Biology of the Immune System Question
Bank
Course
Introduction
Biology of the Immune System explores the structure and function of the body's defense mechanisms against pathogens. The course covers the development and roles of innate and adaptive immune responses, detailing cellular and molecular participants such as lymphocytes, antibodies, cytokines, and antigen-presenting cells. Students will examine topics including immune regulation, immunological memory, tolerance, and the consequences of immune malfunction such as autoimmunity, allergies, and immunodeficiencies. Modern applications such as vaccines, immunotherapy, and transplant immunology are also discussed, providing a foundation for understanding both health and disease states related to immunology.
Recommended Textbook
Cellular and Molecular Immunology 8th Edition by Abul K. Abbas
Available Study Resources on Quizplus
20 Chapters
214 Verified Questions
214 Flashcards
Source URL: https://quizplus.com/study-set/1168 Page 2
Chapter 1: Activation of T Lymphocytes
Available Study Resources on Quizplus for this Chatper
10 Verified Questions
10 Flashcards
Source URL: https://quizplus.com/quiz/23120
Sample Questions
Q1) This molecule has the same downstream effect as addition of the drug phorbol myristate acetate (PMA) to T cells.
A)CD3
B)Lck
C)Zap-70
D)LAT
E)Ras
F)PLC
G)PIP2
H)PIP3
I)IP3
J)DAG
K)Calcineurin
L)NFAT
M)Jun
N)Fos
O)NF- B
Answer: J
To view all questions and flashcards with answers, click on the resource link above.
Page 3
Chapter 2: Antibodies and Antigens
Available Study Resources on Quizplus for this Chatper
10 Verified Questions
10 Flashcards
Source URL: https://quizplus.com/quiz/23121
Sample Questions
Q1) The isotype most closely associated with immediate hypersensitivity (allergic) disease
A)IgA
B)IgD
C)IgE
D)IgG
E)IgM
Answer: C
Q2) The isotype only found in membrane-bound form on naive B cells
A)IgA
B)IgD
C)IgE
D)IgG
E)IgM
Answer: B
To view all questions and flashcards with answers, click on the resource link above. Page 4
Chapter 3: Antigen Processing and Presentation to T Lymphocytes
Available Study Resources on Quizplus for this Chatper
10 Verified Questions
10 Flashcards
Source URL: https://quizplus.com/quiz/23122
Sample Questions
Q1) Site of peptide loading of class I MHC molecules
A)T cell receptor on CD4 T cells
B)Endosomes
C)Endoplasmic reticulum
D)MHC class II compartment/class II vesicle (MIIC/CIIV)
E)Class II-associated invariant chain peptide (CLIP)
F)LMP-2 and LMP-7
G)Acidic proteases
H)T cell receptor on CD8 T cells
I)HLA-DM
Answer: C
Q2) A helper T cell response to a protein antigen requires the participation of antigen-presenting cells that express which of the following types of molecules?
A) Class II MHC and costimulators
B) Class I MHC and CD4
C) Class II MHC and CD8
D) CD4 and costimulators
E) Class II MHC and CD4
Answer: A
To view all questions and flashcards with answers, click on the resource link above. Page 5
Chapter 4: Antigen Receptors and Accessory Molecules of T Lymphocytes
Available Study Resources on Quizplus for this Chatper
14 Verified Questions
14 Flashcards
Source URL: https://quizplus.com/quiz/23123
Sample Questions
Q1) Variable Ig domain
Q2) P-selectin
A)B<sub>7</sub>-1, B<sub>7</sub>-2
B)Class II MHC
C)LFA-3
D)VCAM-1
E)Sialylated Lewis X
Q3) E-selectin
A)B<sub>7</sub>-1, B<sub>7</sub>-2
B)Class II MHC
C)LFA-3
D)VCAM-1
E)Sialylated Lewis X
Q4) Antigen-binding region
Q5) CD28
A)B<sub>7</sub>-1, B<sub>7</sub>-2
B)Class II MHC
C)LFA-3
D)VCAM-1
E)Sialylated Lewis X
To view all questions and flashcards with answers, click on the resource link above. Page 6
Chapter 5: B Cell Activation and Antibody Production
Available Study Resources on Quizplus for this Chatper
11 Verified Questions
11 Flashcards
Source URL: https://quizplus.com/quiz/23124
Sample Questions
Q1) Phagocytosis
A)IgM
B)IgD
C)IgG
D)IgE
E)IgA
Q2) Unclear functional role
A)IgM
B)IgD
C)IgG
D)IgE
E)IgA
Q3) Binds to receptors in the gastrointestinal tract of infants for absorption into the serum
A)IgM
B)IgD
C)IgG
D)IgE
E)IgA
