Issuu

APRIL 15, 2026

Penn Dental Medicine 10:00am – 6:00pm

WELCOME 2026

It is our great pleasure to welcome alumni, faculty, staff, students and friends to Penn Dental Medicine Research Day 2026.

We invite you to join us in celebrating as faculty, students, and research staff once again come together to showcase the breadth and strength of PDM’s research in a single venue. We look forward to a day of exchange and collaboration across disciplines that highlights the quality, depth, and diversity of the School’s research.

We warmly welcome this year’s keynote speakers. Jonathan Epstein, MD, Dean of the Raymond and Ruth Perelman School of Medicine and Executive Vice President of the University of Pennsylvania for the Health System, will deliver the Joseph L. Rabinowitz Memorial Lecture, “Treating Fibrosis with mRNA and CAR T Cells.” Laurie McCauley, DDS, MS, PhD, Provost and Executive Vice President for Academic Affairs at the University of Michigan, will present the PDM Research Day Keynote Lecture, “A Journey in Hormonal Actions, Immunology, Bone Biology and Discovery Science.” We are honored to have you with us for this important day.

Another highlight of the day is the presentation of research awards recognizing excellence and innovation across our community. Among these is the Joseph and Josephine Rabinowitz Award for Excellence in Research, established in 1992 by the late Dr. Joseph Rabinowitz, a longtime member of the School’s Biochemistry faculty, and his wife, Josephine, to support independent and collaborative faculty research. Today, this tradition has grown to include a broader portfolio of awards that celebrate outstanding achievement and encourage interdisciplinary scholarship across Penn Dental Medicine. Research Day will also recognize student and trainee accomplishments through a series of competitive awards and travel opportunities that support continued scholarly development. These include the AADOCR Student Research Day Award and the Student Competition for Advancing Dental Research and its Application (SCADA), as well as Penn Dental Medicine’s AADOCR Travel Awards, the Gail Schupak Travel Award, the Oral Cancer Award and the Vernon Brightman Award. Together, these programs provide critical support for students and junior investigators to present their work at national meetings, foster professional growth, and contribute to the future of dental research and discovery.

Penn Dental Medicine continues to build as a leader in the generation of new knowledge and in the cultivation of the next generation of oral health researchers. We hope the day will spark new collaborations, fresh insights, and continued innovation. Enjoy the day.

RESEARCH DAY COMMITTEE

Dr. Dana T. Graves Chair

Dr. Esra Sahingur Co-chair

Dr. Joseph Fiorellini

Dr. Michael Glick

Dr. George Hajishengallis

Dr. Monica Chenshuang Li

Dr. Rob Ricciardi

Pamela Rice

Mark S. Wolff, D.D.S, PhD

Dana Graves, DDS, DMSc

Morton Amsterdam Dean Vice Dean for Scholarship and Research

9:55 AM OPENING REMARKS

Arthur E. Corby Auditorium

Dana T. Graves, DDS, DMSc

10:00 AM PENN DENTAL MEDICINE FACULTY PRESENTATIONS

Arthur E. Corby Auditorium

MODERATOR: Cagla Akay-Espinoza, MD

“Senescence, Inflammaging and Microbiome Axis in Periodontal Aging”

Esra Sahingur, DDS, MS, PhD

Associate Dean of Graduate Studies & Student Research Associate Professor, Department of Periodontics

MODERATOR: Hyeran Helen Jeon, DDS, MSD, DScD

“Unraveling Clinical and Molecular Pathways of Periodontitis Progression”

Flavia Teles, DDS, MS, DMSc

Professor, Department of Basic & Translational Sciences

MODERATOR: Yijing Su, PhD

“The Healing Blueprint: Enhanced Therapeutic Potentials of GMSCs”

Anh D. Le, DDS, PhD

Chair and Norman Vine Endowed Professor of Oral Rehabilitation, Department of Oral & Maxillofacial Surgery/Pharmacology

11:00 AM THE JOSEPH L. RABINOWITZ MEMORIAL LECTURE

Arthur E. Corby Auditorium

MODERATOR: Henry Daniell, PhD

“Treating Fibrosis with mRNA and CAR T cells”

Jonathan Epstein, MD

Dean of the Raymond and Ruth Perelman School of Medicine and Executive Vice President of the University of Pennsylvania for the Health System

12:00 PM LUNCH

Fonseca Gardens

12:45 PM POSTER PRESENTATIONS AND COMPETITIONS

Schattner Lobby, Lerner Pavilion, and Schattner Patient Waiting

2:45 PM TRANSITION BREAK

3:00 PM PDM RESEARCH DAY KEYNOTE LECTURE

Arthur E. Corby Auditorium

MODERATOR: Alonso Carrasco Labra, DDS, MSc, PhD

“A Journey in Hormonal Actions, Immunology, Bone Biology and Discovery Science”

Laurie McCauley, DDS, MS, PhD

Provost and Executive Vice President for Academic Affairs, University of Michigan

4:15 PM RECEPTION, RECOGNITION AND AWARDS

Fonseca Gardens

Esra Sahingur, DDS, MS, PhD

PDM RESEARCH DAY KEYNOTE SPEAKER

LAURIE McCAULEY, DDS, MS, PhD

Provost and Executive Vice President for Academic Affairs

University of Michigan

Dr. Laurie McCauley serves as provost and executive vice president for academic affairs at the University of Michigan. Her leadership priorities have included student success, support for those with disabilities, and co-leading U-M’s Campus Planning and Strategic Visioning processes.

Dr. McCauley is a member of the National Academy of Medicine and a fellow of the American Association for the Advancement of Science. An NIH-supported researcher for over 25 years, her work focuses on bone biology and prostate cancer skeletal metastasis, contributing to regenerative medicine and treatments for bone loss.

Dr. McCauley is the former dean of the U-M School of Dentistry and the William K. and Mary Anne Najjar Professor of Periodontics as well as a professor of pathology in the Medical School.

THE JOSEPH L. RABINOWITZ MEMORIAL LECTURE

JONATHAN EPSTEIN, MD

Dean of the Raymond and Ruth Perelman School of Medicine and Executive Vice President of the University of Pennsylvania for the Health System

Jonathan A. Epstein, MD, serves as Dean of the Raymond and Ruth Perelman School of Medicine and Executive Vice President of the University of Pennsylvania for the Health System, together comprising Penn Medicine, an $11.9 billion enterprise dedicated to medical education, biomedical research, and patient care.

Founded in 1765, the Perelman School of Medicine is the nation’s first medical school and now includes more than 3,100 faculty and over 4,500 learners, with more than $1 billion in annual sponsored research. The University of Pennsylvania Health System features nationally ranked hospitals and a broad clinical network across primary and specialty care.

Dr. Epstein, a graduate of Harvard College and Harvard Medical School, completed his training at Brigham and Women’s Hospital and joined Penn in 1996. Over nearly three decades, he has held key leadership roles, including Executive Vice Dean and Chief Scientific Officer, helping to shape Penn Medicine into a global leader in research and innovation.

He holds the Robert G. Dunlop Professorship and previously chaired the Department of Cell and Developmental Biology, served as Scientific Director of the Penn Cardiovascular Institute, and co-founded the Penn Institute for Regenerative Medicine.

A leading physician-scientist, his research focuses on congenital heart disease, heart failure, stem cell biology, and epigenetics, with recent advances in mRNA-based therapies. His honors include the Sir William Osler Young Investigator Award and election to the American Academy of Arts and Sciences and the National Academy of Medicine.

JOSEPH AND JOSEPHINE

RABINOWITZ AWARD FOR EXCELLENCE IN RESEARCH

The Joseph and Josephine Rabinowitz Award for Excellence in Research was designed to help Penn Dental Medicine faculty undertake pilot projects that will enable them to successfully apply for extramural sources of funding. Designed through the lens of a researcher, this ongoing grant evaluates research proposals for their scholarly merit, creativity and innovation; the significance of the research in advancing scientific knowledge; the prospects for future extramural funding; the availability of alternate funding sources; and in the case of junior faculty, evidence that the applicant will be working as an independent investigator and forwarding of the School’s research objectives. It was under development as early as 1994 with the first award presented in 2002.

This award was endowed through the generosity of the late Dr. Joseph “Jose” Rabinowitz, an active member of the School’s biochemistry faculty for 29 years, and his wife, the late Dr. Josephine “Josy,” a fellow Penn alum. Josy’s PhD was in the field of education. Her strong endorsement of education and research provided a hand in the development of this grant. Jose was known for his research in lipid and steroid biochemistry, and made the seminal discovery that HMG CoA was a key intermediate in cholesterol biosynthesis. His research helped lead to the development of the important class of cholesterollowering drugs known as statins.

The Rabinowitz family continues to support the values and priorities of this award and congratulates its newest recipients.

