Sickle cell disease is caused by Mutations in the HBB gene. Hemoglobin consists of four protein subunits, typically,
two subunits called alpha-globin and two subunits called beta-globin.
People with sickle cell anemia suffers with high morbidity and with many intercurrent infections, people of study district are with
high economic burden, terminate fatality in childhood state and have the emotional and psychological trauma including the
family members the exact magnitude of the problem in the study district is still obscure.
The study conducted from April 2009 to April 2012 to know the prevalence of sickle cell anemia by month long survey and by
visiting all PHC’S and RH of district and data collected to know the prevalence of sickle cell trait and sickle cell disease total
7763 cases were recorded in present study and age wise, gender wise and caste wise distribution recorded and the data was
analyzed statistically.
