Genetics Exam Practice Tests
Course Introduction
Genetics is a foundational course that explores the principles of heredity and the molecular mechanisms that govern the transmission of genetic information from one generation to the next. Topics include Mendelian inheritance, gene structure and function, genetic variation, population genetics, genetic mapping, and the molecular basis of genetic diseases. Students will also examine modern techniques such as DNA sequencing, genome editing, and biotechnological applications, alongside ethical considerations in genetic research and applications. This course provides a comprehensive understanding essential for advanced study in biology and related fields.
Recommended Textbook
Cellular and Molecular Immunology 8th Edition by Abul K. Abbas
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20 Chapters
214 Verified Questions
214 Flashcards
Source URL: https://quizplus.com/study-set/1168 Page 2
Chapter 1: Activation of T Lymphocytes
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10 Verified Questions
10 Flashcards
Source URL: https://quizplus.com/quiz/23120
Sample Questions
Q1) This molecule becomes an active transcription factor on dephosphorylation.
A)CD3
B)Lck
C)Zap-70
D)LAT
E)Ras
F)PLC
G)PIP2
H)PIP3
I)IP3
J)DAG
K)Calcineurin
L)NFAT
M)Jun
N)Fos
O)NF- B
Answer: L
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Chapter 2: Antibodies and Antigens
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10 Verified Questions
10 Flashcards
Source URL: https://quizplus.com/quiz/23121
Sample Questions
Q1) The isotype only found in membrane-bound form on naive B cells
A)IgA
B)IgD
C)IgE
D)IgG
E)IgM
Answer: B
Q2) A proteolytic fragment of an antibody molecule that contains an intact antigen-binding site
A)Conformational determinant
B)Linear determinant
C)Neoantigenic determinant
D)Hinge region
E)Immunocomplex
F)Fab
G)Fc
H)Tail piece
I)Hapten
Answer: F
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Chapter 3: Antigen Processing and Presentation to T Lymphocytes
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10 Verified Questions
10 Flashcards
Source URL: https://quizplus.com/quiz/23122
Sample Questions
Q1) Site of peptide loading of class I MHC molecules
A)T cell receptor on CD4 T cells
B)Endosomes
C)Endoplasmic reticulum
D)MHC class II compartment/class II vesicle (MIIC/CIIV)
E)Class II-associated invariant chain peptide (CLIP)
F)LMP-2 and LMP-7
G)Acidic proteases
H)T cell receptor on CD8 T cells
I)HLA-DM
Answer: C
Q2) A helper T cell response to a protein antigen requires the participation of antigen-presenting cells that express which of the following types of molecules?
A) Class II MHC and costimulators
B) Class I MHC and CD4
C) Class II MHC and CD8
D) CD4 and costimulators
E) Class II MHC and CD4
Answer: A
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Chapter 4: Antigen Receptors and Accessory Molecules of T Lymphocytes
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14 Verified Questions
14 Flashcards
Source URL: https://quizplus.com/quiz/23123
Sample Questions
Q1) CD4
A)B<sub>7</sub>-1, B<sub>7</sub>-2
B)Class II MHC
C)LFA-3
D)VCAM-1
E)Sialylated Lewis X
Q2) Constant Ig domain
Q3) P-selectin
A)B<sub>7</sub>-1, B<sub>7</sub>-2
B)Class II MHC
C)LFA-3
D)VCAM-1
E)Sialylated Lewis X
Q4) CD3 protein
Q5) CD2
A)B<sub>7</sub>-1, B<sub>7</sub>-2
B)Class II MHC
C)LFA-3
D)VCAM-1
E)Sialylated Lewis X
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Chapter 5: B Cell Activation and Antibody Production
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11 Verified Questions
11 Flashcards
Source URL: https://quizplus.com/quiz/23124
Sample Questions
Q1) An Src family kinase that phosphorylates ITAMs in the cytoplasmic tails of B cell receptor complex proteins
A)Ig
B)Ig
C)C3b
D)C3d
E)CR2
F)CD19
G)CD81
H)Fyn
I)Syk
Q2) T cell-independent antigens
A)IgM
B)IgD
C)IgG
D)IgE
E)IgA
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Page 7