2026 JOSEPH AND JOSEPHINE RABINOWITZ AWARD RECIPIENTS

Lauren C. Yap DMD, MPH

Clinical Assistant Professor, Assistant Program Director for Postdoctoral Pediatric Dentistry Program Department of Preventive and Restorative Sciences, Division of Pediatric Dentistry

Oral Microbiome Changes in Children Placed on a Ketogenic Diet

The ketogenic diet is comprised of a high-fat, low-carbohydrate regimen used for weight management and therapeutic purposes in conditions such as epilepsy, Alzheimer’s disease, and type 2 diabetes. The objective of the study is to determine the effect of the ketogenic diet on the composition and functional potential of the dental plaque microbiome in children. By identifying microbial shifts and changes in metabolic pathways associated with a ketogenic diet, critical insight can be provided into the potential oral health implications of ketogenic dietary therapy. The link between carbohydrate consumption and the pathogenesis of dental caries is well-documented, however the impact of the ketogenic diet on oral ecology remains largely unexplored. This pilot study seeks to characterize changes in dental plaque microbial composition following the initiation of this diet regimen. By investigating these shifts, the project intends to unveil how dietary-induced ketosis modulates oral health, potentially informing novel diagnostic and therapeutic strategies for the pediatric populations.

Wenjing Yu, DDS, PhD, DScD,

DMD

Assistant Professor, Associate Director of Predoctoral Orthodontics Program

Department of Orthodontics

The role of Gli1+ Chondroprogenitor Cells in Degenerative Temporomandibular joint (TMJ) Diseases

Temporomandibular joint disease (TMD) is a degenerative musculoskeletal disorder that causes morphological and functional abnormalities. Degenerative Joint Disorders (DJD) of the temporomandibular joint (TMJ) represent a challenging and multifaceted group of conditions that severely impact the joint’s function and patient’s quality of life. Histologically, the DJD of the TMJ is caused by damage or breakdown of the joint cartilage between bones. Despite its prevalence and impact, there are no specific therapeutics that target its root cause. We hypothesize that a group of chondroprogenitor cells (CPC) plays a critical role in maintaining bone homeostasis and preventing the progression of degenerative joint disease in the TMJ. This proposed study aims to identify novel endogenous stem/progenitor cell sources for cartilage tissue regeneration, with a focus on Gli1+ CPCs, derived from the mandibular condyle, that exhibit cartilage regenerative capacity.

FACULTY PRESENTATIONS

Presentations

SENESCENCE, INFLAMMAGING AND MICROBIOME AXIS IN PERIODONTAL AGING

Esra Sahingur, DDS, MS, PhD

Associate

Dean

of Graduate Studies & Student Research

Associate Professor, Department of

Periodontics

This lecture explores the interplay between inflammation, cellular senescence, and the microbiome in periodontal aging. It highlights how chronic inflammation and microbial dysbiosis drive senescence, leading to a cycle of “inflammaging” that contributes to periodontal disease progression and systemic health connections. The session also introduces emerging therapeutic strategies, including senotherapeutics, targeting senescence and inflammation to improve periodontal outcomes

Educational Objectives

• Describe the role of cellular senescence and SASP in the pathogenesis of periodontal disease.

• Explain the interactions between inflammation, microbial dysbiosis, and aging in periodontal tissues.

• Discuss emerging senotherapeutic approaches and their potential impact on periodontal and systemic health.

UNRAVELING CLINICAL AND MOLECULAR PATHWAYS OF PERIODONTITIS PROGRESSION

Flavia Teles, DDS, MS, DMSc

Professor, Department of Basic & Translational Sciences

Periodontitis is a complex, multifactorial inflammatory disease that results in the destruction of the tooth-supporting tissues and remains one of the most prevalent chronic conditions worldwide. Despite decades of research, the mechanisms that determine why some individuals experience rapid disease progression while others remain stable remain unclear. This lecture explores how integrative clinical and molecular approaches are reshaping our understanding of periodontitis progression, highlighting novel biomarkers, microbial signatures, and host–microbe interactions that define disease trajectories. Through a synthesis of clinical evidence and mechanistic insight, this lecture invites participants to reconsider periodontitis not as a static disease entity but as a dynamic process shaped by continuous host–microbial interactions. Understanding these pathways holds the promise of transforming diagnosis, monitoring, and treatment.

Educational Objectives

• Describe how integrative clinical and molecular approaches—such as longitudinal cohort studies and multi-omics analyses— enhance understanding of the mechanisms driving periodontitis progression and patient heterogeneity.

• Explain the key biological pathways involved in periodontal tissue destruction and resolution failure, including the roles of host inflammatory mediators, complement activation, cellular senescence, and microbial dysbiosis.

• Evaluate emerging translational tools and molecular biomarkers that support early detection, personalized risk assessment, and precision-based interventions in periodontal care.

THE HEALING BLUEPRINT: ENHANCED THERAPEUTIC POTENTIALS OF GMSCS

Anh D. Le, DDS, PhD

Chair and Norman Vine Endowed Professor of Oral Rehabilitation Department of Oral & Maxillofacial Surgery/Pharmacology

Orofacial mesenchymal stem cells, easily accessible and enriched in neural crest properties, rapid proliferation, and multipotent differentiation, are excellent candidate cell sources for potential application in tissue engineering and regenerative therapy. Our research group has extensively characterized mesenchymal stem cells derived from human gingival tissues (GMSCs) as unique stem cells for tissue engineering, soft and hard tissue regeneration, and immunomodulatory functions. Patient derived GMSC could be directly induced into multipotent NPCs (iNPCs) under minimally manipulated culture conditions without the introduction of exogenous genes. These induced GMSCs are also capable of releasing extracellular vesicles (EVs), including exosomes, with potent biological functions and therapeutic effects in several preclinical animal models, providing a safe cell-free therapeutic approach for tissue regeneration.

Educational Objectives

• Orofacial MSCs have enriched neural crest properties

• MSCs derived from gingival tissues (GMSCs) are capable of multipotent differentiation

• MSCs have immunomodulatory functions

FACULTY AND JUNIOR INVESTIGATOR POSTERS

*Junior Investigators include the following categories: Masters students, DScD students, Residents, Postdocs, Research Associates and Junior Faculty

RD-1

HIV Disrupts CD4-Dependent Oral Microbiome–Inflammation Crosstalk in Pediatric Caries

Ibukun J. Abulude1, Aris Llada2, Allison Mann3, Sukhwinder Singh2, Esosa Osagie4, Paul Akhigbe4, Anil Kumar5, Ozoemene Obuekwe6, Vincent P. Richards7, Praise Okoh-Aihe5

Modupe O. Coker5,8,9

University of Pennsylvania School of Dental Medicine, 2Rutgers New Jersey Medical School, Department of Pathology, Immunology and Laboratory Medicine, 3University of Wyoming, Department of Anthropology, 4Institute of Human Virology Nigeria, International Research Centre for Excellence, 5University of Pennsylvania School of Dental Medicine, Center for Clinical and Translational Research, 6University of Benin Teaching Hospital, 7Clemson University, Department of Biological Sciences, 8University of Pennsylvania School of Dental Medicine, Department of Oral Medicine, 9University of Pennsylvania School of Dental Medicine, Department of Basic and Translational Sciences

RD-2

mTOR Activation in Adipo-Precursor Remodels Marrow Niche and Bone Homeostasis

Arwa Abumansour1, Xiaobin Huang1, Shilan Zhang2

Chider Chen3

RD-3

Cross Kingdom Biofilm Analysis on Inlays and Onlays Construct of Piezoelectric Composite

Ahmed Alqalam1, Hyejoo Kim2, Pratik Nag2

Geelsu Hwang2,3,4

University of Pennsylvania School of Dental Medicine, 2University of Pennsylvania School of Dental Medicine, Department of Preventive and Restorative Sciences, 3University of Pennsylvania School of Dental Medicine, Center for Innovation & Precision Dentistry, 4University of Pennsylvania School of Dental Medicine, Center for Clinical and Translational Research

RD-4

In-Vitro Comparative Study of Fit Accuracy Between Conventional, 3D-Printed, and Hybrid Hollow Bulb Obturators Using Digital Superimposition and Heat-Map Analysis

Mohammad Alshemali1

Nupur Patel1,2,3, Brian M. Chang2,4,5,6, Francis Mante7, Yu-Chun Lin7, Harshiv Karia8, Sebastian Ollinger2

1University of Pennsylvania School of Dental Medicine, Department of Prosthodontics, 2University of Pennsylvania School of Dental Medicine, Department of Preventive and Restorative Sciences, 3University of Pennsylvania School of Dental Medicine, Advanced Education Program in Prosthodontics, 4University of Pennsylvania School of Dental Medicine, Department of Oral & Maxillofacial Surgery / Pharmacology, 5Hospital of University of Pennsylvania, Maxillofacial Prosthodontics, 6Hospital of University of Pennsylvania, The Penn Center for Innovative & Personalized Oral Rehabilitation, 7University of Pennsylvania School of Dental Medicine, 8University of Connecticut School of Dental Medicine

RD-5

Designing Bispecific Antibodies Targeting Glycoproteins gB and gD of Herpes Simplex Virus

Doina Atansiu1, Wan Ting Saw1

Harvey M. Friedman2,3, Gary H. Cohen1

1University of Pennsylvania School of Dental Medicine, Department of Basic and Translational Sciences, 2University of Pennsylvania Perelman School of Medicine, Division of Infectious Diseases, 3Penn Institute for RNA Innovation

RD-6

Local Drug Delivery of 1,4 DPCA using PLGA Therapeutic Ligatures: A Novel Strategy for Periodontal Bone Regeneration.

