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Example 1_Standard_Eng

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CHN

Example 1

Test Liposcale®

REPORT DATE

25/03/2025

Lipidic Contour

The Liposcale Test® is an advanced lipoprotein analysis based on Nuclear Magnetic Resonance (NMR) spectroscopy that directly measures lipid content and the number and size of lipoprotein particles. The Liposcale report is divided in two sections. The first section includes information on the traditional lipid panel, concentrations of large, intermediate, and small VLDL, LDL, and HDL particles, average sizes of VLDL, LDL and HDL particle, and well as the lipidic contour. The second section includes information on the extended lipoprotein panel -(including cholesterol and triglyceride content in VLDL, IDL, LDL and HDL particles)-, and patient clinical outcome.

Registro Mercantil de BARCELONA T 38980 , F 109, S 8, H B 65850, I/A 49(29.03.18) C.I.F. A-08222465

PARAMETER

RESULT³

Small LDL particles

LDL-C

LDL Cholesterol

LDL-TG

LDL Triglycerides

Rem C

Remnant cholesterol

VLDL-TG

VLDL Triglycerides

HDL-Ø

HDL particle size

M-HDL-P

Medium HDL particles

HDL-C

HDL Cholesterol

HDL-TG/HDL-C

Ratio of HDL Triglycerides/HDL Cholesterol

< 200

LDL-Ø

LDL particle size

< 100

Moderate/low CV risk

RECOMMENDED VALUE Cardiovascular risk

Lipidic profile¹ TOTAL CHOLESTEROL

S-LDL-P

Very high-risk

High-risk

257 mg/dL < 55

Moderate/low-risk

LDL CHOLESTEROL²

167 mg/dL

HDL CHOLESTEROL

68 mg/dL

> ♂40 ♀50

TRIGLYCERIDES

79 mg/dL

< 150

REMNANT CHOLESTEROL

22 mg/dL

< 30

NON-HDL CHOLESTEROL

189 mg/dL

< 85

< 70

4

< 100

< 130

Particle number (associated with cardiovascular risk) VLDL PARTICLES

31 nmol/L

< 70

LDL PARTICLES

1571 nmol/L

< 700

< 1000

< 1150

LDL PARTICLES (SMALL)

716 nmol/L

< 380

< 550

< 630

HDL PARTICLES

32 µmol/L

> 24

HDL PARTICLES (MEDIUM)

12.0 µmol/L

> 8.2

High CV risk Very high CV risk

What does the Lipidic Contour represent? The lipidic contour is a graphical model which allows a quick and comprehensive evaluation of a patient's lipoprotein metabolism beyond classical parameters. It combines the information from the 10 variables associated with cardiovascular (CV) risk, which are represented in colours: The variable contributes to increase CV risk. The area of the region delimited by the orange curve will decrease when the value is: > the recommended value for S-LDL-P, LDL-C, LDL-TG, Rem C, VLDL-TG and HDL-TG/HDL-C < the recommended value for HDL-Ø, M-HDL-P, HDL-C and LDL-Ø Opposite case. The variable is associated with lower CV risk.

Particle size (diameter) VLDL PARTICLES

42.24 nm

42.03 - 42.36

LDL PARTICLES

21.43 nm

> 20.91

HDL PARTICLES

8.3 nm

> 8.21

Patient outcome is similar to the recommended value. The orange contour represents a moderate/low-risk patient situation compared to the values of a general population of 6.000 individuals (black circle). Orange discontinuous contours represent both high and very high-risk patients (see legend).

¹All parameters have been determined by NMR spectroscopy. There may be variability when compared to other analytical methods. ²LDL cholesterol is calculated directly and does not include IDL cholesterol ³Traffic light colours above have been established for moderate/low-risk patients. 4

Risk categories were defined according to ESC/EAS Guidelines for the Management of Dyslipidaemias (2019). Laboratorios Rubió: Indústria, 29 - Pol. Ind. Comte de Sert 08755 Castellbisbal - Barcelona (España) - (+34) 937 722 509

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