Advanced Immunology Exam Practice Tests
Course Introduction
Advanced Immunology delves into the complex mechanisms governing the immune system, exploring both its cellular and molecular components. This course covers topics such as antigen recognition, immune signaling pathways, lymphocyte development, and the regulation of immune responses. Special emphasis is placed on current research areas, including immunogenetics, autoimmunity, allergy, immunodeficiencies, and the interplay between the immune system and infectious diseases. Students also examine cutting-edge techniques used in immunological research and their applications in vaccine development, immunotherapy, and disease prevention. The course aims to foster a deep understanding of immune regulation and its implications for human health and disease.
Recommended Textbook
Cellular and Molecular Immunology 8th Edition by Abul K. Abbas
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20 Chapters
214 Verified Questions
214 Flashcards
Source URL: https://quizplus.com/study-set/1168
Page 2
Chapter 1: Activation of T Lymphocytes
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10 Verified Questions
10 Flashcards
Source URL: https://quizplus.com/quiz/23120
Sample Questions
Q1) This molecule has the same downstream effect as addition of the drug phorbol myristate acetate (PMA) to T cells.
A)CD3
B)Lck
C)Zap-70
D)LAT
E)Ras
F)PLC
G)PIP2
H)PIP3
I)IP3
J)DAG
K)Calcineurin
L)NFAT
M)Jun
N)Fos
O)NF- B
Answer: J
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Page 3
Chapter 2: Antibodies and Antigens
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10 Verified Questions
10 Flashcards
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Sample Questions
Q1) The isotype found predominantly in mucosal secretions
A)IgA
B)IgD
C)IgE
D)IgG
E)IgM
Answer: A
Q2) A region of an antibody molecule that permits bivalent binding of antibodies to pairs of surface epitopes varying in distance from one another
A)Conformational determinant
B)Linear determinant
C)Neoantigenic determinant
D)Hinge region
E)Immunocomplex
F)Fab
G)Fc
H)Tail piece
I)Hapten
Answer: D
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Chapter 3: Antigen Processing and Presentation to T Lymphocytes
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10 Verified Questions
10 Flashcards
Source URL: https://quizplus.com/quiz/23122
Sample Questions
Q1) Site of peptide loading of class II MHC molecules
A)T cell receptor on CD4+ T cells
B)Endosomes
C)Endoplasmic reticulum
D)MHC class II compartment/class II vesicle (MIIC/CIIV)
E)Class II-associated invariant chain peptide (CLIP)
F)LMP-2 and LMP-7
G)Acidic proteases
H)T cell receptor on CD8+ T cells
I)HLA-DM
Answer: D
Q2) A helper T cell response to a protein antigen requires the participation of antigen-presenting cells that express which of the following types of molecules?
A) Class II MHC and costimulators
B) Class I MHC and CD4
C) Class II MHC and CD8
D) CD4 and costimulators
E) Class II MHC and CD4
Answer: A
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Chapter 4: Antigen Receptors and Accessory Molecules of T Lymphocytes
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14 Verified Questions
14 Flashcards
Source URL: https://quizplus.com/quiz/23123
Sample Questions
Q1) z protein
Q2) Constant Ig domain
Q3) Immunoreceptor tyrosine-based activation motif (ITAM)
Q4) Antigen-binding region
Q5) Complementarity-determining regions
Q6) P-selectin
A)B<sub>7</sub>-1, B<sub>7</sub>-2
B)Class II MHC
C)LFA-3
D)VCAM-1
E)Sialylated Lewis X
Q7) VLA-4
A)B<sub>7</sub>-1, B<sub>7</sub>-2
B)Class II MHC
C)LFA-3
D)VCAM-1
E)Sialylated Lewis X
Q8) CD3 protein
Q9) Variable Ig domain Page 6
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Page 7
Chapter 5: B Cell Activation and Antibody Production
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11 Verified Questions
11 Flashcards
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Sample Questions
Q1) Binds to receptors in the gastrointestinal tract of infants for absorption into the serum
A)IgM
B)IgD
C)IgG
D)IgE
E)IgA
Q2) T cell-independent antigens
A)IgM
B)IgD
C)IgG
D)IgE
E)IgA
Q3) An allergy attack
A)IgM
B)IgD
C)IgG
D)IgE
E)IgA
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8
Chapter 6: Effector Mechanisms of Cell-Mediated Immunity
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10 Verified Questions
10 Flashcards
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Sample Questions
Q1) This membrane molecule is expressed on the surface of activated TH1 cells and promotes macrophage activation.
A)Interferon-
B)Interleukin (IL)-10
C)IL-12
D)CD40L
E)CD40
F)STAT6
G)STAT4
H)IL-5
Q2) This product of TH2 cells promotes immunity to helminthic infections.