To view all questions and flashcards with answers, click on the resource link above. Page 7
Chapter 6: Effector Mechanisms of Cell-Mediated Immunity
Available Study Resources on Quizplus for this Chatper
10 Verified Questions
10 Flashcards
Source URL: https://quizplus.com/quiz/23125
Sample Questions
Q1) A membrane molecule expressed on T cells that promotes migration of TH2 cells into certain inflammatory sites
A)P-selectin
B)L-selectin
C)CCR8
D)Tumor necrosis factor (TNF)
E)VCAM-1
F)LFA-1
G)CCR5
H)CCR4
I)a4b7
J)Cutaneous lymphocyte antigen (CLA)
K)Mip1-a
L)VLA-4
To view all questions and flashcards with answers, click on the resource link above. Page 8
Chapter 7: Cells and Tissues of the Immune System
Available Study Resources on Quizplus for this Chatper
10 Verified Questions
10 Flashcards
Source URL: https://quizplus.com/quiz/23126
Sample Questions
Q1) Toll-like receptors and other receptors are potent activators of various components of the innate immune system. All of the following proteins are expressed in response to signaling by these receptors EXCEPT:
A) Interleukin-12
B) E-selectin
C) Tumor necrosis factor
D) Inducible nitric oxide synthase (iNOS)
E) CD28
Q2) Acute-phase reactant produced by the liver and released into blood
A)Defensin
B)Opsonin
C)Natural antibody
D)Adjuvant
E)Complement
F)Inflammation
G)C-reactive protein
H)Mannose-binding lectin
I)Reactive oxygen intermediate
J)Inducible nitric oxide synthase
To view all questions and flashcards with answers, click on the resource link above. Page 9
Chapter 8: Congenital and Acquired Immunodeficiencies
Available Study Resources on Quizplus for this Chatper
13 Verified Questions
13 Flashcards
Source URL: https://quizplus.com/quiz/23127
Sample Questions
Q1) Impaired CD4+ T cell development and activation due to lack of class II MHC expression, resulting in defective cell-mediated immunity and impaired T cell-dependent humoral immunity
A)X-linked agammaglobulinemia
B)X-linked hyper-IgM syndrome
C)X-linked lymphoproliferative syndrome
D)Bare lymphocyte syndrome
E)Chronic granulomatous disease (CGD)
F)Leukocyte adhesion deficiency-1 (LAD-1)
G)Leukocyte adhesion deficiency-2 (LAD-2)
Q2) Which one of the following is typically NOT associated with T cell immunodeficiencies?
A) Cancer
B) Viral infection
C) Autoimmunity
D) Infection with intracellular microbes
E) Infection with pyogenic bacteria
To view all questions and flashcards with answers, click on the resource link above.
Chapter 9: Cytokines
Available Study Resources on Quizplus for this Chatper
14 Verified Questions
14 Flashcards
Source URL: https://quizplus.com/quiz/23128
Sample Questions
Q1) Induces B cell isotype switching to IgE production
A)Interferon-g
B)Interleukin (IL)-4
C)IL-5
D)Transforming growth factor-b
E)Lymphotoxin
Q2) Mediates neutrophil recruitment into tissues
A)CXCL8 (IL-8)
B)CXCL10 (IP-10)
C)CCL19 (ELC)
D)CCL11 (Eotaxin)
E)CCR5
F)CXCR1
G)CX3CL1 (Fractalkine)
Q3) Stimulates growth and activation of eosinophils
A)Interferon-g
B)Interleukin (IL)-4
C)IL-5
D)Transforming growth factor-b
E)Lymphotoxin
To view all questions and flashcards with answers, click on the resource link above. Page 11
Chapter 10: Diseases Caused by Immune Responses:
Hypersensitivity and Autoimmunity
Available Study Resources on Quizplus for this Chatper
10 Verified Questions
10 Flashcards
Source URL: https://quizplus.com/quiz/23129
Sample Questions
Q1) A 23-year-old medical student is taken to the emergency department because of diffuse facial erythema (redness), tightness of the chest, and difficulty breathing. He reports that the symptoms began shortly after he ate a shellfish dinner at a nearby Thai restaurant. On physical examination, he appears to be in acute distress with elevated heart rate and respiratory rate and a dangerously low blood pressure. He is treated with epinephrine.
A)Type I hypersensitivity
B)Type II hypersensitivity
C)Type III hypersensitivity
D)Type IV hypersensitivity
Q2) Which of the following is NOT associated with increased relative risk of developing systemic lupus erythematosus?
