Effects of Naloxone:
PUBLISHED ON 07/12/24
A Post-OD Care Plan Created by the Support Service Staff of NEXT Distro Presto C and Noelle C PWUD=People Who Use Drugs; PWID=People Who Inject Drugs
We at NEXT Distro want to be able to use our experiences to inform and educate people whether they use drugs, know people who use drugs, or simply engage with drugs, and drug use on a societal level. We know firsthand, and secondhand from participant accounts, that being revived through naloxone, while lifesaving, is usually a very unpleasant experience for both the overdosed individuals and the individual who administers naloxone. Harm reduction organizations have been distributing the lifesaving drug to drug users and their acquaintances across the country. We believe there is not enough discussion around the effects of naloxone on overdosed individuals (especially at higher doses), and there’s a lack of resources available to address this issue.
What do we mean by that?
What people are told about administering naloxone is that the individual overdosing will be “angry”, “upset”, or “uncomfortable” for some time after naloxone administration. We believe these discussions have been disingenuous because they do not name specific side effects, the severity of those effects, and what could be done to improve the traumatic experience of overdose and its reversal. This leaves the individual who overdosed and anyone in the vicinity in a physically and emotionally vulnerable state that can turn traumatic very quickly if not handled appropriately. As a result of this analysis and understanding, we have developed this brief overdose preparedness resource in order to prepare our people for what may come, and to also inform anyone who wishes to gain a greater understanding of the topic at hand.
How does naloxone work? Naloxone is a medication approved by the FDA designed to rapidly reverse opioid overdose. It is an opioid antagonist— meaning that it binds to opioid receptors and can reverse and block the
effects of other opioids. Naloxone is a temporary treatment and can be administered intranasally, intramuscularly, subcutaneously (under the skin), or via intravenous injection. The reason it makes people feel sick is because when those receptors are bound to the naloxone and the effects of other opioids are blocked, the result is acute opioid withdrawal or precipitated withdrawal. Generally, the side effects can last anywhere from 40 to 90 minutes. In order to reduce the chances of precipitated withdrawal, we encourage individuals who use drugs or know PWUD/PWID to learn how to administer and use/carry intramuscular naloxone because you can determine the dosage for the individual much easier. Ideally, you want to use as little naloxone as possible, just enough to bind to the opioid receptors and allow the person who is overdosing to breathe again.
Mental and Physical Side Effects
Naloxone use can put opioid-dependent individuals into precipitated withdrawal. Precipitated withdrawal impacts individuals in a few different ways, including:
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Extreme body temperature dysregulation (extreme hot & extreme cold, one or the other, or simultaneously) Feverish chills/ Goosebumps (what is sometimes called “gooseneck” skin or “goose pimples). Muscle spasms, usually in the arms/ hands/legs Abdominal cramps
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Pupil dilation Uncontrollable bodily movements (restless legs, general restlessness) Extreme malaise Vomiting Yawning Teary eyes Diarrhea Runny nose Headaches Dehydration Anxiety General dysphoria
The pain and mental anguish associated with precipitated withdrawal as well as the overdose itself can be very traumatizing for the individual. Please always take care when discussing this with them and when discussing the event. Please do not disclose anyone’s history of overdose unless instructed otherwise by the affected person(s). Overdosing is