In the recent past, the pharmaceutical modification of drug molecules by complexation with biologically relevant
metals to improve their properties such as stability, dissolution rate, absorption and bioavailability has been extensively studied.
In order to achieve better and enhanced medicinal activity, vanadyl complexes of the widely used lincomycin (Lin-van) and
neomycin (Neo-van) have been synthesized and their physico-chemical properties examined. The UV-Vis absorption properties
of these complexes were determined and their antimicrobial activities were tested against some pathogenic organisms viz:
Proteus vulgaris, Klebsiella pneumonae, Escherichia coli and Staphylococcus aureus. In all cases, Neo-van showed better
antimicrobial activity than Lin-van while both complexes showed better activity than the antibiotic lincomycin and the previously
reported Cu-Lin.
