Arch Immunol Ther Exp, 2005, 53, 364–368 PL ISSN 0004-069X
WWW.AITE–ONLINE .ORG Original Article
Received: 2004.11.17 Accepted: 2005.05.05 Published: 2005.08.15
Simultaneous transplantation of two allogeneic units of cord blood in an adult patient with acute myeloblastic leukemia. A case report
Authors’ Contribution: A Study Design B Data Collection C Statistical Analysis D Data Interpretation E Manuscript Preparation F Literature Search G Funds Collection
Wiesław Wiktor−Jędrzejczak1 ABDEFG , Małgorzata Rokicka1 BDE , Elżbieta Urbanowska1 BDE , Tigran Torosian1 B , Elżbieta Graczyk−Pol1 B , Agnieszka Tomaszewska1 B , Małgorzata Król1 B , Monika Paluszewska1 B , Anna Gronkowska1 B , Bogna Ziarkiewicz−Wróblewska1 B , Justyna Jółkowska2 B and Michał Witt2 B 1 2
Department of Hematology, Oncology, and Internal Diseases and Department of Pathology, Medical University of Warsaw, Warsaw, Poland Division of Molecular and Clinical Genetics, Institute of Human Genetics, Poznań, Poland
Source of support: by the State Committee for Scientific Research (KBN, Poland) grant No. PBZ−KBN−083/P05/2002.
Summary Introduction:
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The major obstacle to the therapeutic use of hematopoietic transplantation is the unavailability of matched, unrelated marrow donors for the large number of potential patients, although all of them have the chance to find sufficiently matched, unrelated cord blood units. However, the use of cord blood as a source of cells for transplantation is limited by its cell number, usually below 1 billion, which allows for routine transplantation only in children weighting less than 30 kg, while most potential recipients possess a higher body mass. This led to the idea of the simultaneous use of several units of cord blood which, combined, would fulfill the requirements for the necessary cell number for an adult recipient. We attempted to simultaneously transplant an adult patient with refractory acute myeloblastic leukemia utilizing two different cord blood units, one fully matched and one mismatched at one locus. The patient became reconstituted with only one unit, the mismatched, as determined using microsatellite markers, and had no signs of relapse of leukemia. Unfortunately, he died of persistent fungal (brain aspergilloma) infection on day +103. The successful engraftment may suggest that a method based on the principle of using more than one cord blood unit for transplantation is feasible in large adult patients and may reach routine application. placental blood • bone marrow transplantation • hematopoiesis
http://www.aite−online/pdf/vol_53/no_4/7747.pdf Dr. Wiesław Wiktor−Jędrzejczak, Department of Hematology, Oncology, and Internal Diseases, Medical University of Warsaw, Banacha 1a, 02−097 Warsaw, Poland, e−mail:wiktor@amwaw.edu.pl