A) Female gender
B) Deficiency in complement protein C2
C) African-American ethnicity
D) Presence of HLA-DR3
E) Defect in B cell maturation
To view all questions and flashcards with answers, click on the resource link above. Page 12
Chapter 11: General Properties of Immune Response
Available Study Resources on Quizplus for this Chatper
6 Verified Questions
6 Flashcards
Source URL: https://quizplus.com/quiz/23130
Sample Questions
Q1) Which of the following cell types is required for all humoral immune responses?
A) Natural killer cells
B) Dendritic cells
C) Cytolytic T lymphocytes
D) B lymphocytes
E) Helper T lymphocytes
Q2) The principal function of the immune system is:
A) Defense against cancer
B) Repair of injured tissues
C) Defense against microbial infections
D) Prevention of inflammatory diseases
E) Protection against environmental toxins
Q3) Which of the following infectious diseases was prevented by the first successful vaccination?
A) Polio
B) Tuberculosis
C) Smallpox
D) Tetanus
E) Rubella
To view all questions and flashcards with answers, click on the resource link above.
Page 13
Chapter 12: The Major Histocompatibility Complex
Available Study Resources on Quizplus for this Chatper
9 Verified Questions
9 Flashcards
Source URL: https://quizplus.com/quiz/23131
Sample Questions
Q1) CD8-binding site
Q2) Inbred mouse strain MHC haplotype
A)HLA- 1 , -B7, -Cw4, -DPw5, -DQw10, -DR8
B)H-2
C)HLA-DQ7
D)I-Ad
E)HLA-B5
F)H-2KdI-AdI-EdDdLd
Q3) Human MHC haplotype
A)HLA- 1 , -B7, -Cw4, -DPw5, -DQw10, -DR8
B)H-2
C)HLA-DQ7
D)I-Ad
E)HLA-B5
F)H-2KdI-AdI-EdDdLd
Q4) 2-Microglobulin
Q5) Peptide-binding groove
Q6) Polymorphic region
To view all questions and flashcards with answers, click on the resource link above. Page 14
Chapter 13: Effector Mechanisms of Humoral Immunity
Available Study Resources on Quizplus for this Chatper
10 Verified Questions
10 Flashcards
Source URL: https://quizplus.com/quiz/23132
Sample Questions
Q1) Generated by factor I-mediated proteolysis, this opsonizing complement fragment binds to CR3 on phagocytes.
A)C3b
B)iC3b
C)C3d
D)C5b
E)C5a
Q2) Generated by factor I-mediated proteolysis, this complement fragment binds to complement receptor 2 (CR2) on B cells and enhances B cell activation.
A)C3b
B)iC3b
C)C3d
D)C5b
E)C5a
To view all questions and flashcards with answers, click on the resource link above. Page 15
Chapter 14: Immediate Hypersensitivity
Available Study Resources on Quizplus for this Chatper
10 Verified Questions
10 Flashcards
Source URL: https://quizplus.com/quiz/23133
Sample Questions
Q1) Which of the following is the most common disorder of immunity that affects 20% of all individuals in the United States?
A) Atopy
B) Diabetes mellitus
C) Leukemia
D) IgA deficiency
E) Latent tuberculosis infection
Q2) Soluble factor that promotes inflammation and late-phase reaction and activates endothelial expression of adhesion molecules critical for sequential neutrophilic infiltrate
A)Histamine
B)Tryptase
C)Prostaglandin D<sub>2</sub>
D)Leukotriene C<sub>4</sub>
E)Platelet-activating factor
F)Interleukin-5
G)Tumor necrosis factor-a
To view all questions and flashcards with answers, click on the resource link above. Page 16
Chapter 15: Innate Immunity
Available Study Resources on Quizplus for this Chatper
12 Verified Questions
12 Flashcards
Source URL: https://quizplus.com/quiz/23134
Sample Questions
Q1) The expression of this molecule is induced on endothelial cells in inflamed tissues, and it mediates rolling of T cells along the endothelial surface.
A)Peripheral lymph node addressin
B)Intercellular adhesion molecule-1 (ICAM-1)
C)Very late activation antigen-4 (VLA-4)
D)E-selectin
E)P-selectin ligand
F)CCR7
G)CXCR5
H)MadCAM-1
I)Vascular cell adhesion molecule-1 (VCAM-1)
Q2) In naive T cell recirculation, entry of the cells into peripheral lymph nodes occurs through which specialized vessel?
