Pyrimidine derivatives are synthesized to possess various pharmacological and biological activities. In the present
work, we have synthesized 3-(4-methoxyphenyl)-1-phenyl prop-2-en-1-one (1) (chalcone) by using 4-methoxybenzaldehyde and
acetophenone in the presence of alcoholic KOH by Claisen-Schmidt condensation reaction. After purification and
characterization by physical and spectral methods, The synthesized chalcone have been converted into 6-(4-methoxyphenyl)-4-
phenyl-1,6-dihydropyrimidin-2-amine (2) by treating with guanidine nitrate in the presence of alcoholic KOH. The structure (2)
has been characterized by spectral analysis.
