Advanced Immunology Test Bank
Course Introduction
Advanced Immunology explores the complex mechanisms of the immune system at the molecular and cellular levels. This course delves into topics such as antigen recognition, immune cell signaling, tolerance, autoimmunity, hypersensitivity, and immunological memory. Students will examine immune responses to pathogens, cancer, and transplantation, as well as the role of the immune system in various diseases. The course emphasizes recent advances in immunological research, experimental techniques, and the development of immunotherapies, preparing students for careers in research, medicine, or biotechnology.
Recommended Textbook
Basic Immunology Functions and Disorders of the Immune System 4th Edition by Abul K. Abbas
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12 Chapters
181 Verified Questions
181 Flashcards
Source URL: https://quizplus.com/study-set/1165 Page 2
Chapter 1: Introduction to the Immune System
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16 Verified Questions
16 Flashcards
Source URL: https://quizplus.com/quiz/23007
Sample Questions
Q1) At 15 months of age, a child received a measles-mumps-rubella vaccine (MMR). At age 22, she is living with a family in Mexico that has not been vaccinated and she is exposed to measles. Despite the exposure, she does not become infected. Which of the following properties of the adaptive immune system is best illustrated by this scenario?
A)Specificity
B)Diversity
C)Specialization
D)Memory
E)Nonreactivity to self
Answer: D
Q2) Antibodies and T lymphocytes are the respective mediators of which two types of immunity?
A)Innate and adaptive
B)Passive and active
C)Specific and nonspecific
D)Humoral and cell-mediated
E)Adult and neonatal
Answer: D
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Chapter 2: Innate Immunity
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17 Verified Questions
17 Flashcards
Source URL: https://quizplus.com/quiz/23008
Sample Questions
Q1) Which of the following statements about the innate immune system is NOT true?
A)Innate immunity is present in all multicellular organisms, including plants and insects.
B)Deficiencies in innate immunity markedly increase host susceptibility to infection, even in the setting of an intact adaptive immune response.
C)Innate immunity is better suited for eliminating virulent, resistant microbes than is adaptive immunity.
D)The innate immune response can be divided into recognition, activation, and effector phases.
E)The innate immune response against microbes influences the type of adaptive immune response that develops.
Answer: C
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Chapter 3: Antigen Capture and Presentation to Lymphocytes
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17 Verified Questions
17 Flashcards
Source URL: https://quizplus.com/quiz/23009
Sample Questions
Q1) Which of the following statements about the antigen-presenting function of macrophages is NOT correct?
A)Macrophages are particularly important at presenting peptides derived from particulate or opsonized antigens that are internalized by phagocytosis.
B)Macrophages become activated by the helper T cells to which they present microbial peptides, and as a result of this activation they become efficient at killing the microbes.
C)Resting macrophages express low levels of class II MHC molecules, but higher class II MHC expression is induced on activation by the T cells to which they present antigen.
D)Macrophages express highly variable, high-affinity receptors for many different antigens, and these receptors facilitate the internalization of the antigens for processing and presentation.
E)Macrophages present antigen to T cells in lymphoid organs and many nonlymphoid organs.
Answer: D
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Chapter 4: Antigen Recognition in the Adaptive Immune System
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17 Verified Questions
17 Flashcards
Source URL: https://quizplus.com/quiz/23010
Sample Questions
Q1) Most T lymphocytes have a dual specificity for which one of the following pairs of molecules?