A)Interferon-
B)Interleukin (IL)-10
C)IL-12
D)CD40L
E)CD40
F)STAT6
G)STAT4
H)IL-5
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Chapter 7: Cells and Tissues of the Immune System
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10 Verified Questions
10 Flashcards
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Sample Questions
Q1) Broad-spectrum antibiotic present in the skin and in neutrophil granules; its synthesis is increased in response to inflammatory cytokines
A)Defensin
B)Opsonin
C)Natural antibody
D)Adjuvant
E)Complement
F)Inflammation
G)C-reactive protein
H)Mannose-binding lectin
I)Reactive oxygen intermediate
J)Inducible nitric oxide synthase
Q2) The signaling pathways triggered by Toll-like receptors typically result in activation of which of the following pairs of transcription factors?
A) NFAT and T-bet
B) AP-1 and GATA-3
C) Fos and STAT-6
D) NFkB and AP-1
E) Lck and Jun
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Chapter 8: Congenital and Acquired Immunodeficiencies
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13 Verified Questions
13 Flashcards
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Sample Questions
Q1) Defect in leukocyte adhesion-dependent functions, resulting from mutations in the gene encoding the CD18 integrin chain, and leading to recurrent bacterial and fungal infections
A)X-linked agammaglobulinemia
B)X-linked hyper-IgM syndrome
C)X-linked lymphoproliferative syndrome
D)Bare lymphocyte syndrome
E)Chronic granulomatous disease (CGD)
F)Leukocyte adhesion deficiency-1 (LAD-1)
G)Leukocyte adhesion deficiency-2 (LAD-2)
Q2) A generalized deficiency in the ability to mount delayed-type hypersensitivity (DTH) responses, as described in question 3, is called:
A) Clinical atopy
B) Clonal ignorance
C) Clinical anergy
D) Clonal deletion
E) Seroconversion
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Chapter 9: Cytokines
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14 Verified Questions
14 Flashcards
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Sample Questions
Q1) Mediates neutrophil recruitment into tissues
A)CXCL8 (IL-8)
B)CXCL10 (IP-10)
C)CCL19 (ELC)
D)CCL11 (Eotaxin)
E)CCR5
F)CXCR1
G)CX3CL1 (Fractalkine)
Q2) Binds to interleukin-8
A)CXCL8 (IL-8)
B)CXCL10 (IP-10)
C)CCL19 (ELC)
D)CCL11 (Eotaxin)
E)CCR5
F)CXCR1
G)CX3CL1 (Fractalkine)
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Chapter 10: Diseases Caused by Immune Responses:
Hypersensitivity and Autoimmunity
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10 Verified Questions
10 Flashcards
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Sample Questions
Q1) All of the following are effector mechanisms of antibody-mediated disease EXCEPT:
A) Opsonization and phagocytosis of cells
B) Fas-dependent apoptosis of cells
C) Complement- and Fc receptor-mediated inflammation and tissue injury
D) Antibody stimulation of cell surface receptors in the absence of the physiologic ligands
E) Fc R crosslinking
Q2) In which of the following disorders is the underlying pathogenic mechanism NOT due to antibody-mediated damage to cells or tissues?
A) Pernicious anemia
B) Autoimmune hemolytic anemia
C) Pemphigus vulgaris
D) Acute rheumatic fever
E) Hyperacute allograft rejection
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Chapter 11: General Properties of Immune Response
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6 Verified Questions
6 Flashcards
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Sample Questions
Q1) Which of the following is a unique property of the adaptive immune system?
A) Highly diverse repertoire of specificities for antigens
B) Self-nonself discrimination
C) Recognition of microbial structures by both cell-associated and soluble receptors
D) Protection against viral infections
E) Responses that have the same kinetics and magnitude on repeated exposure to the same microbe
Q2) Which of the following infectious diseases was prevented by the first successful vaccination?
A) Polio
B) Tuberculosis
C) Smallpox
D) Tetanus
E) Rubella
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14
Chapter 12: The Major Histocompatibility Complex
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9 Verified Questions
9 Flashcards
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Sample Questions
Q1) Polymorphic region
Q2) Inbred mouse strain MHC haplotype
A)HLA- 1
, -B7, -Cw4, -DPw5, -DQw10, -DR8
B)H-2
C)HLA-DQ7
D)I-Ad
E)HLA-B5
F)H-2KdI-AdI-EdDdLd
Q3) CD8-binding site
Q4) 2-Microglobulin
Q5) Peptide-binding groove
Q6) Mouse major histocompatibility complex
A)HLA- 1 , -B7, -Cw4, -DPw5, -DQw10, -DR8
B)H-2
C)HLA-DQ7
D)I-Ad
E)HLA-B5
F)H-2KdI-AdI-EdDdLd
Page 15
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Chapter 13: Effector Mechanisms of Humoral Immunity
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10 Verified Questions
10 Flashcards
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Sample Questions
Q1) Which of the following anatomic regions is normally protected from pathogens only by humoral immune responses and not by cell-mediated immune responses?
A) Skin
B) Intestinal lumen
C) Intestinal epithelium
D) Central nervous system
E) Spleen
Q2) Produced by C3 convertases, this opsonin promotes phagocytosis of microbes.