Lina Baeesa1, Jiaxin Liu1, Azamat Aslanukov2

Ellen Heber-Katz2, George Hajishengallis1

1University of Pennsylvania School of Dental Medicine, Department of Basic and Translational Sciences, 2Lankenau Institute for Medical Research, Clinical Research

RD-7

Treatment Planning for Periodontally Compromised Teeth: To Treat and Maintain or to Extract and Pursue Implant Therapy

Mirza A. Baig

University of Pennsylvania School of Dental Medicine

RD-8

Matrix Mechanics Regulate TumorMyeloid Crosstalk in Oral Squamous Cell Carcinomas

Amanda S. Bluem1, Fathmeh Tavakoli Joorabi1,2, Yu-Chang J. Chen1,2

Kyle H. Vining2,3,4

1University of Pennsylvania School of Engineering and Applied Science, Department of Bioengineering, 2University of Pennsylvania School of Engineering and Applied Science, Department of Materials Science and Engineering, 3University of Pennsylvania School of Dental Medicine, Department of Preventive and Restorative Sciences, 4University of Pennsylvania School of Dental Medicine, Center for Innovation & Precision Dentistry

RD-9

Antibody Responses to Key Epitopes in HSV-2 gC, gD and gE Fluctuate Over Time In Persons with Frequent Genital Recurrences

Tina M. Cairns1, Lauren M. Hook2, Doina Atansiu1, Wan Ting Saw1, Christine Johnston3, Anna Wald3, Harvey M. Friedman2,4

Gary H. Cohen1

FACULTY AND JUNIOR INVESTIGATOR POSTERS

RD-10

Investigating the Mechano-Inflammatory Response of Dental Pulp Stem Cells Using 3D Artificial Extracellular Matrix

BingLing Chen1,2,3, Shuchen Zhang4, Jingyi Liu4,5,6, Hardikk Makkar4,6, Yu-Chang J. Chen5,7, Kyle H. Vining4,5,6,7

University of Pennsylvania School of Arts and Sciences, Department of Biology, 2Children’s Hospital of Philadelphia, Craniofacial Orthodontics, 3University of Pennsylvania School of Dental Medicine, 4University of Pennsylvania School of Dental Medicine, Department of Preventive and Restorative Sciences, 5University of Pennsylvania School of Engineering and Applied Science, Department of Bioengineering, 6University of Pennsylvania School of Dental Medicine, Center for Innovation & Precision Dentistry, 7University of Pennsylvania School of Engineering and Applied Science, Department of Materials Science and Engineering

RD-11

Matrix Stress Relaxation Regulates the Functions of Stem Cell-Derived Dendritic Cells

Yu-Chang J. Chen1,2, Nghi M. Tran2, Shuchen Zhang3, Amanda S. Bluem2, Fathmeh Tavakoli Joorabi1,2, Kexin Zhang1, Hardikk Makkar3,4

Kyle H. Vining1,3,4

University of Pennsylvania School of Engineering and Applied Science, Department of Materials Science and Engineering, 2University of Pennsylvania School of Engineering and Applied Science, Department of Bioengineering, 3University of Pennsylvania School of Dental Medicine, Department of Preventive and Restorative Sciences, 4University of Pennsylvania School of Dental Medicine, Center for Innovation & Precision Dentistry

RD-12

Transcriptomic Profiling of Host Immune Responses to Aggregatibacter actinomycetemcomitans Leukotoxin and Cytolethal Distending Toxin Using Bulk RNA Sequencing

Rebecca Choi1

Kathleen Boesze-Battaglia2, Anuradha Dhingra2, Bruce Shenker2, John Tobias3, Taewan Kim1

University of Pennsylvania School of Dental Medicine, Department of Periodontics, 2University of Pennsylvania School of Dental Medicine, Department of Basic and Translational Science, 3University of Pennsylvania Perelman School of Medicine, Department of Bioinformatics

RD-13

Reliability of Full-Arch Tooth-Supported Digital Impression and Accuracy of Selective Rescanning of Finish Line Under Lock Area Feature

Selina Guo1

Nupur Patel1,2,3

RD-14

Bacteria-Induced Cellular Redistrubiton of β-Catenin -E-Cadherin is Foxo1 Dependent and May Impact Barrier Function

Yu Jung Heo1, Minyoung A. Kwon2,3, Styliani Alimperti4,5

Dana T. Graves1,6,7

1University of Pennsylvania School of Dental Medicine, Department of Basic and Translational Sciences, 2University of Pennsylvania School of Dental Medicine, 3Children’s Hospital of Philadelphia, Craniofacial Orthodontics, 4University of Georgetown, Translational Medicine, 5Georgetown University, Biochemistry and Molecular & Cellular Biology Academic Department, 6University of Pennsylvania School of Dental Medicine, Department of Periodontics, 7University of Pennsylvania Perelman School of Medicine, The Penn Center for Musculoskeletal Disorders

RD-15

Salivary Metagenomic Signatures Reveal Early Microbial Predictors of Periodontitis Progression and Stability

Cecilia C. Horchos1,2,3, Evelyn Santana3, Weiming Hu4,5, Kyle Bittinger5, Lynn Martin3,6

Flavia R.F. Teles2,3,6

1University of Pennsylvania School of Dental Medicine, Center for Clinical and Translational Research, 2University of Pennsylvania School of Dental Medicine, Department of Periodontics, 3University of Pennsylvania School of Dental Medicine, Department of Basic and Translational Sciences, 4Children’s Hospital of Philadelphia, Research Institute, 5Children’s Hospital of Philadelphia, Microbiome Center, 6University of Pennsylvania School of Dental Medicine, Center for Innovation & Precision Dentistry

RD-16

Evaluation of an Injectable Zn–MOF Hydrogel for Antibacterial Treatment of Periodontal Infection

Jiayi Kang1, Keyu Chen2, Marco Tizzano3,4, Matteo Tizzano5, Flavia Teles4, Jiaxin Liu4, Jingyi Liu1,6,7, Rima Amin5

Kyle H. Vining6,7,8

1University of Pennsylvania School of Engineering and Applied Science, Department of Bioengineering, 2University of Michigan, Department of Materials Science and Engineering, 3University of Pennsylvania School of Dental Medicine, Center for Clinical and Translational Research, 4University of Pennsylvania School of Dental Medicine, Department of Basic and Translational Sciences, 5University of Pennsylvania School of Dental Medicine, 6University of Pennsylvania School of Dental Medicine, Department of Preventive and Restorative Sciences, 7University of Pennsylvania School of Dental Medicine, Center for Innovation & Precision Dentistry, 8University of Pennsylvania School of Engineering and Applied Science, Department of Materials Science and Engineering

RD-17

Microstructural, Optical, and Mechanical Characterization of a New Dental Ceramic: Zpex4.m Yttria-Stabilized Zirconia

Min Joo Kim1, Zheng Li2,3

Yu Zhang2,3

1University of Pennsylvania School of Arts and Sciences, Department of Biology, 2University of Pennsylvania School of Dental Medicine, Department of Basic and Translational Sciences, 3University of Pennsylvania School of Dental Medicine, Department of Preventive and Restorative Sciences

RD-18

Inflammatory Profile After Third Molar Extraction is Associated with Supplemental Opioid Use

Miguel A. De Leon1, Stacey A. Secreto1,2, Gaurav Gupta3, Steven Wang1,4, Neeraj Panchal1, Brian P. Ford1, John T. Ford5, Elliot V. Hersh1, Tilo Grosser6

Katherine N. Theken1

1University of Pennsylvania School of Dental Medicine, Department of Oral & Maxillofacial Surgery / Pharmacology, 2University of Pennsylvania School of Dental Medicine, Center for Clinical and Translational Research, 3University of Pennsylvania School of Dental Medicine, 4University of Pennsylvania Perelman School of Medicine, Department of Oral and Maxillofacial Surgery, 5University of Pennsylvania Perelman School of Medicine, 6Bielefeld University

RD-19

DEL-1 is a Novel Endogenous Senolytic Protein that Inhibits SenescenceAssociated Bone Loss

Jong-Hyung Lim

University of Pennsylvania School of Dental Medicine, Department of Basic and Translational Sciences

