatper
20 Verified Questions
20 Flashcards
Source URL: https://quizplus.com/quiz/77405
Sample Questions
Q1) Physiologic conditions in the body that can decrease hemoglobin's oxygen affinity include:
A) Increased pH
B) Decreased 2,3-DPG
C) Increased body temp
D) The presence of abnormal hemoglobins
Q2) ____may be seen in intravascular hemolysis but not in extravascular hemolysis.
A) Hemoglobinuria
B) Splenomegaly
C) Increased LDH
D) Elevated serum bilirubin
Q3) Each hemoglobin molecule consists of heme structures.
A) two
B) four
C) six
D) eight
Q4) Hemoglobin begins to be synthesized at the polychromatophilic stage of red cell development.
A)True
B)False
To view all questions and flashcards with answers, click on the resource link above. Page 6
Chapter 5: The Microcytic Anemias
Available Study Resources on Quizplus for this Chatper
26 Verified Questions
26 Flashcards
Source URL: https://quizplus.com/quiz/77404
Sample Questions
Q1) The alpha thalassemic condition that is incompatible with life is:
A) Hemoglobin H disease
B) Bart's hydrops fetalis
C) Alpha thalassemia trait
D) Silent carrier condition
Q2) The alpha thalassemias result from:
A) Gene deletion
B) Defective alpha genes
C) Iron overload
D) Excessive production of alpha chains
Q3) In iron deficiency anemia, the reticulocyte count will be:
A) Normal
B) Low
C) High
D) Extremely high
Q4) One of the gravest clinical problems for individuals with thalassemia major is:
A) Chronic anemia
B) Iron overload
C) Therapeutic phlebotomy
D) Collapsed veins
Page 7
To view all questions and flashcards with answers, click on the resource link above.
Chapter 6: The Macrocytic Anemias
Available Study Resources on Quizplus for this Chatper
17 Verified Questions
17 Flashcards
Source URL: https://quizplus.com/quiz/77403
Sample Questions
Q1) A bone marrow aspiration/examination is not necessary for patients with megaloblastic anemia.
A)True
B)False
Q2) A key substance required for the incorporation of vitamin B<sub>12</sub> in red cell nuclear synthesis is the presence of:
A) EPO
B) Transferrin
C) Intrinsic factor
D) Cytokines
Q3) An appropriate M:E ratio in the case of megaloblastic anemia would be:
A) 1:3
B) 4:1
C) 5:1
D) 1:10
Q4) Ineffective erythropoiesis is defined as:
A) An increase in the M:E ratio
B) A synthetic defect in hemoglobin
C) Premature destruction of red cell precursors
D) A DNA maturation defect
To view all questions and flashcards with answers, click on the resource link above. Page 8
Chapter 7: Normochromic Anemias: Biochemical,
Membrane, and Miscellaneous Red Blood Cell Disorders
Available Study Resources on Quizplus for this Chatper
20 Verified Questions
20 Flashcards
Source URL: https://quizplus.com/quiz/77402
Sample Questions
Q1) The cell at the tip of the pointer is referred to as a:
A) Stomatocyte
B) Target cell
C) Normal erythrocyte
D) Spherocyte
Q2) Which of the following is most closely associated with G6PD deficiency?
A) Continuous intravascular hemolysis occurs.
B) G6PD is a sex linked inherited disease.
C) Splenectomy is commonly done to control symptoms.
D) The majority of the erythrocytes in these individuals are microcytic.
Q3) One of the least severe clinical manifestations of G6PD deficiency is:
A) Acute hemolytic anemia
B) Favism
C) Neonatal jaundice
D) Congenital non-spherocytic hemolytic anemia
Q4) The RBC inclusions that are composed of denatured hemoglobin are called:
A) Pappenheimer bodies
B) Howell-Jolly bodies
C) Heinz bodies
D) Siderotic granules
To view all questions and flashcards with answers, click on the resource link above. Page 9
Chapter 8: The Normochromic Anemias Caused by
Hemoglobinopathies
Available Study Resources on Quizplus for this Chatper
23 Verified Questions
23 Flashcards
Source URL: https://quizplus.com/quiz/77401
Sample Questions
Q1) When the bone marrow temporarily ceases to produce cells in a sickle cell patient, a(n) _____crisis has occurred.
