International Research Journal of Engineering and Technology (IRJET)
e-ISSN: 2395-0056
Volume: 13 Issue: 01 | Jan 2026
p-ISSN: 2395-0072
www.irjet.net
GREEN SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL ACTIVITY OF COPPER OXIDE NANOPARTICLES USING VACCINIUM MACROCARPON FRUIT EXTRACT C.GAYATHRI1, S.TAMILMANI2, K.THARANI3, R.UMA4. 1, Assistant professor, Sri Vijay Vidyalaya college of Pharmacy, Nallampalli.
2,3,4, Students B. pharm , Sri Vijay Vidyalaya college of Pharmacy, Nallampalli.
-------------------------------------------------------------------------***----------------------------------------------------------------------------ABSTRACT- This study reports the green synthesis of copper oxide nanoparticles (CuO NPs) using Vaccinium macrocarpon fruit extract and evaluates their antimicrobial efficacy. Green synthesis represents a sustainable, eco-friendly, and non-toxic alternative to conventional chemical synthesis approaches. The synthesized CuO nanoparticles were characterized using UV–Visible spectroscopy, X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), and scanning electron microscopy coupled with energy-dispersive X-ray analysis (SEM–EDX). XRD analysis confirmed the monoclinic crystalline structure of the CuO nanoparticles, with an average particle size in the range of 37–43 nm. SEM images revealed predominantly cubic and flower-like morphologies. The antimicrobial activity of the biosynthesized CuO nanoparticles was assessed against selected bacterial strains (Vibrio cholerae, Klebsiella pneumoniae, Staphylococcus epidermidis, and Enterococcus faecalis) and fungal strains (Aspergillus niger, Candida albicans, Candida glabrata, and Aspergillus brasiliensis) using the agar well diffusion method. The green-synthesized CuO nanoparticles demonstrated notable antibacterial and antifungal activity, particularly against Klebsiella pneumoniae and Candida albicans.The findings indicate that Vaccinium macrocarpon-mediated CuO nanoparticles possess strong antimicrobial potential and may serve as effective alternatives for various biomedical applications. Keywords: Vaccinium macrocarpon, Copper oxide (CuO) nanoparticles, Antimicrobial activity, Calcination, UV–Visible spectroscopy.
INTRODUCTION: Cranberries (Vaccinium macrocarpon) are well known for theirVibrant colour , pleasant flavor , and high nutritional value.They are rich in natural compoundsSuch as phenolic acid, flavonoids,and tannins, which play an important role in promoting humanHealth. Cranberry – based products have been widely studied for their ability to prevent andManage urinary tract infections (UTIs).In addition to supporting urinary health,regularconsumption of cranberry and other polyphenol- rich foods as been associate with reduced risk of cardiovascular disease , diabetes, certain cancers, and inflammation.Cranberry extracts have alsoshown promising antibacterial, antiviral, antioxidant, and anti-inflammatory activities , making them valuable in medical and nutritional applications.
Fig. no.1 Cranberry fruit
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