RD-20

Oral Microbiome Changes in Children Placed on a Ketogenic Diet

Amy S. Lin1, Lauren Yap1,2, Yuan Liu3, Evlambia Hajishengallis1,2

University of Pennsylvania School of Dental Medicine, Department of Clinical Pediatric Dentistry, 2Children’s Hospital of Philadelphia, Department of Pediatrics, 3Maurice H. Kornberg School of Dentistry at Temple University, Department of Oral Health Sciences

RD-21

Sublingual Caruncle Taste Buds drive Taste Perception and Salivary Reflexes

Jiaxin Liu1, Ranhui Xi1

Marco Tizzano1,2

University of Pennsylvania School of Dental Medicine, Department of Basic and Translational Sciences, 2University of Pennsylvania School of Dental Medicine, Center for Clinical and Translational Research

RD-22

The ECM-Cytoskeletal-Nuclear Axis Regulates Gingival Immune Homeostasis Through Stiffness-Dependent Nuclear Compaction and DNA Methylation

Hardikk Makkar1,2, Vinayak Vinayak3, Kang I I. Ko4,5, Rebecca G. Wells6,7, Vivek B. Shenoy3,7

Kyle H. Vining1,2,3

University of Pennsylvania School of Dental Medicine, Department of Preventive and Restorative Sciences, 2University of Pennsylvania School of Dental Medicine, Center for Innovation & Precision Dentistry, 3University of Pennsylvania School of Engineering and Applied Science, Department of Materials Science and Engineering, 4University of Pennsylvania School of Dental Medicine, Center for Clinical and Translational Research, 5University of Pennsylvania School of Dental Medicine, Department of Periodontics, 6University of Pennsylvania Perelman School of Medicine, Department of Gastroenterology, 7Center for Engineering Mechanobiology

RD-23

Potential Causes and Management of External Cervical Resorption in a Previously Endodontically Treated Tooth: A Case Report

Angélica Medina Montañez

Meeta Chawla

University of Pennsylvania School of Dental Medicine

RD-24

Biomechanical Assessment of ImplantSupported Prostheses in Fibula Free Flap

Jaw-in-a-Day Reconstruction Using Finite Element Analysis

Dina Mesmar1,2, Won Joo3, Brian M. Chang1,4,5,6

Nupur Patel1,2,7, Brian P. Ford4,8,9

1University of Pennsylvania School of Dental Medicine, Department of Preventive and Restorative Sciences, 2University of Pennsylvania School of Dental Medicine, Advanced Education Program in Prosthodontics, 3Robert Morris University, School of Engineering and Science Engineering, 4University of Pennsylvania School of Dental Medicine, Department of Oral & Maxillofacial Surgery / Pharmacology, 5Hospital of University of Pennsylvania, Maxillofacial Prosthodontics, 6Hospital of University of Pennsylvania, The Penn Center for Innovative & Personalized Oral Rehabilitation, 7University of Pennsylvania School of Dental Medicine, Department of Prosthodontics, 8Philadelphia VA Medical Center, 9Children’s Hospital of Philadelphia, Division of Plastic and Reconstructive Surgery

RD-25

The Upside Down and Restorations: Stranger Biofilms on HydroxyapatiteBased Tooth Models

Pratik Nag1, Hyejoo Kim1

Geelsu Hwang1,2,3

1University of Pennsylvania School of Dental Medicine, Department of Preventive and Restorative Sciences, 2University of Pennsylvania School of Dental Medicine, Center for Innovation & Precision Dentistry, 3University of Pennsylvania School of Dental Medicine, Center for Clinical and Translational Research

RD-26

Pain as Pathology and Prognosticator: Management in Oral and Maxillofacial Surgery

Richard Ni1, Monica Shen2

Brian P. Ford1,3,4

1University of Pennsylvania School of Dental Medicine, Department of Oral & Maxillofacial Surgery / Pharmacology, 2University of Pennsylvania School of Dental Medicine, 3Philadelphia VA Medical Center, 4Children’s Hospital of Philadelphia, Division of Plastic and Reconstructive Surgery

RD-27

Identifying Early Biomarkers Linking Periodontal Inflammation and Alzheimer’s Disease

Madison Orr1, Evelyn Santana2, Flavia R.F. Teles2,3,4

1University of Pennsylvania School of Dental Medicine, 2University of Pennsylvania School of Dental Medicine, Department of Basic and Translational Sciences, 3University of Pennsylvania School of Dental Medicine, Department of Periodontics, 4University of Pennsylvania School of Dental Medicine, Center for Innovation & Precision Dentistry

RD-28

Single-cell Spatial Transcriptomics

Unveil Pathologic Signatures of Inflamed Peri-Implant Free-Flaps

Kawintip Prasongyuenyong1, Brian Kim2, Neeraj Panchal3, Brian P. Ford3, Faizan Alawi4,5

Kang I I. Ko1,6

1University of Pennsylvania School of Dental Medicine, Department of Periodontics, 2University of Pennsylvania School of Dental Medicine, 3University of Pennsylvania School of Dental Medicine, Department of Oral & Maxillofacial Surgery / Pharmacology, 4University of Pennsylvania School of Dental Medicine, Department of Basic and Translational Sciences, 5University of Pennsylvania School of Dental Medicine, Department of Academic Affairs, 6University of Pennsylvania School of Dental Medicine, Center for Clinical and Translational Research

RD-29

Maladaptive Trained Immunity: A Novel Link Between Metabolic DysfunctionAssociated Steatohepatitis and Periodontal Bone Loss

Gundappa Saha1, Jonathan Korostoff2, Triantafyllos Chavakis3

George Hajishengallis1

University of Pennsylvania School of Dental Medicine, Department of Basic and Translational Sciences, 2University of Pennsylvania School of Dental Medicine, Department of Periodontics, 3Technische Universität Dresden, Institute for Clinical Chemistry and Laboratory Medicine, Faculty of Medicine

RD-30

Establishment of a Biorepository Based on a Longitudinal Study of Periodontitis Progression: PerioPredict Biobank (P2B)

Evelyn Santana1, Lynn Martin1,2

Flavia R.F. Teles1,2,3

University of Pennsylvania School of Dental Medicine, Department of Basic and Translational Sciences, 2University of Pennsylvania School of Dental Medicine, Center for Innovation & Precision Dentistry, 3University of Pennsylvania School of Dental Medicine, Department of Periodontics

RD-31

Longitudinal Effects of Simulated Dental Wear in Human Molars

Carinna Solano Vargas1, Diego Contreras2,3, Kristin L. Krueger4, Gavin Hale5, Lillian Befeler5

Myra F. Laird2,6

University of Pennsylvania School of Dental Medicine, 2University of Pennsylvania School of Dental Medicine, Department of Basic and Translational Sciences, 3McGill University, 4Loyola University Chicago, Department of Anthropology, 5Loyola University Chicago, 6University of Pennsylvania School of Dental Medicine, Center for Clinical and Translational Research

RD-32

ECM Stress Relaxation Drives Tumor Invasion and Immune Evasion Through YAP/TAZ and TGF-β Signaling

Fathmeh Tavakoli Joorabi1,2, Amanda S. Bluem2, Dayoon Chang3, Yu-Chang J. Chen1,2

Kyle H. Vining1,3,4

1University of Pennsylvania School of Engineering and Applied Science, Department of Materials Science and Engineering, 2University of Pennsylvania School of Engineering and Applied Science, Department of Bioengineering, 3University of Pennsylvania School of Dental Medicine, Department of Preventive and Restorative Sciences, 4University of Pennsylvania School of Dental Medicine, Center for Innovation & Precision Dentistry

RD-33

Precision Local Delivery of mRNA to Dental Pulp Utilizing Bisphosphonate Conjugated Ionizable Lipid

Jed Thussananutiyakul1,2,3, Jingyi Liu2,4,5, Ilchul Yoon2, Fatma Fenesha6, Gabriella Wandling6

Michael J. Mitchell4, Sarah B. Peters6, Kyle H. Vining2,5,7

1University of Pennsylvania School of Dental Medicine, Department of Orthodontics, 2University of Pennsylvania School of Dental Medicine, Department of Preventive and Restorative Sciences, 3University of Pennsylvania School of Dental Medicine, Center for Clinical and Translational Research, 4University of Pennsylvania School of Engineering and Applied Science, Department of Bioengineering, 5University of Pennsylvania School of Dental Medicine, Center for Innovation & Precision Dentistry, 6The Ohio State University, College of Dentistry, 7University of Pennsylvania School of Engineering and Applied Science, Department of Materials Science and Engineering

RD-34

Inter-Individual Variability in Ibuprofen

Analgesia is Associated with Neutrophil PGE2 Production Capacity

Heba Turkstani1, Miguel A. De Leon2, Berlinda Beauvais2,3, Naser Alkandari1,4, Stacey A. Secreto2,5, John B. Lankalis2, Steven Wang2, Brian P. Ford2, Joseph A. Foote2, Neeraj Panchal2, Elliot V. Hersh2