Chapter 6: Effector Mechanisms of Cell-Mediated Immunity
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10 Verified Questions
10 Flashcards
Source URL: https://quizplus.com/quiz/23125
Sample Questions
Q1) Mediates homing of a subset of T cells into the intestinal mucosa
A)P-selectin
B)L-selectin
C)CCR8
D)Tumor necrosis factor (TNF)
E)VCAM-1
F)LFA-1
G)CCR5
H)CCR4
I)a4b7
J)Cutaneous lymphocyte antigen (CLA)
K)Mip1-a
L)VLA-4
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Chapter 7: Cells and Tissues of the Immune System
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10 Verified Questions
10 Flashcards
Source URL: https://quizplus.com/quiz/23126
Sample Questions
Q1) Superoxide anion, hydroxyl radical, or hydrogen peroxide, produced by activated phagocytes
A)Defensin
B)Opsonin
C)Natural antibody
D)Adjuvant
E)Complement
F)Inflammation
G)C-reactive protein
H)Mannose-binding lectin
I)Reactive oxygen intermediate
J)Inducible nitric oxide synthase
Q2) Toll-like receptors and other receptors are potent activators of various components of the innate immune system. All of the following proteins are expressed in response to signaling by these receptors EXCEPT:
A) Interleukin-12
B) E-selectin
C) Tumor necrosis factor
D) Inducible nitric oxide synthase (iNOS)
E) CD28
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Page 9
Chapter 8: Congenital and Acquired Immunodeficiencies
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13 Verified Questions
13 Flashcards
Source URL: https://quizplus.com/quiz/23127
Sample Questions
Q1) Late gene product; encodes coat proteins gp120 and gp41
A)env
B)gag
C)nef
D)pol
E)rev
F)tat
G)vif
Q2) All of the following may result in an acquired immunodeficiency EXCEPT:
A) Malnutrition
B) Treatment with corticosteroids
C) Disseminated cancer
D) Inherited defect in B cell maturation
E) Infection with human immunodeficiency virus (HIV)
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Chapter 9: Cytokines
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14 Verified Questions
14 Flashcards
Source URL: https://quizplus.com/quiz/23128
Sample Questions
Q1) Expressed as a membrane molecule on the surface of activated T cells, it binds to a receptor found on many cell types, including T cells, and induces apoptosis.
A)TNF-RI
B)CD40
C)Fas ligand
D)RANK
E)Lymphotoxin
Q2) Mediates neutrophil recruitment into tissues
A)CXCL8 (IL-8)
B)CXCL10 (IP-10)
C)CCL19 (ELC)
D)CCL11 (Eotaxin)
E)CCR5
F)CXCR1
G)CX3CL1 (Fractalkine)
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11
Chapter 10: Diseases Caused by Immune Responses:
Hypersensitivity and Autoimmunity
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10 Verified Questions
10 Flashcards
Source URL: https://quizplus.com/quiz/23129
Sample Questions
Q1) Which type of hypersensitivity disease is caused by deposition of antigen-antibody complexes in blood vessel walls?
A) Type I
B) Type II
C) Type III
D) Type IV
E) Type V
Q2) Which of the following statements about immune complex-mediated diseases is NOT true?
A) Immune complexes may contain antibodies bound to either self or foreign antigens.
B) Immune complex-mediated diseases generally show systemic manifestations.
C) Pathologic features of immune complex diseases are determined by the cellular source of the antigen.
D) Small complexes are deposited in vessels more than large complexes, which are usually efficiently phagocytosed.
E) Complexes containing cationic antigens are more likely to produce severe, long-lasting injury by depositing in blood vessels and renal glomeruli.
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12
Chapter 11: General Properties of Immune Response
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6 Verified Questions
6 Flashcards
Source URL: https://quizplus.com/quiz/23130
Sample Questions
Q1) Which of the following cell types is required for all humoral immune responses?