A)A particular allelic form of a major histocompatibility complex (MHC) molecule and a peptide bound to the MHC molecule
B)Both MHC class I and class II molecules
C)Both peptide and glycolipid antigens
D)Both soluble peptides and peptide-MHC complexes
E)MHC molecules and CD4 or CD8
Q2) A 15-year-old girl develops malaise, headache, and low-grade fever, followed by pharyngitis and cervical lymph node enlargement as a result of infectious mononucleosis caused by Epstein-Barr virus (EBV). Her acute symptoms resolve within 2 weeks, and the fatigue improves within 3 months. All of the following are required for CD8 cytotoxic T lymphocyte (CTL) recognition and killing of EBV-infected cells EXCEPT:
A) -Microglobulin
B)HLA-A, -B or -C
C)CD28
D)LFA-1 (leukocyte function-associated antigen-1)
E)TAP (transporter associated with antigen processing)
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Chapter 5: T Cell Mediated Immunity
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15 Verified Questions
15 Flashcards
Source URL: https://quizplus.com/quiz/23011
Sample Questions
Q1) Which one of the following signaling molecules, if mutated, would affect B cell maturation and function primarily without affecting T cell function?
A)Btk
B)Itk
C)Tec
D)PI-3 kinase
E)Zap-70
Q2) Which one of the following statements about the molecule Lck is NOT true?
A)It is a member of the Src family of kinases.
B)It binds to the cytoplasmic tails of T cell coreceptors CD4 or CD8.
C)It phosphorylates ITAM motifs on the CD3 complex.
D)It phosphorylates tyrosine residues on Zap-70 and activates it.
E)It phosphorylates PIP2 to PIP3 and leads to the activation of Itk.
Q3) Which one of the following cell types would be most potent at activating naive T cells?
A)Kupffer cells
B)B cells
C)Follicular dendritic cells
D)Neutrophils
E)Langerhans cells
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Chapter 6: Effector Mechanisms of T Cell Mediated Immunity
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10 Verified Questions
10 Flashcards
Source URL: https://quizplus.com/quiz/23012
Sample Questions
Q1) Which of the following statements about cell-mediated immunity (CMI) is NOT true?
A)Deficiencies in CMI result in susceptibility to infections by viruses and intracellular bacteria.
B)CMI can be adoptively transferred by injecting serum from one individual to another.
C)Delayed-type hypersensitivity (DTH) is not a protective response against intracellular bacteria such as Mycobacterium tuberculosis.
D)The principal form of CMI that protects against viral infections is mediated by CD8 cytolytic T lymphocytes.
E)Phagocytes are essential in the effector phase of CMI responses to bacteria such as Listeria monocytogenes.
Q2) Differentiation of TH2 cells from naive precursor cells is dependent on which of the following?
A)Toll-like receptor (TLR) ligands
B)T-bet
C)Interleukin-12
D)GATA-3
E)Interferon-
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Page 8
Chapter 7: Humoral Immune Responses
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17 Verified Questions
17 Flashcards
Source URL: https://quizplus.com/quiz/23013
Sample Questions
Q1) Which of the following descriptions about affinity maturation is correct?
A)Depends on somatic mutation of V genes
B)Depends on negative selection of B cells that can bind antigen in the germinal center
C)Depends on antigen processing and presentation by dendritic cells within the germinal center
D)Depends on the autoimmune regulator (AIRE) gene
E)Depends on somatic recombination of Ig V genes
Q2) A 5-year-old boy has a history of recurrent pneumococcal pneumonia, Pneumocystis carinii pneumonia (PCP), and bacterial ear infections. His maternal uncle and an older brother experienced the same symptoms, but he has an older sister who is healthy. Laboratory studies indicate normal numbers of B cells and T cells, and the serum contains mostly IgM and very little IgG. Which of the following genes most likely contains a mutation in this patient?
A)AID (activation-induced deaminase)
B)CD40
C)CD40L
D)CD28
E)CTLA-4
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Page 9
Chapter 8: Effector Mechanisms of Humoral Immunity
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13 Verified Questions
13 Flashcards
Source URL: https://quizplus.com/quiz/23014
Sample Questions
Q1) Up to half of the IgG found in the serum of a normal individual is produced by which of the following cells?
A)Naive B cells in lymph nodes
B)Activated B cells in the spleen
C)B cells in germinal centers of lymph nodes
D)B lymphocytes in the gastrointestinal tract
E)Long-lived plasma cells in the bone marrow
Q2) Which of the following statements about Ig Fc receptors is NOT true?