A) aplastic
B) hemolytic
C) vaso-occlusive
D) cardiac
Q2) The Benin haplotype of sickle cell disease is prevalent in which country or countries?
A) Saudi Arabia and Asia
B) Senegal
C) West Africa
D) Central and South Africa
Q3) A blood smear from a patient with sickle cell crisis shows 80 nucleated red cells per 100 leukocytes.The total leukocyte count is 18 \(\times\) 10<sup>9</sup>/L.The corrected white cell count is:
A) 17,200
B) 9,000
C) 10,000
D) 13,400
To view all questions and flashcards with answers, click on the resource link above. Page 10
Chapter 9: Leukopoiesis and Leukopoietic Function
Available Study Resources on Quizplus for this Chatper
20 Verified Questions
20 Flashcards
Source URL: https://quizplus.com/quiz/77400
Sample Questions
Q1) The amount of time a granulocyte spends in the circulation before migrating into the tissues is normally:
A) 8 hours
B) 48 hours
C) 5 days
D) 20 days
Q2) The absolute WBC count refers to the percentage of a particular cell counted from the 100 WBC differential.
A)True
B)False
Q3) The N:C ratio in a myeloblast is:
A) 2:1
B) 4:1
C) 3:1
D) 5:1
Q4) There are ___ maturation stages in the neutrophil.
A) five
B) four
C) three
D) six
To view all questions and flashcards with answers, click on the resource link above. Page 11
Chapter 10: Abnormalities of White Blood Cells:
Quantitative, Qualitative, and the Lipid Storage Diseases
Available Study Resources on Quizplus for this Chatper
20 Verified Questions
20 Flashcards
Source URL: https://quizplus.com/quiz/77399
Sample Questions
Q1) Opsonization of foreign bodies is defined as:
A) Preparing a foreign body for phagocytosis
B) Degranulation of neutrophils
C) Fusion of cytoplasmic granules
D) Bacteriocidal activity
Q2) Which of the following is an unusual complication that may occur in infectious mononucleosis?
A) Splenic infarctions
B) Dactylitis
C) Hemolytic anemia
D) Giant platelets
Q3) A patient who presents with a low white cell count, thrombocytopenia, elevated liver enzymes, and mulberry-like inclusions in the granulocytes is most likely suffering from:
A) May-Hegglin anomaly
B) Chediak-Higashi anomaly
C) Human ehrlichiosis
D) Alder's anomaly
To view all questions and flashcards with answers, click on the resource link above. Page 12
Chapter 11: Acute Leukemias
Available Study Resources on Quizplus for this Chatper
25 Verified Questions
25 Flashcards
Source URL: https://quizplus.com/quiz/77398
Sample Questions
Q1) A patient with AML is likely to have a cytochemical stain panel that is positive for:
A) Sodium fluoride with tartrate resistance
B) MPO, SBB, specific esterase
C) MP0, SBB, nonspecific esterase
D) SBB and TdT
Q2) Pure erythroid leukemia is defined as:
A) Erythroid precursors greater than 30%, myeloblasts less than 20%
B) Erythroid precursors greater than 50%, myeloblasts less than 40%
C) Erythroid precursors less than 50%
D) Erythroid precursors greater than 80%
Q3) The basic pathophysiology mechanism responsible for producing signs and symptoms in leukemia includes all of the following except:
A) Replacement of normal marrow precursors by leukemic cells
B) Decrease in functional leukocytes causing infection
C) Hemorrhage secondary to thrombocytopenia
D) Decreased erythropoietin production
To view all questions and flashcards with answers, click on the resource link above. Page 13
Chapter 12: Chronic Myeloproliferative Disorders
Available Study Resources on Quizplus for this Chatper
24 Verified Questions
24 Flashcards
Source URL: https://quizplus.com/quiz/77397
Sample Questions
Q1) The LAP stain is helpful in distinguishing:
A) A leukemoid reaction from CGL
B) CML from CLL
C) CML from AML
D) CML from ALL
Q2) Tyrosine kinase is an important mediator in leukocyte metabolic pathways because it suppresses:
A) Opsonization
B) Phagocytosis
C) Leukoerythroblastosis
D) Apoptosis
Q3) The accelerated phase of chronic myeloid leukemia is marked by:
A) Increased basophils
B) Thrombocytopenia
C) Increase in blasts
D) Increased fibrosis
To view all questions and flashcards with answers, click on the resource link above.
