The present article describes the synthesis of Imidazo[2,1-b][1,3,4]thiadiazoles bearing pharmacologically important
hydantoin molecules. To synthesize the targeted molecules several imidazothiadiazoles were prepared by condensation of 2-
Amino-5-(4-fluorobenzyl)-1,3,4thiadiazole with phenacyl bromides. Which were subsequently subjected to Knoevenagel
condensation to afford the hydantoin derivatives. Structures of newly synthesized molecules were confirmed by IR, NMR and
Mass spectral studies.