International Journal for Research in Applied Science & Engineering Technology (IJRASET) ISSN: 2321-9653; IC Value: 45.98; SJ Impact Factor: 7.538 Volume 10 Issue VII July 2022- Available at www.ijraset.com III. RESULTS A. Lipinski/Pfizer rules Liquiritin was analysed for Lipinski/Pfizer rules and compared with dexamethasone, remdesivir, hydroxychloroquine and azithromycin (Table 1). A Plant derived drug liquiritin showed zero violation with nine hydrogen-bond acceptor; five hydrogenbond donors and molecular weight of 418.39 g/mol. Moreover, lipophilicity iLog PO/W was found to be 2.21, In dexamethasone, drug showed zero violation for Lipinski rules; it possessed six hydrogen-bond acceptor; three hydrogen-bond donors and molecular weight of 392.46 g/mol. The lipophilicity iLog PO/W was obtained as 2.29. While in remdesivir, druglikeness properties was observed with two violations wherein number of hydrogen bond acceptor was twelve and molecular weight of drug was 602.58 g/mol, lipophilicity iLogPO/W was obtained as 3.40. Similarly, in azithromycin druglikeness properties possessed two violations with fourteen hydrogen bond acceptor and molecular weight of 748.98 g/mol. In hydroxychloroquine, drug showed zero violation with three hydrogen-bond acceptor; two hydrogen-bond donors and molecular weight of 335.87 g/mol. Table 1. Pharmacokinetic study of Liquiritin, Dexomethasone, Remdesivir, Hydroxychloroquine and Azithromycin using Lipinski rules of five. Sr. Name of Compound Structure Molecular Lipinski rules of five No. formula Properties Values 1 Liquiritin C21H22O9 Molecular weight 418.4 (<500 g/mol) g/mol LogP (<5) 2.21 H-Bond donor (<5) 5 H-Bond acceptor 9 (<10) Violation 0 2 Dexamethasone C22H29FO9 Molecular weight 392.46 (<500 g/mol) g/mol LogP (<5) 2.29 H-Bond donor (<5) 3 H-Bond acceptor 6 (<10) Violation 0 3 4 Remdesivir Hydroxychloroquine C22H29FO9 C18H26CIN3O Molecular weight (<500 g/mol) LogP (<5) H-Bond donor (<5) H-Bond acceptor (<10) Violation 602.58 g/mol 3.40 4 12 Molecular weight (<500 g/mol) LogP (<5) H-Bond donor (<5) H-Bond acceptor (<10) Violation 335.9 g/mol 3.58 2 3 ©IJRASET: All Rights are Reserved | SJ Impact Factor 7.538 | ISRA Journal Impact Factor 7.894 | 2 0 3675

Liquiritin from Glycirrhyza Glabra L (Fabaceae) - A Natural Drug, as a Potent Inhibitor