14
Chapter 13: Lymphoproliferative Disorders and Related
Plasma Cell Disorders
Available Study Resources on Quizplus for this Chatper
20 Verified Questions
20 Flashcards
Source URL: https://quizplus.com/quiz/77396
Sample Questions
Q1) An abnormal proliferation of dysfunctional B lymphocytes is commonly associated with:
A) Acute lymphocytic leukemia
B) Chronic lymphocytic leukemia
C) Infectious mononucleosis
D) Hodgkin's disease
Q2) The protein electrophoresis pattern pictured above is most frequently associated with:
A) Hodgkin's lymphoma
B) Multiple myeloma
C) Thalassemia major
D) Essential thrombocytopenia
Q3) The immunoglobulin responsible for secondary immunological response is:
A) Ig A
B) Ig M
C) Ig D
D) Ig G
To view all questions and flashcards with answers, click on the resource link above.
Page 15
Chapter 14: The Myelodysplastic Syndromes
Available Study Resources on Quizplus for this Chatper
20 Verified Questions
20 Flashcards
Source URL: https://quizplus.com/quiz/77395
Sample Questions
Q1) The correct name for the cell at the end of the pointer is a:
A) Ringed sideroblast
B) Reticulocyte
C) Giant platelet
D) Siderocyte
Q2) The blast count in most individuals with MDS is:
A) Less than 10%
B) Less than 40%
C) Less than 5%
D) Less than 20%
Q3) The cell at the tip of the pointer is:
A) A basophil
B) A malignant cell
C) A degenerating neutrophil
D) Not a cell; it's an artifact
Q4) The cell at the tip of the pointer is a:
A) Hairy cell
B) Basket cell
C) Degenerating lymphocyte
D) Giant platelet
To view all questions and flashcards with answers, click on the resource link above. Page 16
Chapter 15: Overview of Hemostasis and Platelet Physiology
Available Study Resources on Quizplus for this Chatper
30 Verified Questions
30 Flashcards
Source URL: https://quizplus.com/quiz/77394
Sample Questions
Q1) Tissue factor pathway inhibitor (TFPI):
A) Prevents activation of factor X by VIIa
B) Activates the common pathway
C) Inhibits fibrinolysis
D) Inhibits the kallikrein proteins
Q2) Which of the following proteins is not made in the liver?
A) Anti-hemophiliac factor
B) Prothrombin
C) Fibrinogen
D) von Willebrand factor
Q3) Which of the following is not a component of the fibrinolytic system?
A) Thrombin
B) Plasmin
C) Tissue-type plasminogen activator (tPA)
D) Urokinase
Q4) All of the coagulation factors have autosomal inheritance features except:
A) Factors I and XII
B) Factors III and VIII
C) Factors VIII and IX
D) Factors V and VII
To view all questions and flashcards with answers, click on the resource link above. Page 17
Chapter 16: Quantitative and Qualitative Platelet Disorders
Available Study Resources on Quizplus for this Chatper
25 Verified Questions
25 Flashcards
Source URL: https://quizplus.com/quiz/77393
Sample Questions
Q1) Which of the following is an autoimmune thrombocytopenic disease process?