Katherine N. Theken2

1University of Pennsylvania School of Dental Medicine, Department of Oral Medicine, 2University of Pennsylvania School of Dental Medicine, Department of Oral & Maxillofacial Surgery / Pharmacology, 3University of Pennsylvania, 4Kuwait University Faculty of Dentistry, Department of Diagnostics, 5University of Pennsylvania School of Dental Medicine, Center for Clinical and Translational Research

RD-35

Hematopoietic Stem Cell Aging as a Driver of Inflammatory Bone Loss

Xudong Wang

George Hajishengallis

University of Pennsylvania School of Dental Medicine, Department of Basic and Translational Sciences

RD-36

Nanoarchitected Platforms for Targeted Enzyme Delivery Toward Cross-Kingdom

Biofilm Inhibition

Ilchul Yoon1, Hyejoo Kim1

Geelsu Hwang1,2,3

RD-37

Voluntary Physical Exercise Modulates Hematopoiesis and Attenuates Periodontitis

Ying Zhou

George Hajishengallis

University of Pennsylvania School of Dental Medicine, Department of Basic and Translational Sciences

STUDENT POSTERS

DMD STUDENT

RESEARCH HONORS

RD-38

Viscoelasticity of Surrounding Matrix Regulates Oral Cancer Spheroid Growth

Dayoon Chang1, Fathmeh Tavakoli Joorabi2,3, Yu-Chang J. Chen2,3, Amanda S. Bluem3

Kyle H. Vining1,2,4

University of Pennsylvania School of Dental Medicine, Department of Preventive and Restorative Sciences, 2University of Pennsylvania School of Engineering and Applied Science, Department of Materials Science and Engineering, 3University of Pennsylvania School of Engineering and Applied Science, Department of Bioengineering, 4University of Pennsylvania School of Dental Medicine, Center for Innovation & Precision Dentistry

RD-39

A Small Synthetic molecule Reduces Pro-Inflammatory Cytokines in a Ligature-Induced Periodontitis Model

Aleena S. Defreitas1, Taewan Kim2, Anuradha Dhingra3

Kathleen Boesze-Battaglia3

University of Pennsylvania School of Dental Medicine, 2University of Pennsylvania School of Dental Medicine, Department of Periodontics, 3University of Pennsylvania School of Dental Medicine, Department of Basic and Translational Sciences

RD-40

Antimicrobial Therapeutic Strategies

Targeting Carcinogenic Acetaldehyde Production by Polymicrobial Oral Cocultures in Oral Squamous Cell Carcinoma

Eliana (Nhi) Diep1, Serena C. Liu2

Daniell Henry2,3

RD-41

Acetaldehyde-Induced DNA Damage: The Oral Microbiome’s Carcinogenic Role

Yesul Kang1

Flavia R.F. Teles1,2,3, Evelyn Santana1

1University of Pennsylvania School of Dental Medicine, Department of Basic and Translational Sciences, 2University of Pennsylvania School of Dental Medicine, Department of Periodontics, 3University of Pennsylvania School of Dental Medicine, Center for Innovation & Precision Dentistry

RD-42

Compensatory E-Cadherin Remodeling Following Bacterial Challenge in the Oral Epithelium

Minyoung A. Kwon1,2, Yu Jung Heo3, Styliani Alimperti4,5

Dana T. Graves3,6,7

1University of Pennsylvania School of Dental Medicine, 2Children’s Hospital of Philadelphia, Craniofacial Orthodontics, 3University of Pennsylvania School of Dental Medicine, Department of Basic and Translational Sciences, 4University of Georgetown, Translational Medicine, 5Georgetown University, Biochemistry and Molecular & Cellular Biology Academic Department, 6University of Pennsylvania School of Dental Medicine, Department of Periodontics, 7University of Pennsylvania Perelman School of Medicine, The Penn Center for Musculoskeletal Disorders

RD-43

Optimization and Standardization of Human Peripheral Blood Mononuclear Cell (PBMC)–Derived Macrophage Culture for Reproducible Inflammatory Analyses

Yin-Chu (Ingrid) Lai1, Katherine Baek1, Miguel A. De Leon2, Berlinda Beauvais2,3, Stacey A. Secreto2,4, Katherine N. Theken2

1University of Pennsylvania School of Dental Medicine, 2University of Pennsylvania School of Dental Medicine, Department of Oral & Maxillofacial Surgery / Pharmacology, 3University of Pennsylvania, 4University of Pennsylvania School of Dental Medicine, Center for Clinical and Translational Research

RD-44

Targeted Delivery of STAT3-siRNA Using a Mineralized Tissue-Targeting Expression System (MiTEX) for Periodontal Disease Therapy

Yuantong (Rachel) Li1, Jingyi Liu1,2,3, Doris Chen1,4, Hardikk Makkar1,3, Yu-Chang J. Chen2,5, Jed Thussananutiyakul1,6,7, Shuchen Zhang1

Kyle H. Vining1,2,3,5

University of Pennsylvania School of Dental Medicine, Department of Preventive and Restorative Sciences, 2University of Pennsylvania School of Engineering and Applied Science, Department of Bioengineering, 3University of Pennsylvania School of Dental Medicine, Center for Innovation & Precision Dentistry, 4University of Pennsylvania School of Dental Medicine, Department of Periodontics, 5University of Pennsylvania School of Engineering and Applied Science, Department of Materials Science and Engineering, 6University of Pennsylvania School of Dental Medicine, Department of Orthodontics, 7University of Pennsylvania School of Dental Medicine, Center for Clinical and Translational Research

RD-45

Antimicrobial Peptide Suppression of Carcinogenic Acetaldehyde Production in OSCC Patients

Serena C. Liu1, Geetanjali Wakade2

Daniell Henry1,2

RD-46

Panoramic Radiographs for Bone Fragility Screening in PWH

Stephanie Moga1, Kevin Fan1, Praise Okoh-Aihe1, Adeyinka Dayo2, Mel Mupparapu2

Temitope T. Omolehinwa1,2

University of Pennsylvania School of Dental Medicine, Center for Clinical and Translational Research, 2University of Pennsylvania School of Dental Medicine, Department of Oral Medicine

RD-47

Progressive Partially Methylated Domain

Erosion and Targeted ZNF471 Silencing

Define Two Independent Epigenetic Programs in Oral Premalignancy

Michael E. Troka1

James C. Gates2

University of Pennsylvania School of Dental Medicine, 2University of Pennsylvania School of Dental Medicine, Department of Oral & Maxillofacial Surgery / Pharmacology

RD-48

Exploring Sex-Dimorphism in Periodontitis

Severity and Progression

Amy M. Wong1, Michael J. Kallan2

Flavia R.F. Teles3,4,5

University of Pennsylvania School of Dental Medicine, 2University of Pennsylvania Perelman School of Medicine, Center for Clinical Epidemiology and Biostatistics, 3University of Pennsylvania School of Dental Medicine, Department of Basic and Translational Sciences, 4University of Pennsylvania School of Dental Medicine, Department of Periodontics, 5University of Pennsylvania School of Dental Medicine, Center for Innovation & Precision Dentistry

DMD STUDENT

SUMMER RESEARCH

RD-49

Spatial Distribution of Streptococcus mutans and Candida albicans Biofilms on 3D-Printed Molar Models

Sachet Amin1

Pratik Nag2, Geelsu Hwang2,3,4

1University of Pennsylvania School of Dental Medicine, 2University of Pennsylvania School of Dental Medicine, Department of Preventive and Restorative Sciences, 3University of Pennsylvania School of Dental Medicine, Center for Innovation & Precision Dentistry, 4University of Pennsylvania School of Dental Medicine, Center for Clinical and Translational Research

RD-50

Quercetin Inhibits MRGPRX2-Mediated Mast Cell Activation; Implication for Periodontal Disease

Bahar Azadi1,2

1University of Pennsylvania School of Dental Medicine, Center for Innovation & Precision Dentistry, 2University of Pennsylvania School of Dental Medicine, Department of Basic and Translational Sciences

RD-51

Transforming Dental Restorations with Embedded BTO-AU Nanoparticles

Victoria Chan1, Ilchul Yoon2, Pratik Nag2

Geelsu Hwang2,3,4

1University of Pennsylvania School of Dental Medicine, 2University of Pennsylvania School of Dental Medicine, Department of Preventive and Restorative Sciences, 3University of Pennsylvania School of Dental Medicine, Center for Innovation & Precision Dentistry, 4University of Pennsylvania School of Dental Medicine, Center for Clinical and Translational Research