A) Efferent lymphatic
B) Thoracic duct
C) Central artery
D) High endothelial venule
E) Sinusoid
To view all questions and flashcards with answers, click on the resource link above. Page 17
Chapter 16: Immunologic Tolerance
Available Study Resources on Quizplus for this Chatper
10 Verified Questions
10 Flashcards
Source URL: https://quizplus.com/quiz/23135
Sample Questions
Q1) Which of the following statements about induction or maintenance of T cell tolerance is NOT true?
A) Central tolerance is induced when immature developing T cells in bone marrow or thymus encounter self antigens.
B) Peripheral T cell tolerance results when mature naive T cells recognize antigens without adequate B7-1- or B7-2-mediated costimulation.
C) Peripheral T cell tolerance results when T cells recognize antigen in the setting of an innate immune response to the antigen.
D) Peripheral T cell tolerance to some antigens is induced when mature T cells recognize antigen and bind B7-1 or B7-2 via the inhibitory CTLA-4 receptor.
E) Peripheral T cell tolerance to an antigen may be induced by persistent and repeated stimulation of lymphocytes by that antigen in tissues.
To view all questions and flashcards with answers, click on the resource link above.
Chapter 17: Lymphocyte Maturation and Expression of Antigen Receptor Genes
Available Study Resources on Quizplus for this Chatper
11 Verified Questions
11 Flashcards
Source URL: https://quizplus.com/quiz/23136
Sample Questions
Q1) Which of the following statements about negative selection during lymphocyte development is most accurate?
A) The mechanism of negative selection is the death of cells whose antigen receptors are not stimulated by self antigens.
B) The mechanism of negative selection is apoptosis actively induced by antigen-receptor recognition of self antigens.
C) Negative selection ensures a self MHC restricted repertoire of T lymphocytes.
D) Negative selection occurs only in T cell maturation and not in B cell maturation.
E) The major mechanism of negative selection is inhibition of antigen receptor expression.
Q2) Homologous segments of this type of gene segment that encode part of the third complementarity determining region (CDR3) of Ig heavy chains and TCR b chains but not Ig light chains or TCR a chains
Q3) A segment that encodes Ig-like domains that form part of the antigen-binding region of an Ig molecule
Q4) Encodes the isotype of antibodies made by naive B cells
To view all questions and flashcards with answers, click on the resource link above.
Page 19
Chapter 18: Immunity to Microbes
Available Study Resources on Quizplus for this Chatper
10 Verified Questions
10 Flashcards
Source URL: https://quizplus.com/quiz/23137
Sample Questions
Q1) Composed of viral proteins synthesized from recombinant viral genes
A)Live attenuated or killed bacteria
B)Live attenuated oral virus
C)Synthetic viral subunit vaccines
D)Conjugate vaccines
E)Recombinant viral vectors
F)DNA vaccines
G)Purified subunit vaccines
Q2) Induction of a T cell-dependent antibody response to polysaccharides, such as Haemophilus influenzae B and pneumococcal capsular polysaccharides
A)Live attenuated or killed bacteria
B)Live attenuated oral virus
C)Synthetic viral subunit vaccines
D)Conjugate vaccines
E)Recombinant viral vectors
F)DNA vaccines
G)Purified subunit vaccines
To view all questions and flashcards with answers, click on the resource link above.
20
Chapter 19: Transplantation Immunology
Available Study Resources on Quizplus for this Chatper
10 Verified Questions
10 Flashcards
Source URL: https://quizplus.com/quiz/23138
Sample Questions
Q1) Nonglycosylated red cell membrane protein missing or mutated in 15% of humans
A)A
B)B
C)O
D)RhD
E)Lewis
Q2) Common glycan that is fucosylated to form the H antigen
A)A
B)B
C)O
D)RhD
E)Lewis
Q3) Formed by a glycosyltransferase enzyme that adds a terminal galactose residue to the H antigen
A)A
B)B
C)O
D)RhD
E)Lewis
To view all questions and flashcards with answers, click on the resource link above.
Page 21
Chapter 20: Immunity to Tumors
Available Study Resources on Quizplus for this Chatper
14 Verified Questions
14 Flashcards
Source URL: https://quizplus.com/quiz/23139
Sample Questions
Q1) A patient presenting with jaundice and a recent 11-kg (20 lb) weight loss who has a history of hepatitis B infection will most likely have elevated levels of this glycoprotein
A)AFP
B)Bcr/Abl
C)CA-125
D)CD20
E)CEA
F)EBNA
G)MAGE
H)p53
I)PSA
J)Ras
To view all questions and flashcards with answers, click on the resource link above.
22