A) Chronic idiopathic thrombocytopenic purpura
B) Hemolytic uremic syndrome
C) von Willebrand's disease
D) Thrombocytopenia with absent radii
Q2) Platelets from patients with these two disorders will not aggregate with ristocetin.
A) Glanzmann's syndrome and von Willebrand's
B) Glanzmann's syndrome and Chediak-Higashi
C) HUS and Bernard-Soulier syndrome
D) von Willebrand's disease and Bernard-Soulier
Q3) Thrombocytosis is defined as a platelet count that is:
A) Greater than 450 \(\times\) 10<sup>9</sup>/L
B) Less than 450 \(\times\)w10<sup>9</sup>/L
C) Greater than 600 \(\times\) 10<sup>9</sup>/L
D) Less than 300 \(\times\) 10<sup>9</sup>/L
To view all questions and flashcards with answers, click on the resource link above.
Chapter 17: Defects of Plasma Clotting Factors
Available Study Resources on Quizplus for this Chatper
20 Verified Questions
20 Flashcards
Source URL: https://quizplus.com/quiz/77392
Sample Questions
Q1) Treatment of patients with factor II, VII, or X deficiency consists of:
A) Administration of prothrombin complex concentrate
B) Administration of cryoprecipitate
C) Administration of FFP
D) Administration of whole blood
Q2) Which of the following is the most useful in differentiating hemophilia A from hemophilia B?
A) A familial pattern of inheritance
B) Patient's history
C) Activated partial thromboplastin time
D) Factor assays
Q3) Factor XI deficiency is also known as:
A) Christmas disease
B) Hemophilia A
C) Hemophilia C
D) Fitzgerald factor deficiency
To view all questions and flashcards with answers, click on the resource link above.
Chapter 18: Fibrinogen, Thrombin, and the Fibrinolytic System
Available Study Resources on Quizplus for this Chatper
20 Verified Questions
20 Flashcards
Source URL: https://quizplus.com/quiz/77391
Sample Questions
Q1) The process of fibrin degradation is called ______and is controlled by the enzyme
A) fibrination, plasmin
B) fibrinolysis, plasmin
C) fibrination, protease
D) fibrinolysis, protease
Q2) Plasmin causes the inactivation of factors:
A) V, VII, X, XI
B) V, VIII, XI, XII
C) VII, VIII, XI, XII
D) X, XI, XII, XIII
Q3) Which of the following hematology disorders will likely trigger an episode of DIC?
A) Sickle cell disease
B) Iron deficiency anemia
C) Idiopathic thrombocythemia
D) Acute progranulocytic leukemia
To view all questions and flashcards with answers, click on the resource link above.
Chapter 19: Introduction to Thrombosis and Anticoagulant Therapy
Available Study Resources on Quizplus for this Chatper
20 Verified Questions
20 Flashcards
Source URL: https://quizplus.com/quiz/77390
Sample Questions
Q1) Factor VIII inhibitors:
A) Are associated with thrombosis
B) Are associated with decreased fibrinogen levels
C) Are usually time and temperature dependent
D) Are corrected with the addition of normal plasma
Q2) Coumadin acts in such a way that it:
A) Alters the synthesis of vitamin K-dependent factors
B) Reduces the circulating level of factors III and V
C) Reduces the circulating level of factor I
D) Cleaves carboxyreductase to generate glutamic acid
Q3) All of the following statements describe factor V Leiden except:
A) It is a cause of activated protein C resistance.
B) It is associated with thrombocytopenia.
C) It is associated with increased risk of thrombosis.
D) Is an inherited disorder.
Q4) Heparin:
A) Inhibits PF3
B) Inhibits thrombin
C) Degrades antithrombin
D) Complexes with protein C
To view all questions and flashcards with answers, click on the resource link above. Page 21