RD-52

Topical Delivery of mRNA Therapeutics to Dentin Using Lipid Nanoparticles

Jimmy Cheng1, Jed Thussananutiyakul2,3,4, Ilchul Yoon3, Michael J. Mitchell5

Kyle H. Vining3,6,7

University of Pennsylvania School of Dental Medicine, 2University of Pennsylvania School of Dental Medicine, Department of Orthodontics, 3University of Pennsylvania School of Dental Medicine, Department of Preventive and Restorative Sciences, 4University of Pennsylvania School of Dental Medicine, Center for Clinical and Translational Research, 5University of Pennsylvania School of Engineering and Applied Science, Department of Bioengineering, 6University of Pennsylvania School of Dental Medicine, Center for Innovation & Precision Dentistry, 7University of Pennsylvania School of Engineering and Applied Science, Department of Materials Science and Engineering

RD-53

The Role of YAP/TAZ in Bone Marrow Mesenchymal Stem Cells

Kaining (Kenny) Feng1

Chider Chen2

University of Pennsylvania School of Dental Medicine, 2University of Pennsylvania School of Dental Medicine, Department of Oral & Maxillofacial Surgery / Pharmacology

RD-54

Effect of Osteoarthritis on Peri-Implantitis

Edwin Lee

University of Pennsylvania School of Dental Medicine

RD-55

Application of Shikonin for Targeted Inhibition of OSCC Cell Viability and Related Tumor-Associated Macrophages

Zicong Li1

Qunzhou Zhang2, Ahn D. Le2

University of Pennsylvania School of Dental Medicine, 2University of Pennsylvania School of Dental Medicine, Department of Oral & Maxillofacial Surgery / Pharmacology

STUDENT POSTERS

RD-56

Reprogramming M2-like Tumor Associated Macrophages by TLR7/8 Agonists Towards M1-like Phenotypes in Oral Cancer

Christina Li

Qunzhou Zhang, Anh Le, Shihong Shi

University of Pennsylvania School of Dental Medicine, Department of Oral & Maxillofacial Surgery / Pharmacology

RD-57

Ferroptosis Drives Pro-Inflammatory Macrophage and Neutrophil Activation in Experimental Periodontitis and is Suppressed by UAMC-3203

Annabella Li1, William S. Kim2, Yeriel Yoon2

Kang I. Ko2

University of Pennsylvania School of Dental Medicine, 2University of Pennsylvania School of Dental Medicine, Department of Periodontics

RD-58

Antibiofilm Impact of Barium Titanate-Gold Nanoparticle Coating on Tooth Surfaces

Emily Luo1

Geelsu Hwang2,3,4

RD-59

Braces vs Clear Aligners: A Comparative Study on Surgical Morbidity in Orthognathic Surgery

Amanda Mavricos1, John Button1,2, Gina Chryssofos3

Brian P. Ford1,4,5

1University of Pennsylvania School of Dental Medicine, Department of Oral & Maxillofacial Surgery / Pharmacology, 2University of Pennsylvania School of Dental Medicine, Center for Integrative Global Oral Health, 3University of Pennsylvania School of Dental Medicine, 4Philadelphia VA Medical Center, 5Children’s Hospital of Philadelphia, Division of Plastic and Reconstructive Surgery

RD-60

MRGPRX2-Dependent Mast Cell Activation by Antimicrobial Polymers for Oral Immunity

Harsha Meduru

University of Pennsylvania School of Dental Medicine

RD-61

Natural Flavonoid Fisetin Mitigates Cellular Senescence in Gingival Epithelial Cells

Jeslyn Mei1, Jenna M. Fattore2, Samuel F. Suslavich3, Megi G. Hysa3,4,5, Xia-Juan Xia3, S Esra S. Sahingur3

1University of Pennsylvania School of Dental Medicine, 2University of Tampa, 3University of Pennsylvania School of Dental Medicine, Department of Periodontics, 4University of Pennsylvania School of Arts and Sciences, Department of Biology, 5University of Pennsylvania

RD-62

Effect of Immediate Implant Bone Augmentation of Post-Op Inflammatory Conditions

Sean Moran

University of Pennsylvania School of Dental Medicine

RD-63

Bite to Bolus: Understanding Food Particle Breakdown and Chewing Efficiency

Artie P. Nayak1, Amy M. Wong1, Stephanie L. Canington2, Taylor Rutigliano1, Geelsu Hwang2,3,4

Myra F. Laird2,5

University of Pennsylvania School of Dental Medicine, 2University of Pennsylvania School of Dental Medicine, Center for Clinical and Translational Research, 3University of Pennsylvania School of Dental Medicine, Department of Preventive and Restorative Sciences, 4University of Pennsylvania School of Dental Medicine, Center for Innovation & Precision Dentistry, 5University of Pennsylvania School of Dental Medicine, Department of Basic and Translational Sciences

RD-64

TSC’s Proliferative and Differentiation Properties for Tissue Regeneration

Gina J. Oh1

Chider Chen2

University of Pennsylvania School of Dental Medicine, 2University of Pennsylvania School of Dental Medicine, Department of Oral & Maxillofacial Surgery / Pharmacology

RD-65

Topography-Dependent Cross-Kingdom Biofilm Formation on Hydroxyapatite

Tooth Models

Rachel Park

University of Pennsylvania School of Dental Medicine

RD-66

Condylar Changes in Temporomandibular Joint Development in Mice Animal Models

Renali Patel1, Shilan Zhang2

Wenjing Yu3

RD-67

Microplastic Exposure as an Emerging Risk Factor for Cardiovascular Disease and Diabetes Mellitus

Parth Patel1

Hyeran Jeon2

University of Pennsylvania School of Dental Medicine, 2University of Pennsylvania School of Dental Medicine, Department of Orthodontics

RD-68

Utilization of Enzyme-Loaded Nanocarriers to Disrupt Oral Biofilms

Dhruvi Patel1

Geelsu Hwang2,3,4

RD-69

Flexural Strength of Compositional Gradient Multilayer Zirconia under High-Speed Sintering

Connor Riesenberger1, Longfei He2,3,4

Yu Zhang2,5

University of Pennsylvania School of Dental Medicine, 2University of Pennsylvania School of Dental Medicine, Department of Preventive and Restorative Sciences, 3Stomatological Hospital of Weifang People’s Hospital, Department of Pediatric Dentistry, 4Children’s Hospital of Philadelphia, Craniofacial Orthodontics, 5University of Pennsylvania School of Dental Medicine, Department of Basic and Translational Sciences

RD-70

Preoperative Psychological Predictors of Outpatient Pain Trajectory Post-ThirdMolar Extraction

Natalie H. Wang1, Emily F. Shekhtman1, Steven Wang2,3, Stacey A. Secreto3,4, Rania A. Habib3, Brian P. Ford3,5,6, Neeraj Panchal3, Elliot V. Hersh3

Katherine N. Theken3

1University of Pennsylvania School of Dental Medicine, 2University of Pennsylvania Perelman School of Medicine, Department of Oral and Maxillofacial Surgery, 3University of Pennsylvania School of Dental Medicine, Department of Oral & Maxillofacial Surgery / Pharmacology, 4University of Pennsylvania School of Dental Medicine, Center for Clinical and Translational Research, 5Philadelphia VA Medical Center, 6Children’s Hospital of Philadelphia, Division of Plastic and Reconstructive Surgery

RD-71

Mesenchymal Stem Cell Behaviors during Rapid Maxillary Expansion

Lia Wilmoth1

Wenjing Yu2

1University of Pennsylvania School of Dental Medicine, 2University of Pennsylvania School of Dental Medicine, Department of Orthodontics

RD-72

Osteoblast-specific FoxO1 Deficiency Mitigates T2DM-Induced Bone Loss

You (Grace) Wu1, Yang Yang2, Longyu Li2, Abdulaziz Hakeem2,3,4, Shuting Yang2

Dana T. Graves2,5,6, Shuying Yang2

1University of Pennsylvania School of Dental Medicine, 2University of Pennsylvania School of Dental Medicine, Department of Basic and Translational Sciences, 3Umm Al Qura University School of Dentistry, Department of Basic and Translation Science, 4University of Pennsylvania Perelman School of Medicine, Department of Orthopaedic Surgery, 5University of Pennsylvania School of Dental Medicine, Department of Periodontics, 6University of Pennsylvania Perelman School of Medicine, The Penn Center for Musculoskeletal Disorders

RD-73

Investigating the Impact of MechanoEducated Dendritic Cells on OSCC Response to Anti-PD1 Therapy

Shuchen Zhang1, Amanda S. Bluem2, Fathmeh Tavakoli Joorabi2,3, Kexin Zhang3

Yu-Chang J. Chen2,3, Kyle H. Vining1,2,3,4

STUDENT POSTERS

DMD STUDENT

OTHER RESEARCH

RD-74

Association Between Obstructive Sleep Apnea and Postoperative Opioid Utilization After Orthognathic Surgery: A Retrospective Cohort Study

