Artificial intelligence did not release a virus—but AI-generated whole-genome designs have crossed a consequential boundary from computational output to physical synthesis and biological function. This N360™ Strategic Brief examines the emerging chain connecting genome models, digital distribution, nucleic-acid synthesis, laboratory assembly and replication in compatible living hosts—distinguishing what has been demonstrated, what has not occurred and why the strategic control problem can no longer be considered theoretical. Linda Restrepo, Editor in Chief