International Research Journal of Engineering and Technology (IRJET)
e-ISSN: 2395-0056
Volume: 13 Issue: 01 | Jan 2026
p-ISSN: 2395-0072
www.irjet.net
FORMULATION AND EVALUATION OF WOUND HEALING CREAM IN CALOTROPIS GIGANTEA USING ANTI-MICROBIL ACTIVITY Dr. K.L. Senthilkumar1, R. Aakash2, A. Aarthi3, G. Abinaya4 1*, Principal, Sri Vijay Vidyalaya College of Pharmacy, Dharmapuri, Tamil Nadu (India) 2, 3, 4, B. Pharm, Students, Sri Vijay Vidyalaya College of Pharmacy, Dharmapuri, Tamil Nadu (India)
----------------------------------------------------------------------------***-------------------------------------------------------------------------ABSTRACT Herbal cosmetics have gained significant attention due to their natural composition and minimal side effects. Among these, herbal creams are widely used for skin care, offering both therapeutic and protective benefits. This study aimed to develop and evaluate a herbal cream incorporating leaves of Calotropis gigantea. The cream was formulated as an oil-in-water emulsion to ensure stability and ease of application on the skin. The formulation was evaluated for key physicochemical properties, including pH, spreadability, viscosity, and overall stability. Additionally, antimicrobial activity and skin irritation tests were conducted to assess the safety and therapeutic potential of the product. Topical application of the Calotropis gigantea cream in excision, incision, and dead space wound models resulted in enhanced wound contraction, increased wound breaking strength, and elevated hydroxyproline content, indicating improved collagen synthesis and accelerated tissue regeneration. The findings suggest that the formulated Calotropis gigantea cream possesses significant wound healing potential along with antimicrobial activity, making it a promising herbal preparation for skin care and wound management. KEY WORDS: Calotropis gigantea extract, shea butter, beeswax, cetostearyl alcohol, water, glycerine
INTRODUCTION Wound healing is a complex and dynamic physiological process that involves a coordinated series of cellular and biochemical events to restore the integrity of damaged tissues. This process occurs in distinct phases, including hemostasis, inflammation, proliferation, and remodeling. Impaired or delayed wound healing can result in chronic wounds, infections, and serious complications, highlighting the importance of effective wound management in healthcare. In recent years, there has been growing interest in herbal medicines for wound healing due to their natural origin, safety, costeffectiveness, and minimal side effects compared to conventional synthetic drugs. Medicinal plants have been traditionally used for treating wounds and skin disorders across various systems of medicine. Among them, Calotropis gigantea, commonly known as Crown Flower or Milkweed, is a widely distributed tropical and subtropical plant with a long history of use in Ayurveda and folk medicine. Different parts of the plant, including leaves, latex, roots, and flowers, exhibit significant therapeutic properties and have been traditionally employed for treating wounds, ulcers, inflammation, and skin infections. The wound healing potential of Calotropis gigantea is largely attributed to its diverse bioactive phytoconstituents, such as flavonoids, alkaloids, terpenoids, tannins, saponins, and glycosides. Its antimicrobial activity helps prevent wound infections, while its anti-inflammatory and analgesic properties reduce pain and swelling. These combined actions accelerate tissue repair, enhance collagen formation, and improve the quality of regenerated tissue. Therefore, the present study focuses on the formulation and evaluation of a herbal wound healing cream using Calotropis gigantea, aiming to develop a safe, effective, and affordable topical preparation for wound management.
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