A)C3b
B)iC3b
C)C3d
D)C5b
E)C5a
Q3) This complement fragment is a component of the membrane attack complex.
A)C3b
B)iC3b
C)C3d
D)C5b
E)C5a
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Page 16
Chapter 14: Immediate Hypersensitivity
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10 Verified Questions
10 Flashcards
Source URL: https://quizplus.com/quiz/23133
Sample Questions
Q1) Protein constituent of granules that contributes to tissue damage in immediate hypersensitivity reactions
A)Histamine
B)Tryptase
C)Prostaglandin D<sub>2</sub>
D)Leukotriene C<sub>4</sub>
E)Platelet-activating factor
F)Interleukin-5
G)Tumor necrosis factor-a
Q2) All of the following are key mediators of immediate hypersensitivity reactions EXCEPT:
A) Mast cells
B) Basophils
C) IgE
D) Macrophages
E) TH2 cells
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17
Chapter 15: Innate Immunity
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12 Verified Questions
12 Flashcards
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Sample Questions
Q1) Location of most T lymphocytes in the spleen
A)Periarteriolar lymphoid sheath
B)Thymic medulla
C)Thymic cortex
D)Parafollicular cortex of lymph node
E)Hematopoietic bone marrow
F)Afferent lymphatic
G)Efferent lymphatic
H)Marginal zone
I)Red pulp of spleen
J)White pulp of spleen
K)Epidermis
L)Dermis
M)Peyer's patch
Q2) Which of the following is the generative lymphoid organ for T lymphocytes?
A) Bone marrow
B) Spleen
C) Lymph node
D) Thymus
E) Tonsil
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Page 18
Chapter 16: Immunologic Tolerance
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10 Verified Questions
10 Flashcards
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Sample Questions
Q1) Mechanism of peripheral tolerance induction of B cells but not T cells
A)Immature (IgM<sup>+</sup>IgD<sup>-</sup>)
B)Thymic cortex
C)Bone marrow
D)Antigen recognition without T cell help
E)Receptor editing
F)Activation-induced cell death
G)Regulatory T cell-mediated suppression
H)Antigen recognition with costimulation
I)Double positive (CD4<sup>+</sup>CD8<sup>+</sup>)
J)Anergy
K)Thymic medulla
Q2) Failure of self-tolerance is the cause of which one of the following types of diseases?
A) Allograft rejection
B) Autoimmunity
C) Atopy
D) Anergy
E) Acne
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Chapter 17: Lymphocyte Maturation and Expression of Antigen Receptor Genes
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11 Verified Questions
11 Flashcards
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Sample Questions
Q1) A segment that encodes Ig-like domains that form part of the antigen-binding region of an Ig molecule
Q2) Which of the following is NOT a required step in B and T lymphocyte maturation?
A) Proliferative expansion of precursor cells
B) Cell surface expression of complete antigen receptor complexes
C) Positive selection
D) Activation of precursors by foreign antigens
E) Pre-antigen receptor expression
Q3) A type of gene segment involved in somatic recombination events in Ig heavy chain and light chain as well as TCR a and b chain gene loci
Q4) Encodes the isotype of antibodies made by naive B cells
Q5) Homologous segments of this type of gene segment that encode part of the third complementarity determining region (CDR3) of Ig heavy chains and TCR b chains but not Ig light chains or TCR a chains
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Chapter 18: Immunity to Microbes
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10 Verified Questions
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Sample Questions
Q1) Good induction of mucosal immunity but risk of developing a viral disease, especially in immunocompromised hosts
A)Live attenuated or killed bacteria
B)Live attenuated oral virus
C)Synthetic viral subunit vaccines
D)Conjugate vaccines
E)Recombinant viral vectors
F)DNA vaccines
G)Purified subunit vaccines
Q2) Composed of viral proteins synthesized from recombinant viral genes
A)Live attenuated or killed bacteria
B)Live attenuated oral virus
C)Synthetic viral subunit vaccines
D)Conjugate vaccines
E)Recombinant viral vectors
F)DNA vaccines
G)Purified subunit vaccines
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Chapter 19: Transplantation Immunology
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10 Verified Questions
10 Flashcards
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Sample Questions
Q1) Common glycan that is fucosylated to form the H antigen
A)A
B)B
C)O
D)RhD
E)Lewis
Q2) Nonglycosylated red cell membrane protein missing or mutated in 15% of humans
A)A
B)B
C)O
D)RhD
E)Lewis
Q3) Formed by a glycosyltransferase enzyme that adds a terminal galactose residue to the H antigen
A)A
B)B
C)O
D)RhD
E)Lewis
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Page 22
Chapter 20: Immunity to Tumors
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14 Verified Questions
14 Flashcards
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Sample Questions
Q1) A patient presenting with jaundice and a recent 11-kg (20 lb) weight loss who has a history of hepatitis B infection will most likely have elevated levels of this glycoprotein
A)AFP
B)Bcr/Abl
C)CA-125
D)CD20
E)CEA
F)EBNA
G)MAGE
H)p53
I)PSA
J)Ras
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