International Research Journal of Engineering and Technology (IRJET)
e-ISSN: 2395-0056
Volume: 13 Issue: 02 | Feb 2026
p-ISSN: 2395-0072
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“SYNTHESIS OF AN HETEROCYCLIC COMPOUND 2- AMINO THIAZOLE” Dr. P.D. GOKULAN*1, Dr. K.L. SENTHIL KUMAR*2, M. ABIRAMI*3, M. ABISHEK*4, M. AKILA*5 1Professor, Sri Vijay Vidyalaya College of Pharmacy, Tamil Nadu, India. 2Principal, Sri Vijay Vidyalaya College of Pharmacy, Tamil Nadu, India. 3, 4, 5B. Pharm Students, Sri Vijay Vidyalaya College of Pharmacy, Tamil Nadu, India.
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ABSTRACT- Heterocyclic compounds are very important in pharmaceutical chemistry, and thiazole derivatives are the most
important of these. This dissertation presents a straightforward and dependable undergraduate methodology for synthesizing 2aminothiazole within a regulated laboratory environment. We closely monitored the product's formation, fine-tuned the most important reaction conditions, and then quickly isolated and purified it. We used IR spectroscopy and physical constants to find out what the compound we made was and how pure it was. This study concentrates on the practical aspects of synthesizing heterocycles and establishes a foundation for further research and development of thiazole-derived applications. This method is a simple, cheap, and reliable way to make 2-aminothiazole. This means that it can be used in both labs and factories. Key words: 2-Aminothiazole: Heterocyclic compound: Chemical synthesis: procedural method: IR Spectroscopy.
I. INTRODUCTION Thiazole is a heterocyclic compound that has both a nitrogen atom and a sulfur atom in an aromatic five-membered ring. Most of the time, 2-aminothiazole and its derivatives are made by reacting with α-halogenocarbonyl compounds. Thiazoles are a very important group of natural and man-made substances [1]. Thiazole derivatives have a lot of different biological effects, including being cardiotonic [2], fungicidal, sedative [3], anesthetic, bactericidal [4], and anti-inflammatory. Famotidine is a drug that is sold to treat peptic ulcers and gastroesophageal reflux. It has two thiazole nuclei. Thiazole derivatives are recognized for their significant antitumor and cytotoxic effects, with many derivatives engineered to target specific pathways. This thiazole compound is an example of one that has been tested in clinical trials and used to treat cancer [5]. Heterocyclic compounds are a big group of organic compounds in which one or more atoms in the ring are not carbon, like nitrogen, sulfur, or oxygen. These compounds are very important in organic and pharmaceutical chemistry because they have a lot of biological activities and are found in many natural and synthetic drugs. Thiazole and its derivatives are some of the most interesting heterocyclic systems because of their important chemical and pharmacological properties. Thiazole is a five-membered ring made up of sulfur and nitrogen atoms that are not the same type. Compounds with the thiazole nucleus have a wide range of biological effects, such as being antibacterial, antifungal, anti-inflammatory, and anticancer. 2-aminothiazole is one of these important derivatives. It is a useful intermediate in the making of many drugs and biologically active molecules. The Hantzsch thiazole method is the most common way to make 2-aminothiazole. It involves combining α-haloketones with thiourea in the right conditions. This method is preferred because it is easy to use, works well, and is good for making things in the lab. By changing the conditions of the reaction, you can get good yields and high purity of the product you want. This study concentrates on the synthesis of 2-aminothiazole employing a straightforward and effective undergraduate-level methodology. The focus is on optimizing reaction conditions, isolating and purifying the product, and characterizing the synthesized compound through physical properties and infrared spectroscopy. This work aims to provide practical exposure to heterocyclic synthesis while highlighting the importance of thiazole derivatives in pharmaceutical chemistry.
FIG 1: structure of 2-Amino thiazole
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