The plasma membrane redox system (PMRS) is an important component of the cell's ability to defend itself against
oxidative stress. Many immune signaling pathways are regulated through redox reactions. Biological systems utilize oxidationreduction reactions to modulate their responses to environmental cues. The role of redox molecules such as NO and ROS as key
mediators of immunity has recently gathered a lot of interest and attention. Beyond the chemical interactions of NO and ROS
that combine to eradicate pathogens, these redox small molecules are effective immune-modulators that regulate cellular
metabolism as well as multiple pro-inflammatory and repair/tissue-restoration pathways.