A) Natural killer cells
B) Dendritic cells
C) Cytolytic T lymphocytes
D) B lymphocytes
E) Helper T lymphocytes
Q2) Which of the following infectious diseases was prevented by the first successful vaccination?
A) Polio
B) Tuberculosis
C) Smallpox
D) Tetanus
E) Rubella
Q3) The principal function of the immune system is:
A) Defense against cancer
B) Repair of injured tissues
C) Defense against microbial infections
D) Prevention of inflammatory diseases
E) Protection against environmental toxins
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Page 13
Chapter 12: The Major Histocompatibility Complex
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9 Verified Questions
9 Flashcards
Source URL: https://quizplus.com/quiz/23131
Sample Questions
Q1) Inbred mouse strain MHC haplotype
A)HLA- 1
, -B7, -Cw4, -DPw5, -DQw10, -DR8
B)H-2
C)HLA-DQ7
D)I-Ad
E)HLA-B5
F)H-2KdI-AdI-EdDdLd
Q2) Mouse major histocompatibility complex
A)HLA- 1
, -B7, -Cw4, -DPw5, -DQw10, -DR8
B)H-2
C)HLA-DQ7
D)I-Ad
E)HLA-B5
F)H-2KdI-AdI-EdDdLd
Q3) Peptide-binding groove
Q4) Polymorphic region
Q5) 2-Microglobulin
Q6) CD8-binding site
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Chapter 13: Effector Mechanisms of Humoral Immunity
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10 Verified Questions
10 Flashcards
Source URL: https://quizplus.com/quiz/23132
Sample Questions
Q1) This complement fragment is a chemoattractant for neutrophils.
A)C3b
B)iC3b
C)C3d
D)C5b
E)C5a
Q2) Generated by factor I-mediated proteolysis, this opsonizing complement fragment binds to CR3 on phagocytes.
A)C3b
B)iC3b
C)C3d
D)C5b
E)C5a
Q3) This complement fragment is a component of the membrane attack complex.
A)C3b
B)iC3b
C)C3d
D)C5b
E)C5a
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Page 15
Chapter 14: Immediate Hypersensitivity
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10 Verified Questions
10 Flashcards
Source URL: https://quizplus.com/quiz/23133
Sample Questions
Q1) Lipoxygenase-pathway product of arachidonic acid metabolism that causes prolonged bronchoconstriction, mucus secretion, and increased vascular permeability
A)Histamine
B)Tryptase
C)Prostaglandin D<sub>2</sub>
D)Leukotriene C<sub>4</sub>
E)Platelet-activating factor
F)Interleukin-5
G)Tumor necrosis factor-a
Q2) Which of the following is the most common disorder of immunity that affects 20% of all individuals in the United States?
A) Atopy
B) Diabetes mellitus
C) Leukemia
D) IgA deficiency
E) Latent tuberculosis infection
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16
Chapter 15: Innate Immunity
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12 Verified Questions
12 Flashcards
Source URL: https://quizplus.com/quiz/23134
Sample Questions
Q1) This vascular addressin binds to integrins on T cells and mediates their homing to intestinal mucosa.
A)Peripheral lymph node addressin
B)Intercellular adhesion molecule-1 (ICAM-1)
C)Very late activation antigen-4 (VLA-4)
D)E-selectin
E)P-selectin ligand
F)CCR7
G)CXCR5
H)MadCAM-1
I)Vascular cell adhesion molecule-1 (VCAM-1)
Q2) In naive T cell recirculation, entry of the cells into peripheral lymph nodes occurs through which specialized vessel?
A) Efferent lymphatic
B) Thoracic duct
C) Central artery
D) High endothelial venule
E) Sinusoid
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Chapter 16: Immunologic Tolerance
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10 Verified Questions
10 Flashcards
Source URL: https://quizplus.com/quiz/23135
Sample Questions
Q1) Mechanism of central tolerance of B cells
A)Immature (IgM<sup>+</sup>IgD<sup>-</sup>)
B)Thymic cortex
C)Bone marrow
D)Antigen recognition without T cell help
E)Receptor editing
F)Activation-induced cell death
G)Regulatory T cell-mediated suppression
H)Antigen recognition with costimulation
I)Double positive (CD4<sup>+</sup>CD8<sup>+</sup>)
J)Anergy
K)Thymic medulla
Q2) Failure of self-tolerance is the cause of which one of the following types of diseases?
