ARTHRITIS & OSTEOPOROSIS
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ND Pharma & Biotech is an European leader company in
Research + Development, that offers imagina:ve and advanced solu:ons to industrial sectors, professionals and technical varied areas within fields that gather from food and alimentary products, to human health, feed, animal and veterinary, biotechnology and discovery of novel chemical en::es and special molecules. Our impressive reference ́s porBolio comprehends actually over 160.000 products, ranging from classic products and raw materials to the most advanced prepara:ons and novel compounds. Our Brand products and formulated compounds act in a specific manner to any alleged problem planted by our clients and co-operators, as well as industry at large. We are constantly researching and growing to offer every day our best, in synchrony with our objec:ves as company, our mission, vision and overall, our values. As a global company, our commercial success is depending exclusively from our ability and the techno-scien:fic capacity to create innova:ve products and brands, making efforts to give such value and doing it accessible to a large amount of consumers and people within the sectors and fields where those products and innova:ons are needed and demanded. Our business strategy and growing plan is outlined by the constant challenge that actual business climate and environment imposed, that all we are suffering alongside planet. Despite this situa:on, we are growing and progressing within our strategy of sustainable business, making possible that our products and services became accessible worldwide and establishing new and promising associa:ons with first- line / high profile business companies to situate ourselves in the cuNng edge of research, innova:on and development, crea:ng consolidated brands that add value to our efforts and let us to share such efforts with our clients, implemen:ng it within their processes and opera:ons. These elements mixed in an efficient way, makes possible the implementa:on of the growing value chain around every product and service within the ascendant line that our business company traced from the very beginning of its ac:vity and the real origin of this small big family that ND Pharma & Biotech is finally. An impressive array of success and achievement valued actually in hundreds of million pounds/euros, as an ac:ve and dynamic porBolio that our scien:fic direc:on administers in conjunc:on with our IP property conforming the highest value within our company, with an impossible to calculate perspec:ve and horizon of development and future goals to reach. Because these and to many other reasons, our company promotes and establish :es and strategic associa:ons with exis:ng companies, most of them leaders within the markets, in order to set the common basis for advancement, progress and mutual prosperity and reciprocal coopera:on.
AMINO ACIDS
Amino acids are at the basis of all life processes, as they are absolutely essen:al for every metabolic process.
Among their most important tasks are the: op:mal transport and op:mal storage of all nutrients (i.e. water, fat, carbohydrates, proteins, minerals and vitamins). The majority of health issues such as obesity, highcholesterol levels, diabetes, insomnia, erec:le dysfunc:on or arthri:s can essen:ally be traced back to metabolic disturbances. This also applies to hair loss and serious cases of wrinkle forma:on.
This is why it is important to act sooner rather than later to ensure that the essen:al amino acids are available to the body in sufficient quan::es.
Unfortunately this cannot be guaranteed nowadays, due to the poor quality of our diet. This is why supplementa:on with amino acids is recommended.
On the following pages you can find a summary of various university studies on the posi:ve effects of amino acids on: • An:-aging • Arthri:s and osteoporosis • Cholesterol • Diabetes • Fat-burning • Healthy skin • Hair loss • Menopause • Sleep, mood and performance • Virility
ARTHRITIS & OSTEOPOROSIS
Amino acids and their significance for arthri:s and osteoporosis. Nutri:onal supplements can help with arthri:s Prof. Dr. Klaus Miehlke (†2009) was classed as the leading expert on bone diseases in Germany. In his wellcited publica:on of 2002 he wrote, “Despite the fact that bone diseases have been on the increase for decades, scien:fic research has been able to provide few innova:ons, as agen:on has been focused more on combaNng typical symptoms. The naturopathic perspec:ve on joint illnesses as a part phenomenon of a modified basic regula:on and matrix degenera:on can lead to significant advantages for those who later become pa:ents as well as for the community. This is because dietary measures taken in compliance with the newest findings from the matrix research can stabilize joint