Ryan A. Alt1, John Button2, Amanda Mavricos1

Brian P. Ford1,3,4

University of Pennsylvania School of Dental Medicine, Department of Oral & Maxillofacial Surgery / Pharmacology, 2University of Pennsylvania School of Dental Medicine, Center for Integrative Global Oral Health, 3Philadelphia VA Medical Center, 4Children’s Hospital of Philadelphia, Division of Plastic and Reconstructive Surgery

RD-75

Effect of Polishing Methods on Surface Roughness and Gloss of Additive Manufactured Restorative Materials

Helen Alvis1, Tariq Alsahafi2

Taiseer Sulaiman2

University of Pennsylvania School of Dental Medicine, 2University of North Carolina at Chapel Hill, Adams School of Dentistry, Department of Restorative Sciences

RD-76

Identifying Meaningful Potentially Modifiable Metabolic Abnormalities in Oral Cancer Patients

Gabriella N. Casiano, Dylan M. Crann

James C. Gates

University of Pennsylvania School of Dental Medicine, Department of Oral & Maxillofacial Surgery / Pharmacology

RD-77

Full Pulpotomy Versus Root Canal Treatment in Mature Permanent Teeth with Symptomatic Irreversible Pulpitis: A Systematic Review and Meta-Analysis

Seowon Chang

University of Pennsylvania School of Dental Medicine

RD-78

Individual Patient Solutions (IPS) Implants® Preprosthetic for Complex Dental Rehabilitation: An Alternative Treatment Modality

Dylan M. Crann1

Brian P. Ford1,2,3

1University of Pennsylvania School of Dental Medicine, Department of Oral & Maxillofacial Surgery / Pharmacology, 2Philadelphia VA Medical Center, 3Children’s Hospital of Philadelphia, Division of Plastic and Reconstructive Surgery

RD-79

Quantifying Epigenetic Aging Acceleration Among Individuals with and without HIV

Sonia Dalal1, Anil Kumar2, Peter Kavecky2, Yijing Su3, Temitope T. Omolehinwa2,3, Modupe O. Coker2,3,4

1University of Pennsylvania School of Dental Medicine, 2University of Pennsylvania School of Dental Medicine, Center for Clinical and Translational Research, 3University of Pennsylvania School of Dental Medicine, Department of Oral Medicine, 4University of Pennsylvania School of Dental Medicine, Department of Basic and Translational Sciences

RD-80

Microbial Community Patterns in Medication-Related Osteonecrosis of the Jaw: A Culture-Based Analysis

Taylor M. DeVine1, Ryan Elder1, Srighana Nadella2

Katherine N. Theken2, Neeraj Panchal2, Puhan He2

1University of Pennsylvania School of Dental Medicine, 2University of Pennsylvania School of Dental Medicine, Department of Oral & Maxillofacial Surgery / Pharmacology

RD-81

Relationship Between Adipokines and Opioid Use Following Third Molar Extraction

Nicole M. Farkouh1, Camille Jordan1,2, Stacey A. Secreto3,4, Steven Wang4,5, Rania A. Habib4, Brian P. Ford4, Neeraj Panchal4, Elliot V. Hersh4

Katherine N. Theken4

University of Pennsylvania School of Dental Medicine, 2University of Pennsylvania School of Arts and Sciences, Department of Biology, 3University of Pennsylvania School of Dental Medicine, Center for Clinical and Translational Research, 4University of Pennsylvania School of Dental Medicine, Department of Oral & Maxillofacial Surgery / Pharmacology, 5University of Pennsylvania Perelman School of Medicine, Department of Oral and Maxillofacial Surgery

RD-82

MOLAR Audit Study: Evaluating Access to Dental Care Across Public and Private Insurance

Sonia Gazula, Alyssia Liu, Heather Loo University of Pennsylvania School of Dental Medicine

RD-83

Variation in Fiber Type Phenotypes Across Development in the Chewing Muscles of Sapajus

Julia M. Gerstman1, Myra F. Laird2,3, Megan A. Holmes4

University of Pennsylvania School of Dental Medicine, 2University of Pennsylvania School of Dental Medicine, Center for Clinical and Translational Research, 3University of Pennsylvania School of Dental Medicine, Department of Basic and Translational Sciences, 4Duke University School of Medicine, Department of Family Medicine and Community Health

RD-84

Grinding Out the Details: How Wear Reshapes Tooth Morphology

Shahd L. Habeb1, Diego Contreras1,2, Tucker Sprayberry1, Stephanie L. Canington1, Kristin L. Krueger3

Myra F. Laird1,4

University of Pennsylvania School of Dental Medicine, Department of Basic and Translational Sciences, 2McGill University, 3Loyola University Chicago, Department of Anthropology, 4University of Pennsylvania School of Dental Medicine, Center for Clinical and Translational Research

RD-85

A Holistic Analysis of the Association Between Temporomandibular Disorders, Obstructive Sleep Apnea, and Psychosocial Conditions: A Review of Literature

Farraz Haider1, Issa Elabed2, Allison Lo2, Taylor M. DeVine2, Anna-Maria Haddad2, Rubba Al-Kafaji2, Mohammad Asfour2, Mutasem Al Jariri2, Hadi Bouali3

Stefania Brazzoli1

University of Pennsylvania School of Dental Medicine, Department of Oral Medicine, 2University of Pennsylvania School of Dental Medicine, 3University of Pennsylvania School of Dental Medicine, Department of Oral & Maxillofacial Surgery / Pharmacology

RD-86

Preoperative Orthodontic Measures of Overjet and Overbite as Predictors of Anesthesia Time, Operative Time, and Complications in Orthognathic Surgery

Matthew Halpert1,2, Jasmine Shokri1,2, John Button2,3, Amanda Mavricos2

Brian P. Ford2,4,5

University of Pennsylvania School of Dental Medicine, Department of Oral Medicine, 2University of Pennsylvania School of Dental Medicine, Department of Oral & Maxillofacial Surgery / Pharmacology, 3University of Pennsylvania School of Dental Medicine, Center for Integrative Global Oral Health, 4Philadelphia VA Medical Center, 5Children’s Hospital of Philadelphia, Division of Plastic and Reconstructive Surgery

RD-87

Detection and Control of Hydrogen Sulfide Produced by Oral CancerAssociated Bacteria

Korrie Han1, Serena C. Liu1

Daniell Henry1,2

1University of Pennsylvania School of Dental Medicine, Department of Basic and Translational Sciences, 2University of Pennsylvania School of Dental Medicine, Center for Clinical and Translational Research

RD-88

Impacts of Intimate Partner Violence on Head and Neck Health and Survivors’ Healthcare Experiences

Lauren A. Hogstrom1, Carolina Guillen1, Lilian Arce1, Maggie Junkin2

Katherine A. France3,4

1University of Pennsylvania School of Dental Medicine, 2Maurice H. Kornberg School of Dentistry at Temple University, 3University of Pennsylvania School of Dental Medicine, Department of Oral Medicine, 4University of Pennsylvania School of Dental Medicine, Care Center for Persons with Disabilities

RD-89

Targeting the STAT3 Signaling Pathway to Modulate Inflammation and Enhance Regenerative Potential in Dental Pulp Stem Cells

Seoyun Jang1, Shuchen Zhang2, BingLing Chen1,3,4

Kyle H. Vining2,5,6

1University of Pennsylvania School of Dental Medicine, 2University of Pennsylvania School of Dental Medicine, Department of Preventive and Restorative Sciences, 3University of Pennsylvania School of Arts and Sciences, Department of Biology, 4Children’s Hospital of Philadelphia, Craniofacial Orthodontics, 5University of Pennsylvania School of Dental Medicine, Center for Innovation & Precision Dentistry, 6University of Pennsylvania School of Engineering and Applied Science, Department of Materials Science and Engineering

RD-90

GIMAP6 is a Novel Regulator of Osteoblast-Mediated Bone Formation

John Kim1, Abdulaziz Hakeem1,2,3, Tarun Sama1, Shuting Yang1, Ken Chen1

Shuying Yang1

1University of Pennsylvania School of Dental Medicine, Department of Basic and Translational Sciences, 2Umm Al Qura University School of Dentistry, Department of Basic and Translation Science, 3University of Pennsylvania Perelman School of Medicine, Department of Orthopaedic Surgery

RD-91

From Accommodation to Standard of Care: Sensory-Adapted Dentistry to Improve Treatment Tolerance in Neurodiverse Young Adults with Autism Spectrum Disorder

Kimberlyn Ledesma, Anngella Orraiz Orraiz

University of Pennsylvania School of Dental Medicine

RD-92

Therapeutic Potential of Optimized GMSC-derived Secretomes on Temporomandibular Joint Osteoarthritis

Annabel S. Liao1, Uddhab Karki2, Shihong Shi2, Qunzhou Zhang2

Ahn D. Le2

University of Pennsylvania School of Dental Medicine, 2University of Pennsylvania School of Dental Medicine, Department of Oral & Maxillofacial Surgery / Pharmacology