A) Allograft rejection
B) Autoimmunity
C) Atopy
D) Anergy
E) Acne
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Chapter 17: Lymphocyte Maturation and Expression of Antigen Receptor Genes
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11 Verified Questions
11 Flashcards
Source URL: https://quizplus.com/quiz/23136
Sample Questions
Q1) Which of the following is NOT a required step in B and T lymphocyte maturation?
A) Proliferative expansion of precursor cells
B) Cell surface expression of complete antigen receptor complexes
C) Positive selection
D) Activation of precursors by foreign antigens
E) Pre-antigen receptor expression
Q2) Which of the following is NOT a property of the V(D)J recombinase?
A) Recognizes specific DNA sequences flanking gene segments in the antigen receptor gene loci
B) Introduces double-stranded nicks in the DNA between recombination signal sequences and the adjacent V, D, or J coding sequences
C) Promotes joining V-to-J, D-to-J, and V-to-D
D) Repairs double-stranded DNA breaks
E) Splices out intronic sequences from primary RNA transcripts
Q3) A segment that encodes Ig-like domains that form part of the antigen-binding region of an Ig molecule
Q4) A type of gene segment involved in somatic recombination events in Ig heavy chain and light chain as well as TCR a and b chain gene loci
Q5) Encodes the isotype of antibodies made by naive B cells
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Chapter 18: Immunity to Microbes
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10 Verified Questions
10 Flashcards
Source URL: https://quizplus.com/quiz/23137
Sample Questions
Q1) Composed of antigens purified from microbes or inactivated toxins, such as the tetanus toxoid vaccine
A)Live attenuated or killed bacteria
B)Live attenuated oral virus
C)Synthetic viral subunit vaccines
D)Conjugate vaccines
E)Recombinant viral vectors
F)DNA vaccines
G)Purified subunit vaccines
Q2) Composed of viral proteins synthesized from recombinant viral genes
A)Live attenuated or killed bacteria
B)Live attenuated oral virus
C)Synthetic viral subunit vaccines
D)Conjugate vaccines
E)Recombinant viral vectors
F)DNA vaccines
G)Purified subunit vaccines
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Chapter 19: Transplantation Immunology
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10 Verified Questions
10 Flashcards
Source URL: https://quizplus.com/quiz/23138
Sample Questions
Q1) Binds FKBP and inhibits cell cycle progression in T cells
A)Azathioprine
B)Cyclosporine
C)Mycophenolate mofetil
D)Rapamycin
E)Anti-CD40L antibody
F)Anti-IL-2R antibody
G)CTLA4-Ig
H)OKT3
I)Corticosteroids
Q2) Nonglycosylated red cell membrane protein missing or mutated in 15% of humans
A)A
B)B
C)O
D)RhD
E)Lewis
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21
Chapter 20: Immunity to Tumors
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14 Verified Questions
14 Flashcards
Source URL: https://quizplus.com/quiz/23139
Sample Questions
Q1) Component of adoptive cellular immunotherapy used with IL-2 and/or chemotherapeutic drugs
A)Killed tumor vaccine
B)DNA vaccines
C)Interleukin (IL)-2
D)IL-4
E)GM-CSF (granulocyte-macrophage colony-stimulating factor)
F)Anti-CD3 antibodies
G)Lymphokine-activated killer cells
H)Anti-Her2/neu antibodies
I)Anti-idiotypic antibodies
J)Dendritic cell vaccine
Q2) Prostate-specific antigen
A)Product of a cellular oncogene
B)Overexpressed unmutated cellular proteins
C)Product of unmutated genes normally silent in most tissues
D)Overexpressed surface glycolipid
E)Oncofetal antigen
F)Tissue differentiation antigen
G)Product of an oncogenic virus
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Page 22