func:ons over the long term and prevent the abnormal produc:on of car:lage/matrix components. The medical recommenda:on regarding the intake of dietary supplements can certainly be jus:fied owing to pre-exis:ng preclinical and clinical inves:ga:ons as well as prac::oner’s personal experience with them.” Professor Miehlke summarizes by sta:ng that in cases of joint or car:lage diseases, it is impera:ve that the human body receives the car:lage-forming substances in sufficient quan::es. A healthy diet alone cannot provide this which is why scien:sts recommend taking nutri:onal supplements containing car:lage-forming substances. Methionine is an important car:lage-forming substance The amino acid methionine is among the car:lageforming substances. Methionine is an essen:al amino acid, meaning it cannot be produced by the body and must therefore be consumed in the diet. Methionine is known as an important organic sulphur donor
ARTHRITIS & OSTEOPOROSIS
Methionine is therefore of par:cular importance in three areas because it: • Contains an:-inflammatory proper:es • Has a pain-relieving effect and • S:mulates the car:lage cells to create more car:laginous :ssue. • Many tests have shown that methionine has this effect on arthri:s pa:ents and that it furthermore does so without causing any side-effects. Arginine supports the crea:on of bone
Osteoporosis belongs to the classic age-related illnesses which mainly women oken suffer from. This bone atrophy disease decreases the bone density by accelera:ng degrada:on of the bone substance. Sufferers have a significantly higher risk of breaking bones, which then affects the en:re skeleton. Vitality
The amino acid arginine is a crucial factor for bone crea:on as among other things, it supports the produc:on of collagen. Collagen is a protein which is the basic component of various connec:ve :ssues (such as car:lage) and bone. In this way, arginine supports growth of the osteoblasts where bone mass is formed.
An arginine deficiency can be the cause of osteoporosis, especially in the case of older women, as proven in a study from 20025. An Italian study from 20036 showed that arginine in combina:on with other amino acids supported the growth of osteoblasts and also encouraged division. Experts therefore recommend that the administra:on of amino acids belong to all osteoporosis treatments, par:cularly as arginine works against bone destroying cells.
Vitamins and minerals are also important
Besides amino acids, specific vitamins and minerals are also important for the joints. Vitamin C is involved in the endogenous synthesis of cor:sol. Cor:sol prevents inflammatory processes in the joints and plays a significant role in the regenera:on of car:lage substance.
ARTHRITIS & OSTEOPOROSIS
Vitamin B6 and magnesium are important joint nutrients as they provide effec:ve protec:on against free radicals. Free radicals are aggressive connectors which exist in many metabolic processes in the body. They agack joint car:lage and can therefore even speed up the breakdown process. This nega:ve influence of free radicals can be reduced by other radical scavengers such as vitamin c, selenium or zinc. The mineral calcium is a key building material for all bones. High-end suppliers of calcium are milk and dairy products such as cheese and yoghurt. Although it is rare to have a calcium deficiency, it is nevertheless important that the calcium obtained from the diet is put to op:mal use. Vitamin D is necessary for this purpose and in this case, the risk of deficiency is much higher.
Vitamin D is important for the u:liza:on of calcium
During the summer, daily exposure of just half an hour covers the demand for vitamin D. The sun’s rays and UV light are able to ac:vate precursors of vitamin D, i.e. the so-called pro vitamin D3. It is very important that the face and arms are not covered by clothes and that sun cream has not been used on the skin. However, in the winter the sun is not powerful enough to produce sufficient vitamin D, even in combina:on with the nutri:on obtained in the diet. It is therefore advisable to take vitamin D in tablet or capsule form as a nutri:onal supplement. It was ini:ally suggested that 5-10 µg per day was a sufficient daily dosage amount, but now it is assumed that in fact 15-20 µg per day is necessary for the human body. This is par:cularly important for older or dependent people, as the skin in these individuals can only produce pro vitamin D3 in small amounts. In addi:on, these people generally find it more difficult to process calcium in the kidneys and liver, which is why they have a par:cularly high demand for vitamin D. This was proven in a study from 2006 where par:cipants were administered vitamin D3 (Cholecalciferol) over a period of three years. The results showed that the possibility of a fall had decreased by up to 65 percent.