A)Some Fc receptors or Fc receptor-associated signaling chains contain ITAMs in their cytoplasmic tails.
B)Some Fc receptors are linked to signal transduction pathways that cause granule exocytosis.
C)There are Fc receptors specific for all common Ig isotypes.
D)Some Fc receptors with ITIMs in their cytoplasmic tails transduce inhibitory signals.
E)Fc receptor signaling may enhance generation of reactive oxygen intermediates in phagocytes.
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Chapter 9: Immunological Tolerance and Autoimmunity
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17 Verified Questions
17 Flashcards
Source URL: https://quizplus.com/quiz/23015
Sample Questions
Q1) Which of the following statements about B cell tolerance is NOT true?
A)Negative signaling induced by monovalent antigens is a mechanism of central B cell tolerance.
B)Exclusion of B cells from follicles is a mechanism of peripheral B cell tolerance.
C)Functional anergy is a mechanism of peripheral B cell tolerance.
D)Receptor editing is a mechanism of central B cell tolerance.
E)Down-regulation of antigen receptor expression is a mechanism of central B cell tolerance.
Q2) Which of the following molecules does NOT promote lymphocyte apoptosis?
A)Bid
B)Caspase-8
C)FADD
D)FLIP
E)Glucocorticoid
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11
Chapter 10: Immune Responses against Tumors and Transplants
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10 Verified Questions
10 Flashcards
Source URL: https://quizplus.com/quiz/23016
Sample Questions
Q1) A 56-year-old woman sees her primary care physician complaining of flank pain and hematuria and is found to have a hematocrit of 56%. She is subsequently diagnosed with advanced renal cell carcinoma. Part of the patient's management involves systemic cytokine therapy; however, the patient develops severe pulmonary edema as a result of the treatment. Which of the following cytokines was most likely used in this patient's therapy?
A)Interleukin (IL)-2
B)IL-6
C)IL-12
D)GM-CSF (granulocyte-macrophage colony-stimulating factor)
E)TNF (tumor necrosis factor)
Q2) Which of the following is NOT a mechanism by which tumors evade immune responses?
A)Decreased synthesis of TAP
B)Increased expression of glycocalyx
C)Lack of costimulatory molecule expression
D)Increased expression of TGF-
E)Increased expression of Fas
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Chapter 11: Hypersensitivity
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14 Verified Questions
14 Flashcards
Source URL: https://quizplus.com/quiz/23017
Sample Questions
Q1) A 14-year-old boy is brought to the pediatrician's office in mid summer because of an itchy, blistering rash on his calves and forearms. The rash developed 24 hours after he returned from a weekend Boy Scout camping trip. The pediatrician suspects the lesion is caused by poison ivy. If the doctor is correct, which one of the following is NOT a prominent component in the immunologic mechanisms causing the skin lesions?
A)T cells
B)IgE-coated mast cells
C)Interferon-
D)Endothelial adhesion molecules
E)Chemokines
Q2) Which of the following would NOT be a likely therapy for treating autoimmune diseases?
A)Corticosteroids
B)Small molecule inhibitor of VLA-4
C)Cyclosporine
D)CTLA-4 antagonist
E)Plasmapheresis
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13
Chapter 12: Congenital and Acquired Immunodeficiencies
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18 Verified Questions
18 Flashcards
Source URL: https://quizplus.com/quiz/23018
Sample Questions
Q1) A 36-year-old man with a history of a positive anti-HIV antibody test comes to the clinic with fever, sore throat, nonproductive cough, and weight loss. The patient has a high serum viral load, quantified by reverse transcriptase polymerase chain reaction (RT-PCR). This patient is LEAST likely to suffer from which of the following?
A)Kaposi's sarcoma
B)Pneumocystis jiroveci pneumonia
C)Encephalopathy
D)Cachexia
E)T cell lymphoma
Q2) Human immunodeficiency virus (HIV) is NOT a:
A)Herpesvirus
B)RNA virus
C)Enveloped virus
D)Retrovirus
E)Lentivirus
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