RD-93

Evaluation of CYP2C9 Polymorphisms as Predictors of NSAID Response After Third Molar Extractions

Sydney Liu1

Katherine N. Theken2

University of Pennsylvania School of Dental Medicine, 2University of Pennsylvania School of Dental Medicine, Department of Oral & Maxillofacial Surgery / Pharmacology

STUDENT POSTERS

RD-94

Bonding Performance of a Universal Adhesive Resin Cementation System on Zirconia, Lithium Disilicate Glass-Ceramic, Enamel, and Dentin Surfaces

Allison Liu1, Asha Sunkara1, Adam Kadan1

Fusun Ozer1, Markus B. Blatz1,2

RD-95

Factors Influencing Access to Dental Care and Maintenance of Oral Health

Dylan N. Ohayon1, Joonhyeog Park2, Jaelyn Liu2, Xinyue Li2, Jinbo Niu2,3

Katherine A. France3,4, Tamara J. Cadet2,3

University of Pennsylvania School of Dental Medicine, 2University of Pennsylvania School of Social Policy and Practice, 3University of Pennsylvania School of Dental Medicine, Department of Oral Medicine, 4University of Pennsylvania School of Dental Medicine, Care Center for Persons with Disabilities

RD-96

Direct vs. Indirect Veneers on Demineralized Enamel: Material Selection, Adhesive Predictability, and Ethical Boundaries After Orthodontic Treatment. A Clinical Case

Anngella Orraiz Orraiz

University of Pennsylvania School of Dental Medicine

RD-97

Clinical Performance of Two Fluoride Releasing Resin Materials in Class I Posterior Restorations After 12 Years

Brittnie Pang1, Markus B. Blatz2,3, Oksana Yakymiv1 Fusun Ozer2

RD-98

The Interplay Between Neutrophils and Mid-Palatal Suture Mesenchymal Stem Cells (MSCs)

Ghazaal Parastooei1,2

Wenjing Yu3

1University of Pennsylvania School of Dental Medicine, 2University of Maryland School of Dentistry, Department of Neural and Pain Sciences, 3University of Pennsylvania School of Dental Medicine, Department of Orthodontics

RD-99

Cell Origins and Key Molecular Regulators of the Craniobase Skeletal Development

Christy Qian1

Chenshuang Li2, Chider Chen3

1University of Pennsylvania School of Dental Medicine, 2University of Pennsylvania School of Dental Medicine, Department of Orthodontics, 3University of Pennsylvania School of Dental Medicine, Department of Oral & Maxillofacial Surgery / Pharmacology

RD-100

Population-Level Harms of Systemic Oral Antibiotic use in the U.S. Dental Care Settings: Preliminary Findings of a Systematic Review

Andrian Radaios1, Matthias Wallach Weinstein, DDS2, Carla Massignan, DDS, MSc, PhD3

Francisca Verdugo-Paiva, DDS, MSc4, Alonso Carrasco-Labra, DDS, MSc, PhD4

1University of Pennsylvania School of Dental Medicine, 2Universidad del Desarrollo, Santiago, Chile, Departamento de Morfología, Facultad de Medicina, 3University of Illinois Chicago College of Dentistry, Chicago, IL, Clinical Associate Professor, Department of Pediatric Dentistry, 4University of Pennsylvania School of Dental Medicine, Center for Integrative Global Oral Health

RD-101

Variability in Occlusal Force Distribution During Instructed Biting Tasks

Taylor Rutigliano1, Artie P. Nayak1, Amy M. Wong1, Stephanie L. Canington2, Geelsu Hwang3,4,5

Myra F. Laird2,5

University of Pennsylvania School of Dental Medicine, 2University of Pennsylvania School of Dental Medicine, Department of Basic and Translational Sciences, 3University of Pennsylvania School of Dental Medicine, Department of Preventive and Restorative Sciences, 4University of Pennsylvania School of Dental Medicine, Center for Innovation & Precision Dentistry, 5University of Pennsylvania School of Dental Medicine, Center for Clinical and Translational Research

RD-102

Comparative Effects of Conventional and High-Speed Sintering on the Translucency of Compositional Gradient Multilayer Zirconia

Spencer J. Sattazahn1,2, Longfei He1,3,4

Yu Zhang1,5

University of Pennsylvania School of Dental Medicine, Department of Preventive and Restorative Sciences, 2Children’s Hospital of Philadelphia, Division of Plastic and Reconstructive Surgery, 3Stomatological Hospital of Weifang People’s Hospital, Department of Pediatric Dentistry, 4Children’s Hospital of Philadelphia, Craniofacial Orthodontics, 5University of Pennsylvania School of Dental Medicine, Department of Basic and Translational Sciences

RD-103

The Influence of Framework Material on Fit Accuracy of Complete Arch Implant Supported Prostheses Fabricated with Different Digital Impression Techniques

Emma S. Savitsky1, Sebastian Ollinger2

Markus B. Blatz2,3

RD-104

Gene-Specific Dental and Oral Manifestations of Epidermolysis Bullosa

Natalie Shah1,2, David Shon3, Marissa Perman4, Hannah Mumber4, Elizabeth Bhoj5

Kei Katsura1,6

Children’s Hospital of Philadelphia, Department of Pediatrics, 2University of Pennsylvania School of Dental Medicine, Department of Clinical Pediatric Dentistry, 3University of Pennsylvania School of Arts and Sciences, Department of Biology, 4University of Pennsylvania Perelman School of Medicine, Department of Dermatology, 5Children’s Hospital of Philadelphia, Division of Human Genetics, 6University of California, San Francisco

RD-105

Preoperative Airway Assessment in Orthognathic Surgery: Implications for Orthodontics

Jasmine Shokri1,2, Matthew Halpert1,2, John Button2,3, Amanda Mavricos2

Brian P. Ford2,4,5

RD-106

Matrix Stiffness Regulates the Morphology of Dental Pulp Stem Cells and their Immunomodulatory Functions

Heewon (Karen) Sohn1, Myung Jin (Jina) Lee1, Yu-Chang J. Chen2,3

Kyle H. Vining1,2,4

University of Pennsylvania School of Dental Medicine, Department of Preventive and Restorative Sciences, 2University of Pennsylvania School of Engineering and Applied Science, Department of Materials Science and Engineering, 3University of Pennsylvania School of Engineering and Applied Science, Department of Bioengineering, 4University of Pennsylvania School of Dental Medicine, Center for Innovation & Precision Dentistry

RD-107

Fisetin Targets Senescence Pathways to Suppress Periodontal Inflammaging

Samuel F. Suslavich1, Jenna M. Fattore2, Xia-Juan Xia1, S M Ziauddin3, Megi G. Hysa1,4,5

S Esra S. Sahingur1

1University of Pennsylvania School of Dental Medicine, Department of Periodontics, 2University of Tampa, 3Adams School of Dentistry, University of North Carolina at Chapel Hill, Department of Periodontology, Endodontics, and Dental Hygiene, 4University of Pennsylvania School of Arts and Sciences, Department of Biology, 5University of Pennsylvania

RD-108

A Digital Twin of the Extraction Socket: Predicting Patient-Specific Alveolar Ridge Resorption

William C. Tsai1, Akshaya N. Bhati2,3, Dayoon Chang4

Yu-Cheng Chang5, Rahul Mangharam2

1University of Pennsylvania School of Dental Medicine, 2University of Pennsylvania School of Engineering and Applied Science, Department of Electrical and Systems Engineering, 3University of Pennsylvania School of Veterinary Medicine, 4University of Pennsylvania School of Dental Medicine, Department of Preventive and Restorative Sciences, 5University of Pennsylvania School of Dental Medicine, Department of Periodontics

RD-109

Association between PTGS1 Polymorphisms and Opioid Use After Third Molar Extraction

Marvin Min Tun

Katherine N. Theken

University of Pennsylvania School of Dental Medicine, Department of Oral & Maxillofacial Surgery / Pharmacology

RD-110

Modeling Pulpitis Inflammation via TNF-α Activation of Peripheral Blood Monocytes

Suyoung Yun1, Kexin Zhang2, Yuchen Jiang1,2, Kyle H. Vining2,3,4,5

University of Pennsylvania School of Dental Medicine, 2University of Pennsylvania School of Engineering and Applied Science, Department of Materials Science and Engineering, 3University of Pennsylvania School of Engineering and Applied Science, Department of Bioengineering, 4University of Pennsylvania School of Dental Medicine, Department of Preventive and Restorative Sciences, 5University of Pennsylvania School of Dental Medicine, Center for Innovation & Precision Dentistry

Invest in discovery. Support Penn Dental Medicine research.

The Fund for Oral Health was established to provide critical support for research pilot funding, bridge funding for labs, facility and equipment enhancements, and other scholarly activities. Scan to donate today.