TABLE OF CONTENTS
Abbreviations ...............................................................................................................................................
XVI
1. History of ocular tumor radiotherapy in Krakow – Bożena Romanowska-Dixon, Barbara Jakubowska ...................................................................................................................................
1
2. Genetic aspects of ocular tumours – Jakub Khzouz, Sarah E. Coupland ...................................
11
Introduction .................................................................................................................................................. Eyelid cancers ............................................................................................................................................... Basal cell carcinoma ............................................................................................................................ Sebaceous carcinoma ......................................................................................................................... Merkel cell carcinoma ......................................................................................................................... Conjunctival cancers .................................................................................................................................. Conjunctival squamous carcinoma and pre-invasive lesions .............................................. Conjunctival melanoma .................................................................................................................... Conjunctival lymphomas .................................................................................................................. Intraocular cancers ..................................................................................................................................... Medulloepithelioma ........................................................................................................................... Retinoblastoma ..................................................................................................................................... Uveal melanoma .................................................................................................................................. Vitreoretinal Lymphoma .................................................................................................................... Summary ........................................................................................................................................................
11 11 11 13 14 15 15 17 18 19 19 20 22 23 24
3. Immunology of ocular tumors – Martine J. Jager, Jinfeng Cao ....................................................
27
Introduction .................................................................................................................................................. Immune checkpoint inhibitors ............................................................................................................... Uveal melanoma: effect of checkpoint inhibitors ........................................................................... Other therapies ............................................................................................................................................ Presence of inflammation in UM ........................................................................................................... Phenotype-genotype comparisons ..................................................................................................... Comparison to other tumors .................................................................................................................. Conjunctival melanoma ............................................................................................................................ Side effects of treatment .......................................................................................................................... Conclusions ...................................................................................................................................................
27 27 28 29 29 29 30 31 32 32
4. Eyelid tumors – Joshua Ford, Bita Esmaeli ...........................................................................................
35
Introduction .................................................................................................................................................. Overview of eyelid malignancies .......................................................................................................... Basal cell carcinoma (BCC) ................................................................................................................
35 36 36
XI