Nutramedic &Cosmetics
ABG10+ May Improve Blood Pressure Levels ®
Results of a new clinical study have confirmed the blood pressure balancing effect of Pharmactive Biotech Products, SLU’s ABG10+®. Aged Black Garlic (ABG10+®) has demonstrated the positive effect in blood pressure in patients exhibiting Grade-1 hypertension receiving prescribed drug treatment.
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ged Black Garlic is a whole raw garlic bulb (Al lium sativum L) that has been aged under con trolled temperatures for a certain period of time. Pharmactive’s proprietary ageing process po tentiates the accumulation of garlic’s bioactive com plex of antioxidant compounds, including polyphe nols, flavonoids, and melanoidins - particularly S-al lyl cysteine (SAC). The study, published in the research journal Nutri ents, was a randomized, triple-blind controlled trial conducted at the Hospital Universitari Arnau de Vi lanova (Lleida, Spain), and in collaboration with the Atherothrombotic Disease Detection and Treatment Unit (UDETMA). Led by Dr. José Carlos Serrano, Ph.D., the study involved 81 volunteers suffering from Sta ge 1 hypertension and who were already on blood pressure-reducing medication. Over a period of 12 weeks, the subjects received 250 mg of ABG10+ daily, which provided 0.25 mg of SAC, or a placebo. No changes were made to diet or lifestyle and the subjects were instructed to conti nue taking their blood pressure medication. Blood pressure measurements were recorded daily at ho me by the participants as well as at baseline and at the end of the study by specialists. The addition of ABG+ supplementation helped bet ter control blood pressure levels, with reductions ob served in both systolic and diastolic blood pressure of 1.8 mmHg and 1.5 mmHg, respectively. Moreover, it was observed via blood serum tests that ABG10+ supplementation may boost the relea se of nitric oxide and increase the body’s antioxidant capacity. ACE (angiotensin converting enzyme) acti vity seemed to be reduced, and lower blood uric acid levels also were observed. “These secondary parameters help us gain an un derstanding of the likely mechanism behind ABG10+’s effect on blood pressure,” explains Alberto Espinel, Open Innovation Director of Pharmactive. “Nitric ox ide is a natural vasorelaxant produced in the body to maintain cardiovascular function, improving blood pressure, and increasing blood flow. Nitric oxide also is a cellular antioxidant and thus helps mitigate oxi dative stress and its associated negative effects on blood vessels and the cardiovascular system. Reduc ing the angiotensin converting enzyme activity is a key strategy to decrease blood pressure in hypertensive patients.” The majority of the volunteers enrolled in the stu dy had a medical history of high blood pressure span
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ning 15 years on average. Despite adhering to their prescribed pharmacological routine, they were still unable to maintain blood pressure levels within a normal range. “This study suggests that incorporat ing food bioactives such as aged black garlic extract into the treatment regimen could serve as a valu able complement to conventional drug therapy, and could contribute to reduced cardiovascular risk,” Es pinel adds. “Such intervention could be especially beneficial for the management of arterial high blood pressure in persons experiencing resistance to drug therapy - all without inducing side effects.” Hypertension is a leading risk factor for cardio vascular disease, including stroke and heart failure. Research has demonstrated that even modest re ductions in blood pressure can lead to meaningful gains in the prevention of such incidents. For exam ple, a reduction of 2mm Hg in systolic blood pressure can reduce the risk of stroke by 10% in middle age. The new study followed favorable outcomes of a 2022 clinical trial involving ABG+, where participants with moderately elevated cholesterol levels achi eved significant reduction in diastolic blood pres sure (5.85 mmHg on average) compared to placebo. “As garlic ages, its fresh compounds like allicin and sulphur undergo chemical changes, forming new com pounds, including SAC and melanoidins,” explains Carlos Rodríguez, Communication Manager. “These compounds create the special flavor, aroma, and col or of aged black garlic which is why it is a culinary fa vorite of chefs. Yet these same bioactive compounds are believed to possess powerful antioxidant and support cardio health.” Pharmactive’s ABG10+ extract is derived from gar lic grown and cultivated in Castilla la Mancha, two hours away from the company’s facility in Madrid, and gently processed using green technology, with out the use of solvents, or chemicals. The ingredient can readily be incorporated into supplements as well as functional foods.
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