ARTHRITIS & OSTEOPOROSIS
1 Miehlke, K. & Inderst, R. (2002) Osteoarthrosen - Welche Möglichkeiten bietet die Ernährung zur Gesunderhaltung der Knorpel/ Knochenmatrix?, Erfahrungsheilkunde, Volume 12, (pp. 838-844) 2 Soeken, K.L., Lee, W.L., Bausell, R.B., Agelli, M. & Berman, B.M. (2002) Safety and efficacy of S-adenosylmethionine (SAMe) for osteoarthri:s, Journal of Family Prac:ce, Volume 51, (pp. 425-430) 3 Ursini, F. & Pipicelli, G. (2009) Nutri:onal Supplementa:on for Osteoarthri:s, Alterna:ve and Complementary Therapies, Volume 15, issue 4, (pp. 173-177) 4 Williams, J.Z., Abumrad, N. & Barbul, A. (2002) Effect of a Specialized Amino Acid Mixture on Human Collagen Deposi:on, Annals of Surgery, Volume 236, issue 3, (pp. 369–375) 5 Ammann, P., Laib, A., Bonjour, J.-P., Meyer, J. M., Rüegsegger, P. & Rizzoli, R. (2002) Dietary essen:al aminoacid supplements increase the bone strength by influencing bone mass & bone microarchitecture in an isocaloric low-protein diet, Journal of Bone and Mineral Research, Volume 17, issue 7, (pp.1264-1272) 6 Torricelli, P., Fini, M., Giavaresi, G., Giardino, R. (2003) Human Osteopenic Bone-Derived Osteoblasts: Essen:al Amino Acids Treatment Effects Ar:ficial Cells, Blood Subs:tutes and Biotechnology, Volume 31, issue 1, (pp. 35-46) 7 Visser, J.J. & Hoekman, K. (1994) Arginine supplementa:on in the preven:on and treatment of osteoporosis, Med Hypotheses, Volume 43, (pp. 339-342) 8 Kodama, M., Kodama, T., Murakami, M. & Kodama, M. (1994) Vitamin C infusion treatment enhances cor:sol produc:on of the adrenal via the pituitary ACTHroute, In vivo, Volume 8, (pp. 1079–1085) 9 Bischoff-Ferrari, H.A., Orav, E.J. & Dawson-Hughes, B. (2006) Effect of Cholecalciferol Plus Calcium on Falling in Ambulatory Older Men and Women -A 3-Year Randomized Controlled Trial Arch, Intern Med., Volume 166, (pp. 424-430)
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ND Pharma & Biotech is a biopharmaceutical company that discovers, develops and commercializes innovative products and therapeutics in areas of unmet medical, food, nutritional, agro, industrial and many other needs. The company mission is to advance the care of people suffering from certain diseases, worldwide and to make life better promoting green chemistry issues and removing certain chemical toxics from our daily lives. Company also acts as a chemical supplier and molecular provider including certain rare molecules and hard-to find compounds, API´s Intermediates, Reactives, etc. Headquartered in Surrey, England, UK, ND Pharma & Biotech Company has operations worldwide thru a network of commercial and industrial partners, both companies and/or corporations. PreserFood, Acarisin, Moldstop, Mycostop, Glaice, Lactolife, Acqualife, SterilFood, Fruitfresh, Kangen, Alkiow, Noopeptil, Nooglutil, Inofish, Zoeltar, Bacterskin, Bacterskin 5000, Pinolipol, Veri-K and Veri-K Series, X-Fresh, Acnifol, Glicospart, Mitoprotect, Citrusol, Inusol, Stevisol, Sucrasol, Acek. 250, PureATP, Aminoprot 100, Asparsol, EcoEff, Anisakill, Calclor, Ferristat, Chiknsafe, Cocqwa, Maltolan DRM, Monkí, Peppersol, Reduxalt, Vegafresh, Sugar 50, Sugar 20, Florafresh, FishFresh, Zelitem, Tancream, Psoriacrem, Ovofresh, Xantamar, Mohostop, PS454 Nitroboost, PS452 Glicoboost, M.A.R.S. (Micro Alcohol Reaction System) and many others, are registered trademarks of ND Pharma & Biotech Co. Ltd. And/or some of its related companies. Marks may not be available everywhere. For product information, territorial availability, terms and conditions and/or any other relevant information please visit us at www.ndpharmabiotech.com or alternatively write us an e-mail to: info@ndpharmabiotech.com, referencing and stating clearly the purpose of your communication.
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